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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Frontiers in Medicine

Epstein–Barr virus-associated inflammatory polyp of the proximal cervical trachea causing central airway obstruction: a case report

Ziran Lei, Ning Zheng, Linlin Wang, Ling Fang, Xiang Wu

Background Intraluminal lesions of the central airway can cause severe obstruction and are usually malignant. Epstein–Barr virus (EBV)-associated inflammatory tracheal polyps are extremely rare and may mimic airway tumors or EBV-associated lymphoproliferative disorders. Case presentation A 35-year-old woman presented with progressive dyspnea and wheezing for 1 month. Contrast-enhanced chest computed tomography and bronchoscopy revealed a solitary intraluminal polypoid lesion arising from the left anterior wall of t …

03.09.2026journal-article

Frontiers in Allergy

Clinical phenotypes, endotypes, and biomarker profiles of immediate rituximab hypersensitivity reactions: a prospective pharmacovigilance study

Narapong Yotinnoratham, Wannada Laisuan, Kumutnart Chanprapaph, Silada Kanokrungsee, Chavachol Setthaudom, Supornchai Onpun, Pungjai Mongkolpathumrat, Supranee Buranapraditkun, Apinya Chungcharoenpanich, Nichapha Dechapaphapitak, Supa Oncham, Nattakirana Tongdee, Sananya Khamkaew, Ratchaya Lertnawapan, Jettanong Klaewsongkram

Background Rituximab (RTX) has been associated with immediate hypersensitivity reactions (HSRs) involving multiple phenotypes and endotypes. Objective To characterize the clinical phenotypes and endotypes of immediate RTX HSRs. Methods A prospective study was conducted as part of a pharmacovigilance program from July 2020 to December 2021. Participants who experienced immediate RTX HSRs were enrolled. Skin testing, basophil activation testing (BAT), IFN- γ ELISpot assays, and IgG anti-drug antibody (ADA) ELISA assa …

03.09.2026journal-article

IPS Journal of Basic and Clinical Medicine

Kidney Function Responses to Ethanol Extracts of Chia Seed (Salvia hispanica L.) and Tiger Nut (Cyperus esculentus L.) in Alloxan-Induced Diabetic Rats

Chinyere S. Nwaka, Andrew C. Nwaka

Diabetic nephropathy is a common and progressive complication of poorly controlled diabetes mellitus, and there is growing interest in plant-derived agents that can slow or reverse this damage. This study evaluated the effect of ethanol extracts of chia seed (Salvia hispanica), tiger nut (Cyperus esculentus), and their combination on kidney function parameters in alloxan-induced diabetic rats. Sixty-three male Wistar rats were assigned to nine groups (n = 7): normal control (A), diabetic untreated (B), diabetic rat …

03.09.2026journal-article

Cosmetics

Effect of Topical HealFast Silver Ointment on Pain and Early Wound-Healing Parameters After Caesarean Section: A Randomized Placebo-Controlled Clinical Trial

Wafaa Uthman Ahmed, Bafreen hawez Hamadameen, Dastan Abdullah Salih, Shukur Wasman Smail, Abubakr Mohammed Amin, Mohammed Awat Ali

Background: Caesarean section is associated with postoperative pain and wound-related morbidity. Topical agents that promote early wound healing may enhance postoperative recovery. This randomized, placebo-controlled clinical trial evaluated the effect of HealFast Silver Ointment on pain and early wound-healing parameters after Caesarean section. Methods: Two hundred women who underwent Caesarean section were randomly allocated into two groups: a placebo group and a HealFast Silver Ointment group, each consisting o …

03.09.2026journal-article

Journal of Pure and Applied Microbiology

Evaluating the Diagnostic Accuracy of Serological Tests for Brucellosis in Clinical Specimens

Hiba Sami, Kashish Noor, Parvez A. Khan, Lubna Zafar, Aamir Bin Sabir, Latif Zafar Jilani, S. Zeeshan Ahmad Hashmi, Haleema Ahmad, Adil Raza, Nazish Fatima

