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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

The Laryngoscope

Treatment of Congenital Cytomegalovirus Beyond the Neonatal Period: A Single‐Arm Meta‐Analysis

Thamiris D. D. Cabral, Marcela Mafra, Jaime Plane, Matheus Sewastjanow‐Silva, Isadora Martins Nascimento, Asitha D. L. Jayawardena, Abby Meyer, Andrew Redmann, Luke Jakubowski

ABSTRACT Objective To evaluate hearing outcomes in postneonatal treatment of congenital cytomegalovirus (cCMV) infection and assess the effect of treatment initiated after the first month of life. Data Sources PubMed, Embase, Web of Science, and Cochrane Library were systematically searched. Review Methods Articles reporting antiviral treatment of cCMV, with Ganciclovir (GCV) or Valganciclovir (VGCV) in the postneonatal period were included. Outcomes of interest included viral load (urine and plasma), neutropenia, …

02.09.2026journal-article

Physics in Medicine & Biology

Biologically optimized 3D range modulators for fast conformal carbon ion therapy: in vitro validation, treatment planning, and robustness analysis

Sae Hyun Hailey Ahn, Domenico Ivan Filosa, Peter Lysakovski, Stephan Brons, Amir Abdollahi, Jürgen Debus, Ivana Dokic, Thomas Tessonnier, Andrea Mairani

Abstract Objective. Patient-specific 3D range modulators (RMs) allow rapid and conformal particle therapy with monoenergetic beams and may support motion management and ultra-high dose rate (UHDR) studies. For carbon ions, however, relative biological effectiveness (RBE) varies strongly with depth, so RM geometry should be optimized for biological effect rather than physical dose alone. This work presents a translational pathway for biologically optimized 3D RMs (bio-RMs) for carbon ion therapy, evaluated through d …

02.09.2026journal-article

JAMA Dermatology

Delphi Consensus Statement on Treatment of Severe Alopecia Areata in US Adults

Samantha Gregoire, Eliza Dewey, Ursula Biba, Katherine Sanchez, Hanna Englander, Lana Salloum, Sherry Ershadi, Debby Cheng, Basil Alex McIntosh, Nikki Zangenah, Maria Vazquez-Machado, Aneri Parekh, Lisa Kam, Nora Bensellam, Crystal Aguh, Wilma Bergfeld, Valerie D. Callender, Leslie Castelo-Soccio, Brittany Craiglow, Dirk Elston, Ronda Farah, Jennifer Fu, Carolyn Goh, Emma Guttman-Yassky, Kathie P. Huang, Ali Jabbari, Chesahna Kindred, Justin Ko, Mark Lebwohl, Kristen I. Lo Sicco, Amy McMichael, Natasha A. Mesinkovska, Paradi Mirmirani, Melissa Piliang, Maryanne Senna, Jerry Shapiro, Jennifer Soung, Susan Taylor, Antonella Tosti, Benjamin Ungar

Importance Alopecia areata (AA) is an autoimmune hair loss disorder that affects more than 7 million people in the US. Before US Food and Drug Administration–approved trials of Janus kinase inhibitors, numerous treatments had been explored, with variable efficacy and quality of evidence. The absence of standardized treatment guidelines may lead to poor treatment outcomes and payer coverage. Objective To establish a consensus on treatment for adults with severe AA in the US. Evidence Review Systematic literature rev …

02.09.2026journal-article

International Journal of Biology and Life Sciences

Pan-cancer Expression Analysis of CXCL1/8/10 and Their Relationship with Prognosis and Tumor Microenvironment

Peng Xie, Zhuizhui Jiao, Tingting Yin

Objective To analyze the expression characteristics and prognostic value of CXCL family members (CXCL1/8/10) across pan-cancer using bioinformatics approaches. Methods Transcriptomic and clinical data of 33 tumor types were obtained from the TCGA database. Differential expression was evaluated by the Wilcoxon rank-sum test. Prognostic significance was assessed using Kaplan-Meier survival curves and univariate Cox regression. Spearman correlation analysis was applied to examine associations with immune subtypes, tum …

02.09.2026journal-article

PLOS One

MR-based radiomics of mesorectal fat for improved prediction of perirectal lymph node metastasis and extramural venous invasion in locally advanced rectal cancer

