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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Clinical Research in Cardiology

Routine versus selective use of a femoral protection wire in transfemoral TAVI: a single-centre analysis of vascular complications

Marc Adrian Rogmann, Victor Klingemann, Max Meertens, Majid Ahoopai, Karl-Philipp Rommel, Philipp Lurz, Ralph S. von Bardeleben, Martin Geyer

Abstract Background Transfemoral transcatheter aortic valve implantation (TAVI) is the treatment of choice for severe aortic stenosis in patients with elevated surgical risk. However, vascular complications remain a major source of morbidity and mortality. The protection wire technique was introduced to prevent major access-related complications, but its role in contemporary TAVI practice is uncertain. Aims To evaluate whether routine protection wire use reduces vascular complications in contemporary transfemoral T …

03.09.2026journal-article

The Economic and Labour Relations Review

When work hurts: The health consequences of job stress and part-time work among a longitudinal sample of older European workers

Sabela Siaba, Berta Rivera, Luis Currais

Abstract In the context of population ageing and extended working lives, understanding how employment quality affects older workers’ health is of growing policy relevance. Although previous research has linked working conditions to health, significant gaps remain in panel designs, unobserved heterogeneity, measurement validity, and sample representativeness. Using longitudinal microdata from the Survey of Health, Ageing, and Retirement in Europe (SHARE), we estimate individual fixed-effects models over a 12-year pe …

03.09.2026journal-article

Frontiers in Public Health

Explainable ensemble transfer learning for skin lesion classification with multi-method explainability validation

Nemili Sravani, Srinivas Koppu

Introduction Skin cancer is among the most prevalent and life-threatening malignancies worldwide. Early and accurate detection significantly improves therapeutic outcomes. Automated classification of dermoscopic skin lesions remains challenging due to class imbalance, inter-class visual similarity, and lack of interpretable predictions. This study proposes an accurate and interpretable weighted soft voting ensemble for multi-class skin lesion classification. Methods A weighted soft voting ensemble of three heteroge …

03.09.2026journal-article

Frontiers in Immunology

Clinical remission trajectories and histopathological associations in patients with IgA nephropathy treated with targeted-release budesonide: a real-world cohort study

Dafeng He, Jun Xu, Bo Gao, Mingzhu Jiang, Wenjin Liu, Chuanyan Zhao, Xinrui Li, Chunlei Lu, Mengyue Zhu, Hongbin Mou, Guangyu Bi

Background Targeted-release (TR) budesonide provides upstream mucosal immunomodulation in IgA nephropathy (IgAN) by targeting the gut-associated lymphoid tissue. However, the extent to which distinct downstream immune-inflammatory phenotypes and established structural chronicity shape real-world remission trajectories remains insufficiently characterized. Methods We retrospectively analyzed 57 adults with biopsy-proven primary IgAN treated with TR-budesonide. Prespecified milestones were Very Early Response (VER) a …

03.09.2026journal-article

Experimental & Molecular Medicine

Proteomic analysis of pancreatic endocrine cells by mechanistic single-cell isolation identifies membrane pathways

Lihi Grinberg, Worood Sirhan, Marina Kurtz, Michael Assa, Assaf Malka, Shira Perez, Corine Katina, Yishai Levin, Ron Piran

Abstract To better understand diabetes and normoglycemia, pancreatic islet biology requires a precise molecular understanding of islet cell types at both the transcriptomic and proteomic levels. While transcriptomic analyses are well established, comprehensive proteomic characterization has been lacking, limiting our knowledge of islet molecular complexity. Here we introduce a nonenzymatic, mechanistic single-cell isolation technology using laser microdissection (LMD7), facilitating proteomic and transcriptomic ana …

03.09.2026journal-article

INTERNATIONAL JOURNAL OF HEALTH AND PHARMACEUTICAL RESEARCH

Personality Traits, Social Support and Perinatal Depression Among Women Attending Tertiary Health Institutions in Makurdi, Nigeria

Agada Onmonya Abo

Perinatal depression is a significant public health concern affecting women during pregnancy and the postpartum period. This study examined personality traits, social support, and perinatal depression among women attending tertiary health institutions in Makurdi Local Government Area, Benue State, Nigeria. A cross-sectional survey design was adopted involving 396 perinatal women, 254 prenatal and 142 postpartum attending antenatal clinics and immunization units in selected health institutions (Federal Medical Cente …

03.09.2026journal-article

INTERNATIONAL JOURNAL OF HEALTH AND PHARMACEUTICAL RESEARCH

Body Image Perception, Lifestyle Behaviours and Awareness of Obesity Among Adults