Brucellosis, a prevalent zoonotic disease in India, causes nonspecific symptoms. Humans contract it via infected animals or by consuming unpasteurized dairy products. This study evaluates the effectiveness of ELISA, Rose Bengal Plate Test (RBPT), and SAT in diagnosing brucellosis from clinical samples. A prospective study was conducted involving 218 patients with unknown fever, arthritis, and neurological symptoms. A detailed history was collected using a pre-designed questionnaire. This study aims to evaluate the …

03.09.2026journal-article

American Journal of Audiology

Survey of Audiologists' Clinical Practice Patterns and Perceptions of Electrophysiological Assessments

Kelsey Mankel, Caitlin N. Price, Allie Austin, Mira Milman

Purpose: Electrophysiological assessments in audiology are used for neurodiagnostic evaluations, newborn hearing screenings, and estimating auditory thresholds when behavioral responses are unobtainable or unreliable. Nonetheless, evidence suggests that many electrophysiological tools remain underutilized. This study examined current practice patterns, perceptions, and barriers related to electrophysiological testing among audiologists in the United States. Method: An online survey distributed between January and A …

1 Zitationen
03.09.2026journal-article

Biosensors

Periodontal Disease Diagnosis by a Chemically Etched Single-Mode Fiber-Optic Biosensor for Label-Free Detection of Matrix Metalloproteinase-8 (MMP-8)

Rigoberto Tovar, Sarkis Sozkes, Marzhan Sypabekova

A miniature label-free biosensor based on a chemically etched single-mode optical fiber (SMF) is reported for the detection of matrix metalloproteinase-8 (MMP-8), a salivary biomarker of active periodontitis with a clinical decision threshold of 20 ng/mL. Fibers etched in 48% hydrofluoric acid to a waist diameter of 16.0 ± 1.4 µm gave a mean refractive index (RI) sensitivity of 376.8%/RIU and an RI limit of detection (LOD) of 5.9 × 10−4 RIU. Fibers were tested with MMP-8 spiked into phosphate-buffered saline (PBS) …

03.09.2026journal-article

Journal of Developmental Biology

Diaphragmatic Mitochondrial Myopathy in a Patient-Derived Mouse Model of Barth Syndrome

Kristen Tentler, Paige L. Snider, Catalina Matias, Jeffrey J. Brault, Simon J. Conway

Barth syndrome (BTHS) is a rare, X-linked genetic disorder caused by mutations in the enzyme TAFAZZIN (TAZ), resulting in insufficient cardiolipin (CL) remodeling and mitochondrial dysfunction. While BTHS respiratory distress and breathing difficulties are commonly reported, the precise role of intrinsic respiratory tissue vulnerabilities has only recently begun to be appreciated. Historically, BTHS respiratory distress is frequently attributed to secondary consequences like cardiomyopathy or generalized skeletal m …

03.09.2026journal-article

Greenation Computer and Information Review

Analysis of the Security of Off-Site Medical Record Storage in Relation to Patient Information Confidentiality at Hospital X

Ujang Rahmat, Yayang Ayu Nuraeni

This study employed a qualitative descriptive design to examine how the security of off-site medical record storage protects patient information confidentiality, particularly when records are stored outside the hospital because of limited filing-space capacity. Three informants were purposively selected: the Head of the Medical Records Unit, a Medical Records Filing Officer, and a Medical Records Archiving Officer. Data were collected through observation, interviews, and documentation. Data analysis followed the Mi …

03.09.2026journal-article

Acupuncture & Electro-Therapeutics Research: International Journal of Integrated Medicine

Development of a Nomogram Prediction Model for Activities of Daily Living Improvement After Acupuncture Combined With Physiotherapy and Occupational Therapy in Patients With Ischaemic Stroke

Fang Li, Longlong Su, Peng Zhang

Objective To develop a nomogram for predicting ADL improvement among patients with ischaemic stroke receiving acupuncture combined with physiotherapy (PT) and occupational therapy (OT) and to identify independent predictors of poor ADL improvement. Methods A total of 253 patients with ischaemic stroke were retrospectively included, comprising a development cohort of 190 patients admitted between April 2024 and April 2026 and an earlier, nonoverlapping temporal validation cohort of 63 patients admitted between Decem …