Yaniga Swaengdee, Sararas Khongwirotphan, Jaravee Lasode, Phakakarn Kuecharoen, Phathayphout Phetvilay, Thitithep Limvorapitak, Anapat Sanpavat, Sira Sriswasdi, Piyaporn Boonsirikamchai, Yothin Rakvongthai

Objective Accurately assessing residual disease after neoadjuvant chemoradiotherapy (nCRT) in locally advanced rectal cancer (LARC) remains challenging. Residual extramural venous invasion (EMVI) and perirectal lymph node (PLN) metastasis indicate adverse outcomes, but treatment-related changes obscure their detection on post-treatment MRI. This study developed MRI-based radiomics models to predict residual EMVI and PLN metastasis using post-nCRT restaging MRI. Materials and methods In this retrospective study, 219 …

02.09.2026journal-article

Southern African Journal of HIV Medicine

Adherence thresholds of tenofovir diphosphate in dried blood spots for HIV treatment and pre-exposure prophylaxis: A scoping review

Mohammed K. Alghamdi, Mohammed W. Ali, Anel Schoonees, Tamara Kredo, Eric Decloedt, Roland van Rensburg

Background: Tenofovir (TFV) is a key antiretroviral used in HIV pre-exposure prophylaxis (PrEP) and treatment, with efficacy contingent on adherence. Quantifying TFV concentrations in dried blood spots (DBS) as tenofovir diphosphate (TFV-DP) is a robust method for determining long-term adherence. However, standardised TFV-DP adherence thresholds in DBS have not been established. Objectives: To map the existing literature on TFV-DP concentration thresholds in DBS for assessing adherence to TFV-based HIV prevention a …

02.09.2026journal-article

Journal of Cancer Research and Clinical Oncology

Time to subsequent therapy (TTST) as an endpoint in clinical studies: development of standardized documentation of subsequent therapy through systematic literature review, expert interviews, and Delphi survey

Bianca Biedenweg, Thorsten Ruppert, Thomas Kohlmann, Martin Danner, Anja Mehnert-Theuerkauf, Diana Lüftner, Ulrike Filippig, Janine Ziemann, Ulrike Osowski, Peter Kaskel

Abstract Background The endpoint Time to Subsequent Therapy (TTST) is an intermediate endpoint used in research and regulatory assessments. TTST denotes initiation of subsequent therapy and is a clearly definable, clinically relevant event for healthcare professionals. However, it has not been systematically established to which extent TTST is subjectively meaningful to patients. The objective of this study was to define TTST as a patient-relevant intermediate endpoint. Methods The study examined five oncological i …

02.09.2026journal-article

Microbiology Spectrum

Persistence of Plasmodium falciparum DNA detection after antimalarial treatment and the implication of gametocytes: a prospective cohort study in a non-endemic setting

Azza Bouzayene, Valentin Joste, Tristan Candau, Rizwana Zaffaroullah, Véronique Sarrasin, Nicolas Argy, Sandrine Cojean, Sandrine Houzé

ABSTRACT Highly sensitive molecular assays are increasingly used for malaria diagnosis but are not recommended for follow-up, as Plasmodium falciparum DNA detection may persist after effective antimalarial treatment, complicating these tests’ clinical interpretation. The biological basis of this persistence remains poorly defined. We investigated the potential role of gametocytes in the context of treated infections. In a prospective cohort of 100 successfully treated patients, we analyzed 379 blood samples collect …

02.09.2026journal-article

Sage Sphere International Journal

Ureteroscopia flexible versus litotricia extracorpórea en el tratamiento de litiasis renal

Adriana Micaela Aguayo Peralta, Joel Sebastian Chango Yosa, Anthony Bryan Cevallos Falcones, María Daniela Paladines García, Nathaly Pamela Mora Pinos

Introducción: La litiasis renal constituye una enfermedad frecuente cuya elección terapéutica depende del tamaño, localización y características del cálculo, así como de las condiciones individuales del paciente. La ureteroscopia flexible (UF) y la litotricia extracorpórea (LEC) representan alternativas mínimamente invasivas ampliamente utilizadas. Objetivo: Sintetizar la evidencia científica sobre la eficacia y los resultados clínicos de la UF frente a la LEC en el tratamiento de la litiasis renal. Metodología: Se …

02.09.2026journal-article

NMR in Biomedicine

1 H HR‐MAS NMR Metabolomics in Combination With Transcriptomic Correlation Provides New Insights Into Metabolic Heterogeneity Across Breast Cancer Immunohistochemical Subtypes

