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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Frontiers in Medicine

Mixed pain: has pain medicine overlooked Its most common phenotype for over 20 years? A perspective on mechanistic interaction, the nociplastic paradox, and the future of pain classification

Rainer Freynhagen, Antonio Alcántara Montero

Pain medicine has progressively evolved from a binary classification of nociceptive and neuropathic pain toward a broader mechanistic framework that now includes nociplastic pain. While this evolution has substantially improved our understanding of chronic pain, it has not resolved a persistent clinical reality: most patients do not present with mechanistically pure pain states. Instead, nociceptive, neuropathic, and nociplastic mechanisms frequently coexist within the same individual and interact in ways that chal …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Case Report: Left ventricular pseudoaneurysm presenting with ventricular tachycardia

Esra Polat, Mahmut Arslan, Yusuf Çorbacıoğlu, Ahmet Khalousi, Rauf Önder, Candan Güngör

Left ventricular pseudoaneurysm is a rare and life-threatening disorder that can present with a wide range of clinical manifestations, from an asymptomatic disease to sudden cardiac death. This case report presents a 38-year-old patient with no history of cardiovascular disease who presented with ventricular tachycardia and was diagnosed with left ventricular pseudoaneurysm following multiple cardiac imaging investigations. Given the high risk of rupture, early diagnosis of this rare condition is of critical import …

03.09.2026journal-article

Frontiers in Public Health

The impact of oral health literacy on oral health in lung cancer patients: the mediating role of psychosocial factors

Nan Zhang, Yingao Liu, Tiane Fa

Background Lung cancer patients often have poor oral health due to treatment toxicities, increasing risks of oral mucositis, and pulmonary infection. Oral health literacy (OHL) is a key determinant, and psychosocial factors such as anxiety and family support also play roles. However, prior studies examined only single dimensions, not underlying mechanisms. This study aims to build a mediation model linking OHL, psychosocial factors, and oral health status in lung cancer patients, providing exploratory evidence for …

03.09.2026journal-article

Frontiers in Public Health

A co-production study of an art-based media campaign intervention to encourage early breast cancer screening uptake among Black women in England

Tarela Juliet Ike, Dung Ezekiel Jidong, Mieyebi Lawrence Ike, Evangelyn Ebi Ayobi, Peremi Richmond Ike, Oluwakorede Florence Adebowale, Gabriella Rooks, Nusrat Husain

Background Breast cancer is one of the most common cancers that affects women globally. Of central concern are Black women in the United Kingdom who are disproportionately affected, present late and suffer higher mortality due to poor early screening uptake. Informed by an interpretative phenomenological analytical lens, this study makes an original and significant contribution to address the gap by working with 15 Black women from the north of England to co-produce an art-based media campaign intervention designed …

03.09.2026journal-article

Frontiers in Medicine

Neoadjuvant pembrolizumab-based therapy versus dual HER2 blockade in early breast cancer: comparable surgical complication rates in a real-world cohort

Kerstin Wimmer, Katharina Kantner, Ruth Exner, Rupert Bartsch, Zsuzsanna Bago-Horvath, Stefan Konrad, Florian Fitzal, Maximilian Marhold

Background Neoadjuvant systemic therapy (NST) has become a cornerstone in the management of aggressive early breast cancer (BC) subtypes, including triple-negative (eTNBC) and HER2-positive disease. Immune checkpoint inhibition with pembrolizumab represents an active immunotherapeutic approach, whereas dual HER2 blockade with trastuzumab and pertuzumab constitutes passive immunotherapy in early HER2-positive BC. Although both strategies demonstrate substantial antitumor efficacy, real-world data directly comparing …

03.09.2026journal-article

Frontiers in Medicine

Metachronous bilateral diabetic mastopathy mimicking breast cancer in a woman with long-standing type 2 diabetes: a case report

Zhixiang Kuang, Wei Ding, Li Li

Background Diabetic mastopathy is an uncommon benign fibroinflammatory disorder of the breast that often resembles malignancy on clinical examination and imaging. Most reports involve younger women with long-standing type 1 diabetes. Metachronous bilateral disease in an older woman with type 2 diabetes is less often described. Case presentation A 69-year-old woman with a 38-year history of type 2 diabetes treated with self-administered insulin had previously undergone partial excision of a suspicious right-breast m …