03.09.2026journal-article

JAMA Oncology

Bicistronic CD19/CD22 CAR T-Cell Therapy in Pediatric B-Cell Acute Lymphoblastic Leukemia

Xinyu Wan, Yanjing Tang, Jiaoyang Cai, Lili Song, Tianyi Wang, Wenjie Li, Liu Yang, Xiang Wang, Chengjuan Luo, Hua Zhu, Kang An, Meng Su, Jing Zhang, Jing Yang, Wenhua Shi, Chengming Fei, Weidong Shen, Rujun Jia, Xiaomin Yang, Junqian Tang, Junxian Wu, Jiakang Gu, Jiayi Mo, Jun Huang, Yue Li, Geyao Zhou, Lixia Ding, Jianwei Liang, Jun Wang, Zichao Zhou, Xiaodong Wang, Qing Cao, Jian Zhang, Hong Ren, Juan Qian, Peifang Xiao, Hailong He, Hui Jiang, Shaoyan Hu, Ningling Wang

Importance CD19-directed chimeric antigen receptor (CAR) T-cell therapy induces high remission rates in relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL), but relapse, which is often due to antigen loss, remains a major challenge. Dual-targeting CD19/CD22 CAR T-cell strategies may be associated with reduced antigen-negative relapse and improved remission durability. Objective To evaluate the safety and efficacy of bicistronic CD19/CD22 CAR T-cell therapy in pediatric patients with relapsed or refra …

03.09.2026journal-article

Journal of Clinical Medicine

Effects of Physical Activity on Motor Development, Balance, and Psychosocial Well-Being in Children and Adolescents with Down Syndrome: A Systematic Review

Ignazio Leale, Manuel Gómez-López, Martina Macaluso, Daniela Smirni, Michele Roccella, Marianna Alesi, Giuseppe Battaglia

Background: Physical activity is relevant for physical and psychosocial development in children and adolescents with Down syndrome. However, evidence regarding the effects of structured physical activity interventions across different motor and psychosocial domains remains limited and heterogeneous. This systematic review aimed to examine the effects of structured physical activity interventions on motor and psychosocial outcomes in this population. Methods: The review was conducted according to PRISMA guidelines a …

03.09.2026journal-article

Healthcare

Organization and Quality of Emergency Thoracic Surgical Care in Multidisciplinary Hospitals of Almaty, Kazakhstan: A Multicomponent Study Combining Hospital Data, Patient-Reported Experience, and Healthcare Professional Perspectives

Sultan Zhanbyrbaev, Maksut Kulzhanov, Aueskhan Dzhumabekov, Alfiya Igissenova, Gulstan Esetova, Nadira Aitambayeva, Gulbanu Berdiyarova, Nazerke Narymbayeva, Aigul Tazhiyeva

Background: Emergency thoracic conditions remain an important cause of hospitalization, emergency surgery, and mortality, requiring well-organized multidisciplinary thoracic surgical services. Objectives: To comprehensively evaluate the organization of emergency thoracic surgical care in multidisciplinary hospitals in Almaty using retrospective hospital data together with patient and healthcare professional-reported assessments. Methods: A multicomponent study was conducted comprising three complementary components …

03.09.2026journal-article

Frontiers in Medicine

Development and validation of an interpretable machine learning model for predicting postoperative fever after flexible ureteroscopic lithotripsy: a single-center retrospective cohort study

Xiaofei Lu, Chunping Yu, Zhiyong Ding, Sheng Luo, Xiaopeng Hu

Background This study aimed to develop and validate an interpretable machine learning model to predict postoperative fever (POF) after flexible ureteroscopic lithotripsy (fURL). Objective This study adopted a single-center retrospective temporal cohort design. Strictly adhering to predefined inclusion and exclusion criteria, patients with upper urinary tract stones (maximum diameter < 3 cm) who underwent flexible ureteroscopic lithotripsy (fURL) from January 2019 to December 2024 were enrolled as the derivation …

