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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

Oral Diseases

Intratumoral Administration of Recombinant Murine Interleukin‐12 Prevents Tumor Progression and Bone Invasion

Shun Kasahara, Miki Kashiwagi, Toshihiro Inubushi, Akinari Sugauchi, Wu Deyong, Kyoko Kurioka, Kazuaki Miyagawa, Takuma Matsuda, Soju Seki, Mikihiko Kogo, Susumu Tanaka, Toshihiro Uchihashi

ABSTRACT Objective Oral squamous cell carcinoma (OSCC) frequently invades the mandibular bone, leading to metastasis and poor prognosis. This study aimed to evaluate the therapeutic effects of locally administered interleukin‐12 (IL‐12) using an immunocompetent mouse model mimicking the clinical features of mandibular bone invasion. Methods The effects of IL‐12 on tumor growth and bone resorption were evaluated using subcutaneous and bone invasion models of OSCC in both immunocompetent and athymic mice. Bone resorp …

02.09.2026journal-article

Indian Journal of Palliative Care

Feasibility of Telemedicine for Cancer Pain Management: A Pragmatic Randomised Controlled Trial

Kusumkali Das, Gunaseelan Karunanithi, Mahalakshmy Thulasingam

Objectives: To evaluate the feasibility of implementing telemedicine for cancer pain management through assessment of patient adherence, quality of life, and satisfaction with palliative care. Materials and Methods: Longitudinal open-label randomised controlled trial (n = 170). Participants were randomised to standard care or standard care plus 4-week telemedicine intervention after baseline in-person assessment using Brief Pain Inventory (BPI) (pain), EQ-5D-5L (QoL) and medication details. All participants receive …

02.09.2026journal-article

Academy for Practical Oncology

Comparative analysis of immunohistochemical and molecular genetic typing of breast cancer based on rAM100 panel

A. G. Kudaybergenova, Yu. Yu. Andreeva, R. M. Paltuev, S. N. Aleksakhina, A. S. Artemyeva, E. A. Baychorov, S. Yu. Bakharev, A. A. Bozhok, V. A. Vasin, V. I. Vladimirov, O. A. Volynshchikova, A. Yu. Vorontsov, E. A. Gaysina, A. A. Gofman, E. N. Imyanitov, V. V. Klimenko, A. V. Komyakhov, M. M. Konstantinova, I. A. Koroleva, I. A. Lalak, D. L. Matevosyan, N. M. Mudzhiri, O. I. Sevryukova, V. F. Semiglazov, T. Yu. Semiglazova, M. M. Urezkova, L. A. Churilova, S. R. Abdullaeva, Yu. A. Belaya, V. N. Dmitriev, A. S. Chichkanova, M. V. Shomova

AIM : To assess the degree of concordance between the immunohistochemical (IHC) phenotype of breast cancer and the results of multigene mRNA expression analysis using the RAM100 panel with NanoString nCounter technology and to discuss the implications of discordance for IHC reference assessment. METHODS : The study included 84 cases of invasive breast cancer; all underwent IHC analysis using a standard panel (estrogen receptors (ER), progesterone receptors (PR), HER2 and the proliferative activity marker Ki-67) and …

02.09.2026journal-article

Current Oncology

Comparative Pharmacovigilance Analysis of Safety Signals Among Advanced Prostate Cancer Therapies Using FAERS (FDA Adverse Event Reporting System)

Zaid Ahmed, Rashid Sayyid, Omid Yazdanpanah, Ravand Samaeekia, Arash Rezazadeh Kalebasty, David I. Lee, Mohammed Shahait

Therapeutic options for advanced prostate cancer have expanded in recent years, incorporating multiple-system treatment approaches with differing mechanisms of action. However, comparative real-world safety data following drug approval remain limited. As such, the aim of this study is to characterize adverse events and disproportionate safety signals among advanced prostate cancer therapies using the FDA Adverse Event Reporting System (FAERS). A retrospective pharmacovigilance study of FAERS reports evaluated enzal …

02.09.2026journal-article

Problems of Gathering Treatment and Transportation of Oil and Oil Products

PHYSICAL AND MATHEMATICAL MODEL AND CALCULATION METHOD FOR TWO-PHASE FLOW OF A GAS-CONDENSATE MIXTURE IN A GATHERING PIPELINE SYSTEM

