Medizin: neue Gesundheitspublikationen – Seite 128

04.09.2026journal-article

Clinical Pharmacology & Therapeutics

Physiologically Based Pharmacokinetic Modeling to Assess Transporter‐Mediated Drug–Drug Interactions in Support of Labeling Recommendations for Zavegepant Nasal Spray

Alice Ke, Ernesto Callegari, Manthena V.S. Varma, Mayur K Ladumor, Chieko Muto, Richard J. Bertz, Hannah M. Jones, Vaishali Sahasrabudhe, Jing Liu

Zavegepant nasal spray, a calcitonin gene‐related peptide receptor antagonist indicated for acute treatment of migraine with or without aura in adults, is a substrate for organic anion transporting polypeptide 1B3 (OATP1B3), Na + /taurocholate cotransporting polypeptide (NTCP), P‐glycoprotein (P‐gp), and cytochrome P450 3A4 (CYP3A4). In clinical drug–drug interaction (DDI) studies, oral zavegepant exposure increased in the presence of multiple‐dose (MD) rifampin or itraconazole; however, no interaction was observed …

04.09.2026journal-article

Innovative Medicine of Kuban

Morphological and Functional Diagnosis of Precancerous Cervical Lesions in Premenopausal Women Using Advanced Diagnostic Methods

G. D. Reymnazarova, A. F. Asatulaev, B. A. Magrupov

Background : Cervical cancer remains a major public health challenge in Uzbekistan, with 2,654 new cases diagnosed in 2022. The premenopausal period (40–55 years) represents a particularly difficult stage for cervical cancer detection, as epithelial atrophy and migration of the transformation zone into the endocervical canal reduce the sensitivity of conventional cytology. Objective: To characterize morphometric, ultrastructural, nanotopographic, and immunohistochemical features of precancerous cervical lesions in …

04.09.2026journal-article

Medicine

Clinical and CT features of patients with pneumatosis intestinalis

Weiheng He, Yihui Yin, Yongqi Zhu, Huimin Rao, Lin Lu

This study investigates the clinical and abdominal computed tomography (CT) characteristics of pneumatosis intestinalis (PI). This retrospective single-center study included 58 patients with PI. Clinical data and CT images were reviewed. CT findings included location, extent, and associated features, and PI was classified into 3 morphological patterns: bandlike, grapelike, and beadlike. Inter-observer agreement was evaluated, and subgroup analysis was performed using analysis of variance and chi-square tests. The m …

04.09.2026journal-article

Medicine

Association between alpha-1-acid glycoprotein and serum uric acid in young and middle-aged US women

Jiangtao Zhu, Mengge Feng, Wenqi Wu, Jianhua Zhang, Guoliang Xu, Yujie Ma

Evidence on the association between alpha-1-acid glycoprotein (AGP), a systemic inflammatory marker, and serum uric acid (SUA) remains limited, particularly among young and middle-aged women. Using cross-sectional data from 614 US women aged 20 to 49 years from the 2015 to 2018 National Health and Nutrition Examination Survey, we assessed the AGP-SUA relationship and the mediating role of the triglyceride-glucose index using multiple linear regression, smooth curve fitting, and mediation analysis. After full adjust …

04.09.2026journal-article

Medicine

Tobacco and alcohol use, fruit and vegetable consumption, physical activity habits, and participation in routine checkups and cancer screenings among adults aged 40 and older with and without chronic diseases

Elif Nur Yildirim-Ozturk, Mehmet Uyar

The study aimed to investigate tobacco and alcohol use, fruit and vegetable consumption, physical activity habits, and participation in routine checkups and cancer screenings in adults aged 40 years and older with and without a diagnosis of chronic disease. It also aimed to compare the frequentist and Bayesian statistical methods used for comparisons and to evaluate the practical significance of these associations using effect sizes. The study was cross-sectional. The data used in the study came from the Turkey Hea …

04.09.2026journal-article

Medicine

A novel hemostatic suture technique for uterine rupture complicated by placenta accreta spectrum

Ruiyan Shang, Jing Yang, Li Li, Yiyi Zhuge

Rationale: Uterine rupture secondary to the placenta accreta spectrum (PAS) is a life-threatening obstetric emergency. Intractable massive hemorrhage in this setting often necessitates emergent hysterectomy, while effective fertility-sparing surgical options for such critical bleeding remain limited. This report highlights the utility of a novel suturing technique for achieving effective hemostasis and fertility preservation in patients with PAS-related uterine rupture. Patient concerns: A 36-year-old Asian woman d …