03.09.2026journal-article

Journal of Clinical Microbiology

Development and evaluation of an ARTIC-based amplicon sequencing assay for whole-genome characterization of respiratory syncytial virus

Keri Smith, James Martinez, Harrison Yu, Jason Harrison, Caleb Umunna, Blake Bertrand, Michael Heck, Ellen N. Kersh, Nandhakumar Balakrishnan, Tonia Parrott, Arunachalam Ramaiah

ABSTRACT Respiratory syncytial virus (RSV), a ~15.2 kb negative-sense RNA virus, causes acute respiratory infections in infants and older adults. Its two subtypes, RSV-A and RSV-B, evolve rapidly, making ongoing monitoring of circulating strains essential. The Georgia Public Health Laboratory (GPHL) developed and evaluated an amplicon-based whole-genome sequencing (WGS) assay for RSV surveillance. A total of 214 de-identified remnant clinical specimens (102 RSV-A and 112 RSV-B) with RT-PCR C q values <31 were inclu …

03.09.2026journal-article

Uludağ Üniversitesi Tıp Fakültesi Dergisi

Retrospective Evaluation of Demographic and Clinical Features of Gastrointestinal Stromal Tumors

Nihal Yücel Çamcı, Nesrin Uğraş, Adem Deligönül, Özkan Kanat

This study aimed to retrospectively examine the demographic, clinical, and pathological characteristics; prognostic risk factors; treatments administered; clinical course; and survival times of patients diagnosed with gastrointestinal stromal tumors (GIST) and treated and followed up at Department of Medical Oncology at the Bursa Uludağ University Faculty of Medicine in Bursa. Medical records of 54 patients diagnosed with GIST between 2002 and 2017 were reviewed retrospectively through the hospital record system. T …

03.09.2026journal-article

Journal of Clinical Medicine

Time to Exudative Recurrence After Complete Fluid Resolution Following Anti-VEGF Loading in Neovascular Age-Related Macular Degeneration

Kyungyun Kook, Dohee Park, GeonIl Lee, Yong-Sok Ji

Background/Objectives: The timing of exudative recurrence after complete fluid resolution following anti-vascular endothelial growth factor (anti-VEGF) loading in neovascular age-related macular degeneration (nAMD) is unpredictable. We prespecified two questions: whether the speed of fluid resolution during loading, or the baseline pigment epithelial detachment (PED) type, predict recurrence timing. Methods: We retrospectively analyzed 72 treatment-naïve nAMD eyes that achieved complete resolution of subretinal flu …

03.09.2026journal-article

Frontiers in Clinical Diabetes and Healthcare

Single-cell RNA sequencing in diabetic foot ulcers: pathogenesis, biomarkers, and translational potential

Shuhan Yang, Siqian Wang, Ruiyi Yang, Ke Xu, Xiaofeng Yang, Yifeng Zhao

Diabetic foot ulcer (DFU), a common diabetic complication driven by impaired angiogenesis, neuropathy and metabolic disorders, has complex pathogenesis and poses great challenges to clinical management. Single-cell RNA sequencing (scRNA-seq), an emerging transcriptomic technique, allows disease profiling at single-cell resolution. This review summarizes recent advances in scRNA-seq-based DFU research, revealing that JMJD3-mediated macrophage polarization failure and dysregulated IGF-1-SP1-CD248 pathway hinder wound …

03.09.2026journal-article

Frontiers in Pediatrics

Case Report: Gait training using a wearable ankle-exoskeleton in a pediatric patient with Guillain–Barré syndrome

David Cordero-Cuevas, Jimena Figueroa-Valero, Elizabeth Pérez-Rodríguez, Raide Alfonso González-Carbonell

Introduction Guillain–Barré syndrome (GBS) is an acute inflammatory demyelinating polyradiculoneuropathy that can lead to severe gait impairment and functional limitations in pediatric patients. Although conventional physiotherapy (CT) is the standard of care, recovery is often prolonged and characterized by persistent deficits in strength and motor control. Wearable ankle-exoskeletons have emerged as a potential adjunctive tool for task-specific gait training; however, their application in pediatric GBS remains la …