Adesimisola Hephzibah Alowolodu

In the world at large, it is estimated that in 2022, 890 million adults live with obesity, which is 16% of the adult population. Moreover, 43% of the world’s adults are either overweight or obese. Obesity prevalence in Nigeria is about 15% among the adult population. Obesity is also more prevalent among women, urban dwellers, and people living in the south compared to the north. Obesity is caused by various factors, including lifestyle factors, biological factors, sociocultural factors, and environmental factors. L …

03.09.2026journal-article

Pituitary

Importance of clinical profiling to determine excess mortality in prolactinomas: insights from a large, registry-based cohort

Tarik Ziyad Tarik Shwaish, Davide Gori, Claudio Sartori, Federica Guaraldi

Abstract Purpose Population-based studies overall report no excess mortality among patients with prolactinoma compared with the general population. However, since prolactinomas are clinically heterogeneous, mortality may not be uniform across data-driven patient profiles. Methods We analyzed 3,378 adult prolactinoma cases (26,118 person-years) from the Surveillance, Epidemiology, and End Results database (2004–2022). Standardized mortality ratios (SMRs) were calculated using US life tables matched by age, sex, cale …

03.09.2026journal-article

Neurocritical Care

Time-Stamped Annotations in High-Frequency Physiological Data: Evaluating an Approach for Assessing Annotation Plausibility in the CENTER-TBI Dataset

Sara Turella, Erta Beqiri, Stefan Yu Bögli, Bogdan Ianosi, Ihsane Olakorede, Tommaso Zoerle, Jeanette Tas, Raimund Helbok, Peter Smielewski, the Smart Neuromonitoring to Support Precision Medicine in Acute Central Nervous Injury (SOPRANI) collaborators and the CENTER-TBI High-Resolution Sub-Study Participants and Investigators, Audny Anke, Ronny Beer, Bo-Michael Bellander, David Nelson, Andras Buki, Giorgio Chevallard, Arturo Chieregato, Giuseppe Citerio, Endre Czeiter, Bart Depreitere, George Eapen, Shirin Frisvold, Stefan Jankowski, Daniel Kondziella, Lars-Owe Koskinen, Geert Meyfroidt, Kirsten Moeller, Anna Piippo-Karjalainen, Rahul Raj, Andreea Radoi, Juan Sahuquillo, Arminas Ragauskas, Saulius Rocka, Jonathan Rhodes, Rolf Rossaint, Ana Stevanovic, Oliver Sakowitz, Nina Sundström, Riikka Takala, Tomas Tamosuitis

Abstract Background/Objective High-resolution neuromonitoring data with time-stamped clinical annotations offer valuable insights into treatment responses, though reliability is limited by manual documentation. This study aims to develop and demonstrate a three-step methodological framework to evaluate the plausibility of time-stamped clinical annotations using a high-frequency dataset. The framework integrates visual inspection of reference annotations and automated classification based on predefined physiological …

03.09.2026journal-article

Eastern Mediterranean Health Journal

Assessing the predictors of treatment-seeking and health care access barriers among transgender individuals in Pakistan

Athar Memon, Sameena Ourangzaib, Benjamin R. Bates, Shiraz Shaikh

Background: Transgender individuals in Pakistan face barriers to health care access, increasing the risk of serious disease transmission. Aim: To identify the predictors of treatment-seeking intention and health care access delays among transgender individuals in Karachi, Pakistan. Methods: Between December 2024 and April 2025 we interviewed 360 individuals, aged ≥18 years, who identified as transgender and had accessed health care within the past 12 months. We analysed the data using SPSS version 20 and conducted …

03.09.2026journal-article

European Journal of Endocrinology

Adverse health outcomes across the life course in individuals with six rare bone diseases: a 10-year population-based cohort study

Pascal Gaechter, Christian Meier, Emanuel Christ, Fahim Ebrahimi, Alexander Kutz, Gabor Szinnai

Abstract Background Rare bone diseases comprise a heterogeneous group of complex and disabling conditions. Evidence on age-specific hospitalization patterns and in-hospital outcomes across multiple rare bone diseases is limited. Methods Population-based cohort study using national hospitalization data (01/2012–12/2021). Among 11,092,151 hospitalizations, 2,875 admissions of children and adults with rare bone diseases were identified via ICD-10 codes (X-linked hypophosphatemia, osteogenesis imperfecta, fibrous dyspl …

03.09.2026journal-article

British Journal of Nursing

Changing a Future Nurse undergraduate nursing programme to include more mental health content: initial evaluation

Laurence Baldwin, Judith McLeod, Rachel Bage, Frances Nicol, Maya Dixon, Lyndsay Khan, Helen Alcock-Towse, Donna-Marie Gordon, Catherine Shiels

The 2018 Nursing and Midwifery Council's ‘Future Nurse’ standards introduced increased genericism to UK nursing education, prompting criticism from specialist fields concerned about diluted field-specific knowledge. This article reports on a curriculum innovation at one UK university that addressed local implementation challenges through targeted module development to include an increased number of field-specific modules alongside core content. Among others, two new modules were introduced, one on mental health for …

03.09.2026journal-article

Sustainability

Protecting Blue Skies and Health: Can “Key Controlled Areas for Air Pollution Prevention and Control” Contribute to the Sustainable Development of Residents’ Health?

