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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

Journal of Craniofacial Surgery

Correlation Between CT Manifestations and Treatment Strategy in Nasal Bone Fractures

Weihua Ren, Xi Wu, Lijiao Guo, Guoyong Song, Guangjun Ma, Yue Zhang

Objective: To determine the association between detailed CT manifestations of nasal bone fracture and treatment strategy, emphasizing whether CT-derived structural severity can stratify conservative treatment, closed reduction, and open reduction/septorhinoplasty. Methods: This retrospective imaging-based analysis included 80 patients with nasal bone fractures treated between January 2023 and May 2026. Thin-section CT indicators included maximum displacement, bony overlap, fracture laterality, fracture-line count, …

02.09.2026journal-article

Journal of Medical Clinical Case Reports

Breast Cancer, Disability, and Caregiving: An Evidence Mapping Review of Psychosocial Needs, Barriers to Care, and Support Interventions

Georgia Konstantopoulou, Eirini Chytopoulou

Background: Women with pre-existing disabilities may experience substantial inequalities across the breast cancer care continuum, including barriers to screening, communication, diagnosis, treatment, and psychosocial support. Although disability-related disparities in breast cancer screening are increasingly recognized, evidence concerning psychosocial needs, caregiver involvement, and supportive adaptations remain fragmented. Objective: This evidence mapping review aimed to identify and conceptually organize resea …

02.09.2026journal-article

Frontiers in Oncology

Immunotherapy role in bladder cancer treatment: a review of literature

Nishanth Thalambedu, Krishna Vasipalli, Nikhila Sampath Kumar, Sruthi Vellanki, Anup Kumar Trikannad, Manoja Gullapalli, Shi Ming Tu, Anuradha Kunthur

Immunotherapy has changed the landscape of bladder cancer treatment in recent years, both for localized and metastatic bladder cancer. While bacillus Calmette–Guérin (BCG) remains the gold standard for high-risk non–muscle-invasive bladder cancer, the development of checkpoint inhibitors continues to increase treatment options for patients who are intolerant or unresponsive to BCG. In the setting of muscle-invasive bladder cancer, perioperative checkpoint blockade has shown promising pathologic response rates and s …

02.09.2026journal-article

Molecular Oncology

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen

Cyclin‐dependent kinases (CDK) drive the progression through the cell cycle and thereby form classical targets for cancer therapy. Targeting androgen receptor (AR) is effective against prostate cancer (PC), but frequently leads to development of incurable castration‐resistant PC (CRPC). We show that emergence of CRPC is associated with significant upregulation of CDK2 cyclins and downregulation of CDK4/6 cyclins. This rewiring renders CRPC cells dependent on the high CDK2 activity, and CDK2‐specific inhibitors effi …

02.09.2026journal-article

Proceedings of the National Academy of Sciences

Breast cancer prevention by prophylactic Lalba mRNA-LNP vaccination

Jun Nishida, Marco Seehawer, Ernesto Rojas Jimenez, Pengze Yan, Triet M. Bui, Pierre Foidart, Hiromi Muramatsu, Marie-Anne Goyette, Xinran Cai, Zheqi Li, Mitchell B. Beattie, Norbert Pardi, Kornelia Polyak

Tumor-suppressive immunity is more evident in early-stage compared to advanced tumors making it the ideal point for cancer interceptive immunotherapies. We previously described that higher peripheral T cell diversity is associated with more pronounced CD8 + T cell infiltration in ductal carcinoma in situ of the breast, implying a close interaction between peripheral and intratumor immunity. Here, we developed lipid nanoparticle (LNP)-encapsulated messenger ribonucleic acid (mRNA) vaccines expressing the alpha-lacta …

02.09.2026journal-article

Haemophilia

The Essential Role of Psychosocial Care in Comprehensive Haemophilia Treatment: Global Perspectives From Haemophilia Treatment Centres and National Member Organizations

Amanda Stahl, Kathaleen Schnur, Silvina Graña

ABSTRACT Psychosocial care is a critical component of comprehensive haemophilia management, though its availability varies across regions and between clinical and community settings. This paper examines the landscape of psychosocial services offered through Haemophilia Treatment Centres (HTCs) and National Member Organizations (NMOs), both of which promote mental health, treatment adherence, and quality of life (QoL) using different frameworks. The delivery of psychosocial care in clinical settings, including staff …

02.09.2026journal-article

Journal of Cancer Survivorship

A mixed-methods systematic review of the psycho-social outcomes and experiences of therapeutic tattooing for cancer survivors