Irene Garcia‐Bocanegra, Jesus David Urbano‐Gamez, Antonio Perez‐Cardona, Laura Barrios, Maria Isabel Somoza‐Ramírez, Luis Vicioso, Elena Pardo‐Susacasa, Gema Diaz‐Cordoba, Maria Mercedes Acebal‐Blanco, Francisco Sendra‐Portero, Maria Luisa Garcia‐Martin

ABSTRACT Advances in molecular characterization have significantly redefined our understanding of breast tumor heterogeneity, enabling improved diagnostics and the development of tailored therapeutic strategies. In particular, integrative omics approaches offer a broader scope for exploring the molecular and biochemical complexity of breast cancer. Notably, metabolomics through high‐resolution magic angle spinning (HR‐MAS) NMR spectroscopy enables nondestructive metabolic profiling of intact tissue samples, preserv …

02.09.2026journal-article

International Journal of Stroke

Remote Ischemic Conditioning in the Acute Treatment of Ischemic and Hemorrhagic Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Kaden Lam, Bogna Anna Drozdowska, Ryan Rosentreter, William Betzner, Jianhai Zhang, Mahesh Kate, Carlos Camara-Lemarroy, Zahinoor Ismail, Eric Edward Smith, Aravind Ganesh

Background Remote ischemic conditioning (RIC), a low-cost, non-invasive therapy involving brief cycles of limb ischemia and reperfusion, may be a neuroprotective adjuvant or alternative to reperfusion therapies in acute ischemic stroke (AIS) and may also have therapeutic effects in hemorrhagic stroke (HS). This systematic review and meta-analysis evaluated the efficacy of RIC in AIS and HS. Methods This review was conducted in accordance with PRISMA guidelines and was registered in PROSPERO (CRD42024549594). Litera …

02.09.2026journal-article

International Journal of Nanoscience

Green Ferrite-Based Nanocomposites: Emerging Multifunctional Materials for Sustainable Wastewater Treatment and Environmental Remediation

Ruchika Sharma, Pooja Sharma, Ajay Kumar Sharma, Dhirendra Kumar, Thakur Sudesh Kumar Raunija, Vipin Kumar Jain

In the era of scarcity of potable water, there is need of immediate attention for sustainable treatment of wastewater. Water has such a strong tendency to dissolve other substances and that's why sometimes referred to as the universal solvent. Significant impact of water pollution is summarized such as human health, water pollution can lead to the spread of waterborne diseases, such as cholera, typhoid, and dysentery. Exposure to contaminated water can also cause cancer, neurological damage, and reproductive proble …

02.09.2026journal-article

Archives of Osteoporosis

Teriparatide treatment of osteoporosis in solid organ transplant recipients—a single-center experience

Talia Diker Cohen, Ilana Shraga-Slutzky, Keren Kaminer, Alexander Gorshtein, Idit Dotan, Gloria Tsvetov

Abstract Summary Solid organ transplant recipients face high fracture risk with limited evidence guiding anabolic therapy. In this real-world cohort, teriparatide was associated with significant improvements in bone mineral density and acceptable safety without adverse graft effects. These findings support selective anabolic treatment in high-risk transplant recipients and highlight the need for prospective studies. Purpose Solid organ transplant (SOT) recipients are at high risk for osteoporosis and fragility frac …

02.09.2026journal-article

European Spine Journal

Osteoporotic thoracolumbar fractures: age-modified Osteoporotic Fracture–based treatment decisions and length of hospital stay in elderly patients – a prospective single-centre cohort study

Dina Wilma Wiersbicki, Juliane Neumann, Tim Stelzner, Erik Schreiber, Thomas Neumuth, Christoph-Eckhard Heyde, Anna Voelker

Abstract Purpose Treatment decisions for osteoporotic thoracolumbar vertebral fractures (OVF) in elderly patients are challenging. The AO Spine–DGOU Osteoporotic Fracture (OF) classification and OF-score support treatment allocation but do not explicitly account for chronological age, despite its known prognostic relevance. In addition, determinants of length of hospital stay (LOS) in older and very old patients with OVF remain incompletely defined. Methods In this prospective single-centre cohort study, patients a …

