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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
31.08.2026journal-article

Journal of Evaluation in Clinical Practice

The Relationship Between Loneliness and Geriatric Feelings of Burdensomeness in Hospitalized Older Adults

Hüsna Ceylan, Adeviye Aydin

ABSTRACT Objective This study aimed to examine the relationship between loneliness and geriatric feelings of burdensomeness in hospitalized older adults. Methods The study was conducted with 337 older adults hospitalized in a province in Türkiye. Data were collected through face‐to‐face interviews between April and July 2025 using the Sociodemographic Information Form, the Loneliness Scale for Older Adults, and the Geriatric Feelings of burdensomeness Scale. Data analysis included descriptive statistics (mean, stan …

31.08.2026journal-article

Nature Aging

Mapping structural aging across human tissues reveals tissue-specific trajectories and coordinated deterioration

Anamika Yadav, Kyle Alvarez, Anna Chechenina, Kevin Y. Yip, Eytan Ruppin, Alexandre Colas, Jacqueline C. Yano Maher, Veronica Gomez-Lobo, Caroline Kumsta, Sanju Sinha

Abstract Organ structure, including the organization of cells, vasculature and extracellular matrix, underpins its function, yet how structure changes with age remains mostly unknown. Here we developed PathStAR, a framework that quantifies tissue structural aging from routine histopathology images, without being trained to predict chronological age. Applying PathStAR to 25,306 post-mortem biopsies from 40 tissues in 970 donors aged 21–70 years revealed that organ structural aging progresses via distinct, nonlinear …

31.08.2026journal-article

BMC Nephrology

Kidney transplantation in older people (KTOP): a longitudinal, qualitative study of kidney transplant experiences in older, frail adults

Lina Johansson, Shone Surendran, Annabel Rule, Nicola Thomas, Amarpreet K. Thind, Michelle Willicombe, Edwina A. Brown

Abstract Background Transplantation rates are increasing in those who are older and frail, driven by an aging dialysis population. This longitudinal, qualitative study explores how older adults navigate the journey from dialysis to transplantation and how frailty is experienced at each stage. Methods Twenty-one participants aged ≥ 60 years were recruited, all of whom were on dialysis awaiting kidney transplantation, with an Edmonton Frail Scale score of ≥ 6, indicating frailty or vulnerable to frailty. Participants …

31.08.2026journal-article

BMC Primary Care

Sodium-containing medications and laxative use among older primary care patients requiring sodium restriction: findings from the LAXAP study

Amelia González Gamarra, Gema Montemayor Galán, Patrocinio José Motos Díaz, Diana Fernández Torre, Javier Legrá Rodríguez, Fabio Yeray Cabrera Pérez, Marta Cano Gómez, Soledad Escolar Llamazares, José Mª Fandós Olona, Fernando Fernández Moyano, Pablo Hernández Hernández, Ana Javierre Miranda, Jorge Pérez González, Javier Santa Cruz Hernández, Mª José Busto Martínez, Silvia Canivell

Abstract Background High sodium intake is a global health concern, contributing to conditions like hypertension, chronic kidney disease (CKD), and cardiovascular diseases (CVDs). While efforts have been made to reduce sodium in diets, the sodium content in medications is often overlooked, posing additional risks. High sodium content is generally associated with specific pharmaceutical formulations rather than being an inherent component of most medications, particularly effervescent formulations containing sodium s …

31.08.2026journal-article

International Journal Of Community Medicine And Public Health

Urolithin A-induced mitophagy: a mitochondrial therapeutic axis for decelerating musculoskeletal aging and modulating knee osteoarthritis pain

Aavrati Rastogi, Roop B. Kalia, Mukesh Bairwa

Knee osteoarthritis (OA) is a disease characterized by cellular energy dysregulation, in which structural joint deterioration and chronic pain are caused by mitochondrial dysfunction. OA is now recognized as a multifactorial condition caused by disturbed cellular homeostasis, metabolic imbalance, and typical biological processes of aging, notably mitochondrial dysfunction. However, it was once thought to be caused by mechanical wear and cartilage degradation

31.08.2026journal-article

Frontiers in Aging Neuroscience

Interpretable machine learning model based on multimodal MRI radiomics for Alzheimer's disease diagnosis

