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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

EMBO Molecular Medicine

FFAR2 activation induces IL-22-dependent intestinal immune responses to suppress CNS autoimmunity

Bojan Jevtić, Milica Lazarević, Goran Stegnjaić, Suzana Stanisavljević, Ivan Pilipović, Neda Nikolovski, Zorana Milosavljević, Miljana Momčilović, Ivan Koprivica, Natalija Jonić, Dragica Mićanović, Nataša Radulović, Maša Marković, Ksenija Mirković, Danijela Mišić, Uroš Gašić, Filip Nikolić, Nikola Veselinović, Henrike Körner, Lukas Grimm, Dmitri Lodygin, Alexander Flügel, Graeme Fraser, Tamara Saksida, Mirjana Dimitrijević, Ivana Stojanović, Đorđe Miljković

Abstract Short-chain fatty acids (SCFA) protect against central nervous system (CNS) autoimmunity, but the receptor-mediated mechanisms underlying these effects remain poorly understood, limiting their therapeutic exploitation. Here, we show that selective oral activation of free fatty acid receptor 2 (FFAR2) with the synthetic agonist Cpd1 effectively ameliorates established experimental autoimmune encephalomyelitis (EAE), demonstrating therapeutic efficacy after the onset of the autoimmune response. Cpd1 treatmen …

03.09.2026journal-article

Revista de Economía del Rosario

Mental Health Disability and Labor Market Participation

Clifton M. Chow, Jose Ordaz

This paper presents the first application of stochastic frontier regression and bivariate probit selection methods to estimate reservation wages for individuals with psychiatric disabilities. Using Employment Intervention Demonstration Program data (n = 1.648), we compare these methods among Supported Employment participants. The stochastic frontier approach yields an average reservation wage of $5.25 per hour, while bivariate probit produces $4.50 per hour. Reliability tests indicate that bivariate probit shows gr …

03.09.2026journal-article

Journal of Medical Internet Research

Digital Health Engagement Behaviors in US Family Caregivers: Trend Analysis Using the Health Information National Trends Survey 2019-2022 Data

Lena Lee, Elisa Son, Li Yang, Chantal Gerrard, Jenny Yarmovsky, Gwenyth Wallen

Abstract Background Digital health has provided caregivers with access to supportive resources without space-time restrictions. Caregivers’ digital health engagement behaviors can help them track their own health and that of care recipients as well as communicate with others. While digital health tools have become more prevalent since the COVID-19 pandemic, the trend in caregiver engagement has been less explored. Objective This study examined the trends and factors associated with selected digital health engagemen …

03.09.2026journal-article

AlQalam Journal of Medical and Applied Sciences

Clinical Effects and Safety of Deep Dry Needling for Upper Trapezius Myofascial Pain Syndrome: A Prospective Single-Group Study in Tripoli, Libya

Fatima Gazah

Myofascial pain syndrome (MPS) is a common musculoskeletal condition characterised by myofascial trigger points, pain, and functional limitations. Although dry needling is widely used in physiotherapy for myofascial pain, locally derived clinical evidence from Libya remains limited. This study evaluated the short-term clinical effects and safety of deep dry needling in patients with upper trapezius myofascial pain syndrome. A prospective, quasi-experimental, one-group pretest–posttest case series was conducted in t …

03.09.2026journal-article

Journal of Business, Social and Technology

Role Overload, Technostress, and Job Performance: The Mediating Role of Work Engagement and Burnout in Public Sector Digital Transformation

Mayora Lolly Ishimora, Fanny Martdianty

Background: Focusing on the context of the implementation of the Digital Administration System X is important considering that the digital transformation of the Institution X through the PRESISI agenda has the potential to create dual work demands for personnel who must adapt technologically while maintaining operational performance. Objective: This study aims to examine the influence of role overload and technostress on the job performance of personnel in executive positions at the Headquarters of Institution X by …

03.09.2026journal-article

Suicide and Life-Threatening Behavior

Nighttime Sensory–Behavioral Activation and Admission Suicidality in Young Inpatients With Major Depressive Disorder: A Retrospective Clinical‐Record Study