02.09.2026journal-article

PLOS One

Integrative proteomics reveals MSH6 to modulate PARP inhibitor sensitivity in BRCA1/2-proficient ovarian cancer

Ou Deng, Thales Da Costa Nepomuceno, Bin Fang, Eric A. Welsh, Victoria Izumi, Rachael H. Martin, Erin M. George, John M. Koomen, Alvaro N. Monteiro, Uwe Rix

Ovarian cancer remains a leading cause of gynecologic cancer–related deaths worldwide. Deficiencies in BRCA1/2 are well-established biomarkers that predict sensitivity to poly(ADP-ribose) polymerase inhibitors (PARPis). However, emerging evidence indicates that a subset of BRCA -proficient tumors also responds to PARPi therapy, suggesting the presence of additional molecular mechanisms. We hypothesized that the composition of the PARP1 protein complex and PARylation-mediated signaling contribute to PARPi response i …

02.09.2026journal-article

Biosensors

A Portable Colorimetric Biosensor Platform for Urinary Colorectal Cancer Biomarker Testing in Low-Resource Settings

Prashanthi Kovur, Scott MacKay, Songtian Bai, James Cook, Claudia Torres-Calzada, Dipanjan Bhattacharyya, Upasana Singh, David S. Wishart

Early detection of colorectal cancer (CRC) is challenging in low-resource settings because access to colonoscopy and centralized laboratory testing is limited. Urine-based metabolite biomarkers offer a non-invasive alternative for CRC triage, but translating a laboratory assay into a point-of-care (PoC) system requires standardized fluid handling, operator-independent timing, field-compatible reagents, and quantitative calibration. Here, we present a low-cost, semi-automated PoC platform integrating a validated, se …

02.09.2026journal-article

Problems of Gathering Treatment and Transportation of Oil and Oil Products

USE OF BIRD FEATHERS AS OIL SORBENTS TO REMOVE HYDROCARBONS FROM WATER SURFACE

I.G. Shaikhiev, A.A. Fazullina

Hydrocarbon spills are one of the urgent environmental problems of our time. To eliminate accidental oil and petroleum product spills from water surfaces there are used various methods: mechanical, chemical, physicochemical, thermal, and biological. The most common method for hydrocarbon removing from natural water body surface is sorption, based on the use of various materials as oil sorbents. Agricultural waste of plant and animal origin has been found to be promising oil sorbents. This article summarizes literat …

02.09.2026journal-article

Clinical Cancer Research

Clinical, Genomic, and Spatial Transcriptomic Features of Pancreatic Adenosquamous Carcinoma Support Subtype-Specific Therapeutic Strategies

S. Daniel Haldar, Meredith Wetzel, Jiayun Lu, Jae W. Lee, Hassan Sinan, Christopher D. Jakubowski, Fen Saj, Dean Pavlick, Ryon P. Graf, Julia Quintanilha, Gerald Li, Jerry Mitchell, Jeffrey S. Ross, Anirban Maitra, Milind Javle, Shubham Pant, Hao Wang, Richard Burkhart, Daniel A. Laheru, Elizabeth M. Jaffee, Elana J. Fertig, Elizabeth D. Thompson, Dimitrios N. Sidiropoulos, Luciane T. Kagohara, Nilofer S. Azad

Abstract Purpose: Pancreatic adenosquamous carcinoma (ASQ) is a rare variant with poorly defined clinical and molecular features compared with conventional pancreatic ductal adenocarcinoma (PDAC). This study aimed to characterize the clinical outcomes, genomic landscape, and spatial transcriptomic architecture of ASQ. Experimental Design: We retrospectively evaluated the clinicopathologic features, treatment patterns, and survival of patients with ASQ treated at Johns Hopkins from 2013 to 2023 (n = 178). Genomic la …

02.09.2026journal-article

International Journal of Sports Physical Therapy

Calcific Patellar Tendinopathy. A Case Report Integrating Diagnostic Ultrasound Throughout a Multi-Modal Treatment Approach

Ian Young, Adam Salzman, James Dunning, Joshua Prall, Sam Fischer, Brittany Forbes, James Escaloni

Background Calcific tendinopathy can be difficult to diagnose and manage from a traditional, non-invasive physical therapy perspective. However, there is preliminary evidence supporting the use of diagnostic ultrasound and dry needling interventions to evaluate and treat the pain and disability associated with this chronic condition. The purpose of this case report was to describe the integration of diagnostic ultrasound in the successful evaluation and multi-modal treatment of a patient with calcific patellar tend …

