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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

British Journal of Nursing

Management of urinary tract infections in paediatrics

Bronagh Hafford

Urinary tract infections (UTIs) are a common cause of morbidity in the paediatric population, with prevalence varying according to age, sex, and circumcision status. Differentiating between upper and lower tract infections is crucial, as upper UTIs carry a greater risk of renal scarring and long-term complications. Accurate diagnosis and timely management reduce acute symptoms and prevent sequelae such as chronic kidney disease and hypertension. Current guidance recommends urgent referral for infants under 3 months …

03.09.2026journal-article

British Journal of Nursing

Person-centred colostomy care through caring and emotional perspectives

Chang Lyu, Leah Macaden

Person-centred care (PCC) emphasises the overall identification of patients as individuals with emotional, social and psychological needs, especially in cases of profound changes in self-image, such as colostomy care. This article is a reflective case analysis of the care received by Mr Z. Mr Z is a retired professional who experienced emotional withdrawal after a permanent colostomy. This case analysis draws on the experience and insights gained during a clinical placement in the gastrointestinal surgery ward, hig …

03.09.2026journal-article

European Journal of Dental Education

Learning Clinical Procedures Through Social Media: A Multi‐Institutional Study of Preclinical and Clinical Dental Students in Turkey

Abdul Kerim Atlı, Emel Karaman

ABSTRACT Introduction Social media platforms are increasingly used by dental students to support learning and preparation for clinical procedures. Although previous studies have described general patterns of social media use in dental education, evidence directly comparing preclinical and clinical students remains limited. This study aimed to evaluate how dental students in Turkey use social media for learning clinical procedures and to examine differences associated with clinical experience. Methods This cross‐sec …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Development and validation of a clinical-pharmacogenomic prediction model for clopidogrel-related high on-treatment platelet reactivity in patients with coronary artery disease

Ruihua Sun, Yu Du

Objective This study aimed to develop and validate a prediction model combining clinical indicators and pharmacogenomic markers for predicting clopidogrel-related high on-treatment platelet reactivity (HPR) after approximately 7 days of dual antiplatelet therapy in patients with coronary artery disease (CAD), and to identify its influencing factors to support individualized antiplatelet therapy. The model is intended for use before platelet function testing results are available, to identify patients at high risk o …

03.09.2026journal-article

Clinical Pharmacology & Therapeutics

Advances in New Approach Methodologies at FDA 's Division of Applied Regulatory Science

Ksenia Blinova, Kimberly Chiu, Anik Chaturbedi, Jahan Cooper, Tromondae K. Feaster, Paula L. Hyland, Lidiya Stavitskaya, Wendy W. Wu, Jeffry Florian, Rodney Rouse

New Approach Methodologies (NAMs) represent a paradigm shift in drug development and regulatory science, offering human‐relevant alternatives to traditional preclinical models. This mini‐review highlights recent advances in NAM development, validation, and regulatory application from FDA's Division of Applied Regulatory Science (DARS). We describe in silico NAMs including quantitative systems pharmacology (QSP) modeling for opioid overdose scenarios, (quantitative) structure–activity relationship ((Q)SAR) modeling …

03.09.2026journal-article

Regional Anesthesia & Pain Medicine

Prolonging peripheral ropivacaine nerve block with an in situ-formed hydrogel carrier: randomized controlled trial in an ovine model

Hans Vangsnes Vingen, Ana Ćuk, Axel R Sauter, Olav Spigset, Finn Andersen, Fredrik Strebel Skedsmo, Marianne Hiorth, Marija T Garvin, Tor Å Myklebust, Audun Stubhaug, Henning A Haga

Background Local anesthetics are effective for regional anesthesia but have a relatively short duration of action. This motivates the development of sustained-release delivery systems. The aim of this study was to evaluate whether an in situ-forming hydrogel composed of poloxamers and alginate could prolong the duration of ropivacaine-induced sensory and motor blockade. Methods In this randomized and blinded two-period cross-over study, 10 female sheep received ultrasound-guided sciatic nerve injections of either 2 …

03.09.2026journal-article

INTERNATIONAL JOURNAL OF HEALTH AND PHARMACEUTICAL RESEARCH

Assessing Healthcare Workers’ Knowledge, Attitudes, and Perceptions of Electronic Health Record Implementation in Government-Owned Hospitals in Calabar Metropolis, Cross River State, Nigeria

Elemi Éko EDU

The use of Electronic Health Records (EHRs) has been widely promoted as a means of improving healthcare delivery, yet their effective utilisation depends largely on the readiness and perspectives of healthcare workers. In Calabar Metropolis, limited evidence exists on how healthcare professionals understand and respond to EHR systems in routine practice. This study therefore assessed the knowledge, attitude, and perception of healthcare workers towards Electronic Health Records in Government-Owned Hospitals in Cala …