03.09.2026journal-article

Frontiers in Surgery

Comparison of multivariable logistic regression and machine learning models for predicting pharyngocutaneous fistula after surgery for laryngeal and hypopharyngeal carcinoma

Xiaoqin Ji, Huiling Zhao

Purpose The aim of this study was to comprehensively compare multifactorial logistic regression and various machine learning models in predicting pharyngocutaneous fistula (PCF) following laryngectomy in patients with laryngeal carcinoma and hypopharyngeal carcinoma. Methods Utilizing a significant dataset from West China Hospital, Sichuan University, we retrospectively analyzed the medical records of 2,863 patients diagnosed with laryngeal or hypopharyngeal cancer who underwent surgical treatment from 17 March 200 …

03.09.2026journal-article

Frontiers in Neuroscience

Functional recovery patterns from discharge to 12 months after endovascular treatment for aneurysmal subarachnoid hemorrhage: a multicenter cohort study

Qiao Wu, LongXiang Ma, Yang Chen, ZhenRan Zhao, JinFang Liu, Bin Zhang, HeChun Xia

Background Functional status after aneurysmal subarachnoid hemorrhage (aSAH) may improve after discharge, but paired assessments at discharge and long-term follow-up have rarely been used to distinguish delayed recovery from persistent disability. We characterized discharge-to-12-month recovery patterns after endovascular treatment and identified factors associated with persistent disability among patients with poor functional status at discharge. Methods This multicenter retrospective cohort study consecutively en …

03.09.2026journal-article

Frontiers in Pediatrics

Congenital hepatic fibrosis and related ciliopathies across the life course: current management, disease burden, and unmet needs in the era of genomic diagnosis and translational therapeutics

Ao Wang, Jie He, Keliang Liu, Jinfeng Fu, Jianxun Chen

Congenital hepatic fibrosis (CHF) is a rare autosomal recessive hepatobiliary developmental disorder characterised by extensive fibrosis of the portal tracts and ductal plate malformation, representing a significant cause of portal hypertension in children and adolescents. Despite its low incidence, the disease exhibits considerable clinical heterogeneity, ranging from asymptomatic presentations to severe complications of portal hypertension, thereby posing substantial diagnostic and management challenges. The long …

03.09.2026journal-article

Frontiers in Psychiatry

Psychosocial recovery and nutritional rehabilitation in residential treatment for anorexia nervosa: an exploratory longitudinal multi-frequency bioelectrical impedance analysis study

Francesco Monaco, Annarita Vignapiano, Stefania Landi, Rossella Bonifacio, Daniela Falchetta, Emanuela Ferrara, Ernesta Panarello, Bruno Attianese, Annaluce Caputo, Luca Steardo, Gennaro Sosto, Giulio Corrivetti

Background Nutritional rehabilitation is widely considered a prerequisite for recovery in anorexia nervosa (AN), given the profound effects of malnutrition on cognitive, emotional, and behavioral functioning. However, whether psychiatric improvement during residential treatment is directly coupled with the degree of nutritional restoration remains insufficiently understood. This study investigated longitudinal changes in body composition and psychosocial outcomes during residential psychiatric rehabilitation for AN …

03.09.2026journal-article

Journal of Clinical Laboratory Analysis

Development of a Machine Learning Algorithm for Differential Diagnosis Between Primary Immune Thrombocytopenia and Connective Tissue Disease‐Related Thrombocytopenia in Pediatric Patients

Furong Kang, Mei Yan, Yingbin Yue, Xuemei Wang, Yu Liu

ABSTRACT Background To develop a machine learning model for early differentiation of primary immune thrombocytopenia (pITP) from connective tissue disease‐related thrombocytopenia (CTD‐TP) in children presenting with thrombocytopenia. Method A retrospective study was conducted on 387 newly diagnosed children with thrombocytopenia. All patients were clinically diagnosed and divided into a training set and a test set in a 7:3 ratio. Six machine learning algorithms, including XGboost, RF, SVM, LR, GBDT, BPNN, were use …