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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

World Economy and Management research

MicroRNA-234-3p inhibits the progression of ovarian cancer by regulating the WNK2/Ras/MEK/ERG signaling pathway tears or tendinopathy: a double-blind randomized controlled trial

Manyun Sun, Weixin Li, Qi Liu, Juan Shi

Ovarian cancer (OC) is the most lethal gynecological malignancy, characterized by late diagnosis, high recurrence rates, and limited effective targeted therapies. MicroRNAs (miRNAs) play critical roles in OC progression by post-transcriptionally regulating oncogenes and tumor suppressors. In this study, we investigated the expression, function, and molecular mechanism of miR-234-3p in OC. We found that miR-234-3p was significantly downregulated in OC tissues and cell lines compared with normal ovarian epithelium. O …

02.09.2026journal-article

Annals of African Medicine

Quantitative Apparent Diffusion Coefficient (ADC) Mapping as a Preoperative Biomarker for Tumor Grade and Myometrial Invasion in Endometrial Carcinoma

Kamlesh Kumar Ratre, Manish Kumar, Priya Singh, Priti Kumari

Abstract Background: The decision to perform systematic lymphadenectomy in endometrial carcinoma (EC) depends heavily on preoperative staging. We investigated the utility of diffusion-weighted imaging (DWI) and quantitative apparent diffusion coefficient (ADC) mapping to noninvasively predict the presence of EC and its histological tumor grade. Materials and Methods: This prospective case–control study included 30 women with histopathologically confirmed EC (cases) and 30 women with normal endometrium (controls). P …

02.09.2026journal-article

Nature

Late-life semaglutide treatment slows ageing and extends lifespan in female mice

Yufan Feng, Marine Barthez, Yifei Wang, Yibing Chen, Huixian Qiu, Chih-Ling Wang, Kartoosh Heydari, Melaine Delcroix, Lene Juel Rasmussen, Vilhelm A. Bohr, Danica Chen

Abstract Pharmacological glucagon-like peptide-1 receptor (GLP-1R) activation reduces food intake and is an effective therapy for type 2 diabetes and obesity 1 . The use of GLP-1 medicines has revealed pleiotropic beneficial effects beyond glucose and weight control 2–5 , but little is known about the underlying basis of the pleiotropic effects. Here, treatment of 20-month-old female C57BL/6 mice with the GLP-1R agonist semaglutide for 3 months improved physiological function, attenuated hallmarks of ageing and mod …

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02.09.2026journal-article

ACS ES&T Water

Activated Carbon Reshapes the Relationship between Mercury Methylation and Sulfate Reduction in a Sediment Bioelectrochemical Treatment System

Matthew J. Berens, Andrew Wood, Randall Kolka, Chan Lan Chun

Abstract Mercury (Hg) methylation is tightly linked to the activity of sulfate-reducing bacteria (SRB). Bioelectrochemical systems (BESs) have been proposed to remediate excess sulfate in freshwater systems, but their effects on coupled Hg and sulfur cycling remain poorly understood. Here, we developed a novel BES to investigate how applied voltage and activated carbon (AC) interact to regulate sulfate reduction and Hg(II) methylation kinetics in sediments from a sulfate-impacted stream. Methylation potentials did …

02.09.2026journal-article

Clinical Infectious Diseases

Cefepime versus piperacillin-tazobactam for the treatment of Pseudomonas aeruginosa pneumonia

Raneem H Pallotta, Walaiporn Wangchinda, Samantha R Sallerson, Gregory E Eschenauer, Vincent D Marshall, Virginia M Pierce, Jason M Pogue, Samuel L Aitken

Abstract Background Both piperacillin-tazobactam and cefepime are widely used for the treatment of pneumonia caused by Pseudomonas aeruginosa. Despite this, no studies have directly compared these agents for this purpose. Methods We performed a single-center retrospective cohort study of patients with pneumonia caused by P. aeruginosa treated with piperacillin-tazobactam or cefepime. The co-primary outcomes were 30-day mortality and a 30-day desirability of outcome ranking (DOOR) incorporating clinical failure, res …