03.09.2026journal-article

Blood

Precision transfusion medicine in the omics era

Angelo D'Alessandro

Abstract Transfusion medicine has practiced a form of precision medicine for decades through compatibility testing, infectious disease screening, component manufacturing, traceability, and hemovigilance. Yet blood is still often treated primarily as a commodity—collected, processed, stored, and transfused—rather than as a dynamic biological product rich in molecular information. This Perspective argues that the field is uniquely positioned to extend its long-standing precision framework into a more molecular, longi …

03.09.2026journal-article

ACS Applied Materials & Interfaces

Engineered Hierarchical Porosity in Three-Dimensional-Printed Hydrogel Scaffolds Enhances Mesenchymal Stem Cell Therapy for Chronic Diabetic Wounds

Zhigen Yuan, Lei Mi, Yuan Ai, Yi Liu, Wei Gao, Churuo Zeng, Dehong Yang, Kexin Deng

Abstract Unhealing chronic diabetic wounds is a major clinical challenge, as it is rooted in the complex pathological microenvironment, including neuropathy, angiopathy, and chronic inflammation. Traditional treatment methods cannot fundamentally solve these problems. Inspired by outdoor rock climbing, this study developed a multifunctional bioactive hydrogel scaffold with hierarchical pore sizes (CSP hydrogel) to remodel the wound microenvironment and boost regenerative repair. Fabricated through 3D printing and p …

03.09.2026journal-article

Facilities

Digitally enabled stakeholder collaboration for sustainable urban facilities management: insights from Abu Dhabi’s public sector

Abeer Alhammadi, Alex Opoku

Purpose This study aims to investigate how facilities management (FM) digital technologies impact stakeholder collaboration, how key sustainability drivers and collaboration affect sustainable building FM, and the moderating effect of digital technologies on sustainability drivers’ influence on sustainable building FM. It compares managers’ and users’ perspectives, providing empirical evidence from Abu Dhabi’s public buildings managed by the Department of Culture and Tourism and the Department of Municipalities and …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

PVN-centered multi-omics and single-cell analyses suggest shared inflammatory and immune features in acute myocardial infarction-associated ventricular arrhythmia and atrial fibrillation

Wenlong Wang, Wenbo Zhao, Yuran Chen, Xin Wang, Chunrui Ji, Jingmei Sun, Yu Bai, Yuhang Yang, Xiufen Qu

Objective Acute myocardial infarction (AMI) increases the risk of arrhythmias, particularly ventricular arrhythmias (VA), and atrial fibrillation (AF) is also common after AMI. The paraventricular nucleus (PVN) is a key regulator of sympathetic outflow. This study used a PVN-centered strategy to investigate molecular changes after AMI, prioritize candidate molecules associated with VA, and assess whether related inflammatory and immune features are also present in AF cohorts. Methods An AMI model was established in …

03.09.2026journal-article

Trials

Optimizing patient recruitment in community pharmacies using implementation science principles: a Study Within A Trial (SWAT)

Kirstin Messner, Alexa Rosenthaler, Manuel Leuenberger, Meret Berger, Lena Walz, Isabelle Arnet, Samuel Allemann

Abstract Background Decentralized trial approaches involving community pharmacies have gained increasing attention. However, recruitment in community pharmacies faces complex conditions and tailored strategies are necessary. Applying implementation science principles is a promising but underrepresented approach to facilitate recruitment processes. On the example of adherence-enhancing services, we aimed to investigate influencing factors to trial recruitment in the community pharmacy setting and to identify impleme …

03.09.2026journal-article

Frontiers in Medicine

Direct visualization-guided endoscopic management of complex colonic diverticular disease: a proof-of-concept case series

Tianjie Han, Junshan Li

Background Complex colonic diverticular disease, including diverticular bleeding, inflammatory diverticular disease, presents substantial therapeutic challenges for conventional colonoscopy because of limited intradiverticular visualization, difficult access, and restricted maneuverability. Failure to precisely localize the culprit lesion or inflammatory nidus may lead to recurrent symptoms, delayed treatment, or surgical intervention. The EyeMax direct visualization system, originally designed for pancreatobiliary …

03.09.2026journal-article

Frontiers in Immunology

Mammalian cell-derived extracellular vesicles remodel the immune-repair microenvironment in osteoarthritis: from pathological signal transmission to regenerative therapy