04.09.2026journal-article

Medicine

Comparative evaluation of large language models for text-based diagnostic reasoning in fetal central nervous system MRI

Runze Yu, Miao Peng, Huiying Li, Simeng Liu, Tong Su, Hanjie Guan, Yufeng Shen, Yuhui Deng, Deli Zhao

Fetal magnetic resonance imaging (MRI) plays an important role in evaluating prenatal central nervous system (CNS) abnormalities, but expert interpretation and counseling remain challenging. Large language models (LLMs) may support text-based diagnostic reasoning, yet their performance in fetal CNS MRI has not been well characterized. The study aimed to compare ChatGPT, Gemini, and DeepSeek in text-based diagnostic reasoning for fetal CNS MRI cases. This retrospective single-center study included 85 fetal MRI cases …

04.09.2026journal-article

Journal of Community Hospital Internal Medicine Perspectives

Survival outcome of Gallbladder cancer in the US: An updated surveillance, epidemiology, and end results-based analysis of age and gender disparities

Ayrton Bangolo, Behzad Amoozgar, Budoor Alqinai, Ravleen Chowdhary, Rishabh Goyal

Introduction: Gallbladder cancer (GBC) is a rare but highly lethal malignancy with significant variability in mortality based on demographic and clinical factors. This study aims to analyze the impact of gender, age, tumor stage, and treatment modalities on mortality in GBC patients, providing a comprehensive overview of the factors influencing survival outcomes. Methods: We conducted a retrospective analysis of 1,527 patients diagnosed with GBC between 2005 and 2021. Data were collected on demographic variables, t …

04.09.2026journal-article

Journal of Community Hospital Internal Medicine Perspectives

Recurrent Ischemic Colitis Associated with Chronic Low-Flow Physiology: Diagnostic and Therapeutic Implications

Mustafa Sadek, Alaa Almallouhi

Ischemic colitis is the most common form of intestinal ischemia and is typically associated with acute hypoperfusion states such as shock or dehydration.1 Chronic low-flow states related to persistently low baseline blood pressure may represent an underrecognized contributor to recurrent disease in the absence of classic acute triggers.2 We present a case of a 54-year-old woman with recurrent, biopsy-proven ischemic colitis occurring in the setting of persistently low blood pressure documented across multiple clini …

04.09.2026journal-article

Journal of Clinical Psychology

Connected to Others and Kind to Self: Social Connection and Self‐Affiliation Change in Open‐Ended Psychotherapy

Andreas Voldstad, Ole André Solbakken, Jesús Montero‐Marín, Jon Trygve Monsen, Erkki Heinonen

ABSTRACT Objective Social connection predicts health, but remains largely underexplored as an outcome of psychotherapy. A friendly relationship to oneself is linked to positive relationships to others, but it is not clear how they influence each other across time during and after treatment. This study evaluates change in a measure of social connection and support, the Quantity and Quality of Social Relations (QQSR), and investigates its longitudinal associations with the Structural Analysis of Social Behavior Intro …

04.09.2026journal-article

Annals of Surgery

Single-dose Preoperative Glucocorticoids in Major Gastrointestinal Surgery

Rathin Gosavi, Baxter Smith, Kavindu Hathurusinghe, Anjana Ravi, Sarah A. Martin, Walston Reginald Martis, Vignesh Narasimhan, Geraldine Oo

Objective: To evaluate the clinical efficacy and safety of single-dose preoperative systemic glucocorticoids in adults undergoing major gastrointestinal surgery. Summary of Background Data: Major gastrointestinal surgery induces a systemic inflammatory response that contributes to postoperative morbidity and delayed recovery. Single-dose glucocorticoids attenuate inflammation, but uncertainty remains regarding clinical benefit, safety, and optimal dosing. Methods: A PRISMA-compliant systematic review and meta-analy …

04.09.2026journal-article

Pediatric Critical Care Medicine

Peripheral IV Versus Extended Dwell Catheter Longevity in the PICU: Single-Center Retrospective Cohort, 2023–2024

Olivier Cusson, Stephen A. Kutcher, Anne Tsampalieros, Dayre McNally

Objectives: To review the longevity of extended dwell catheters (EDCs) vs. peripheral IV catheters (PIVs) in pediatric critical care and explore factors associated with catheter duration. Design: Retrospective cohort study between September 2023 and August 2024. Setting: A single mixed cardiac and general PICU in an academic health care center in Ottawa, Canada. Patients: A total of 400 vascular access catheters were included, comprising 329 PIVs and 71 EDCs in 238 unique patients. Interventions: None. Measurements …

