EUVIMEDEuropean Health Evidence
Uhr 7/7Sources Journal Tree
Easy Demo

EUVIMED Themenbrowser · Onkologie · Seite 22

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

Themen erkunden

Aktuelle Forschung nach Fachgebiet

24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

JAMA Surgery

An Exosomal Signature for Preoperative Detection of Occult Liver Metastasis in Pancreatic Cancer

Takayuki Noma, Jingyang Yin, Junfeng Zhang, Caiming Xu, Mitsuro Kanda, Song Cheol Kim, Yuji Morine, Mitsuo Shimada, Vincent Chung, Ali H. Zaidi, Daniel Von Hoff, Huaizhi Wang, Ajay Goel

Importance Early liver metastasis (early-LiM) after pancreatectomy represents an aggressive biological phenotype of pancreatic ductal adenocarcinoma (PDAC) and is associated with markedly poor survival. Reliable preoperative biomarkers to identify occult hepatic micrometastasis remain lacking. Objective To develop and externally validate a circulating exosomal microRNA (exo-miRNA)–based machine learning model for preoperative detection of occult early-LiM in PDAC. Design, Setting, and Participants This multicenter …

02.09.2026journal-article

CRO (Clinical & Refractive Optometry) Journal

Teprotumumab Treatment for Thyroid Eye Disease in a Patient with Pre-Existing Hearing Loss: Worth the Risk?

Wyatt Hyke, Cheryl Polinsky, Lisa Schifanella

Thyroid eye disease (TED) can lead to reduced vision from corneal scarring or optic nerve compression. Other manifestations of thyroid eye disease that can be troubling for TED patients include proptosis, extraocular muscle restrictions and diplopia, soft tissue swelling, dry eye, and conjunctival injection over the extraocular muscle insertions. Intravenous teprotumumab was approved by the Food and Drug Administration (FDA) in 2020 for the treatment of active TED. Teprotumumab can cause potentially permanent sever …

02.09.2026journal-article

Animals

Clinical Findings, Treatment and Long-Term Outcome in 37 Cats with Non-Associative Immune-Mediated Hemolytic Anemia: A Retrospective Observational Study of Two Treatment Cohorts

Lisa-Maria Kulmer, Pavlos G. Doulidis, Iwan A. Burgener, Nicole Luckschander-Zeller

Background: Non-associative immune-mediated hemolytic anemia (IMHA) is uncommon in cats and carries substantial mortality. Glucocorticoids are first-line treatment, and cyclosporin A (CsA) is frequently added, but data on the clinical course and long-term outcome are limited. We describe clinical findings, treatment, adverse events and outcome in cats with non-associative IMHA. Methods: In this retrospective observational single-center study (October 2014–October 2024), 37 cats diagnosed by the 2019 ACVIM consensus …

02.09.2026journal-article

Water Science & Technology

Antimicrobial resistance control in wastewater treatment plants: from removal efficiency to resistance-risk reduction

Timoth Mkilima

ABSTRACT Flow diagram showing AMR-related constituents moving from municipal, hospital-influenced, and industrial or pha rmaceutical wastewater through primary treatment, biological treatment, solids separation, and disinfection or advanced polishi ng. Outputs include treated effluent, reclaimed water, sludge or biosolids, and residual streams. These connect to receiving wat ers, irrigation or reuse, land application or further handling, and return-to-treatment or separate management pathways. Resista nce-risk endp …

02.09.2026journal-article

Scientific Reports

Extensively drug-resistant ESBL-producing enterobacterales and coexisting antimicrobial resistance genes are associated with mortality in critically ill patients with cancer

Samah Mohammed Refay, Noha Gaber Sayed, Waleed M. El Kazzaz

Abstract ESBL-producing bacteria are a problem in patients with cancer. The emergence of XDR phenotypes with ESBLs increases mortality. We aimed to evaluate ESBL-producing bacteria, the prevalence of MDR and XDR phenotypes, ESBL genes, and mortality predictors in patients with cancer in the ICU. Different clinical cultures were collected from patients in oncology ICUs. We used the VITEK2 system to identify isolates and assess antibiotic sensitivity, and the combination disk method to detect ESBL phenotypes. β-lacta …