Lin Zhang, Xuxu Yang, Yang Yu, Lidan Yang

Osteoarthritis is a whole-joint disease involving articular cartilage, synovium, subchondral bone, fat pad, meniscus, blood vessels, and sensory nerves. Its core pathology is not simply passive wear of the cartilage matrix, but rather reciprocal driving forces among mechanical stress, low-grade inflammation, cellular senescence, immunometabolic reprogramming, and failure of endogenous repair. As lipid bilayer-enclosed intercellular information carriers, Extracellular vesicles (EVs) carry proteins, lipids, nucleic a …

03.09.2026journal-article

Frontiers in Medicine

Case Report: Extremely elevated ascitic fluid amylase as a diagnostic clue for peritoneal mucormycosis caused by Rhizopus microsporus following exertional heatstroke

Guanghui Chen, Haibo Lei, Guyi Wang, Yanyan Zhou

Background Mucormycosis is a rapidly progressive, life-threatening fungal infection that typically affects immunocompromised hosts. Disseminated peritoneal mucormycosis is extremely rare and often diagnosed late. Heatstroke is an under-recognized predisposing condition. Case presentation A 54-year-old male brickworker developed peritoneal mucormycosis caused by Rhizopus microsporus following exertional heatstroke. On day 11 after heatstroke, he developed massive ascites. Ascitic fluid amylase was markedly elevated …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Evolution of electrocardiographic manifestations mimicking acute coronary syndrome secondary to hypoparathyroidism: a case report

Gerile Zhang, Riletu Ge, Jing Gao, Yuzhen Zhou

Objective To promptly identify electrocardiographic (ECG) manifestations, including deep T-wave inversions and QT-interval prolongation, secondary to hypoparathyroidism and to improve its diagnostic accuracy and therapeutic management. Methods We conducted a comprehensive analysis of the integrated treatment for a patient presenting with chest pain and evolving ECG changes secondary to hypoparathyroidism, supplemented by a review of the relevant literature. Results In this case, a patient diagnosed with hypoparathy …

03.09.2026journal-article

International Journal of STD & AIDS

Anti–IL-17 therapy in people living with HIV who have cutaneous psoriasis: A four-patient case series

Melike Merve Güçlü, Fatma Aslı Hapa, Fatma Elif Yıldırım

Aim To describe the clinical, immunological, virological and safety outcomes observed during anti–IL-17 therapy in patients living with HIV who had cutaneous psoriasis. Method Four patients living with HIV who had cutaneous psoriasis and were treated with anti–IL-17 agents were included in this case series. Psoriasis Area Severity Index (PASI) scores, CD4 cell counts, HIV RNA levels, treatment duration and adverse events were obtained from medical records. Results Three patients received secukinumab and one receive …

03.09.2026journal-article

Frontiers in Reproductive Health

Preoperative imaging for endometriosis awareness: an online survey study

Bassem Gerges, Allie Eathorne, George Condous

Introduction In 2024, an international consensus statement on non-invasive imaging techniques for the diagnosis of pelvic deep endometriosis was published, recommending transvaginal sonography as the first-line imaging modality because of cost, availability, and low impact on the environment. Despite the increasing body of evidence supporting the use of imaging in the preoperative diagnosis of endometriosis, there is a paucity of data to confirm patient awareness. The aim of this study was to use an online survey o …

03.09.2026journal-article

Frontiers in Public Health

Validating and applying a multidimensional scale to measure public security police stressors in China

Jue Deng, Jianping Ma, Yuanhua Ou, Xianghui Lai, Zhenqiang Li, Xiaoli Zhu

Background Policing is a highly stressful occupation, with considerable implications for officers' mental health and wellbeing. Despite increasing research on police stress, there remains a critical need for culturally relevant and up-to-date measurement tools, particularly in Eastern countries like China. This study aimed to develop and validate a revised version of the Police Stress Scale (PSS)—the Revised Chinese Public Security Police Stressors Scale (CPSPSS-R)—a tool assessing stressors affecting Chinese publi …

03.09.2026journal-article

BMC Public Health

Case-area targeted interventions (CATI) among household contacts and neighboring households after identifying cholera hotspot: a study protocol for the effectiveness of Oral Cholera Vaccine (OCV) and its potential impact on cholera control

Imam Tauheed, Afroza Akter, Md. Taufiqur Rahman Bhuiyan, Md. Shahinur Rahaman, Al Amin Ahmed Shakil, Sadia Sabrina, Istiaque Hossain, Hassan Afrad, Prasanta Kumar Biswas, Md. Amiruli Islam Bhuiyan, Sadia Isfat Ara Rahman, Marjahan Akhtar, Faisal Ahmmed, Andrew S Azman, Jason B Harris, Nicholas R. Thomson, Tahmina Shirin, John D. Clemens, Firdausi Qadri, Fahima Chowdhury

