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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Regional Anesthesia & Pain Medicine

Procedure-specific effects of intravenous lidocaine in adult spine surgery: a systematic review and meta-analysis of randomized controlled trials

Vitor A Felippe, Carlos D A Bersot, Gabriel L Gonzalez, Gustavo R M Wegner, Estevao L C Braga, Carolina C C Silva, Giulia D Matheus, Bruno V M Santiago, Leonardo B Santos, Marcos A Lessa

Background and objectives Perioperative intravenous lidocaine infusion has been proposed as an opioid-sparing analgesic adjunct in spine surgery, but previous meta-analyses pooled heterogeneous procedures and may have obscured procedure-specific treatment effects. We evaluated the analgesic and opioid-sparing effects of perioperative intravenous lidocaine in adult spine surgery and whether efficacy differs by procedure type. Methods We searched PubMed, Embase, Web of Science, and the Cochrane Library from inception …

03.09.2026journal-article

Healthcare

A Multi-Indicator Concentration Index for Primary-Care Reimbursement Analytics: Evidence from the Albanian Health-Insurance System

Tomi Thomo, Gjergji Koja, Bujar Elezi

Background: Public payers must regularly decide which prescribers to look at more closely, with records covering thousands of doctors per quarter and review capacity for only a fraction. How that choice is made bears on equitable access to reimbursed medicines as well as on public funds. Methods: We propose a multi-indicator concentration index scoring each prescriber 0–100 as the sum of nine weighted sub-scores, each measuring the doctor’s deviation from their primary-care centre median on one indicator from the p …

03.09.2026journal-article

Frontiers in Oncology

Factors influencing oncologists’ decisions for germline BRCA testing and adjuvant therapy selection in HER2-negative early breast cancer

Qixin Li, M. Janelle Cambron-Mellott, Xiaoqing Xu, Nicole Kashine-Tack, Jennifer F. Hayes, Kathryn Emily Mishkin, Alexandra Gordon, Oliver Will, Lauren A. Howell, Alejandro Noval, Kathleen Beusterien

Introduction With advances in targeted early breast cancer (eBC) treatment, research is needed to understand the factors influencing biomarker testing and respective treatment selection among physicians in routine clinical practice. The purpose of this study was to evaluate factors influencing oncologist decisions for germline BReast Cancer gene (BRCA) mutation (gBRCAm) testing and adjuvant therapy in human epidermal growth factor receptor 2-negative (HER2-) early breast cancer (eBC). Materials and methods US oncol …

03.09.2026journal-article

Egyptian Rheumatology and Rehabilitation

Hand grip strength: age- and gender-stratified normative data in Egyptian population-based study by the Egyptian Academy of Bone and Muscle Health

Yasser El Miedany, Maha Elgaafary, Walaa Elwakil, Rahma A. Elziaty, Reem Sadek, Reem H. Abd Alrahman, Sarah Hossam Abdelrahman, Mohamed Eldaramlly Omar, Abdelrahman Rashwan Radwan, Waleed Hassan, Marwa Yahia, Olfat Gamal Elsaeid, Asmaa Elbanhawy, Marwa Abdrabo, Mohamed El Koumy, Israa Qutob, Bassant Samir, Safaa Mahran

Abstract Objective This study aimed to establish age- and gender-stratified normative data for hand grip strength (HGS) in a population-based sample of healthy Egyptian adults and to analyze its relationship with various socio-demographic and anthropometric parameters. Methods This cross-sectional study evaluated 2,247 healthy Egyptian participants (900 men, 1,347 women). HGS was measured in kilograms (kg) using a digital hand dynamometer following a standardized bilateral protocol. Anthropometric data (including B …

03.09.2026journal-article

Nutrition Today

Gut Microbiome Testing: From Laboratory Methods to Clinical Meaning

Lauren Cornell

As direct-to-consumer (DTC) gut microbiome testing continues to move into mainstream nutrition and medical practice, clinicians are increasingly confronted with reports built on laboratory methods that sound sophisticated but vary widely in what they can realistically deliver. This second article in a 2-part series is designed to demystify the science behind these tests by clearly explaining the primary methodologies they rely on, including 16S rRNA sequencing, quantitative polymerase chain reaction (qPCR), shotgun …

03.09.2026journal-article

Journal of Patient-Reported Outcomes

Identifying risk of prescription analgesic misuse in chronic pain: screening utility and clinical cut-offs of the Japanese PROMIS Rx Misuse 7a in a low-opioid prescribing environment

Keiko Yamada, Tomohiko Nishigami, Takashi Kimura, Kenta Wakaizumi, Miho Nakanishi, Noriyo Takahashi, Takao Setsu, Takeru Shiroiwa, Kazuhiro Yoshiuchi

Abstract Background Most screening tools for prescription analgesic misuse were developed in high-opioid prescribing contexts. This study evaluated the measurement properties and screening utility of the Japanese version of the PROMIS Prescription Pain Medication Misuse–Short Form 7a (PROMIS Rx Misuse 7a) in a strictly regulated, low-opioid prescribing environment. Methodology A cross-sectional web-based survey was conducted among 500 Japanese adults with chronic pain who were currently prescribed analgesics. The s …

03.09.2026journal-article

Frontiers in Oncology

Clinical trial design for primary brain tumors: a problem-based framework for neuro-oncology practice

Diego Gómez-Puerto, Jesús Yaringaño, Antonio Di Muzio, Oriol Mirallas, María Vieito

Background Primary brain tumor trials may produce an uninterpretable or non-generalizable answer when biological mismatch, inadequate intratumoral exposure, restrictive eligibility, molecular rarity, unstable controls, and disease-specific endpoint ambiguity are addressed separately. The practical problem is not the absence of modern methods, but failure to select and combine them according to the dominant threat to the development decision. Methods We performed a practice-facing narrative synthesis of methodologic …