02.09.2026journal-article

Problems of Gathering Treatment and Transportation of Oil and Oil Products

STABILIZATION OF MULTIPHASE HYDROCARBON FLOW IN OIL AND GAS GATHERING PIPELINES IN FIELDS WITH COMPLEX TOPOGRAPHY

E.F. Khamatdinov, G.E. Korobkov

Integrated oil and gas gathering and transportation systems have become widely used in the development of remote fields. These areas are often characterized by significant logistical and infrastructural constraints. When organizing joint collection of oil and gas via field gathering pipelines at oil and gas, as well as oil and gas condensate fields, certain factors may arise that adversely affect the stable transportation of multiphase hydrocarbon flows to wellstream treatment facilities.This creates tasks whose so …

02.09.2026journal-article

Nature Cell Biology

Multi-stromal organoid co-culture modelling reveals epithelial–fibroblast heterogeneity in pancreatic cancer and pancreatitis

Wenlong Li, Muntadher Jihad, Eloise G. Lloyd, Marta Zaccaria, Gianluca Mucciolo, Gideon Nsubuga, Alwin Koonan-Lonappan, Joaquín Araos Henríquez, Priscilla S. W. Cheng, Sneha Harish, Sally Mills, Paul M. Johnson, Weike Luo, Alejandro Alonso Montero, Rebecca Brais, Alex Deamer, Ania M. Piskorz, Julia Jones, Jodi L. Miller, Bristi Basu, Paul D. W. Kirk, Mireia Vallespinos, Giulia Biffi

Abstract Interactions between epithelial cells and fibroblasts influence disease progression and treatment response in pancreatic ductal adenocarcinoma (PDAC). While the diversity of fibroblasts in PDAC is increasingly recognized, it remains unclear how these cells differ from fibroblasts found in pancreatic inflammation. Chronic pancreatitis is a stroma-rich inflammatory disease and a risk factor for PDAC, making it a useful setting to study how epithelial cells and fibroblasts change during disease. Here we compa …

02.09.2026journal-article

Problems of Gathering Treatment and Transportation of Oil and Oil Products

STUDY OF GROUTING COMPOSITION FOR RESTORING THE TIGHTNESS OF THE PRODUCTION WELL CASING AND ELIMINATING WATER INFLUX

G.S. Dubinsky, V.G. Mukhametshin

This article presents the results of a study of a composite fast-hardening cement slurry based on urea-formaldehyde synthetic resin, designed for effective waterproofing and repair and insulation work. Unlike similar products, this fast-hardening cement slurry effectively cures over a wide temperature range from 20°C to 100°C. The curing time and rate of the analyzed cement slurry are regulated by the hardener concentration and type over a wide time frame, from several tens of minutes to 5-8 hours. The flexural str …

02.09.2026journal-article

JAMA Psychiatry

Serial Ketamine Infusions for Treatment-Resistant Bipolar Depression

Diana K. Orsini, Sara Di Luch, George Tomlinson, Gabrielle F. M. Lovell, Shreya Vasudeva, Nelson B. Rodrigues, Danica E. Johnson, Alastair J. Flint, Cristian-Daniel Llach, Roger S. McIntyre, Rodrigo B. Mansur, Keyvan Karkouti, Amer M. Burhan, Erica Kaczmarek, Noah Chisamore, Anuj Bhatia, Neilesh Soneji, Anahita Joshi, Deep Grewal, Rachel Laframboise, Joshua D. Rosenblat

Importance Antidepressant efficacy of intravenous (IV) ketamine has been demonstrated in major depressive disorder; however, the efficacy and safety of ketamine for bipolar depression remain largely unknown, with limited data available in this specific population. Objective To evaluate the efficacy, safety, and tolerability of adjunctive IV ketamine compared with midazolam for treatment-resistant bipolar I or II depression (TRBD). Design, Setting, and Participants The Ket-BD study (Ketamine for Treatment-Resistant …

02.09.2026journal-article

Journal of Electronic Materials

HTL-Free Perovskite Solar Cells with a Carbon Electrode and Enhanced Stability, Through a Scalable Polymer Treatment Method