Nuerbiya Keranmu, Dilireba Aizezi, Xingyong Pan, Longtao Yang, Ying Liu, Jun Liu

Objective Alzheimer's disease (AD), the most common neurodegenerative disorder, is a leading cause of cognitive impairment and dementia in older adults. This study aimed to develop an interpretable machine learning model using multimodal MRI radiomics for the diagnosis of Alzheimer's disease. Materials and methods A total of 110 subjects (48 AD, 62 healthy control subjects) underwent 3D T1WI, DWI, and T2WI scans. Radiomics features were extracted from eight AD-related brain regions and selected using a three-step a …

31.08.2026journal-article

Alzheimer's & Dementia

Building a dementia‐capable workforce: Implementation and evaluation of a state‐mandated dementia training program for memory care staff

Sara Crance, Gillian Hamilton, Calli Carlson, Kellie Garrett, Tory Roberg

Abstract As dementia prevalence rises, developing a dementia‐capable workforce is a national priority. Training requirements vary widely across states, and many memory care staff receive limited dementia education. Although evidence supports dementia training, little is known about translating policy into practice. This paper describes the implementation and evaluation of a statewide mandated dementia training initiative in Arizona. After passage of AZ HB2764 (2024), developed and supported by the Alzheimer's Assoc …

31.08.2026journal-article

Alzheimer's & Dementia

A strategic pathway for the ethical development of AI tools in dementia care

Nicole Deaner, Morgan Daven, Aanand D. Naik, Marwan Sabbagh, Andrew Breithaupt, Katherine Possin, Susan Alford, Ashley Alexander, Aaron Daniels, Lisa Dezzutti, Viviana F. Bumaschny, the Alzheimer's Association Innovation Roundtable

Abstract Artificial intelligence (AI) is rapidly entering dementia clinical practice, offering opportunities across the care continuum. However, cognitive decline creates a unique ethical challenge. This perspective article proposes a strategy to ensure the responsible development and deployment of AI tools for dementia. An interdisciplinary workgroup of the Alzheimer's Association Innovation Roundtable synthesized ethical frameworks, regulatory standards, and empirical evidence to generate expert consensus. The re …

31.08.2026journal-article

Journal of General Internal Medicine

Breaking Barriers: Advancing Gender Equity in Geriatric Medicine. Results of an International Survey

Anna Rudzińska, Ian Perera, Sofia Duque, Marina Kotsani, Robert Kupis, Jerzy Gąsowski, Mirko Petrovic, Anne Ekdahl, Karolina Piotrowicz

Abstract Introduction Although there are more women than men working in the healthcare system in Europe, reports of gender-related inequities within the healthcare workforce are still emerging. Our study aimed to gather insights from women, representing different healthcare professions, who work in the field of geriatric medicine and gerontology, to better understand their perspectives and experiences. Methods In February 2025, we distributed an anonymous online survey to women affiliated with the PROGRAMMING COST …

31.08.2026journal-article

Nursing and Health Sciences Journal (NHSJ)

Enhancing household disaster preparedness among older adults using the N-TORM intervention: A quasi-experimental study in rural Indonesia

Diki Ardiansyah, Roviatul Imaniah, Rita Fitri Yulita, Susilawati Susilawati, Asep Badrujamaludin, Khrisna Wisnusakti, Firman Sugiharto

Older adults in earthquake-prone low- and middle-income countries (LMICs) face disproportionate disaster-related morbidity and mortality. Culturally adapted, nurse-led preparedness programs for this demographic in seismically active LMIC settings remain largely unexplored. This study evaluated the effectiveness of the Nurses Taking on Readiness Measures (N-TORM) intervention on household emergency preparedness (HEP) among older adults (≥ 60 years) residing near Indonesia’s Lembang Fault. A quasi-experimental, non-e …

31.08.2026journal-article

Pharmaceuticals

Lithium as a Potential Senostatic Agent in Central Nervous System Aging and Bipolar Disorder

Janusz K. Rybakowski, Cezary Mydlak, Nadzieja Klimek, Krzysztof Książek

Lithium remains the gold-standard maintenance treatment for bipolar disorder (BD) and is distinguished by its unique anti-suicidal and neuroprotective properties. Beyond its established psychiatric efficacy, growing evidence suggests that lithium may modulate fundamental mechanisms of biological aging. In parallel, cellular senescence has emerged as a central process linking oxidative stress, chronic inflammation, mitochondrial dysfunction, and impaired cellular resilience with neurodegeneration and psychiatric dis …

31.08.2026journal-article

European Journal of Anaesthesiology

Hospital exposome and physiological resilience are associated with postoperative delirium, major complications, and long-term cognitive decline in older adults undergoing cancer surgery