A.B. Shabarov, E.A. Padin, L.A. Puldas, M.A. Aleksandrov

This paper proposes a physical and mathematical model of two-phase gas condensate flow in a pipeline system. The presented model is characterized by a comprehensive description of hydraulic and thermal losses. An algorithm for numerically solving the system of the proposed model equations is described. The model was tested using a section of a gas gathering system (GGS) at a large gas condensate field. It is shown that the developed model has a high degree of convergence in terms of pressure and temperature drop ac …

02.09.2026journal-article

Journal of Chemical Technology and Metallurgy

STUDY OF WEAR RESISTANCE OF METAL ALLOY 100Cr6 AS A RESULT OF VARIOUS HEAT TREATMENT MODES

Boyan Yordanov, Iliyan Mitov, Todor Todorov, Rositsa Gavrilova

This study investigates the abrasive wear resistance of 100Cr6 (AISI 52100) bearing steel under three distinct heat treatment conditions: spheroidising annealing (as-delivered), normalising at 880°C, and oil quenching from 840°C followed by low-temperature tempering at 160°C. Cylindrical specimens were subjected to abrasive wear testing using a silicon carbide disc (P80 grit) under a constant load of 450 g over test durations of 25 and 60 min. Wear resistance was evaluated by the mass loss method, and microstructur …

02.09.2026journal-article

International Journal of Gynecological Pathology

POLD1 and Endometrial Cancer: Molecular Mechanisms, Genomic Pathology, and Emerging Therapeutics

Anas Houlal, Mousa Mobarki, Shaqraa Musawi, Michel Péoc’h, Georgia Karpathiou

Endometrial cancer (EC) is a major gynecologic malignancy whose classification and treatment paradigms are evolving because of molecular profiling. Mutations in DNA polymerases, particularly in DNA polymerase epsilon ( POLE ) and DNA polymerase delta 1 ( POLD1 ), have become central to a subset of ultramutated ECs with crucial clinical and prognostic effects. The molecular mechanisms of POLD1 dysfunction in EC, its clinical manifestations, emerging diagnostic challenges, and therapeutic opportunities are explored i …

02.09.2026journal-article

Advanced Healthcare Materials

A Modular Prussian Blue Nanozyme‐Based Microneedle Platform With Flexible Therapeutic Formulations for Localized Treatment of Traumatic Brain Injury

Xiang Wang, Ge Gao, Jinhua Li, Yilong Wang

ABSTRACT Secondary injury after traumatic brain injury (TBI) is characterized by excessive reactive oxygen species (ROS) production and persistent neuroinflammation, which remain difficult to control using a single therapeutic agent. Herein, a dissolvable microneedle platform based on Prussian blue (PB) nanoparticles was developed to locally deliver curcumin (Cur) or edaravone (EDA) into injured brain tissue through a transiently disrupted blood–brain barrier. The microneedles were fabricated from hyaluronic acid/c …

02.09.2026journal-article

Biomolecules

MACC1 Hyperactivates Receptor Tyrosine Kinase Signaling Through Phosphorylation-Dependent Adaptor Activity in Colorectal Cancer Cells

Fabian Zincke, Dennis Kobelt, Susan Kläger, Fiona Pachl, Gerrit Erdmann, Mathias Dahlmann, Wolfgang Walther, Bernhard Küster, Ulrike Stein

Understanding the mechanisms of metastasis is one of the most pressing issues in cancer therapy. Metastasis-associated in colon cancer 1 (MACC1) is an important biomarker and functional driver of tumor progression and metastasis. However, the molecular mechanisms underlying its activity remain incompletely understood. Here, we demonstrate that MACC1 acts as an important adaptor protein that promotes hyperactivation of receptor tyrosine kinase (RTK) signaling pathways in colorectal cancer (CRC) cells. Based on mass …

02.09.2026journal-article

Children

Talk to Me, Not Just My Parent: Teen and Caregiver Perspectives on Implementing Screening, Brief Intervention, and Referral to Treatment Equitably in Pediatric Inpatient Settings for Teens with Chronic Illness