03.09.2026journal-article

Frontiers in Oncology

Molecular classification of endometrial cancer in fertility-sparing-treatment: toward a personalized clinical approach

Filippo Alberto Ferrari, Giorgio Bogani, Matteo Pavone, Elena Olearo, Andrea Puppo, Marcello Ceccaroni

Molecular classification has emerged as a promising tool to improve patient selection and prognostic stratification in fertility sparing treatment (FST) for endometrial cancer (EC). Although FST is currently considered a valid option for carefully selected patients with early stage, low grade endometrioid EC, recurrence rates remain substantial and conventional clinicopathologic criteria inadequately capture tumor biological heterogeneity. Current evidence suggests that NSMP tumors represent the most favorable subg …

03.09.2026journal-article

Frontiers in Public Health

Self-confidence and body image among adults engaged in daily bodybuilding exercise compared with non-exercising adults: a case-control study

Hayder Ameer Jabor, Bahaa Mirza Skal, Hasan Naeem Kareem, Richard Mottershead

Background Regular bodybuilding and resistance training may positively influence psychological wellbeing, particularly self-confidence and body image perception. This study aimed to compare self-confidence and body image between adults engaged in daily bodybuilding exercise and non-exercising adults in Iraq. Methods A case-control study was conducted in Al-Diwaniyah City, Iraq, between August 2025 and April 2026. A total of 188 participants were enrolled using a purposive sampling method, including 94 adults engage …

03.09.2026journal-article

Journal of Law and Social Politics

Engaging a School’s Leadership Team in Re-envisioning Professional Learning for Public Secondary Educators through the PAR Experience in Cambodia

Sarom Mok, Ramy Chhun, Sophay Sim, Satya Yen, Sophal Yoeun

Background: Professional development (PD) for public secondary educators is commonly one-size-fits-all, fragmented, and short-term, lacking a coherent vision for collaborative teaching and learning. Such opportunities rarely model the creativity and depth required in classrooms, leading teachers to doubt district-mandated sessions and limit participation to compulsory trainings. Despite growing interest in Participatory Action Research (PAR), little evidence exists on how it can reshape professional learning within …

03.09.2026journal-article

Eastern Mediterranean Health Journal

Medication adherence among multimorbid individuals in Saudi Arabia

Haifa Alturki, Nawaf Alnuwaysir, Ghaya Almutairi, Shahad Alonazi, Rayouf Al Otaibi, Reham Alharbi, Joury Dabbour

Background: Multimorbidity is increasingly common among adults in Saudi Arabia. As treatment regimens become more complex, medication adherence becomes more challenging. Understanding the behavioural drivers of non-adherence is essential to improving outcomes and reducing preventable complications. Aim: To assess the prevalence of medication adherence among individuals aged ≥45 with multimorbidity, examine the association between the number and type of chronic conditions and adherence, and identify key reasons behi …

03.09.2026journal-article

British Journal of Nursing

Management of urinary tract infections in paediatrics

Bronagh Hafford

Urinary tract infections (UTIs) are a common cause of morbidity in the paediatric population, with prevalence varying according to age, sex, and circumcision status. Differentiating between upper and lower tract infections is crucial, as upper UTIs carry a greater risk of renal scarring and long-term complications. Accurate diagnosis and timely management reduce acute symptoms and prevent sequelae such as chronic kidney disease and hypertension. Current guidance recommends urgent referral for infants under 3 months …

03.09.2026journal-article

British Journal of Nursing

Person-centred colostomy care through caring and emotional perspectives

Chang Lyu, Leah Macaden

Person-centred care (PCC) emphasises the overall identification of patients as individuals with emotional, social and psychological needs, especially in cases of profound changes in self-image, such as colostomy care. This article is a reflective case analysis of the care received by Mr Z. Mr Z is a retired professional who experienced emotional withdrawal after a permanent colostomy. This case analysis draws on the experience and insights gained during a clinical placement in the gastrointestinal surgery ward, hig …

03.09.2026journal-article

European Journal of Dental Education

Learning Clinical Procedures Through Social Media: A Multi‐Institutional Study of Preclinical and Clinical Dental Students in Turkey