Xinqi Huang, Xiaolong Kuang, Hongxing Wang

ABSTRACT Introduction Suicide risk assessment during psychiatric admission may benefit from clinically observable information beyond overall depressive symptom severity. This study examined whether clinician‐documented nighttime sensory–behavioral activation was associated with admission suicidality in young inpatients with major depressive disorder (MDD). Methods This retrospective study included 406 inpatients aged 15–35 years with moderate‐to‐severe MDD. Nighttime sensory–behavioral activation was coded as none, …

03.09.2026journal-article

Experimental & Molecular Medicine

Proteomic analysis of pancreatic endocrine cells by mechanistic single-cell isolation identifies membrane pathways

Lihi Grinberg, Worood Sirhan, Marina Kurtz, Michael Assa, Assaf Malka, Shira Perez, Corine Katina, Yishai Levin, Ron Piran

Abstract To better understand diabetes and normoglycemia, pancreatic islet biology requires a precise molecular understanding of islet cell types at both the transcriptomic and proteomic levels. While transcriptomic analyses are well established, comprehensive proteomic characterization has been lacking, limiting our knowledge of islet molecular complexity. Here we introduce a nonenzymatic, mechanistic single-cell isolation technology using laser microdissection (LMD7), facilitating proteomic and transcriptomic ana …

03.09.2026journal-article

Healthcare

Challenges, Potential Solutions in Recruiting and Retaining Participants for Alcohol Use Disorder Research: A Literature Review

Jaskaran Lamba, Jonathan Shaw, Jason Zimmerman, Brian Kavin, Tara Menon, Charles Trevelyan, Shawn Koh

Objectives: This review aimed to identify the participant-, logistical-, and system-level factors that impede recruitment and retention in AUD research; to examine the strategies proposed to address them, including community-based and technology-assisted approaches; and to appraise the strength of the evidence supporting each strategy in order to define priorities for future work. Methods: A narrative review with thematic content analysis was conducted. PubMed/MEDLINE, PsycINFO, Scopus, Web of Science, CINAHL, and …

03.09.2026journal-article

Medical Technology and Public Health Journal

Effectiveness of Specific Interventions to Address Stunting in East Java Province in 2023: An Ecological Analysis

Nurul Jannatul Firdausi, Cicik Swi Antika, Agung Dwi Laksono, Waritsah Sukarjiyah

The Indonesian Health Survey in 2023 indicates that the prevalence of stunting in Indonesia remains high, at approximately 21.5%. The objective of the present study is to evaluate the efficacy of specific strategies designed to mitigate stunting in East Java Province. The research utilised secondary data, which was gathered ecologically. The study utilised a cross-sectional design, with the prevalence of stunting serving as the dependent variable and eleven distinct interventions as independent variables. The analy …

03.09.2026journal-article

Frontiers in Medicine

The impact of maternal hepatitis B virus infection on IVF/ICSI-assisted pregnancy outcomes: a propensity score-matched cohort study

Wenwen Jiang, Suqin Zhu, Rongshan Li, Yan Sun, Xiaojing Chen, Beihong Zheng

Background Hepatitis B virus (HBV) infection is highly prevalent among women of reproductive age in China, yet whether maternal HBV carrier status affects the outcomes of assisted reproduction remains unclear. Published studies have yielded conflicting results, most were underpowered or inadequately controlled for confounders, and few have tracked outcomes beyond early pregnancy. This study used propensity score matching to evaluate the impact of maternal HBV infection on laboratory, clinical pregnancy, obstetric, …

03.09.2026journal-article

Frontiers in Oncology

Performance evaluation of large language models in bladder cancer patient education Q&A: a cross-sectional study

Dian Wan, Youwen Li, Zheng Dong, Chen Dai, Jinghe Ye, Song Li, Sunlu Jiang

Background Bladder cancer ranks among the most prevalent urological tumors worldwide, with its global incidence continuing to rise steadily. Although patient education materials (PEMs) play a crucial role in enhancing disease comprehension and supporting joint clinical decision-making, current online resources frequently surpass the readability thresholds recommended for the general public. Large language models (LLMs) hold promise for health communication, yet no systematic assessment has been conducted regarding …

03.09.2026journal-article

Frontiers in Medicine

Safety profiles of cyclosporine and tacrolimus in pregnancy: a pharmacovigilance analysis using the FDA Adverse Event Reporting System

Yanhong Deng, Senling Feng, Shengying Shi, Zhongwen Yuan, Zhengrong Mei, Jinjin Yin, Dongdong Jing, Shaozhi Liu