Adam Daly, Isobel Walsh, Johannes Karl, Pamela Gallagher, Simon Dunne

Abstract Purpose Increasing rates of cancer survivorship suggest more individuals will face the challenges associated with living in a changed body post-treatment. Therapeutic tattooing is an intervention to address these challenges. However, no previous systematic review has synthesised the existing evidence on the psycho-social outcomes and experiences of cancer survivors who have received therapeutic tattoos. This review addresses this important gap within the literature. Methods Seven databases were searched in …

02.09.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Comparative Effectiveness of Oral Ivermectin, 1% Permethrin Shampoo, and 4% Dimethicone Liquid Gel in Treatment of Pediculosis Capitis among School Children in Chachoengsao Province, Thailand

Arisa Vannaratha, Supanut Buakaew, Nitkamol Santiwananont, Thidaporn Srisub, Arthitaya Sutthithum, Sudarat Reugjui, Patanin Julsurang, Hatthakorn Lueang-urai, Wirakarn Liamsakul, Rungtawan Boonsombat, Patanawadee Luenpan, Supasek Thangto, Toon Ruang-areerate, Nuanlaong Kaeothaisong, Detchvijitr Suwanpakdee, Picha Suwannahitatorn

ABSTRACT. Pediculosis capitis remains a persistent public health issue, especially in developing countries where resistance to standard neurotoxic pediculicides like permethrin is increasingly prevalent. This study aimed to compare the effectiveness of alternative treatment options against the standard care in a resource-limited setting. We conducted a single-blind randomized controlled trial involving three primary schools in Chachoengsao Province, Thailand (ClinicalTrials.gov: NCT06332872). Eighty-five female par …

02.09.2026journal-article

International Journal of Molecular Sciences

Evaluation of Camptothecin Through Computational and Experimental Approaches Targeting Membrane Receptors on Breast Cancer Cells for Potential Therapeutic Applications

Elmer Joel Millan-Casarrubias, Lucero Ruiz-Mazón, Eduardo Pérez Salazar, Pedro Cortés Reynosa, Yazmín Mariela Hernández-Rodríguez, Oscar Eduardo Cigarroa-Mayorga

Breast cancer remains among the leading causes of incidence and mortality worldwide. Consequently, identifying new treatments and strategies is of critical importance. Evidence indicates that camptothecin and its derivatives may exert anticancer effects in various cancer cell lines, including colon, lung, and ovarian cancers. However, their effects in breast cancer are not yet fully understood. Prior theoretical studies employing docking and molecular dynamics suggest that camptothecin could bind to the HER2 and EG …

02.09.2026journal-article

Cancer Discovery

Functionally active lymphoid aggregates correlate with improved prognosis in brain metastases

Noor E. Nader, Alexandra R. Glathar, Elaine V. Byrnes, Marion Joy, Tengziyi Ge, Andrew Elliott, Ryan Jaehne, Caroline J. Layding, Curtis Mamoru. Tatsuoka, Gabriel Sica, Rajesh Acharya, Riyue Bao, Anthony R. Cillo, Aron Y. Joon, Swaminathan Kumar, Rami B. Yanes, Xiancheng Wu, Luisa M. Solis Soto, Claudio A. Arrechedera, Auriole Tamegnon, Beatriz Sanchez-Espiridion, Hussein A. Tawbi, Elizabeth M. Burton, Michael A. Davies, Thomas M. Pearce, Timothy F. Burns, Laura P. Stabile, Xiaoran Zhang, Tullia C. Bruno

Abstract B cells and their cellular neighborhoods, i.e., lymphoid aggregates (LAs) and tertiary lymphoid structures (TLS), have not been extensively studied in melanoma brain metastases (BM) or lung adenocarcinoma (LUAD) BM, despite their prognostic value and role in immunotherapeutic responses. In this study, we evaluated the prognostic benefit and heterogeneity of B cell infiltration and LA formation in more than 200 patients with melanoma-BM or LUAD-BM. We found that LAs were associated with increased intratumor …

02.09.2026journal-article

Endocrine Oncology

Corticotroph Tumour Progression 37 Years After Bilateral Adrenalectomy with Temozolomide-Naive Response to Pembrolizumab

Edward Mignone, Luke Ephraums, Ian Chapman, Esther Quick, Sunita M C De Sousa, Jui Ho

