European Journal of Preventive Cardiology
Cigarette smoking, coronary plaque burden and phenotype: a multimodality meta-analysis and implications for coronary artery calcium scoring in prevention
Abstract Aims Cigarette smoking is a major modifiable risk factor for cardiovascular disease. Despite the widespread use of coronary artery calcium (CAC) scoring as a risk stratifier for preventive therapy, smokers frequently present with acute coronary syndromes despite minimal coronary calcification. We performed a multimodality meta-analysis to quantify the association between smoking and coronary plaque burden and phenotype using CCTA, IVUS, and OCT. Methods and results We systematically searched multiple datab …