Background The increasing use of calcineurin inhibitors (CNIs) among pregnant women highlights the importance of continuous safety surveillance. This study aimed to characterize the real-world safety signals of cyclosporine (CsA) and tacrolimus (TAC) during pregnancy using data from the FDA Adverse Event Reporting System (FAERS) database. Methods We applied four disproportionality data-mining algorithms (reporting odds ratio, proportional reporting ratio, Bayesian confidence propagation neural network, and empirica …

03.09.2026journal-article

Clinical Research in Cardiology

Routine versus selective use of a femoral protection wire in transfemoral TAVI: a single-centre analysis of vascular complications

Marc Adrian Rogmann, Victor Klingemann, Max Meertens, Majid Ahoopai, Karl-Philipp Rommel, Philipp Lurz, Ralph S. von Bardeleben, Martin Geyer

Abstract Background Transfemoral transcatheter aortic valve implantation (TAVI) is the treatment of choice for severe aortic stenosis in patients with elevated surgical risk. However, vascular complications remain a major source of morbidity and mortality. The protection wire technique was introduced to prevent major access-related complications, but its role in contemporary TAVI practice is uncertain. Aims To evaluate whether routine protection wire use reduces vascular complications in contemporary transfemoral T …

03.09.2026journal-article

BMC Public Health

Socio-economic factors associated with online health information seeking in the European Union: a panel data analysis (2016–2024)

Hasan Fehmi Demirci

Abstract Objective This study aims to investigate socio-economic factors associated with online health information seeking in the digital health environment across 27 European Union countries between 2016 and 2024. Method The analysis used a balanced panel dataset comprising 27 European Union countries for the period 2016 through 2024. The independent variables used include tertiary education attainment, income inequality (Gini coefficient), GDP per capita, internet access, age dependency ratio, and government and …

03.09.2026journal-article

The Economic and Labour Relations Review

When work hurts: The health consequences of job stress and part-time work among a longitudinal sample of older European workers

Sabela Siaba, Berta Rivera, Luis Currais

Abstract In the context of population ageing and extended working lives, understanding how employment quality affects older workers’ health is of growing policy relevance. Although previous research has linked working conditions to health, significant gaps remain in panel designs, unobserved heterogeneity, measurement validity, and sample representativeness. Using longitudinal microdata from the Survey of Health, Ageing, and Retirement in Europe (SHARE), we estimate individual fixed-effects models over a 12-year pe …

03.09.2026journal-article

Italian Journal of Pediatrics

The Digital Pact of Imola: development and implementation of a community-based public health initiative to promote healthy digital habits in childhood and adolescence

Irene Bonomelli, Laura Serra, Elisabetta Zucchini, Alessandra Ronchi, Laura Cavallazzi, Valentina Totti, Paolo Bottau

Abstract Background Digital media exposure in childhood and adolescence is an increasing public-health concern. Pediatric recommendations emphasize not only the duration of screen exposure, but also content, context, timing, parental co-use, developmental stage, and the activities displaced by screen use. Community-based approaches may help families receive coherent and developmentally appropriate guidance across healthcare, educational, family, and social settings. Methods This manuscript describes the development …

03.09.2026journal-article

Academia Biology

Honey as a functional food: composition, bioactive compounds, health benefits and applications

Houssam Lakhmili, Zineb Lakouam, Khawla Benbnidak, Karima Warda, Abdelilah El Abbassi

Honey is a natural bee-derived product that has been valued for centuries as both a food and a traditional remedy. While its composition is dominated by carbohydrates, accumulating evidence suggests that many of its health-promoting properties may be substantially influenced by its minor non-glucidic constituents, including phenolic acids, flavonoids, amino acids, proteins, organic acids, enzymes, vitamins, and minerals. This review provides a comprehensive overview of the physicochemical composition of honey and c …

03.09.2026journal-article

Frontiers in Public Health

Explainable ensemble transfer learning for skin lesion classification with multi-method explainability validation

Nemili Sravani, Srinivas Koppu

Introduction Skin cancer is among the most prevalent and life-threatening malignancies worldwide. Early and accurate detection significantly improves therapeutic outcomes. Automated classification of dermoscopic skin lesions remains challenging due to class imbalance, inter-class visual similarity, and lack of interpretable predictions. This study proposes an accurate and interpretable weighted soft voting ensemble for multi-class skin lesion classification. Methods A weighted soft voting ensemble of three heteroge …