Abstract Summary Corticotroph tumour progression (CTP) following bilateral adrenalectomy for Cushing’s disease usually emerges within the first decade; substantially delayed presentations are uncommon and longer term surveillance recommendations remain imprecise. We report a patient presenting with CTP 37 years after adrenalectomy, representing one of the latest onset cases in the literature. Tumour profiling demonstrated an aggressive molecular phenotype including ATRX loss, MEN1 inactivation and CDK4 amplificatio …

02.09.2026journal-article

The Journal of ECT

Association of Pre-ECT Anxiety Symptoms With Electroconvulsive Therapy Treatment Efficacy in Schizophrenia

Birong Chen, Hasvinjit Kaur D/O Gulwant Singh, Nisha Chandwani, Jonathan Jie Lee, Shih Ee Goh, Xiao Wei Tan

Objectives: Pre-ECT anxiety symptoms are common among patients undergoing Electroconvulsive Therapy (ECT). In this retrospective observational cohort study, we aim to explore the association between pre-ECT anxiety symptoms and ECT treatment outcomes in patients with schizophrenia. Methods: We conducted a retrospective analysis of 979 patients with schizophrenia or schizoaffective disorder who received ECT at a tertiary public psychiatric hospital in Singapore. Patients were categorized into two groups based on the …

02.09.2026journal-article

PLOS Global Public Health

Trends in advanced HIV disease, treatment interruption, and viraemia in KwaZulu-Natal, South Africa

Sanele S. Mbeje, Lilishia Gounder, Johan S. van der Molen, Lungile Hobe, Thulani Ngwenya, Mlungisi Khanyile, Kwena Tlhaku, Benjamin Chimukangara, Thokozani Khubone, Yukteshwar Sookrajh, Sharana Mahomed, Jennifer A. Brown, Nigel Garrett, Jienchi Dorward, Lara Lewis

Advanced HIV disease (AHD), treatment interruption and viraemia remain key challenges to effectiveness of HIV programmes in South Africa. Understanding the trends of these measures and their variation across geographic regions can inform more targeted and responsive interventions. We conducted a retrospective cohort study using routine, de-identified data from TIER.Net, a national HIV electronic register. We curated data from 116 primary care clinics in eThekwini, uMgungudlovu, and uMkhanyakude Districts in KwaZulu …

02.09.2026journal-article

Cell Death & Disease

Survival of cancer cells following taxol-induced apoptosis is supported by ZEB1-mediated ferroptosis sensitivity

Rachel Hausman, Wells S. Brown, Shannon J. Awrey, Hossein Tavakoli, Denise J. Montell, Paul C. McDonald, Shoukat Dedhar

Abstract Chemotherapy remains the mainstay treatment of many solid cancers; however, resistance and recurrence compromise patient outcomes. We investigated chemotherapy resistance mechanisms in Triple Negative Breast Cancer (TNBC) by examining cells that survive chemotherapy-induced apoptotic caspase activation. Using a biosensor that permanently labels cells surviving executioner caspase activation with GFP, we identified a GFP+ population that survives transient paclitaxel treatment. These GFP+ cells display a st …

02.09.2026journal-article

Frontiers in Medicine

Individualized approach to palliative care integration for patients with metastatic non-small cell lung cancer

Carley Mitchell, Roshni S. Kailar, Melinda L. Hsu

Early integration of palliative care is recommended for all patients with advanced solid tumor malignancies. However, this practice has not been widely adopted for various reasons. Recent therapeutic advancements along with improved understanding of tumor biology have contributed to greater prognostic uncertainty and changes in symptom burden, highlighted nicely within the metastatic non-small cell lung cancer population. These changes call for a more nuanced approach to palliative care referral which could be faci …

02.09.2026journal-article

Journal of Biological Studies

Role of selected interleukins and hormonal biomarkers in screening for human papillomavirus infection and cervical cancer in women

Sura A. Hashim, S.K. Al-Qaisi, Shahad Saad Alwan

The roles of immunological and hormonal indicators in screening women with HPV infection and cervical cancer (CC) were investigated. The present study was conducted in Diyala Province during the period from January to March 2026. A total of 90 blood samples were collected from women who visited Al-Batoul Teaching Hospital and women's clinics. Serum levels of IL-1β, IL-2R, FSH, and estrogen, as well as HPV, were detected using ELISA and the Biorex technique. HPV-infected women represented 43.33% of the participants, …

02.09.2026journal-article

Academy for Practical Oncology

Cancer and inflammation

L. A. Ashrafyan

Inflammation influences all stages of tumor development and progression, as well as therapeutic response. Only through careful study of every aspect of the biology of the malignant process can we make real advances in the fight against cancer. A combination of anti-inflammatory approaches targeting the tumor microenvironment should be combined with the use of more complex and selective tumor-killing drugs. The future of anticancer therapy lies in drugs targeting procarcinogenic inflammation.