Xi Gu, Sijia Qiao, Xinran Yuan

This paper examines whether the establishment of “Key Controlled Areas for Air Pollution Prevention and Control” and its associated policy package in China improved residents’ health. Based on data from the China Health and Retirement Longitudinal Study (CHARLS) 2011–2018, Our study finds that this command-and-control environmental regulation is associated with notable declines in residents’ morbidity from asthma, lung disease, and heart disease, while also producing preventive effects. Potential channel analysis i …

03.09.2026journal-article

World Journal of Traditional Chinese Medicine

Simultaneous Harvesting of PINK1, Parkin, and FUNDC1 Ligands from Herbal Medicines Using “Net Fishing” Strategy

Zhong-Yu Fu, Min Zhang, Fan Zhang, Cheng-Zhu Song, Yang-Yang Fu, Tao Wang, Xu-Dong He, Mei Zhang, Jie Yu, Xing-Xin Yang

Abstract Objective: Targeting mitophagy represents a promising therapeutic strategy for human diseases. This study aimed to develop an efficient approach to simultaneously identify natural ligands for PTEN-induced kinase 1 (PINK1), Parkin, and FUN14 domain containing 1 (FUNDC1) – core regulators of mitophagy – from complex herbal medicine (HM) extracts. Materials and Methods: We established a novel capture strategy where PINK1, Parkin, and FUNDC1 proteins were individually and physically adsorbed on the surface of …

03.09.2026journal-article

Diabetic Medicine

A novel deep intronic EIF2AK3 variant disrupts splicing and causes Wolcott–Rallison syndrome

Alaa Al Assi, Georgia Bonfield, James Russ‐Silsby, Suhel Ahmed, Thomas W. Laver, Kadri Karaer, Bayram Özhan, Ayca Altincik, Kashyap A. Patel, Jayne A. L. Houghton, Sarah E. Flanagan, Matthew B. Johnson, Elisa De Franco

Abstract Aim Deep intronic variants can disrupt splicing and cause monogenic disease but are missed by routine genetic testing. This study assessed the contribution of deep intronic variants to Wolcott–Rallison syndrome (WRS), a recessive disorder characterized by early‐onset diabetes and progressive multisystem disease caused by loss‐of‐function EIF2AK3 variants. Methods We investigated a cohort of 116 individuals referred to the Exeter Genomics Laboratory for genetic testing who had diabetes diagnosed at ≤2 years …

03.09.2026journal-article

Frontiers in Medicine

Fulminant group A streptococcal necrotizing fasciitis presenting as severe calf pain after pharyngitis in an adolescent: a case report

Lisa Roncoroni, Jan Kühle, Lampros Kousoulas, Katharina Müller-Peltzer, Dawid L. Staudacher

Background Invasive Group A Streptococcus (GAS) infection can rapidly progress to life-threatening conditions, including necrotizing fasciitis (NF) and streptococcal toxic shock syndrome (STSS). While typically associated with cutaneous breaches or underlying comorbidities, hematogenous seeding following primary pharyngeal infection is a rare but documented phenomenon. Early diagnosis is often complicated by subtle skin changes and the rarity of the disease. Case A previously healthy 17-year-old female presented wi …

03.09.2026journal-article

Frontiers in Immunology

HIV associated immune aging among people living with HIV: implications for long-term antiretroviral therapy and potential HIV cure interventions in sub-Saharan Africa

Praiscillia Kia, Edward Kankaka, Patricia Kankundiye, Marcel Tongo, Rose Nabatanzi, Tokameh Mahmoudi, Damalie Nakanjako

Background Clinical and biological consequences of accelerated immune aging are substantial, with growing evidence of increased risk of non-communicable diseases (NCD) among people living with HIV (PLHIV). However, there is limited understanding of reliable biomarkers of immune aging, singly or in combination, that can be used for monitoring HIV treatment in large longitudinal cohorts in sub-Saharan Africa (SSA). This review describes candidate biomarkers of immune aging during HIV treatment and their potential cli …

03.09.2026journal-article

Frontiers in Medicine

AI-enabled language technologies for language-mediated learning and clinical communication in international undergraduate dental education: a scoping review