Abstract Background Cholera outbreaks and epidemics are often unpredictable and response strategies are frequently delayed due to resource constraints, scarcity of vaccine and logistical challenges. In Bangladesh, the risk of cholera infection is very high and studies have showed a greater than 20% risk among household contacts of cholera patients within the first 7 days after initial case presentation. As a more directed alternative to both reactive as well as routine largescale vaccination campaigns, which in Dha …

03.09.2026journal-article

Frontiers in Communication

Organizational dedifferentiation: neural gradient axes and communication hierarchy in healthcare organizations

Moeki Nemoto

Communication failures remain a leading cause of sentinel events in healthcare settings, yet the mechanisms by which organizational communication hierarchies form, function, and fail remain undertheorized. Prior work reconceptualized the Balanced Scorecard (BSC) as a constitutive communication mechanism through Communication Constitutes Organization (CCO) four flows theory; however, a principled account of why such hierarchies erode over time was lacking. This paper proposes that three functional gradient axes of t …

03.09.2026journal-article

Human Resources for Health

Building a One Health mobile laboratory workforce: strengthening public health preparedness across Europe and Africa

Aryse Martins Melo, Beate Becker-Ziaja, Markus Keller, Duncan Sangale, Dewi Ismajani Puradiredja, Theresa Habermann, Juliane Bönecke, Alexandru Tomazatos, Johannes R. Peham, Birgit Michalek, Andry Aasamäe, Georg G. Duscher, Lisa Winkelmayer, Denise Framke, Monique-Theres Schranz, Daniela Gleißner, Martin Groschup, Fereshteh Haghighi, Patrick Slowikowski, Katrin Schwabe, Lida Politi, Kassiani Mellou, Anastasia Flountzi, Dafni Dimitriadou, Ioanna Spiliopoulou, Grigoris Spanakos, Andriani Varela, Ramadhani Libenaga, Mariagoreth Beda, Edna Mgimba, Andrew Ugolole, Jackson Rashidi, Anselmi Munga, Proscovia Kagaruki, Shabani Motto, Ambele Mwafulango, Nyambura Moremi, Peter Mkama, Jürgen May, Muna Affara

Abstract The emergence and re-emergence of infectious diseases remain a major public health threat in Europe. The Horizon Europe-funded MOBILISE project addresses this challenge by establishing a One Health Mobile Laboratory capable of handling risk group 3 and 4 pathogens, while strengthening outbreak preparedness through targeted capacity-building activities and the development of a rapid-response expert network. A key component of the project is a training-of-trainers (ToT) model, which enables participants to p …

03.09.2026journal-article

Asclepius International Journal of Scientific Health Science

CANABIDIOL NO TRATAMENTO DA FIBROMIALGIA: EVIDÊNCIAS SOBRE EFICÁCIA, SEGURANÇA E CONTROLE DOS SINTOMAS

Bruna Angélica Strunkis, Thomaz Funari Neto, João Paulo Junqueira Cervantes Santos, Peterson Rose Pereira, Lucas Paconio, Jordano Bruno Vivan, João Gabriel Gomes Queiroz, Guilherme Prates Bohrer, Karla Suzany Oliveira de Andrade

A fibromialgia é uma síndrome de dor crônica caracterizada por dor musculoesquelética generalizada, fadiga, alterações do sono, dificuldades cognitivas e importante comprometimento da qualidade de vida. A resposta incompleta de parte dos pacientes às estratégias terapêuticas convencionais tem estimulado o interesse por intervenções sobre o sistema endocanabinoide, incluindo o canabidiol (CBD) e outros produtos derivados de Cannabis sativa. O objetivo desta revisão foi analisar as evidências sobre eficácia, seguranç …

03.09.2026journal-article

Eastern Mediterranean Health Journal

Characteristics, circumstances and forensic findings on immersion deaths in Saudi Arabia

Dalia Alsaif, Nasser Al-Shahrani, Abdullah Al Ekli, Mohammed Al-Shehri, Abdullah Al-Zahrani, Mona Al-Shammari, Sahar Y. Issa

Background: Drowning is a preventable cause of death; however, forensic evidence on immersion deaths in coastal areas of Saudi Arabia remains limited. Aim: To describe the characteristics, circumstances and forensic findings on immersion deaths in the Eastern Province of Saudi Arabia. Methods: We reviewed and analysed data on 189 cases of immersion deaths referred to Dammam Forensic Medicine Centre from April 1999 to January 2024, including the victims’ demographic characteristics, type of water body, cause and man …