02.09.2026journal-article

Journal of Adolescent and Young Adult Oncology

Quality of Life of Adolescents and Young Adults with Cancer at Gustave Roussy Institute: The Role of Management in Enhancing Care and Ensuring Performance

Morgane Cousin, Nathalie Sanquirgo, Lucy Metayer, Miguel Maiz, Benjamin Verret, Nathalie Gaspar

The Gustave Roussy Institute (IGR) is considered the leading cancer center in Europe. Since 2012, a multidisciplinary team dedicated to adolescents and young adults (AYAs)—known as SPIAJA—has been developing a comprehensive care model for patients in this age group treated at the IGR. This mobile unit, integrated into the pediatrics department, collaborates with several adult care departments and offers a wide range of specialized services. Based on both interviews and observations, this qualitative study highlight …

02.09.2026journal-article

ACS Omega

Bridging the Resolution Gap in Recurrent Prostate Cancer Imaging: Quantum Dots as PSMA-Targeted Optical Probes

Yugmee Gidiya, Jiya Chaudhary, Annafew Biswas, Mandy Liao, Marine Ramaroson, Ken-ichiro Kamei

Abstract Recurrent prostate cancer (RPC) remains a major clinical challenge driven by residual and disseminated tumor cells exhibiting pronounced molecular and spatial heterogeneity. Prostate-specific membrane antigen (PSMA)-targeted positron emission tomography enables sensitive whole-body detection of recurrent lesions; however, its millimeter-scale spatial resolution and limited multiplexing capacity constrain the characterization of cellular heterogeneity and micrometastatic disease. Quantum dots (QDs) are nano …

02.09.2026journal-article

Problems of Gathering Treatment and Transportation of Oil and Oil Products

QUANTITATIVE ACCOUNTING AND REDUCTION OF CUMULATIVE TECHNOLOGICAL GAS LOSSES UNDER OPTIMIZATION OF GAS DISTRIBUTION NETWORK OPERATING REGIMES

A.M. Magomedov

Technological gas releases through safety relief valves (SRV) of gas distribution networks remain one of the least studied sources of natural gas losses: standard dispatch-control instrumentation registers only the fact and duration of valve actuation without determining the released gas volume (estimated at up to 20 million m/year for the Moscow Region alone). The aim of this work is to develop a methodology for the quantitative assessment and reduction of cumulative technological gas losses from the already recor …

02.09.2026journal-article

Psycho-Oncologie

Correction: Wang et al. Psychological resilience and treatment adherence in rheumatoid arthritis–cancer comorbidity: Evidence-based intervention pathways. Psycho-Oncologie. 2026; 20(2): 4355.

Yafang Wang, Aifeng Song, Lin Kang, Jingjing Sun, Wei Wei

In the original publication [1], there was an error in the authors’ order. The wrong authors’ order is: Wei Wei1,*, Yafang Wang1,2, Aifeng Song2, Lin Kang3, Jingjing Sun4 It should be updated to: Yafang Wang1,2, Aifeng Song2, Lin Kang3, Jingjing Sun4, Wei Wei1,*

02.09.2026journal-article

Pediatric Dermatology

Clinicopathologic Characteristics, Treatment Outcomes of Pediatric Mycosis Fungoides in Turkey: A National Multicenter Retrospective Cohort

Dilek Bayramgürler, Dilek Seçkin, Ayşe Deniz Yücelten, Esin Diremsizoğlu, Esra Adışen, Bengü Nisa Akay, Salih Levent Çınar, Pelin Kartal, Aslı Aksu, Burhan Engin, Arzu Ferhatosmanoğlu, Mehmet Melikoğlu, Zeynep Karaca Ural, Tuğba Kevser Uzunçakmak, Serkan Yazıcı, Esma İnan Yüksel, Ayşegül Yalçınkaya İyidal, Özlem Özbağçıvan, Emre Güven, Gizem Nur Öztürk Dönmez, Muhammed Salih Karagöz, Hatice Erdi Şanlı