02.09.2026journal-article

Targets

Tiny Messengers, Actionable Targets: sEV-Driven Epigenetic Changes in Cancer

Nagendra Verma, Swati Arora, Katrina Croghan

Small extracellular vesicles (sEVs) are pivotal mediators of intercellular epigenetic communication in cancer. Following MISEV2023, we use the size- and isolation-based term sEV throughout, because most primary studies cited here cannot resolve which biogenetic route generated the vesicles they analyzed. By selectively packaging and transferring noncoding RNAs (ncRNAs), DNA fragments, chromatin-modifying enzymes, and metabolic effectors, sEVs reprogram recipient-cell chromatin architecture without altering the unde …

02.09.2026journal-article

Problems of Gathering Treatment and Transportation of Oil and Oil Products

DEVELOPMENT OF AN ALGORITHM FOR DETERMINING THE SATURATED VAPOR PRESSURE OF STABLE CONDENSATE IN REAL TIME

E.V. Rudykh, E.V. Shakirova, A.K. Vlaskin, A.N. Buglov

At the gas condensate stabilization unit, product quality control is carried out by regular laboratory analysis of the saturated vapor pressure (VP) of stable condensate. In the current practice, condensate samples are taken twice a day for VP subsequent monitoring. This approach requires significant time and resources personnel participation, transportation of samples and waiting for analysis results. In addition, the obtained VP values are received with a delay, which limits the efficiency of making technological …

02.09.2026journal-article

Problems of Gathering Treatment and Transportation of Oil and Oil Products

ANALYSIS OF TECHNOLOGIES AND EQUIPMENT FOR THE TREATMENT OF WASTEWATER CONTAINING ETHYLENE GLYCOL

A.V. Rumyantseva, A.V. Markelov, S.Z. Kalaeva, G.M. Kuznetsova

The article presents a comprehensive analysis of modern technologies and equipment for ethylene glycol removing from industrial airport wastewater. The relevance of the topic is due to intensive use of deicing fluids by Russian civil aviation, which creates a significant environmental burden on natural water bodies due to the toxicity of glycols and their high biological oxygen demand. Furthermore, the irreversible discharge of this reagent leads to direct economic losses for aviation enterprises. The paper examine …

02.09.2026journal-article

Reports

Hospital Length of Stay and Associated Factors in Patients with Oral Cavity Cancer in Germany: A Retrospective Multicenter Analysis of Inpatient Administrative Data

Lisa Lotta Cirkel, Isabel Klein, Karel Kostev

Background: Oral cavity cancer is a clinically relevant subgroup of head and neck malignancies and is associated with substantial treatment burden and healthcare utilization. Hospital length of stay (LOS) is an important indicator of inpatient resource use and complexity of care, yet large multicenter data from Germany are limited. Methods: This retrospective multicenter analysis used anonymized inpatient administrative data from 49 German hospitals; eligible oral cavity cancer hospitalizations were contributed by …

02.09.2026journal-article

Current Oncology

Identifying Distinct Quality-of-Life Profiles in Prostate Cancer Patients: A Latent Profile Approach

Linan Cheng

Background: Prostate cancer substantially affects patients’ quality of life (QoL). However, whether distinct QoL profiles exist among patients remains unclear. Objective: This study aimed to identify latent QoL profiles among patients with prostate cancer and explore factors associated with profile membership. Methods: A cross-sectional study included 200 patients with prostate cancer recruited from a tertiary hospital in China between May and December 2024. QoL was assessed using the Functional Assessment of Cance …

02.09.2026journal-article

Journal of Surgical Oncology

Morbidity and Mortality of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in Patients Aged 70 Years and Older: A Two‐Center 10‐Year Experience

Ali Ediz Kıvanç, Mehmet Oduncu, Pırıltı Özcan, Özgül Düzgün, Neşet Köksal

ABSTRACT Background and Objectives Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is established for peritoneal surface malignancies, but its use in older patients is debated. We assessed CRS‐HIPEC morbidity and mortality in patients aged ≥ 70 years using a cohort of younger patients as a comparator. Methods We retrospectively reviewed consecutive patients aged ≥ 70 and < 70 undergoing CRS‐HIPEC for peritoneal carcinomatosis at two centers (2017−2026). Peritoneal carcinomatosis i …