03.09.2026journal-article

Frontiers in Immunology

Clinical remission trajectories and histopathological associations in patients with IgA nephropathy treated with targeted-release budesonide: a real-world cohort study

Dafeng He, Jun Xu, Bo Gao, Mingzhu Jiang, Wenjin Liu, Chuanyan Zhao, Xinrui Li, Chunlei Lu, Mengyue Zhu, Hongbin Mou, Guangyu Bi

Background Targeted-release (TR) budesonide provides upstream mucosal immunomodulation in IgA nephropathy (IgAN) by targeting the gut-associated lymphoid tissue. However, the extent to which distinct downstream immune-inflammatory phenotypes and established structural chronicity shape real-world remission trajectories remains insufficiently characterized. Methods We retrospectively analyzed 57 adults with biopsy-proven primary IgAN treated with TR-budesonide. Prespecified milestones were Very Early Response (VER) a …

03.09.2026journal-article

Journal of Advances in Medicine and Medical Research

Age-related BAX and Ki-67 Expression in Regional Lymph Nodes of Infants who Died from Measles: A Retrospective Immunohistochemical Study

Doniyor Saidovich Turdimatov

Background: Measles can produce substantial lymphoid tissue injury and immunosuppression, but age-related patterns of apoptotic and proliferative activity in regional lymph nodes during fatal measles in infancy remain insufficiently characterised. Aims: To evaluate age-related changes in BAX and Ki-67 immunohistochemical expression in regional lymph nodes of infants who died from measles. Study Design: A retrospective morphological and immunohistochemical study of archived autopsy specimens. Methodology: Regional l …

03.09.2026journal-article

Agriculture and Human Values

The diverse human/bird relationships in backyard bird keeping: implications for health and welfare

Niamh Mahon, Orla Shortall, Carol Kyle

Abstract In 2024 registration of all captive bird flocks became mandatory in Great Britain to improve disease surveillance at a time of increasing avian influenza outbreaks. However, little is known about how health and welfare practices are shaped by the diversity of relationships that characterise UK backyard birdkeeping. We use this moment of change to (1) examine the relationships between backyard keepers, their birds, and the poultry industry, and, (2) explore how registration legislation is responded to by ba …

03.09.2026journal-article

INTERNATIONAL JOURNAL OF HEALTH AND PHARMACEUTICAL RESEARCH

Body Image Perception, Lifestyle Behaviours and Awareness of Obesity Among Adults

Adesimisola Hephzibah Alowolodu

In the world at large, it is estimated that in 2022, 890 million adults live with obesity, which is 16% of the adult population. Moreover, 43% of the world’s adults are either overweight or obese. Obesity prevalence in Nigeria is about 15% among the adult population. Obesity is also more prevalent among women, urban dwellers, and people living in the south compared to the north. Obesity is caused by various factors, including lifestyle factors, biological factors, sociocultural factors, and environmental factors. L …

03.09.2026journal-article

INTERNATIONAL JOURNAL OF HEALTH AND PHARMACEUTICAL RESEARCH

Personality Traits, Social Support and Perinatal Depression Among Women Attending Tertiary Health Institutions in Makurdi, Nigeria

Agada Onmonya Abo

Perinatal depression is a significant public health concern affecting women during pregnancy and the postpartum period. This study examined personality traits, social support, and perinatal depression among women attending tertiary health institutions in Makurdi Local Government Area, Benue State, Nigeria. A cross-sectional survey design was adopted involving 396 perinatal women, 254 prenatal and 142 postpartum attending antenatal clinics and immunization units in selected health institutions (Federal Medical Cente …

03.09.2026journal-article

Journal of Clinical Medicine

Preoperative Alanine Aminotransferase and Postoperative ALT Elevation: A Retrospective Cohort Study

Jisun Choi, Hyun Young Lim, Jeayoun Kim, Seungwon Lee, MiHye Park

Background: Modestly elevated serum alanine aminotransferase (ALT) levels are associated with increased morbidity and mortality in the general population; however, the perioperative significance of mildly elevated preoperative ALT levels in surgical patients remains unclear. Methods: This retrospective cohort study included adults undergoing non-hepatic, non-cardiac surgery at Samsung Medical Center. Patients with preoperative ALT measured within 3 months and <2 times the upper limit of normal (ULN) were eligible. …