Abdul Kerim Atlı, Emel Karaman

ABSTRACT Introduction Social media platforms are increasingly used by dental students to support learning and preparation for clinical procedures. Although previous studies have described general patterns of social media use in dental education, evidence directly comparing preclinical and clinical students remains limited. This study aimed to evaluate how dental students in Turkey use social media for learning clinical procedures and to examine differences associated with clinical experience. Methods This cross‐sec …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Development and validation of a clinical-pharmacogenomic prediction model for clopidogrel-related high on-treatment platelet reactivity in patients with coronary artery disease

Ruihua Sun, Yu Du

Objective This study aimed to develop and validate a prediction model combining clinical indicators and pharmacogenomic markers for predicting clopidogrel-related high on-treatment platelet reactivity (HPR) after approximately 7 days of dual antiplatelet therapy in patients with coronary artery disease (CAD), and to identify its influencing factors to support individualized antiplatelet therapy. The model is intended for use before platelet function testing results are available, to identify patients at high risk o …

03.09.2026journal-article

Clinical Pharmacology & Therapeutics

Advances in New Approach Methodologies at FDA 's Division of Applied Regulatory Science

Ksenia Blinova, Kimberly Chiu, Anik Chaturbedi, Jahan Cooper, Tromondae K. Feaster, Paula L. Hyland, Lidiya Stavitskaya, Wendy W. Wu, Jeffry Florian, Rodney Rouse

New Approach Methodologies (NAMs) represent a paradigm shift in drug development and regulatory science, offering human‐relevant alternatives to traditional preclinical models. This mini‐review highlights recent advances in NAM development, validation, and regulatory application from FDA's Division of Applied Regulatory Science (DARS). We describe in silico NAMs including quantitative systems pharmacology (QSP) modeling for opioid overdose scenarios, (quantitative) structure–activity relationship ((Q)SAR) modeling …

03.09.2026journal-article

Regional Anesthesia & Pain Medicine

Prolonging peripheral ropivacaine nerve block with an in situ-formed hydrogel carrier: randomized controlled trial in an ovine model

Hans Vangsnes Vingen, Ana Ćuk, Axel R Sauter, Olav Spigset, Finn Andersen, Fredrik Strebel Skedsmo, Marianne Hiorth, Marija T Garvin, Tor Å Myklebust, Audun Stubhaug, Henning A Haga

Background Local anesthetics are effective for regional anesthesia but have a relatively short duration of action. This motivates the development of sustained-release delivery systems. The aim of this study was to evaluate whether an in situ-forming hydrogel composed of poloxamers and alginate could prolong the duration of ropivacaine-induced sensory and motor blockade. Methods In this randomized and blinded two-period cross-over study, 10 female sheep received ultrasound-guided sciatic nerve injections of either 2 …

03.09.2026journal-article

INTERNATIONAL JOURNAL OF HEALTH AND PHARMACEUTICAL RESEARCH

Assessing Healthcare Workers’ Knowledge, Attitudes, and Perceptions of Electronic Health Record Implementation in Government-Owned Hospitals in Calabar Metropolis, Cross River State, Nigeria

Elemi Éko EDU

The use of Electronic Health Records (EHRs) has been widely promoted as a means of improving healthcare delivery, yet their effective utilisation depends largely on the readiness and perspectives of healthcare workers. In Calabar Metropolis, limited evidence exists on how healthcare professionals understand and respond to EHR systems in routine practice. This study therefore assessed the knowledge, attitude, and perception of healthcare workers towards Electronic Health Records in Government-Owned Hospitals in Cala …

03.09.2026journal-article

Blood

Precision transfusion medicine in the omics era

Angelo D'Alessandro

Abstract Transfusion medicine has practiced a form of precision medicine for decades through compatibility testing, infectious disease screening, component manufacturing, traceability, and hemovigilance. Yet blood is still often treated primarily as a commodity—collected, processed, stored, and transfused—rather than as a dynamic biological product rich in molecular information. This Perspective argues that the field is uniquely positioned to extend its long-standing precision framework into a more molecular, longi …

03.09.2026journal-article

ACS Applied Materials & Interfaces

Engineered Hierarchical Porosity in Three-Dimensional-Printed Hydrogel Scaffolds Enhances Mesenchymal Stem Cell Therapy for Chronic Diabetic Wounds