Faith Summersett Williams, Sarah Welch, Ella Kuffour, Emily Lynott, Sheridan Grettenberger, Kennedy Curtis, Yiyang Liu, Ruth Debono, Maria H. Rahmandar, Sara Becker

Background/Objectives: While screening, brief intervention, and referral to treatment (SBIRT) is a widely recommended evidence-based approach for early detection and intervention for alcohol and other drug (AOD) use, limited guidance exists for implementing SBIRT among hospitalized adolescents with chronic medical conditions (A-CMCs). This exploratory qualitative study examined A-CMC and caregiver perspectives on factors that may shape the acceptability, feasibility, and equitable implementation of a proposed inpat …

02.09.2026journal-article

Toxins

Dystonia 3×3: A Training Guideline for Beginners in Botulinum Neurotoxin Treatment of Cervical Dystonia

Sebastian Paus, Andreas Funke, Jürgen Hamacher, Bernhard Haslinger, Jan Heckelmann, Chi Wang Ip, Wolfgang H. Jost, Anatol Kivi, Stephan Klebe, John-Ih Lee, Ebba Lohmann, Frederic Mack, Axel Schramm, Andrea Stenner, Pawel Tacik, Uwe Walter, David T. Weise

Cervical dystonia (CD) is a hyperkinetic movement disorder characterized by involuntary muscle contractions leading to abnormal postures of the head and neck. The injection of botulinum neurotoxin type A (BoNT-A) into the muscles involved is the treatment of choice for CD. BoNT-A therapy of CD requires appropriate training, which has not been standardized in Germany. To address the key challenges in BoNT-A education, an expert panel developed a simplified step-by-step treatment guideline for beginners, adapted from …

02.09.2026journal-article

Cancer Immunology Research

Elevated CHAF1A Suppresses Type I Interferon Production and Causes Immunotherapy Resistance in Esophageal Squamous Cell Carcinoma

Yue Ma, Mengde Shi, Ming Ma, Siru Li, Nana Cui, Yingjue Li, Tianjiao Dang, Rui Yang, Yang Bai, Bojun Wang, Chunhui Zhang, Chao Liu, Yanqiao Zhang

Abstract In esophageal squamous cell carcinoma (ESCC), chemoradiotherapy potentiates the effects of immune checkpoint inhibitors by activating the tumor-intrinsic innate immune response. However, ESCC cells frequently suppress this activation, which contributes to the high rates of immunotherapy resistance (70%–80%) observed clinically. Thus, identifying intracellular suppressors of this innate immune response remains an unmet critical need. Herein, through multiomics analyses, we identify the chromatin assembly fa …

02.09.2026journal-article

Journal of Biomedical Optics

Single-fiber reflectance spectroscopy system using unmodified clinical laser fibers for tissue optical property recovery for photodynamic therapy treatment planning

Timothy M. Baran

SignificanceEstimation of tissue optical properties in workflow- and resource-constrained clinical settings is required to support photodynamic therapy (PDT) treatment planning, yet large-scale clinical translation remains limited by spectroscopy probe cost, complexity, and the need for probe-specific inverse models. Single-fiber reflectance (SFR) spectroscopy offers a simple and low-cost option, but previous implementations relied on customized angle-polished fibers.AimThe objective was to develop a proof-of-conce …

02.09.2026journal-article

Problems of Gathering Treatment and Transportation of Oil and Oil Products

APPLICATION OF HIGH-FREQUENCY CAPACITIVE PLASMA OF LOW PRESSURE TO INCREASE THE EFFICIENCY OF SEPARATION OF OIL-WATER EMULSIONS BY POLYMER MEMBRANES

V.O. Dryakhlov

In recent decades, the use of polymer membranes has attracted considerable interest due to their high performance and energy efficiency. However, the main limitation to the widespread adoption of such membranes is their susceptibility to oiling and subsequent contamination by petroleum components. To address this issue, surface modification methods are being actively developed, and one of the most promising approaches is environmentally friendly treatment with low-pressure high-frequency plasma. This treatment allo …

02.09.2026journal-article

Biomedical Materials

Research progress and future trends in advanced biomaterials for the treatment of liver fibrosis