04.09.2026journal-article

Egyptian Journal of Radiology and Nuclear Medicine

Deep learning-based segmentation of abdominal aortic aneurysm: a systematic review and meta-analysis of performance and clinical applicability

Negin Letafatkar, Saisree Reddy Adla Jala, Kavya Priya Somu, Mohammad Amouzadeh-Lichahi, Gokhan Anil, Hariprasad Reddy Korsapati, Casra Saeedi, Behrad Eftekhari, Abinash Mahapatro, Maryam Jafari, Amirhossein Pourebrahimi, Arman Habibi, Faezeh Pourshakoori, Ali Fatehi Hassanabad, Ehsan Amini-Salehi

Abstract Background Abdominal aortic aneurysm (AAA) management relies heavily on imaging for surveillance, treatment planning, and follow-up. Deep learning (DL)-based segmentation may improve the efficiency and reproducibility of AAA image analysis; however, reported performance varies across studies. This study aimed to systematically review and quantitatively summarize the performance of DL models for AAA-related segmentation. Methods PubMed, Embase, Scopus, and Web of Science were searched for studies applying D …

04.09.2026journal-article

Journal of Medicine Pharmacology and Medical Devises Technology

Fasting by the Clock: A Randomized Comparison of 12:12, 14:10 and 16:8 Time-Restricted Eating for Weight and Metabolic Outcomes in Adults With Overweight or Obesity

Prakash MV, George Neon

Background: Time-restricted eating (TRE) is increasingly used for weight management, but the optimal daily fasting duration remains uncertain, particularly in Indian adults with overweight or obesity. Objective: To compare the effects of 12:12, 14:10 and 16:8 TRE regimens on weight reduction and metabolic outcomes. Methods: This prospective randomized three-arm study included 186 adults with BMI 25.0–39.9 kg/m² at Pushpagiri Medical Institute of Medical Sciences and Research Centre from November 2025 to April 2026. …

04.09.2026journal-article

Magnetic Resonance in Medicine

Fast Reconstruction of Motion‐Corrupted Data With Mobile‐GRAPPA: Motion and δB0 Inhomogeneity Correction Leveraging Efficient GRAPPA

Yimeng Lin, Nan Wang, Daniel Abraham, Daniel Polak, Xiaozhi Cao, Aizada Nurdinova, Stephen Cauley, Kawin Setsompop

ABSTRACT Purpose To develop an accurate and computationally efficient motion‐corrected MRI reconstruction framework that incorporates hundreds to thousands of motion and estimates from high‐temporal‐resolution tracking. Methods We propose Mobile‐GRAPPA, a k‐space preprocessing approach that uses MLP‐parameterized local GRAPPA operators to jointly correct trajectory perturbations, coil reweighting, and ‐induced phase changes before standard downstream reconstruction. Reconstruction accuracy, noise propagation, spati …

04.09.2026journal-article

Angewandte Chemie International Edition

Liquid Metal Molecular Medicine

Peimeng Wu, Liangfei Duan, Jing Liu

ABSTRACT Biomolecules are central to disease onset, diagnosis, and treatment, yet materials capable of actively interacting with biological targets remain limited. Gallium‐based liquid metals and their derivative composites possess a metallic liquid core, a dynamic oxide interface, and releasable metal species, which support diverse molecular interactions and regulatory processes. However, current advances remain scattered across different biomedical applications and are often discussed mainly from a materials pers …

04.09.2026journal-article

Asian Journal of Medicine and Health

Design, Development, and Characterization of Luliconazole-loaded Bilosomal Gel for Enhanced Cutaneous Delivery

Deepak Prashar, Sarbjot Singh, Anita Devi, Anish Verma, Navdeep Kaur, Anuneet Kaur, Ayushi Singla

Luliconazole (LZ) is a broad-spectrum antifungal agent whose topical performance is limited by poor aqueous solubility and restricted skin penetration. This study aimed to develop and characterise LZ-loaded bilosomes incorporated into a topical gel to enhance cutaneous delivery. Eight bilosomal formulations were prepared by thin-film hydration using soy phosphatidylcholine, cholesterol and Span 80, followed by incorporation of the optimised bilosomal suspension into a Carbopol/HPMC gel. The formulations were assess …

