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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Clinical Microbiology Reviews

Emerging tick-borne viral diseases in East Asia: pathology-driven insights into pathogenesis and disease causality

Yuichiro Hirata, Yusuke Sakai, Tadaki Suzuki

SUMMARY Tick-borne viral infections have emerged as a significant and growing public health concern. In East Asia, severe fever with thrombocytopenia syndrome (SFTS) has served as a prototypical disease in which pathological analyses have substantially advanced the understanding of disease pathogenesis. SFTS is characterized by profound immune dysregulation driven by viral tropism for plasmablast-lineage B cells, leading to cytokine storm and hemophagocytic syndrome. Complementary analyses of human clinical specime …

03.09.2026journal-article

Magnetic Resonance Materials in Physics, Biology and Medicine

Age-dependent macromolecule signals in the human motor cortex and thalamus: implications for metabolites quantification at 7 T

Xinyu Liu, Gianna Nossa, Ying Xiao, Selin Scherrer, Sven Egger, Benedikt Lauber, Wolfgang Taube, Ulrike Dydak, Lijing Xin

Abstract Objective Macromolecular (MM) signals overlap with metabolite signals, but MM content differences across age and brain region and their influences on brain metabolites quantification have remained elusive. While most studies assume universal MM content when assessing neurochemical levels, region- and age-related MM differences could result in inaccurate quantification of metabolites. This study assesses MM differences linked to specific brain regions and age by analyzing their influence on metabolite signa …

03.09.2026journal-article

International Journal of Clinical Pharmacy

A qualitative analysis to identify implementation strategies for a deprescribing clinical practice guideline using the CFIR-ERIC Matching Tool: perspectives from consumers and professional stakeholders

Hui Wen Quek, Xisco Reus, Kenneth Lee, Veronika Seda, Leon Adams, Osvaldo P. Almeida, Gillian E. Caughey, Jennifer Gowan, Kerryn Hart, Andrew Heredia, Anne-Marie Hill, Lisa Kalisch Ellett, Dina LoGiudice, Arduino A. Mangoni, Anthony Marinucci, Treasure McGuire, Nilufeur McKay, Vasi Naganathan, Christopher Ng, Maz Osborne, Kevan R. Polkinghorne, Constance D. Pond, Sepehr Shakib, Angela Shiu, Andrew Stafford, Tim Whitmore, Christopher Etherton-Beer, Amy Page

Abstract Introduction Deprescribing is the planned withdrawal or dose reduction of medicines when harms outweigh benefits or when they are no longer required. Following publication of the Clinical Practice Guideline for Deprescribing in Older People in September 2025, supporting its uptake into routine practice is a critical next step. Aim This study aimed to identify implementation strategies, informed by stakeholder-perceived barriers, to support the implementation of deprescribing guidelines. Method A qualitativ …

03.09.2026journal-article

Veredas do Direito

DIAGNOSIS OF THE LEVEL OF ADOPTION OF GREEN LOGISTICS PRACTICES IN FREIGHT TRANSPORT COMPANIES IN LÁZARO CÁRDENAS, MICHOACÁN

María Del Mar Plancarte Muñoz, Ofelia Barrios Vargas, Luis Fernando Hernández Díaz, Samuel David Soriano López, Samuel Fernando Cárdenas Betancourt

The objective of this research was to diagnose the level of adoption of green logistics practices in federal freight transportation companies operating in Lázaro Cárdenas, Michoacán. A quantitative, descriptive, non-experimental, and cross-sectional study was conducted using a structured questionnaire that assessed the dimensions of fleet management, route optimization, energy efficiency, environmental management, and information technologies. The results show a moderate level of adoption of green practices. The sa …

03.09.2026journal-article

General Thoracic and Cardiovascular Surgery

Impact of preoperative nutritional status on longitudinal changes in pulmonary function and prognosis after lung cancer surgery