Benteng Li, Ruisi Zhu, Yonggang Lv, Guobao Chen

Abstract Liver fibrosis is a hallmark pathological feature of chronic liver diseases and poses a major threat to the health of millions of people worldwide. Without timely diagnosis and effective intervention, liver fibrosis can progress to cirrhosis, liver failure, and even hepatocellular carcinoma (HCC). The limited availability of donor organs for orthotopic liver transplantation has driven the continuous search for alternative therapeutic strategies. However, conventional approaches, including pharmacotherapy, …

02.09.2026journal-article

Academy for Practical Oncology

The significance of power doppler imaging and ultrasound tomography for the early diagnosis of endometrial and ovarian cancer

S. V. Ivashina, L. A. Ashrafyan, N. A. Babaeva, O. I. Aleshikova

AIM : To evaluate the possibilities of energy Doppler ultrasonography and ultrasound tomography in the early diagnosis of endometrial cancer and ovarian cancer. To evaluate the intraendometrial blood flow of endometrial polyps and endometrial cancer, as well as the intraovarian blood flow of benign and malignant ovarian tumors using high-tech ultrasound methods Introduction: Early diagnosis of endometrial cancer and ovarian cancer continues to be a complex and relevant problem. The use of energy Doppler ultrasonogr …

01.09.2026journal-article

Journal of the American Veterinary Medical Association

American Association of Veterinary Parasitologists Hookworm Task Force review on best practices for diagnosis and treatment of multidrug-resistant hookworms

Ray M. Kaplan, Pablo D. Jimenez Castro, Antoinette E. Marsh, Jeba R. J. Jesudoss Chelladurai, John S. Gilleard

Abstract Ancylostoma caninum , the canine hookworm, is the most common and clinically important gastrointestinal nematode parasite infecting dogs in the US. Common clinical signs associated with acute infections include anemia, melena, hematochezia, dehydration, and poor weight gain or weight loss. In the past few years, multiple anthelmintic drug resistance to fenbendazole, moxidectin, and pyrantel pamoate has been documented in A caninum in the US, and cases of drug-resistant canine hookworms are increasingly bei …

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01.09.2026journal-article

Pediatrics in Review

Beyond Survival: Outpatient Treatment for Functional Recovery After Brain Injury

Emily Kivlehan, Uchenna Ewulonu Pelzer, Sophie Leib, Brian D. Wishart

Abstract Acquired brain injuries (ABIs), including hypoxic-ischemic and traumatic injuries, are leading causes of long-term disability in children. While acute treatment has advanced, many survivors face persistent cognitive, emotional, and physical challenges that require coordinated outpatient care. This review aims to equip pediatric providers with the knowledge and tools necessary to provide longitudinal, comprehensive, and family-centered outpatient care for children recovering from ABIs. This review begins wi …

01.09.2026journal-article

Journal of Korean Neurosurgical Society

Treatment of Brain Abscess in Patient with Eisenmenger Syndrome

Su Jeong Sung, Dae Lim Koo, Songyi Park, Dong Hoon Shin, Haechan Cho, You Jung Ok, Jin-Young Hwang, Hack-Lyoung Kim, Yoon Hwan Byun

Eisenmenger syndrome (ES) is a complex multisystem disorder caused by untreated congenital heart disease. Management of brain abscess in ES is challenging, as treatment decisions must balance infection control with altered cardiopulmonary physiology, necessitating a multidisciplinary approach. We present a case of a 45-year-old male with ES and symptomatic brain abscess treated successfully with abscess aspiration under monitored anesthesia care and appropriate antibiotic therapy. We share our experience, outline k …

01.09.2026journal-article

S.S. Korsakov Journal of Neurology and Psychiatry

Ketogenic diet in the treatment of drug-resistant epilepsy in children: Assessment of clinical efficacy, health care resource consumption, and direct medical costs

E.G. Lukyanova, A.G. Tolkushin, S.O. Ayvazyan, K.V. Osipova, E.A. Pyrieva, A.I. Krapivkin, V.A. Zhestkov