04.09.2026journal-article

Egyptian Journal of Radiology and Nuclear Medicine

Dynamic acromiohumeral impingement at the painful arc: dynamic digital radiography and multi-position CT with CT-derived 3D pose-based visualization: a case report

Xiao Teng, Liu Yang, Wenyuan Li, Ziwen Ma, Delin Wang

Abstract Background Dynamic shoulder pain limited to a narrow range of abduction may not be adequately explained by static imaging alone. This case report described an angle-specific painful arc evaluated with dynamic digital radiography and multi-position computed tomography with CT-derived three-dimensional pose-based visualization. Case presentation A 32-year-old right-hand-dominant male patient presented with severe right shoulder pain 1 week after an overhead reaching injury. Active abduction was limited to 85 …

04.09.2026journal-article

American Journal of Lifestyle Medicine

Resilience, Social Support, and Health-Promoting Lifestyle Behaviors Among Adolescents in Post-Conflict Communities: A Cross-Sectional Study

Radhwan Hussein Ibrahim, Sahir Mallaah Mohammad Ali, Salwa Hazim Al Mukhtar

Adolescents living in post-conflict communities face social, economic, and psychological challenges that may influence their health behaviors and overall well-being. However, evidence regarding health-promoting lifestyle behaviors among adolescents in these settings remains limited. This study aimed to assess health-promoting lifestyle behaviors among adolescents living in post-conflict communities and identify associated factors. A descriptive cross-sectional study was conducted among 420 adolescents aged 13–19 ye …

04.09.2026journal-article

Critical Care Medicine

Feasibility and Operator-Reported Utility of Transesophageal Lung Ultrasound As an Adjunct to Resuscitative Transesophageal Echocardiography in the Evaluation of Shock: A Multicenter Observational Study

Vladyslav Dieiev, Pedro D. Salinas, Felipe Teran, Clark G. Owyang, Dylan Rupska, Aniruddh Kapoor, Zubair Siddiqui, Daniel Strama, Cindy Ndiaye, Nathaniel A. Sands, Aarthi Kaviyarasu, Katharine M. Burns, on behalf of the Resuscitative Transesophageal Echocardiography Collaborative Registry (rTEECoRe) Investigators

Objectives: To describe the utilization, feasibility, and operator-reported diagnostic and management impact of transesophageal lung ultrasound (TELUS) integrated into resuscitative transesophageal echocardiography (TEE) for the assessment of mechanically ventilated adults with shock. Design: Multicenter observational cohort study using prospectively collected data. Setting: Twenty-three hospitals from the Resuscitative Transesophageal Echocardiography Collaborative Registry (rTEECoRe) network. Patients: From 1213 …

04.09.2026journal-article

BMC Complementary Medicine and Therapies

Traditional health service use and cardiometabolic biomarker profiles among Indonesian adults with diabetes mellitus or hypertension: a national cross-sectional study

Raden M. Febriyanti, Aalbrecht A. Irawan, Dhika S. Pangestu, Sofa D. Alfian, Jutti Levita, Ajeng Diantini

Abstract Background Traditional health services (THS) are widely used in Indonesia, but their sociodemographic patterning and relationship with cardiometabolic biomarkers remain unclear. THS use among adults with physician-diagnosed diabetes mellitus and/or hypertension was assessed, and its associations with glycemic, lipid, and blood-pressure profiles were examined. Methods Data from the 2023 Indonesian Health Survey were analyzed for adults aged ≥ 15 years with complete exposure, biomarker, covariate, and survey …

04.09.2026journal-article

Medicine

Umbilical vein recanalization with a diameter greater than 6.48mm may promote deterioration of liver reserve function

Feng Ding, Yuan Yang, Jing Wang, Liping Chen

This study aimed to investigate the clinical characteristics of cirrhotic patients with umbilical vein recanalization (UVR) and explore the effects of UVR on portal hypertension and liver reserve function (LRF). A total of 122 cirrhotic patients were enrolled and stratified into UVR and non-UVR groups based on the presence or absence of UVR. Clinical and laboratory indices, including hepatic biochemical parameters, portal venous system diameters, portal vein thrombosis, portal pressure gradient (PPG), Child-Pugh cl …

04.09.2026journal-article

Medicine

Renal outcomes associated with sodium–glucose cotransporter 2 inhibitor use in kidney transplant recipients with type 2 or posttransplant diabetes