Kentaro Miura, Daisuke Nakamura, Sachie Koike, Shuji Mishima, Yukihiro Terada, Shunichiro Matsuoka, Hirotaka Kumeda, Takashi Eguchi, Kazutoshi Hamanaka, Kimihiro Shimizu

Abstract Objective Preoperative nutritional status is a known prognostic factor in lung cancer surgery. However, its effect on postoperative pulmonary function over time remains unclear. This study evaluated the association between preoperative nutritional status and longitudinal respiratory changes andoutcomes after curative resection. Methods Patients who underwent resection for non-small cell lung cancer between January 2020 and December 2024 were prospectively analyzed. Patients were classified by prognostic nu …

03.09.2026journal-article

Journal of the Endocrine Society

Intermediate risk thyroid cancer management: physician survey

Annu R Suresh, Amanda Kung, Jiling Chou, Jacqueline Jonklaas

Abstract Context Variability exists in use of radioactive iodine (RAI) treatment in intermediate risk (IR) thyroid cancer. Objective The study surveyed clinicians about their use of RAI in theoretical cases of patients with IR thyroid cancer. Design A survey presented patient cases with pathology results and two variations consisting of baseline thyroglobulin levels of ≤5 ng/mL and >5 ng/mL. Respondents were queried as to their use of RAI therapy in each case. Univariate Bayesian cumulative ordinal regression mo …

03.09.2026journal-article

Frontiers in Medicine

Spirituality, religious affiliation, and health in Germany: a cross-sectional study including Bayesian network modeling

Christian S. Kessler, Michael Jeitler, Miriam Ortiz, Benno Brinkhaus, Maren M. Michaelsen, Julia K. Schiele, Florian Jeserich, Tido von Schoen-Angerer, Michael Teut, Manfred Wischnewsky

Background Spirituality has been proposed as a relevant dimension of health, yet its distribution in the general population and its associations with health-related factors remain insufficiently characterized. This study examined how self-reported spirituality and religious affiliation are distributed in Germany and how they are associated with chronic disease burden, health-related quality of life, nutrition-related attitudes, and attitudes toward traditional, complementary, and integrative medicine (TCIM). Method …

03.09.2026journal-article

Frontiers in Medicine

Artificial intelligence in personalized computed tomography dose optimization: a systematic review of techniques and clinical outcomes

Nora Almuqbil

Introduction Artificial intelligence (AI) for personalized computed tomography (CT) dose optimization has gained increasing attention due to its potential to reduce radiation exposure while maintaining image quality. CT dose optimization tailors according to individual patient characteristics, including age, weight, body composition, and clinical condition. The study aims to evaluate AI techniques in CT dose optimization, focusing on reducing radiation exposure while maintaining image quality. Methods The relevant …

03.09.2026journal-article

Clinical Journal of the American Society of Nephrology

A Randomized Pilot Trial of a Nephrologist Communication Tool for Discussing Conservative Management

Susan P. Y. Wong, Olivia Gaughran, David K. Prince, Jane Schell, Daniel Y. Lam, Dawn Bates, Grady Paden, Erin K. Kross

Background: It is difficult for patients to make informed decisions about kidney failure unless they know all their treatment options. Conservative management is an important option infrequently presented alongside other kidney failure treatments by nephrologists. Methods: We conducted a randomized pilot trial testing the feasibility and acceptability of a communication tool, called Conservative Kidney Management Jumpstart Tool, in assisting nephrologists with discussing conservative management with their patients. …

03.09.2026journal-article

Supportive Care in Cancer

Goal-directed nutritional support in preserving muscle mass and optimising recovery in treatment of oesophageal cancer: results of a prospective non-randomised cluster trial

Iris Barth, Iris Stelwagen, Linda B. M. Weerink, Dorienke Gort-van Dijk, Hanna Meinders, Milos Milovanovic, Jan Willem Haveman, Marc J. van Det, Gerard Dijkstra, Marjo J. E. Campmans-Kuijpers