ABSTRACT Background and Objectives This study aimed to characterize the clinical spectrum, diagnostic delay, treatment patterns, and outcomes of pediatric mycosis fungoides (MF) and to identify predictors of early response. Methods This national multicenter retrospective study included patients diagnosed with histopathologically confirmed MF before 18 years of age. Demographic, clinical, histopathologic, immunophenotypic, staging, treatment, and follow‐up data were collected. Early response at 3–6 months (partial/c …

02.09.2026journal-article

Current Oncology

Pretreatment Ki67-to-ADC Ratio Predicts Prognosis in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy: A Retrospective Cohort Study

Jun Fan, Lin Lin, Yang Tao, Yanjia Fan, Yudi Jin, Fajin Lv

(1) Background: Neoadjuvant chemotherapy (NAC) is important for breast cancer, but prognosis varies widely. Ki67 and apparent diffusion coefficient (ADC) reflect proliferation and cellularity, respectively. This study evaluated the prognostic value of the Ki67/ADC ratio (KA) and post-treatment ADC change (δADC) in breast cancer patients receiving NAC, and developed a survival prediction model incorporating these indicators. (2) Methods: Two cohorts of breast cancer patients treated with NAC were collected. Pre- and …

02.09.2026journal-article

Pain Medicine

Assessment and Treatment of Acute Low Back Pain: A Multidisciplinary Clinical Practice Guideline

Andrea C Skelly, Devan Kansagara, Jessica Oswald, Roger Chou, For the Acute Low Back Pain Guideline Project Guideline Development Group, Daniel P Alford, James Babington, Andrew Chang, Beth Darnall, Mark Holtsman, Heather Jackson, Anthony Lisi, Tom Norris, Rosemary Carol Polomano, Sean D Rundell, Raymond Y Teets, Erika Brodt, American Academy of Pain Medicine (AAPM) LBP Guideline Consultants, Ajay Wasan, Mark Wallace, Steven Cohen

Abstract Purpose To create an evidence-based guideline for the evaluation and management of acute low back pain. Methods A multidisciplinary guideline development group formulated recommendations based on systematic review (PROSPERO Registration 537276) of evidence and using a protocol based on the Grading of Recommendation Assessment, Development, and Evaluation (GRADE) working group methodology. Intended users and settings Clinicians providing care to individuals presenting with acute low back pain (<6 weeks d …

02.09.2026journal-article

Diseases of the Esophagus

Oncological outcomes and recurrence patterns after robot-assisted versus video-assisted esophagectomy for cT3br/cT4b esophageal cancer

Tetsuya Abe, Eiji Higaki, Takahiro Hosoi, Kosuke Inada, Kotaro Ozaki, Byonggu An, Junpei Yamaguchi, Koji Komori, Seiji Ito

Summary Robot-assisted minimally invasive esophagectomy (RAMIE) is increasingly utilized for locally advanced esophageal cancer; however, its clinical utility in challenging cases such as clinical T3 borderline resectable (cT3br) or cT4b tumors remains poorly understood. We retrospectively analyzed 60 patients with cT3br/cT4b esophageal cancer who underwent RAMIE (n=22) or video-assisted thoracoscopic esophagectomy (VATS) (n=38) after preoperative chemotherapy or chemoradiotherapy between 2014 and 2024. Three-year …

02.09.2026journal-article

Environmental Research Letters

Wastewater treatment-induced carbonate chemistry alteration and its implications for ocean alkalinity enhancement

Kuan-Ting Li, Hsin-Yi Wang, Hsiao-Chun Tseng, Tzong-Yueh Chen, Ruei-Feng Shiu, Lan-Feng Fan, Wen-Chen Chou

Abstract Municipal wastewater treatment plants (WWTPs) are important components of urban carbon cycling and have been proposed as potential platforms for ocean alkalinity enhancement (OAE). However, carbonate-system transformations across full-scale treatment processes remain poorly constrained. Here, we present a process-resolved snapshot of total alkalinity (TA), dissolved inorganic carbon (DIC), pH, pCO₂, dissolved CH₄, and dissolved N₂O across five sequential treatment units at a full-scale coastal WWTP in Taiw …