Wenjuan Qiang, Xiaohong Deng, Tiezhou Hou, Le Qiang

Background International undergraduate dental students often learn and communicate in a language other than their first language, affecting terminology acquisition, clinical reasoning, patient explanations, informed consent, clinical communication, and patient safety. AI-enabled language technologies—including generative artificial intelligence (GenAI), large language models (LLMs), and neural machine translation (NMT)—may support these tasks, but their use in this population has not been systematically mapped. Met …

03.09.2026journal-article

Frontiers in Pediatrics

Clinical utility of renal and urinary tract point-of-care ultrasound in the neonatal intensive care unit: insights from a case series

Gayatri Morajkar, Sujata Deshpande, Sachin Verma, Vivek Goyal, Jayanta Hazarika, Prasoon Bansal, Yogen Singh, Pradeep Suryawanshi

Background Clinical decision-making in acutely ill neonates often depends on the timely identification of the underlying pathology. Bedside point-of-care ultrasound (POCUS), performed by the treating clinician, allows immediate correlation of imaging findings with evolving clinical status. However, its role in evaluating renal and urinary tract abnormalities in neonates remains relatively underexplored and is not yet widely integrated into routine practice. Methods This multicenter case series included data from fo …

03.09.2026journal-article

Frontiers in Public Health

Fusing meteorological factors and baidu search index with an adapted deformtime model to predict influenza-like illness in Beijing

Lingling Shen, Yajun Xiong, Zhaobin Sun

Background Influenza-like illness (ILI) poses a significant burden on public health systems, particularly in densely populated megacities. Accurate and timely forecasting is crucial for early warning and resource allocation. While deep learning models have shown promise, capturing the complex, non-linear coupling between environmental drivers and human behavior remains a challenge. Methods We used weekly ILI% surveillance data from Beijing (2010–2019), complemented by 20 meteorological variables and 322 Baidu Searc …

03.09.2026journal-article

Journal of Palliative Medicine

Liminal Personhood and Continuity of Moral Identity in Clinical Care

Harvey Max Chochinov, Marianne Sofronas, Joseph J. Fins

Capacity-based frameworks of personhood risk marginalizing individuals whose agency, cognition, or consciousness are diminished by illness, brain injury, or proximity to death. This article introduces the concept of liminal personhood , which describes the persistence of moral and relational identity even as conventional markers of personhood fade. Drawing on ethical, philosophical, and neuroethical scholarship, the paper argues that failing to recognize enduring personhood can fracture patient identity and erode c …

03.09.2026journal-article

Frontiers in Public Health

Association between physical fitness and myopia among school-entry students: a school-based cross-sectional study

ChengChao Duan, Yi Ba, Honglin Song, Yaqi Xue

Objective We examined whether school physical-fitness performance was associated with screening-defined current myopia in primary grade 1 and junior middle grade 1 students. We also explored item-level fitness profiles in relation to current myopia status. Methods We analyzed routine health-screening records collected in 2025 from three schools in Xicheng District, Beijing. Screening-defined current myopia required unaided visual acuity <5.0 together with a non-cycloplegic spherical equivalent ≤ −0.50 D in the s …

03.09.2026journal-article

Frontiers in Public Health

Beyond visual comfort: comparing pupillometry and subjective measures of cognitive strain in workplace lighting

D-Filipa Ferreira, Ana-Carolina Fonseca, Simão Ferreira, Luís Pinto-Coelho, Matilde A. Rodrigues

Introduction This study evaluated the discriminative sensitivity of pupillometry, relative to subjective self-report measures, as an objective indicator of cognitive load during screen-based tasks performed under two workplace illuminance levels (300 and 500 lux). Inadequate workplace illuminance is associated with visual fatigue, stress, and impaired attention, yet its effect on cognitive strain during screen-based tasks remains underexplored through objective physiological indicators, particularly given the confo …

03.09.2026journal-article

Frontiers in Public Health

Safety of Sabin-derived inactivated poliovirus vaccine in adult booster recipients: a systematic review and meta-analysis

Muhammad Hussain, Muhammad Hassan, Abdul Hannan, Arham Kamil, Muhammad Tayyab Azam, Zain Ul Abideen Shahid, Hasibullah Aminpoor, Suhaylah Gore, Faizan Ahmed, Anna Guseva

Background Poliomyelitis remains a public health concern in select regions. Sabin strain-derived inactivated poliovirus vaccine (sIPV) offers a potentially safer and cost-effective alternative to conventional IPV (cIPV) for adult booster immunization. Objective To systematically review and meta-analyze evidence on the safety of sIPV in adults. Methods We searched PubMed, Embase, Cochrane, and Scopus through January 2026 for randomized controlled trials comparing sIPV with cIPV/w-IPV or placebo in adults. Safety out …