Maria Bidikoudi, Christina Tiflidis, Elias Stathatos

Abstract Perovskite solar cells with a carbon electrode (C-PSCs) are considered the most promising and viable structure for the upscaling and future commercialization of PSCs. With the ability to be fabricated with industrially compatible methods and with no need for employing hole transport materials, C-PSCs are not randomly moving to the forefront of PSC research at the moment. In this work, hole transport material (HTM)-free C-PSCs have been fabricated under entirely ambient conditions. The devices employ an add …

02.09.2026journal-article

Journal of Orthopaedic & Sports Physical Therapy

Can Clinicians Predict Which Patients Respond Best to a Specific Treatment? A Systematic Review of Low Back Pain Moderators in Primary Care

Tayla Douglas, Hazel Jenkins, Leticia Correa, Leandro Nogueira, Annika Young, Mark Hancock

OBJECTIVE: To synthesise and critically evaluate evidence on treatment effect moderators in the primary care management of low back pain (LBP). DESIGN: Systematic review of randomised controlled trials (RCTs) and secondary analyses of RCTs. LITERATURE SEARCH: Medline, EMBASE, CINAHL and Cochrane Library were searched from inception to August 2025. STUDY SELECTION CRITERIA: RCTs investigating moderators for primary care interventions in non-specific LBP. DATA SYNTHESIS: Data were synthesised by exploring data cluste …

02.09.2026journal-article

Pharmaceutical Science and Technology

InSilico Jargons~ Discussions & Amplification: Relationing with Colo Rectal Cancer

Deepak Bhattacharya, Kavita Chanania, Chandra Tripathy

Background: Computational drug alias InSilico studies have become popular & dependable research planks. Basic & multi-disciplinary scientific-&-technical jargons are used aplenty. Clinicians of all levels & support resource persons are evincing interest to grasp. InSilico is a vague-bogus-Anglo-Latin term meaning ‘experiments using computer platforms only’ wherein ‘platform’ means ‘software-&-hardware’. Problem: Computer involves all the sciences butted-&-bounded by humanities processed-&-packaged logically gets to …

02.09.2026journal-article

Neuro-Oncology Advances

Metabolomic and lipidomic profiling reveals distinct subtypes of glioblastoma IDH-wildtype and shared metabolic features with astrocytoma IDH-mutant grade 4

John Paul Aboubechara, Yin Liu, Oliver Fiehn, Muhammad Sulman, Alexander Del Bosque, Diego Cantillo, Lina A Dahabiyeh, Ruben Fragoso, Jonathan W Riess, Rawad Hodeify, Orin Bloch, Vihar Patel, Orwa Aboud

Abstract Background Glioblastoma IDH-wildtype (GBM) is a metabolically diverse and aggressive brain tumor. While transcriptomic subtypes are well-defined, they lack a direct understanding of the tumor’s metabolism. We used integrated, untargeted metabolomics and lipidomics to define the functional metabolic landscape of GBM and astrocytoma, IDH-mutant, Grade 4, and to identify intrinsic metabolic subtypes with specific vulnerabilities. Methods Brain tissue from GBM patients (n = 38), astrocytoma IDH-mutant, Grade 4 …

02.09.2026journal-article

Clinical Cancer Research

DNMT3B Plays Antagonistic Roles with SMARCB1 and Is a Targetable Vulnerability in Rhabdoid Tumors

Céline Chauvin, Ryszard Wimmer, Ludovica Brunetti, Joanna Cyrta, Ana Boranijasevic, Mamy Andrianteranagna, Julien Masliah-Planchon, Kévin Beccaria, Sandrina Turczynski, Grégory Thomson, Maëva Veyssière, Rachida Bouarich-Bourimi, Zhi-Yan Han, Owen Hoare, Aurore Coulomb, Mylène Bohec, Sylvain Baulande, Gaëlle Pierron, Olivier Delattre, Arnault Tauziède-Espariat, Nicolas Servant, Alexandre Baffet, Franck Bourdeaut

Abstract Purpose: Rhabdoid tumors (RT) are highly aggressive pediatric cancers driven by the biallelic inactivation of the SMARCB1 tumor-suppressor gene, the sole recurrent genetic alteration. SMARCB1 encodes a core subunit of the SWI/SNF chromatin remodeling complex; its loss disrupts epigenetic gene regulation, supporting the classification of RT as prototypical epigenetically driven cancers and highlighting the therapeutic potential of targeting epigenetic modifiers. Notably, previous studies have reported the o …