02.09.2026journal-article

Journal of the Egyptian National Cancer Institute

Pilot study on RECAF (Receptor for Alpha-Fetoprotein) expression in pediatric acute leukemia: insights from flow cytometry analysis

Soha Raouf Youssef, Mohamed Hany Mohammady, Shams ElDoha Galal ElDin Zaiema

Abstract Background Acute leukemia is the most common cancer in children, highlighting the importance of early diagnosis. RECAF is an AFP receptor that is abnormally re-expressed in various malignant tumors, serving as a promising biomarker for tumors. Aim This study aimed to assess the clinical utility of RECAF expression by flow cytometry immunophenotyping in pediatric de novo acute leukemia patients. Methods Our study was conducted in 80 pediatric patients with acute leukemia, comprising 40 newly diagnosed ALL p …

02.09.2026journal-article

Life

Immunogenic Cell Death Induced by EEO in Breast Cancer Cells Promotes Dendritic Cell Activation in a CRT-Dependent Manner

Seong-Ah Shin, Sun Young Moon, Seyeon Choi, Minji Kim, Moonsu Kim, Jun Hyuck Lee, Seulah Lee, Ki Hyun Kim, Hyun Ho Park, Ui Joung Youn, Chang Sup Lee

Cancer immunotherapy faces significant challenges in treating “cold” tumors, which respond poorly to current strategies. Breast cancer is a major cause of cancer-related mortality in women and is a representative immunosuppressive cold tumor. The luminal A subtype of breast cancer exhibits an immune-cold phenotype, with MCF-7 cells used as a representative cell model. Here, we identified (3β,5α,8α)-5,8-epidioxyergost-6-en-3β-ol (EEO), isolated from Gymnopilus orientispectabilis, as an inducer of immunogenic cell de …

02.09.2026journal-article

BMC Primary Care

The role of general practitioners in German cancer care: a scoping review

Anne Werner, Julia Katzur, Anne Schrimpf, Jutta Bleidorn, Markus Bleckwenn

Abstract Background General practitioners (GPs) play an important role in the care of patients with cancer across the entire cancer continuum, from diagnosis to palliative care. Despite their broad range of responsibilities, structures to facilitate the systematic involvement of GPs into cancer care remain insufficient in Germany. To date, the specific role and contribution of GPs within the German cancer care system have not been comprehensively synthesized. Objective This scoping review aimed to summarize the ava …

02.09.2026journal-article

Emergency Medicine Journal

Initial treatment of presumed pacemaker or implantable cardioverter defibrillator malfunctions: algorithm and rationale

Matthias Mueller, Christoph Weiser, Michael Pfeffer, Thomas Mitteregger

The increasing prevalence of permanent pacemakers (PPMs) and implantable cardioverter defibrillators (ICDs) has led to a rising number of device malfunctions, which can have painful or even life-threatening consequences. As device technology advances, emergency personnel frequently face uncertainty in the initial management of these complex patients, given limited access to device reprogramming or interrogation outside specialised cardiology settings. This paper presents practical algorithm-based approaches for the …

02.09.2026journal-article

npj Antimicrobials and Resistance

Treatment of Herpes simplex encephalitis with the helicase-primase inhibitor pritelivir in an immunocompromised patient

Catherina Lueck, Christina Rautenberg, Alexander Birkmann, Susanne Bonsmann, Alessandra Marini, Melanie Sumner, Thomas Schroeder, Sebastian Voigt

Abstract Pritelivir, a novel helicase-primase inhibitor, has successfully completed a global Phase 3 trial for refractory herpes simplex virus (HSV) infections in immunocompromised patients. This case report is the first clinical use of pritelivir in Herpes simplex encephalitis (HSE). An allogeneic hematopoietic cell transplant recipient developed HSE and was treated with acyclovir. After 1.5 months, while still on valacyclovir prophylaxis, HSE relapsed, confirmed by Magnetic Resonance Imaging (MRI) and HSV1 DNA de …