02.09.2026journal-article

Frontiers in Oncology

Migrastatics: an overview of the current scenario and future cancer treatments

Irene Olivas-Cano, M. Angeles Juanes

Metastasis is the main cause of cancer-related death worldwide. Thus, significant efforts have been directed towards inhibiting metastasis to avoid regrowth or relapse after cytostatic and/or cytotoxic cancer treatments. Drugs targeting cell-invasiveness are known as migrastatics and primarily target the cytoskeleton to impair cell motility and/or invasive mechanisms. However, the cytoskeleton is essential to perform many fundamental processes, including cell division. Consequently, migrastatics often prompt high t …

02.09.2026journal-article

Pharmaceutics

Extracellular Vesicle–Lipid Hybrid Systems for RNA Delivery in Cancer: Structural Classification, Functional Delivery, and Translational Challenges

Lu Lu, Yige Qiu, Jiayu Wu, Wei Dou, Jing Yang, Bo Zhang

RNA therapeutics offer considerable potential for cancer treatment. Their therapeutic application, however, remains limited by rapid degradation, inefficient cellular uptake, and restricted intracellular release. Extracellular vesicles (EVs) are cell-derived membrane vesicles that have been exploited as promising vehicles for drug delivery due to their high biocompatibility and low immunogenicity, whereas liposomes and lipid nanoparticles provide tunable lipid composition and efficient loading of exogenous nucleic …

02.09.2026journal-article

ACS Photonics

Ultrasensitive Whispering-Gallery Extracellular Vesicle Biosensor for Early Gastric Cancer Detection

Chenjie Xu, Bing Duan, Mingyuan Liu, Xiangji Li, Yixuan Zhao, Tao Yang, Yisu Yang, Haosu Zhan, Qi-Tao Cao, Jin-hui Chen, Li Min, Daquan Yang

Abstract Extracellular vesicles (EVs) have emerged as superior tools compared with plasma tumor biomarkers for gastric cancer detection. However, clinical practice of EV detection for early stage gastric cancer (EGC) discrimination remains limited, primarily hindered by the low sensitivity of current detection technologies and the intrinsic complexity of EVs. Here, we propose a label-free microfluidic microsensor for the ultrasensitive and rapid detection of EVs in mixed environments. An estimated detection limit o …

02.09.2026journal-article

Proceedings of the National Academy of Sciences

Targeting CTGF + cancer-associated fibroblasts disrupts tumor–stroma crosstalk in pancreatic ductal adenocarcinoma

Yiwen Shen, Qingyan Sun, Yunzhe Wang, Sichao Tian, Yuzhu Li, Dong Lu, Shiqun Wang, Jinmei Jin, Hao Zhang, Hongzhuan Chen, Zhao Zhang, Jiangjiang Qin, Weidong Zhang, Xin Luan

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a heavily fibrotic tumor microenvironment (TME), primarily driven by cancer-associated fibroblasts (CAFs). Due to the high heterogeneity and diverse biological behaviors of CAFs, the current strategies targeting CAFs have limited benefits in clinic. This study identifies a subset of CAFs marked by high expression of connective tissue growth factor (CTGF), which enhances tumor cell migration and correlates with advanced PDAC stages. By combining in silico s …

02.09.2026journal-article

JAMA Network Open

Dietary Fat Intake and Mortality Among Patients With Nonmetastatic Prostate Cancer

Yiwen Zhang, Megan R. Shanahan, Hannah E. Guard, Jiachen Ji, Maria Celia Fernandez, Nadia Boufaied, Jane B. Vaselkiv, Binkai Liu, Chaoran Ma, Rebecca E. Graff, Stacy Loeb, Caroline Himbert, Yuan Ma, Edward L. Giovannucci, David P. Labbé, Lorelei A. Mucci

Importance There are 3.5 million prostate cancer survivors in the US, with a need for evidence-based lifestyle recommendations that improve survivorship. Objective To assess whether consumption of specific dietary fats after diagnosis is associated with long-term survival among patients with nonmetastatic prostate cancer. Design, Setting, and Participants This study, nested in the Health Professionals Follow-Up Study, a cohort of male health professionals from across 50 US states ongoing since 1986, included partic …

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