02.09.2026journal-article

Practice Nursing

Skin cancer detection: a primary care essential

Margaret Perry

Skin cancers occur in countries around the world and appear in various forms, each type presenting differently. Early diagnosis and treatment yield the best outcomes, with most types being curable if they are detected and treated promptly. This article outlines the different types of skin cancer, as well as risk factors, diagnosis and treatment, with a focus on the role of general practice nurses in recognition of suspicious lesions and the required course of action. It aims to improve nurses' confidence when seein …

02.09.2026journal-article

Applied Biosciences

Pure Mycelium Sheets from Edible Mushrooms for Sustainable Packaging: A Comparative Assessment of Glycerol and ZnONPs Treatment

Sasikan Channgam, Gad Elsayed Mohamed Salem, Thatsanee Luangharn, Supachai Pisuchpen, Thomas Karbowiak, Pornchai Rachtanapun, Wirongrong Tongdeesoontorn

Increasingly, mycelium-based biomaterials are being investigated as sustainable alternatives to conventional packaging materials, but their inherent brittleness limits their practical application. The present study investigated the properties of pure mycelium sheets sourced from Ganoderma sp., Lentinus sp., and Pleurotus sp., employing glycerol plasticization and zinc oxide nanoparticles (ZnONPs). The findings revealed that growth and structural attributes varied according to the species, with Ganoderma and Lentinu …

02.09.2026journal-article

Journal of the Egyptian National Cancer Institute

Multi-omics integration uncovers epigenetic control of metabolic reprogramming in triple-negative breast cancer

Esraa M Hashem, Mai S. Mabrouk

Abstract Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by the absence of estrogen, progesterone, and HER2 receptors, limiting effective targeted therapies. Increasing evidence suggests that metabolic reprogramming, a hallmark of TNBC progression, is driven by underlying epigenetic mechanisms such as DNA methylation. The represented study performed an integrative analysis of transcriptomic (RNA-seq) and methylome data to uncover the metabolic–epigenetic interplay in TNBC. Differential g …

02.09.2026journal-article

Annals of Plastic Surgery

Final Tongue Size in the Treatment of Macroglossia Associated With Beckwith-Wiedemann Syndrome

Renato da Silva Freitas, Lucas Guimarães Alves, Maitê Mateus, Isabella Correa de Oliveira, Marc Domit Werner Linnenkamp, Isis Juliane Guarezi Nasser, Eduardo Angeli-Freitas

Beckwith-Wiedemann syndrome (BWS) is a rare congenital disorder whose main clinical feature is macroglossia. This frequent manifestation may impair respiratory, feeding, speech, and orofacial developmental functions. When significant functional and/or aesthetic repercussions are evident, surgical excision is the primary management approach, with several techniques described. In this study, we analyzed medical records from 29 patients diagnosed with BWS and macroglossia, and evaluated 26 cases of partial glossectomy …

02.09.2026journal-article

Current Oncology

Tumour GDF-15 Expression and Clinical Outcomes in Intermediate-Risk Metastatic Clear-Cell Renal Cell Carcinoma Treated with Second-Line Nivolumab

Orhun Akdogan, Betul Ogut, Osman Sutcuoglu, Melike Urganci, Burcu Ulas Kahya, Ipek Isik Gonul, Hatice Azra Begum Salimoglu, Tuba Ugur Tuzcu, Ozan Yazici, Ahmet Ozet, Nuriye Ozdemir

Background: Immune checkpoint inhibitors have improved outcomes in metastatic clear-cell renal cell carcinoma (mRCC), yet clinically applicable tissue biomarkers remain limited. Growth differentiation factor-15 (GDF-15) promotes tumour immune evasion and has emerged as a potential therapeutic target in immuno-oncology. We evaluated the prognostic significance of tumour GDF-15 expression in patients with intermediate-risk clear-cell mRCC treated with second-line nivolumab. Methods: Forty-six patients with intermedia …

02.09.2026journal-article

ASCE MAGAZINE

Barreras y factores asociados al tamizaje y diagnóstico temprano del cáncer cervicouterino en mujeres de zonas rurales: una revisión sistemática