02.09.2026journal-article

Perspectives of the ASHA Special Interest Groups

Ghanaian Speech-Language Pathologists and Stuttering Treatment: Changes in Knowledge and Confidence After Professional Development

Emmanuel Kwaku Addo, Rodney Gabel, Stephanie Lebsack

Purpose: Speech-language pathologists (SLPs) worldwide face challenges in treating people who stutter, often citing inadequate knowledge and confidence, particularly in assessment and intervention. This study explored the strengths and areas of need among Ghanaian SLPs in treating stuttering. A secondary aim examined changes in SLPs' self-rated knowledge and confidence levels before and after a 6-week asynchronous online stuttering professional development (PD) program. Method: A secondary data set comprising 34 re …

02.09.2026journal-article

IECCMEXICO

Cancer Care Inequities: Social Determinants, Diagnostic Delays, and Health-System Strategies for Equitable Access

Andrés Omar Triviño Pinto, Lisset Georgett Saldaña Cortés, José Arnulfo Pérez Carrillo, Blas David Santana Perez, Aldo Bolivar Zavala Segovia, María Fernanda Carbajal Hernández, Jorge Angel Velasco Espinal, Alexa Fernanda Uriostegui Navarro

Inequities in access to cancer diagnosis and treatment remain a major challenge for contemporary health systems, particularly among populations affected by socioeconomic disadvantage, financial vulnerability, geographic isolation, limited health literacy, and fragmented healthcare pathways. This study analyzed the interaction between social determinants of health and structural characteristics of healthcare systems that influence timely access to oncology services. A documentary, integrative, descriptive, and analy …

02.09.2026journal-article

Pharmacia

Post-treatment serum interleukin-6 is independently associated with disease progression in patients with advanced non-small cell lung cancer and coexisting COPD: a multicenter real-world cohort study

Akram Hasan Kareem, Samer Imad Mohammed, Ahmed Abdali Shihad

An observational multicenter cohort study involving 120 patients treated with chemotherapy alone or in combination with pembrolizumab or atezolizumab was conducted. Interleukin-6 (IL-6) levels were measured after six cycles, and response of tumor was estimated with the Response Evaluation Criteria in Solid Tumors (RECIST). Receiver operating characteristic (ROC) analysis was conducted. IL-6 levels were significantly reduced in the chemo-immunotherapy groups compared with the chemotherapy group ( p < 0.001). Pati …

02.09.2026journal-article

Journal of Adolescent and Young Adult Oncology

Ho‘oulu Me Ke Ikaika: A Community-Support Group that Improves Long-Term Emotional and Social Health of Adolescent and Young Adult Survivors of Childhood Cancer

Maile Enos, Kiyomi Goto, Joyce Wong, Patricia W. Nishimoto, Erin O. Bantum, Ian Pagano, Dianne Fochtman, Paulette M. Yamada

Purpose: Survivors of childhood cancer have unique needs, requiring tailored psychosocial support. To ascertain the effectiveness of a community-based survivorship group’s services on changes in emotional and social self-efficacy, perceived purpose and meaning in life, loneliness, and post-traumatic growth from pre- to postretreat among minority adolescent and young adult (AYA) survivors over a 2-year period. Methods: Two annual residential retreats were attended by 15 and 13 AYA survivors, respectively. Experienti …

02.09.2026journal-article

Journal of Sustainable Mining

Microwave thermal pre-treatment to improve nickel extraction from lateritic ore

Johana Borda, Daniel Sosa, Robinson Torres

Two heat treatment processes for a nickeliferous laterite sample are presented, one by the conventional muffle route and the other by microwave. The heating was carried out in order to improve the dissolution of nickel in an acid medium. The study describes the changes observed in the mineral for the increase in temperature as a consequence of radiation in the microwave and in the muffle. The changes in the mineral crystalline phases were analyzed by X-ray diffraction. The leaching media consisted of a 1 M sulfuric …