Objective. To evaluate the impact of the ketogenic diet (KD) on clinical outcomes, health resource consumption, including medication burden, hospitalization rates, and outpatient care, and direct medical costs (DMCs) in pediatric patients with drug-resistant epilepsy (DRE). Material and methods. A retrospective, non-interventional observational study was conducted at a specialized medical center. Data were collected from 58 children diagnosed with DRE: 29 patients received the ketogenic diet, while 29 patients comp …

01.09.2026journal-article

CVIR Oncology

Percutaneous CT-guided cryoablation of desmoid tumors: single-center experience with volumetric midterm outcome

Moritz Schaaf, Tim Sattler, Johann Spatz, Stefanie Surwald, Julian Schraut, Tobias F. Jakobs

Abstract Purpose Desmoid tumors are rare mesenchymal neoplasms with a propensity for local recurrence and significant morbidity. Percutaneous cryoablation has emerged as a promising treatment option, yet data on volumetric outcomes remain limited. This small study evaluated the safety and preliminary efficacy of percutaneous CT-guided cryoablation of desmoid tumors with systematic volumetric assessment of tumor volume. Materials and methods A retrospective single-center analysis was performed on 13 consecutive pati …

01.09.2026journal-article

Cancer Medicine

Eosinophil Proportion May Serve as a Candidate Biomarker for Adverse Events in Patients With Urothelial Carcinoma Treated With Enfortumab Vedotin

Kunihiro Odagiri, Toshiharu Morikawa, Taku Naiki, Yosuke Sugiyama, Yoshihiko Tasaki, Yoshihisa Mimura, Aya Naiki‐Ito, Takashi Nagai, Toshiki Etani, Keitaro Iida, Daiki Ishikawa, Yusuke Noda, Nobuhiko Shimizu, Maria Aoki, Masakazu Gonda, Rika Banno, Hiroki Kubota, Ryosuke Ando, Yukihiro Umemoto, Noriyasu Kawai, Yoko Furukawa‐Hibi, Takahiro Yasui

ABSTRACT Enfortumab vedotin (EV) is a crucial treatment for patients with metastatic urothelial carcinoma (mUC). However, a significant proportion of patients experience adverse events (AEs). The identification of biomarkers for AEs is imperative for the detection and treatment of AEs at an early stage. In this exploratory study, we aimed to identify biomarkers of AEs in patients with mUC treated with EV. We retrospectively examined 10 factors identified from the data of 116 patients with mUC treated with EV to ide …

01.09.2026journal-article

Journal of Obstetrics and Gynaecology Research

DNA Methylation Testing in Cervical Cancer: A Triage Tool for HPV ‐Based Screening and Post‐Treatment Surveillance

Yuance Xu, Xiaoting Zhou, Lina Guo, Rongjun Lyu

ABSTRACT Background High‐risk HPV screening achieves high sensitivity but low specificity, resulting in excessive colposcopy referrals. DNA methylation biomarkers could refine risk stratification across the cervical cancer care continuum. Objective To evaluate the diagnostic performance and clinical implementation of DNA methylation testing in HPV‐positive triage and post‐treatment surveillance. Methods Narrative review of prospective cohorts and randomized trials (2013–2024) evaluating methylation markers in cervi …

01.09.2026journal-article

International Journal of Health Management Review

SURGICAL AND ORTHODONTIC TREATMENT OF TEMPOROMANDIBULAR JOINT ANKYLOSIS

Giacomo Gobbo Trojan, Pamela Rufina Stefanello Wideck, Isabella Rayane de Souza Torres, Lívia Numeriano de Sá Gomes Vilarim, Victoria Carminatti Silveira, Rene Rodrigues Vieira, Maria Eduarda Cardoso Malheiros de Sena, Rebeca Pires de Castro, Laís Gomes do Nascimento

Temporomandibular joint (TMJ) ankylosis is characterized by the bony, fibrous, or fibro-osseous fusion of articular surfaces, resulting in severe limitation of mouth opening and compromising masticatory and phonatory functions, as well as oral hygiene. When it manifests during childhood or persists for extended periods, it can lead to craniofacial developmental disorders, such as facial asymmetry, micrognathia, retrognathism, and malocclusions. This study aimed to analyze the main surgical and orthodontic approache …