Abstract Purpose Oesophageal cancer (OEC) treated with neoadjuvant chemoradiotherapy (CRT) followed by oesophagectomy is associated with muscle loss and impaired recovery. We aim to evaluate whether a goal-directed nutritional support protocol (GDNS) is associated with muscle loss and improved survival after CRT and oesophagectomy compared with usual care. Methods Adults with OEC undergoing CRT and oesophagectomy were included. In this trial, a tertiary centre provided GDNS, and a secondary hospital offered usual c …

03.09.2026journal-article

PLOS One

IFC-HFlowVAE: A self-enhancing generative framework with structural anchoring for imbalanced clinical data augmentation

Lu Yuwen, Shuyu Chen

Class imbalance and limited minority-class samples remain major challenges for developing reliable clinical diagnostic models, as insufficient observations often fail to capture complex minority-class distributions. Existing augmentation methods either rely on heuristic interpolation or suffer from instability when learning sparse and heterogeneous medical tabular data. This study proposes IFC-HFlowVAE, an iterative feedback and consensus framework built upon a flow-enhanced heterogeneous variational autoencoder fo …

03.09.2026journal-article

PLOS Digital Health

Implementation of an opioid use disorder (OUD) machine-learning phenotype in real-time for the ADAPT clinical trial

Huan Li, Mark Iscoe, John Lutz, Carolina Diniz Hopper, Sabrina Fried, Josue Minaya, Caroline Raymond King, Olga Reykhart, Hyung Paek, Daniella Meeker, Edward R. Melnick, R. Andrew Taylor

We developed and deploy a real‑time, electronic health record‑integrated machine learning phenotype to identify emergency department patients with opioid use disorder for prospective clinical trial screening and buprenorphine initiation. We conducted a multi‑phase study across three emergency departments in a single United States health system from 2014 to 2025. Using visit‑level data available at or before triage, we trained a random‑forest classifier to estimate opioid use disorder risk and embedded scoring in th …

03.09.2026journal-article

Journal of Pediatric Hematology/Oncology

Oral Cyanocobalamin Treatment in Infants Under 1 Year With Nutritional Vitamin B12 Deficiency: A Retrospective Comparison of 500 and 1000 µg Dose Regimens

Gökçe P. Reis İskenderoğlu, Erol Erduran, Nilgün Eroğlu, Ayşenur Bahadır

Background: Vitamin B12 deficiency is a significant health problem in infancy, particularly in developing countries. Oral treatment has emerged as an alternative to intramuscular therapy, but optimal dosing in infants remains unclear. Methods: This retrospective study included 93 infants aged 1 to 12 months diagnosed with nutritional vitamin B12 deficiency. Patients received either 500 or 1000 µg oral cyanocobalamin. Laboratory parameters were evaluated at baseline, 2 months, and 4 months. Results: Both treatment g …

03.09.2026journal-article

Journal of Imaging Informatics in Medicine

Artificial Intelligence for Cerebral Aneurysm Management: Integrating Imaging, Hemodynamics, and Clinical Decision Support

Reza Bozorgpour, Pilhwan Kim, Jacob Rammer

Abstract Cerebral aneurysms are complex vascular lesions whose rupture can result in subarachnoid hemorrhage (SAH), a condition associated with substantial morbidity and mortality. Although current clinical risk assessment relies primarily on morphological characteristics such as aneurysm size and location, these factors alone are often insufficient for individualized rupture risk prediction. Advances in artificial intelligence (AI) and machine learning (ML) have enabled the integration of imaging, clinical, morpho …

03.09.2026journal-article

South Asian Journal of Cancer

A retrospective analysis of treatment patterns and outcomes in carcinoma of the external auditory canal

Bal Krishna Mishra, Akhil Kapoor, Anuj Gupta, Bipinesh Sansar, Ayushi Pragya, Aseem Mishra, Ashutosh Mukherji, Sambit S Nanda, Ankita Rungta Kapoor, Ajay Kumar Choubey, Arvind Suresh, Satyendra Narayan Singh, Shreya Shukla