Shengjie Pan, Gang Wang

BACKGROUND Postoperative delirium (POD) and long-term cognitive decline remain frequent and incompletely explained complications in older adults undergoing cancer surgery. Hospital environmental exposures (exposomes) may be associated with age-related physiological vulnerability, yet prospective evidence integrating ward-level exposome data with multidomain physiological resilience is limited. OBJECTIVE To examine the associations of hospital environmental burden and physiological resilience with POD, major complic …

31.08.2026journal-article

Frontiers in Public Health

Functional impairment profiles and long-term care implications among community health service-managed older adults with disability in China: a latent profile and network analysis study

Ruishan Liu, Yiheng Chen, Ting Niu, Dingyi Zhang, Yuelin Li, Yulin Lu, Dan Yang

Objective To identify functional impairment profiles among older adults with disability managed within a community health service catchment in China and examine classification-adjusted associations between living arrangement and profile membership. Methods This cross-sectional study included 361 older adults with disability from 13 communities in Kunming, China, surveyed from January to March 2026. Functional ability was assessed using the Specification for Ability Assessment of Older Adults (GB/T 42195–2022). Late …

31.08.2026journal-article

Bioengineering

DiAbot: A Conversational AI System Coupling Large Language Models with an Interpretable Decision Tree for CDR-Style Dementia Screening

Hala Alshamlan

Alzheimer’s disease and related dementias are projected to affect more than 150 million people worldwide by 2050. Early staging with validated instruments such as the Clinical Dementia Rating (CDR) scale is essential for timely intervention, yet access to clinician-administered CDR assessment remains constrained by workforce, time, and geographic barriers. This study complements a previously published machine learning pipeline for Alzheimer’s disease prediction by addressing the downstream task of dementia staging. …

31.08.2026journal-article

Asian Spine Journal

Differential association of psoas and paraspinal muscle volumes with appendicular lean mass index: AI-derived lumbar computed tomography three-dimensional volumetric indices in older Korean Women: an observational study

Eun Chae Lee, Jang Hyuk Cho, Dong Gyu Lee

Study Design: Retrospective cross-sectional study.Purpose: To investigate the relationship between sarcopenia-related markers and artificial intelligence (AI)–derived three-dimensional (3D) volumetric indices of lumbar muscles.Overview of Literature: Sarcopenia is characterized by loss of skeletal muscle mass and physical function. Although appendicular skeletal muscle mass (ASM) is widely used for sarcopenia assessment, reliable evaluation of lumbar paraspinal muscles remains limited. AIbased 3D volumetric analysi …

31.08.2026journal-article

Journal of Korean Gerontological Nursing

Risk factors for falls and fall-related injuries among community-dwelling older adults in Korea: A longitudinal study

Beomman Ha, Seonho Kim

Purpose: This study aimed to identify risk factors for falls and fall-related injuries among community-dwelling older adults in Korea. Methods: This longitudinal study analyzed 3,186 adults aged 65 or older using nationally representative data from the Korean Longitudinal Study of Aging across three waves (2018, 2020, and 2022). We conducted multiple logistic regression analyses to identify risk factors for falls and fall-related injuries. Results: Over the 4-year follow-up, 148 participants (4.6%) experienced a fa …

31.08.2026journal-article

JNCI: Journal of the National Cancer Institute

Predictive validity of a 10-item frailty index based on a comprehensive geriatric assessment (FI-CGA-10) in older Japanese adults with cancer

Tomohiro F Nishijima, Mototsugu Shimokawa, Kohei Arimizu, Taito Esaki, Masaru Morita, Hyman B Muss

Abstract Background The 10-Item Frailty Index Based on a Comprehensive Geriatric Assessment (FI-CGA-10) is a content- and construct-validated measure for quantifying frailty from a CGA. For criterion validation, we assessed its predictive validity for overall survival (OS) in older adults with cancer. Methods This prospective cohort study included 1,630 patients with cancer who underwent CGA at a geriatric oncology service (median age 80 years). The FI-CGA-10 comprises ten CGA domains; deficits in each domain were …

31.08.2026journal-article

Geriatrics & Gerontology International

Possible Sarcopenia and Subsequent Cognitive Function in Older Chinese Adults: Limited Evidence for Mediation by Frailty