Guillermo Edinson Guzmán, Fabio Figueroa, Santiago Granados, Oriana Arias-Valderrama, Juan Lukas Ordóñez, Carlos Eduardo Durán

Posttransplant diabetes mellitus (PTDM) increases the risk of graft failure and mortality. Sodium–glucose cotransporter 2 inhibitors (SGLT2i) improve cardiovascular and renal outcomes in type 2 diabetes mellitus (T2DM), but evidence in kidney transplant recipients (KTRs) with T2DM or PTDM remains limited. We conducted a retrospective cohort study including adult KTRs with pretransplant T2DM or PTDM. Exposure was defined as continuous SGLT2i use for ≥90 days. The primary outcome was a composite of graft loss, all-ca …

04.09.2026journal-article

Medicine

Primary mediastinal ectopic thyroid in a 43-year-old woman

Zheng Wang, Shuo Liang, Kunpeng Li, Xike Lu, Xin Li, Daqiang Sun

Rationale: Primary mediastinal ectopic thyroid (PMET) is exceedingly rare, and its imaging features often overlap with those of thymic epithelial tumors, lymphoma, Castleman disease, and paraganglioma. The absence of anatomical continuity with the cervical thyroid and the presence of an independent intrathoracic blood supply are important considerations in differential diagnosis and surgical planning. This report aims to highlight the diagnostic value of thyroid-like enhancement and the absence of cervical continui …

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Aktuelle Forschung nach Fachgebiet

Physiologically Based Pharmacokinetic Modeling to Assess Transporter‐Mediated Drug–Drug Interactions in Support of Labeling Recommendations for Zavegepant Nasal Spray

Morphological and Functional Diagnosis of Precancerous Cervical Lesions in Premenopausal Women Using Advanced Diagnostic Methods

Clinical and CT features of patients with pneumatosis intestinalis

Association between alpha-1-acid glycoprotein and serum uric acid in young and middle-aged US women

Tobacco and alcohol use, fruit and vegetable consumption, physical activity habits, and participation in routine checkups and cancer screenings among adults aged 40 and older with and without chronic diseases

A novel hemostatic suture technique for uterine rupture complicated by placenta accreta spectrum

Comparative evaluation of large language models for text-based diagnostic reasoning in fetal central nervous system MRI

Survival outcome of Gallbladder cancer in the US: An updated surveillance, epidemiology, and end results-based analysis of age and gender disparities

Recurrent Ischemic Colitis Associated with Chronic Low-Flow Physiology: Diagnostic and Therapeutic Implications

Connected to Others and Kind to Self: Social Connection and Self‐Affiliation Change in Open‐Ended Psychotherapy

Single-dose Preoperative Glucocorticoids in Major Gastrointestinal Surgery

Peripheral IV Versus Extended Dwell Catheter Longevity in the PICU: Single-Center Retrospective Cohort, 2023–2024

Deep learning-based segmentation of abdominal aortic aneurysm: a systematic review and meta-analysis of performance and clinical applicability

Fasting by the Clock: A Randomized Comparison of 12:12, 14:10 and 16:8 Time-Restricted Eating for Weight and Metabolic Outcomes in Adults With Overweight or Obesity

Fast Reconstruction of Motion‐Corrupted Data With Mobile‐GRAPPA: Motion and δB0 Inhomogeneity Correction Leveraging Efficient GRAPPA

Liquid Metal Molecular Medicine

Design, Development, and Characterization of Luliconazole-loaded Bilosomal Gel for Enhanced Cutaneous Delivery

Dynamic acromiohumeral impingement at the painful arc: dynamic digital radiography and multi-position CT with CT-derived 3D pose-based visualization: a case report

Resilience, Social Support, and Health-Promoting Lifestyle Behaviors Among Adolescents in Post-Conflict Communities: A Cross-Sectional Study

Feasibility and Operator-Reported Utility of Transesophageal Lung Ultrasound As an Adjunct to Resuscitative Transesophageal Echocardiography in the Evaluation of Shock: A Multicenter Observational Study

Traditional health service use and cardiometabolic biomarker profiles among Indonesian adults with diabetes mellitus or hypertension: a national cross-sectional study

Umbilical vein recanalization with a diameter greater than 6.48mm may promote deterioration of liver reserve function

Renal outcomes associated with sodium–glucose cotransporter 2 inhibitor use in kidney transplant recipients with type 2 or posttransplant diabetes

Primary mediastinal ectopic thyroid in a 43-year-old woman