Objectives: Carcinoma of the external auditory canal (EAC) is a rare form of head and neck cancer, which accounts for <0.2% of the total head and neck cancer burden. The treatment typically involves a multidisciplinary approach, with surgery being the cornerstone for early-stage disease, while advanced-stage cases often require radiation therapy and chemotherapy. The presented retrospective analysis examines 15 patients to identify the optimal therapeutic strategies for managing EAC. Material and Methods: This retr …

03.09.2026journal-article

European Journal of Trauma and Emergency Surgery

ABCB5⁺ mesenchymal stem cells enable high-ratio cellular augmentation of bone grafts without loss of osteogenic function

Jakob Hofmann, Tim Niklas Bewersdorf, Ulrike Sommer, Kai Borcherding, Karsten Thiel, Christoph Ganss, Matthias Gerstner, Markus H. Frank, Gerhard Schmidmaier, Mark Andreas Kluth, Tobias Grossner

Abstract Autologous bone grafting remains the standard for reconstruction of bone defects but is constrained by limited graft volume and loss of osteogenic capacity when expanded with acellular materials. We hypothesized that allogeneic ABCB5⁺ mesenchymal stem cells (MSCs) can serve as a biologic cell source to augment bone marrow-derived MSC (BM-MSC) populations without impairing osteogenesis. Primary human BM-MSCs from five donors were combined with GMP-manufactured ABCB5⁺ MSCs at graded replacement ratios (0–95% …

03.09.2026journal-article

Clinical Kidney Journal

Rituximab therapy achieves comparable remission to cyclophosphamide in ANCA-associated vasculitis with severe KIDNEY involvement

Nishant Chaudhari, Azm Ul Hussain, Lee Quill, Joshua Harridine, Kashif Eqbal, Lorraine Harper, Dimitrios Chanouzas

Abstract Introduction The RAVE/RITUXIVAS trials established rituximab (RTX) therapy in ANCA-associated vasculitis (AAV). However, RAVE excluded patients with severe renal involvement (creatinine &gt; 354 µmol/L). Whilst RITUXIVAS did not, treatment included RTX with 2 cyclophosphamide (CYC) pulses. This study reports outcomes in AAV patients with severe renal involvement treated with RTX alone compared to CYC, together with high dose steroids. Methods Data were collected retrospectively for all consecutive AAV pres …

03.09.2026journal-article

ACS Applied Materials & Interfaces

Non-Annealing Treatment Mechanism of Electron Transport Layers for High-Performance Inverted Perovskite Solar Cells

Jiangping Xing, Weixuan Liu, Haifan Zhou, Qinghua Cao, Deping Xiong, Aliaksandr Smirnov, Xiaoli Zhang, Hui Liu

Abstract Inverted perovskite solar cells (IPSCs) have presented great potential in the photovoltaic field due to their outstanding optoelectronic properties. However, the widely used electron transport layer of [6,6]-phenyl-C61-butyric acid methyl ester (PCBM) in IPSCs presents some issues such as poor passivation effect, insufficient film coverage, and suboptimal energy-level alignment, and the influence of annealing treatment of PCBM on device performance has rarely been investigated. Therefore, in this work, we …

03.09.2026journal-article

Developmental Medicine & Child Neurology

Risk factor profiles in infants born preterm and at term with cerebral palsy in Argentina: Findings from the Argentine Cerebral Palsy Register

M. Mercedes Ruiz Brunner, Carla Gil, María Elisabeth Cieri, Ana Laura Condinanzi, L. Johana Escobar Zuluaga, Federico Sanchez, Gulam Khandaker, Israt Jahan, Nadia Badawi, Eduardo Cuestas

Aim To describe the patterns of co‐occurrence between previously documented risk factors and gestational age in infants with cerebral palsy (CP) registered in the Argentine Cerebral Palsy Register (Registro Argentino De Parálisis Cerebral [RAR‐PC]). Method This register‐based, cross‐sectional study analysed data from individuals with confirmed CP registered in the RAR‐PC. Family interviews and medical record reviews were conducted. The variables analysed included CP characteristics, a predefined set of prenatal, pe …