Jessica Andrea Encalada Falconí, Luis Alberto Erosa-De Haro, Jesús Javier Ñaccha Urbano, Milena Mishelle Paredes Sandoval, Nathaly Elvia Sánchez Navarrete

El cáncer cervicouterino, constituye un importante problema de salud pública, aunque dispone de medidas eficaces de prevención, y detección temprana; sin embargo, las mujeres que residen en zonas rurales, enfrentan dificultades que limitan su acceso a los programas de tamizaje, lo que incrementa el riesgo de diagnósticos tardíos, y reduce las posibilidades de tratamiento oportuno. Por ello, el objetivo fue; identificar, analizar y sintetizar, la evidencia disponible sobre las barreras, y los factores asociados al a …

02.09.2026journal-article

Analytical Chemistry

Ultrasensitive Breath Analysis of Lung Cancer Biomarkers Using a Carboxyl-Functionalized Hyper-cross-linked Polymer–Based SPME Coupled with GC─MS

Huanhuan Li, Mingyu Wang, Mingwei Wang, Hongyuan Yan

Abstract Exhaled breath analysis offers a noninvasive route for disease screening, yet its practical implementation is constrained by ultratrace analyte levels, high humidity, and limited selectivity of existing enrichment materials. Herein, we report the rational design of a carboxyl-functionalized hyper-cross-linked polymer (HCPs-COOH) as a high-performance solid-phase microextraction (SPME) coating and its integration into a two-step preconcentration workflow for breath analysis. The HCPs-COOH exhibits an ultrah …

02.09.2026journal-article

International Journal of Secondary Metabolite

Evaluation of the anti-carcinogenic effect of tea tree oil (Melaleuca alternifolia) on SK-BR-3 breast cancer cells

Mehmet Fatih Seyhan, Hümeyra Dağdagül, Özge Nur Eroğlu, İrem Okumuş

Breast cancer cells that overexpress HER2 are related to poorer survival outcomes compared to HER2-negative tumors and are recognized for their higher aggressiveness. The study aimed to evaluate the possible effects of Melaleuca alternifolia (tea tree oil, TTO), a plant known for its broad antimicrobial and anticancer characteristics, on cell viability, cell migration, and oxidative stress in SK-BR-3 cells, which represent HER2+ breast cancer, for the first time. The efficacy of different concentrations of TTO on c …

02.09.2026journal-article

Ibnosina Journal of Medicine and Biomedical Sciences

Mechanistic Insights into IL-17 Pathway Modulation in Breast Cancer by Pteridaceae Bioactive Compounds: A Network Pharmacology and Molecular Docking Approach

Purodhika Gupta, Pankaj Sharma, Ashish K. Yadav, Priya Bansal, Abhishek Kumar

Abstract This study assessed the pharmacological prospects of Pteridaceae phytoconstituents using an integrated network pharmacology (NP) and computational molecular docking (MD) strategy. Various peer-reviewed literature databases, including ScienceDirect, PubMed, Scopus, and Google Scholar, were used to gather bioactive constituents reported from this family. Absorption, Distribution, Metabolism, Excretion and Toxicology (ADMET) parameters, drug-likeness rules, and bioavailability scores were evaluated using Swis …

02.09.2026journal-article

Neuro-Oncology Practice

Dutch Linguistic Intraoperative Protocol Extended: new standardized items and tasks for language monitoring in awake glioma surgery for mild to severe aphasia

Marike Donders-Kamphuis, Arnaud Vincent, Saskia Mooijman, Ellen Collée, Clemens Dirven, Rob Nabuurs, Bram Bulté, Dorien Vandenborre, Evy Visch-Brink, Elke De Witte, Djaina Satoer

Abstract Background Awake surgery is the standard treatment for low-grade glioma patients in eloquent areas, but also seems to result in better surgical outcomes in glioblastoma patients. The Dutch Linguistic Intraoperative Protocol (DuLIP) is a validated tool for intraoperative language monitoring. However, in clinical practice, there is a need for additional items and tasks. Therefore, we aimed to develop and standardize an extended version of DuLIP (DuLIP-Extended). Methods We developed 1) Extra items for word r …