Zhigen Yuan, Lei Mi, Yuan Ai, Yi Liu, Wei Gao, Churuo Zeng, Dehong Yang, Kexin Deng

Abstract Unhealing chronic diabetic wounds is a major clinical challenge, as it is rooted in the complex pathological microenvironment, including neuropathy, angiopathy, and chronic inflammation. Traditional treatment methods cannot fundamentally solve these problems. Inspired by outdoor rock climbing, this study developed a multifunctional bioactive hydrogel scaffold with hierarchical pore sizes (CSP hydrogel) to remodel the wound microenvironment and boost regenerative repair. Fabricated through 3D printing and p …

03.09.2026journal-article

Borneo Nursing Journal (BNJ)

Asuhan Kebidanan Pada Ibu Nifas Multipara Post Sectio Caesarea Dengan Postpartum Blues

Gelintina Kurniawati, Sulikah, Agung Suharto, Tutiek Herlina

Postpartum blues merupakan gangguan psikologis ringan yang sering terjadi pada masa nifas dan ditandai dengan perubahan suasana hati, mudah menangis, cemas, serta kesulitan beradaptasi dengan peran sebagai ibu. Meskipun lebih sering terjadi pada ibu primipara, kondisi ini juga dapat dialami oleh ibu multipara sehingga memerlukan deteksi dini dan penatalaksanaan yang tepat. Penelitia ini bertujuan mendeskripsikan penerapan asuhan kebidanan pada ibu nifas multipara post sectio caesarea yang mengalami postpartum blues …

03.09.2026journal-article

Facilities

Digitally enabled stakeholder collaboration for sustainable urban facilities management: insights from Abu Dhabi’s public sector

Abeer Alhammadi, Alex Opoku

Purpose This study aims to investigate how facilities management (FM) digital technologies impact stakeholder collaboration, how key sustainability drivers and collaboration affect sustainable building FM, and the moderating effect of digital technologies on sustainability drivers’ influence on sustainable building FM. It compares managers’ and users’ perspectives, providing empirical evidence from Abu Dhabi’s public buildings managed by the Department of Culture and Tourism and the Department of Municipalities and …

03.09.2026journal-article

Eastern Mediterranean Health Journal

Implications of the geographical distribution of Shisha outlets for targeted tobacco control policies in Oman

Salma Al Kalbani

Background: The availability and accessibility of Shisha strongly influence smoking behaviours, thus raising public health concerns and necessitating targeted interventions. Aim: To examine the geographic distribution of Shisha outlets in Oman and its implications for tobacco control policies. Methods: We obtained anonymised secondary data from the Oman Ministry of Economy on 1074 registered shisha outlets established across Oman's 11 governorates between January 2020 and October 2024. We analysed the data using SP …

03.09.2026journal-article

Children

Health-Related Quality of Life in Children with Acute Leukaemia and Central Nervous System Tumours: Current Evidence and Future Directions

Lyazat Manzhuova, Timur Saliev, Aigul Bazarbayeva, Maira Kabakova, Gulzhan Kashaganova, Aizhan Kudaibergenova, Zaure Dushimova

Remarkable advances in paediatric oncology over recent decades have transformed acute leukaemia and central nervous system (CNS) tumours from largely fatal diagnoses to conditions with survival rates exceeding 80% in many cases. This epidemiological success, however, has shifted the clinical and research focus toward survivorship and the long-term consequences of curative therapies. Health-related quality of life (HRQoL) has emerged as a critical outcome measure that captures the multidimensional impact of disease …

03.09.2026journal-article

Frontiers in Communication

Organizational dedifferentiation: neural gradient axes and communication hierarchy in healthcare organizations

Moeki Nemoto

Communication failures remain a leading cause of sentinel events in healthcare settings, yet the mechanisms by which organizational communication hierarchies form, function, and fail remain undertheorized. Prior work reconceptualized the Balanced Scorecard (BSC) as a constitutive communication mechanism through Communication Constitutes Organization (CCO) four flows theory; however, a principled account of why such hierarchies erode over time was lacking. This paper proposes that three functional gradient axes of t …