Daming Qiu, Dongyun Cao, Yihuan Liu

ABSTRACT Aim To examine the longitudinal association between possible sarcopenia and subsequent cognitive function in older Chinese adults and whether a 27‐item frailty index accounted for this association. Methods We analyzed China Health and Retirement Longitudinal Study data using a primary three‐stage sequence: possible sarcopenia, physical activity and covariates in 2011; frailty in 2013; and cognition in 2015. Multiple imputation ( m = 20), bootstrap estimation with Rubin pooling and independent R 4.5.0 repli …

31.08.2026journal-article

Viruses

Examining Age as Moderating Associations Between Methamphetamine Abstinence and Cognitive Function in People with HIV

Victoria O. Chentsova, Jennifer E. Iudicello, Anya Umlauf, Akashi K. Suon, Igor Grant, Mariana Cherner

Objective: This study examined associations of days of methamphetamine (METH) abstinence with neurocognitive functioning and whether age moderates this relationship in people with HIV (PWH). Methods: Retrospective data from 122 PWH with lifetime METH use disorder (MUD) were analyzed. Linear, piecewise, and curvilinear models were compared to characterize the association between length of METH abstinence and Global neuropsychological test T-scores. An interaction term between METH Abstinence Days and Age Group (49) …

31.08.2026journal-article

BMC Endocrine Disorders

Reserve-informed cardiovascular-kidney-metabolic risk stratification for cardiometabolic multimorbidity progression in middle-aged and older adults: a multi-cohort study

Cheng Shen, Bohao Xue, Jin Li

Abstract Background Cardiovascular-kidney-metabolic (CKM) assessment may not capture heterogeneity in vulnerability to cardiometabolic multimorbidity (CMM). We evaluated whether objective functional reserve could provide a complementary phenotyping layer. Methods We analysed CHARLS as the development cohort, HRS VBS as the primary supportive replication cohort, ELSA as a simplified transportability cohort, and SHARE W6 DBS as a grip-only robustness cohort. Equal-weight cohort-specific CKM domain counts were crossed …

31.08.2026journal-article

Studia mythologica Slavica

Why People Go to Mediums: Motivations and Embodied Experience among Clients of the Three-Legged Stool Practice in Hungary

Emese Ilyefalvi

This article examines contemporary mediumship in Hungary through ethnographic research among practitioners of a three‑legged stool technique and their clients. Drawing on interviews, participant observation and analysis of séance practices, the study explores why people seek contact with the dead and how these encounters generate experiential certainty, address crises and produce new forms of meaning. By situating the Hungarian material within broader European and global contexts, the article shows how individualis …

31.08.2026journal-article

Bioinformation

Mistreatment and coping among the urban geriatric population

Faizunnisa Mohamed Asadullah Roomy

Elder abuse is an underreported concern among urban elderly populations in India. Therefore, it is of interest to assess the mistreatment prevalence and coping strategies among elderly individuals in Chennai. Higher mistreatment was associated with age above 70 years, retirement and assistive device use. Better coping was associated with higher education, income and assistive device use. Thus, targeted interventions are needed to reduce elder abuse and strengthen resilience among elderly individuals.

31.08.2026journal-article

GSC Advanced Research and Reviews

HEALTH LOCUS OF CONTROL, MEDICATION ADHERENCE AND QUALITY OF LIFE AS PREDICTORS OF DEATH ANXIETY AMONG PEOPLE LIVING WITH HIV/AIDS

Ojie Owen Isa, Joshua Edet Ifere, Peter Odey, Regina Onung Odey

Introduction: The diagnosis of an incurable disease can trigger a profound existential crisis as everyday life and the future are threatened for both patients and their families. As an existential issue, death anxiety stems from the conscious awareness of our own mortality. Aim: The study therefore attempts to examine the potential influence that health locus of control, medication adherence, and quality of life could have on death anxiety among HIV/AIDS patients. Methodology: The study utilized a cross sectional s …

31.08.2026journal-article

European Journal of Multidisciplinary Health Sciences

A Bibliometric Analysis of Research on Depression and Exercise in Older Adults

Canan Yüksel Haji, Emine Nacar, Sinem Suner-Keklik

Depression is a common mental disorder worldwide and significantly affects older adults. Considering the potential role of exercise in depression management, examining research trends in this field using bibliometric methods is important. Accordingly, this study aimed to provide a systematic overview of the development of the literature by analysing English-language publications indexed in the Web of Science Core Collection using search terms related to depression, exercise, and older adults, without applying publi …