03.09.2026journal-article

Journal of Travel Medicine

Orthopaedic Injuries among International Travellers in Nepal

Abhishek Shrestha, Ishwor Ghimire Padhya, Jasmine Shrestha, Pratigya Aryal, Prativa Pandey

Highlight/Teaser International travellers in Pokhara experience a considerable burden of orthopaedic injuries. This study describes their injury patterns, management, and outcomes, providing evidence to strengthen preventive advice, trauma preparedness, and clinical services in popular adventure-travel destinations.

03.09.2026journal-article

Frontiers in Surgery

When microsurgery is not an option: staged delayed reverse sural artery flap with ischaemic preconditioning for limb salvage in an elderly patient with chronic post-traumatic osteomyelitis—a case report

Zhun Shen Tan, Adzim Poh Yuen Wen, Farzana Ansarutheen, Mohd Yazid Bajuri

Lower extremity reconstruction in elderly patients with post-traumatic osteomyelitis presents a formidable challenge. We report a 70-year-old female with hypertension, dyslipidaemia, and bilateral knee osteoarthritis who sustained a Gustilo-Anderson type IIIB open right ankle fracture with exposed calcaneus following a fall. The course was complicated by chronic osteomyelitis, managed with partial talectomy and total calcanectomy, antibiotic-impregnated cement spacer placement, cement exchange and prolonged culture …

03.09.2026journal-article

Frontiers in Natural Products

Antifungal and antibiofilm activity of crude hydroalcoholic extract and fractions of Myrcia neoobscura leaves against a clinical isolate of Candida krusei

Leticia Bachmann, Eduarda Rensi Botelho, Patrícia Helena Arrabal, Pâmela Elise Munzlinger, Patryne Luana da Silva Dantas, Larissa Mascarenhas Krepsky, Lucas Ferriolli Mariotto, Michele Debiasi Alberton, Tatiani Karini Rensi Botelho

Infections caused by biofilm-forming Candida sp. Are responsible for high morbidity and mortality rates. With the scarcity of therapeutic options and the increase in resistance to antifungal drugs, new treatment options are needed. Myrcia neoobscura is a tree endemic to the Atlantic Rainforest, belonging to the genus Myrcia , several of whose species have demonstrated important antifungal activities. The aim of this study was to evaluate the antifungal and antibiofilm activity of the crude hydroalcoholic extract an …

03.09.2026journal-article

Frontiers in Medicine

Case Report: Electrode perforation with normal pacemaker parameters leading to hemorrhagic shock: a rare case report of the “penetration-exit-re-entry” phenomenon

Zuoan Qin, Jian Yang, Li Luo, Shi Chen, Fei Yang

Background Permanent pacemaker implantation via subclavian vein puncture may induce rare but life-threatening iatrogenic vascular injury. Vascular perforation with pacing lead penetration-exit-re-entry trajectory accompanied by normal intraoperative pacing parameters is reported extremely rarely, which greatly increases the risk of missed diagnosis. Case presentation A 70-year-old female patient with complete atrioventricular block received dual-chamber pacemaker implantation. All intraoperative lead electrical ind …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Perfluorooctanoic acid–associated complement factor B upregulation and atrial fibrillation–related molecular alterations: integrated network toxicology, Mendelian randomization, molecular dynamics, and HL-1 cell analyses

Dan Li, Chuanfeng Bai, Jinping Zhao

Background Perfluorooctanoic acid (PFOA) is a persistent environmental pollutant associated with cardiovascular dysfunction, but the molecular links between PFOA exposure and atrial fibrillation (AF) remain unclear. We aimed to prioritize a candidate mediator connecting PFOA with AF and examine its associated molecular effects in atrial cardiomyocytes. Methods PFOA-associated or computationally predicted genes from CTD, STITCH, and SwissTargetPrediction were integrated with AF-associated genes. Complement factor B …