03.09.2026journal-article

Clinical Infectious Diseases

A Multistate Investigation of Serious Adverse Events, including Deaths, following Ceftriaxone Injections, September 2024–August 2025

Rebecca Pierce, Radhika Agarwal, Dumbani Kayira, Maribeth C Lovegrove, Nimalie D Stone, Kelly M Hatfield, Jennifer Lind Lyles, Melissa Morrison, Wes Stubblefield, Sherri L Davidson, Karen Landers, Scott Harris, Rachana Bhattarai, Theresa Dulski, Juliet Stoltey, Lauren Biehle, Josh Hoffner, Argentina Charles, JoAnna Wagner, Haley Beeman, Michael J Curran, Grace Lee, Riley Moore, Jacy Walters, Gargi Patel, Dat Tran, Jenna Sinkevitch, Marco Tori, Christopher Wilson, Simone Godwin, Shehzana Hussaini, Allison G Lafferty, Shaina Bernard, Shannon Ruelle, Catherine O Dasenbrock, Meredith Sheridan, Frank Wackes, Rachna Kapoor, Ramesh Gopalaswamy, Kiran M Perkins

Abstract Background Reports of ceftriaxone serious adverse events (SAEs), including deaths, from multiple jurisdictions during December 2024–January 2025 prompted a nationwide investigation to evaluate product safety, characterize SAEs, and assess for changes in baseline adverse event occurrence via national databases. Methods In February 2025, CDC issued a national call for cases, defined as SAEs involving death or CPR within six hours of ceftriaxone injection, not otherwise explained and occurring in non-ICU sett …

03.09.2026journal-article

Peace Economics, Peace Science and Public Policy

Introducing the Tactics and Resources Dataset: Resources, Sponsors and Escalation of Non-state Actors

Tom Konzack

Abstract To cut through inconsistent findings on non-state violence born of contested concepts and uneven data, I introduce the Tactics and Resources Dataset (TRD): a panel dataset on 649 violent and non-violent political non-state organisations. It focuses on their tactical choices and the types and origins of resources provided to them, alongside political, social, and economic indicators and key historical junctures. TRD offers a robust empirical foundation for studying how various types of resources and externa …

03.09.2026journal-article

Cell and Gene Therapy Insights

Benchmarking emerging chromatographic platforms for mRNA-LNP characterization and scalable process enablement

Sergeja Lebar, Tristan Kovačič, Ana Ferjančič Budihna, Jeremie Parot, Alicja Molska, Nejc Pavlin, Mojca Bavčar, Tjaša Leban, Mojca Tajnik, Mojca Tajnik Sbaizero, Andreja Gramc Livk

Lipid nanoparticles (LNPs) are now the leading delivery platform for nucleic acid therapeutics, supporting applications from prophylactic mRNA vaccines to in vivo gene editing, in vivo CAR-T, protein replacement, and personalized cancer immunotherapy. As formulations incorporate novel ionizable lipids, targeting ligands, and multi-component payloads, analytical complexity increases, and no single method can capture all critical quality attributes (CQAs). This study benchmarks the PATfix LNP Switcher Platform agains …

03.09.2026journal-article

Culture, Medicine, and Psychiatry

From ‘Sensory’ to ‘Anxiety’: Embodied States, Relational Care, and Ethical Transformation in Parental Care for U.S. Neurodivergent Childhood

Elsa Davidson

Abstract This paper draws on an ethnography of care for social–emotional differences in middle-class North American childhood to explore the relation between care practices employed by parents of neurodivergent, or neuroatypical, children, and emergent ethics of care. Focusing on a single case of asymmetrical care, that between a mother and a neurodivergent child, I draw on video-recorded interviews as well other ethnographic material to highlight how practices of care emphasizing forms of bodily and emotional conn …

03.09.2026journal-article

Journal of Clinical Ultrasound

Ultrasonographic Evaluation of Cavum Septum Pellucidum Dimensions and Morphology in the Second Half of Pregnancy: A Prospective Cross‐Sectional Study

Somayeh Shirazinezhad, Somayeh Khanjani, Sonia Rostami Ghorbani, Mohammadreza Elhaie

ABSTRACT Objective To determine normative ultrasonographic dimensions, morphology, and visualization rate of the cavum septum pellucidum (CSP) in structurally normal singleton fetuses between 19 and 40 weeks of gestation and to assess correlations with gestational age and fetal biometric parameters. Methods This prospective cross‐sectional study enrolled 600 consecutive singleton pregnancies with normal fetal anatomy at Beheshti Hospital, Isfahan, Iran (2024–2025). Transabdominal ultrasound was performed in standar …

03.09.2026journal-article

Chinese Journal of International Review

China's Public Diplomacy: Evolution, Domestic Dimensions, and Implications

Dongnu Guo

This paper highlights how China has operated public diplomacy differently. Integrating key scholarly works from China and the West, this paper demonstrates a fundamental distinction: China conceptualizes public diplomacy as a resource to promote the narrative of national rejuvenation and regime legitimacy. This paper also indicates that public diplomacy is a crucial instrument of soft power, and through examining the evolution, paradigm shift, domestic dimensions, as well as implications of China's public diplomacy …

03.09.2026journal-article

Journal of Microscopy and Ultrastructure

Hyalinization in Dentistry: Pathogenesis, Mechanisms, and Clinical Implications

Roja Lakshmi Karri, Hasini Nelakurthi, Amrutha Rudraraju, NavaratnaSowmya Chinta

Abstract Hyalinization is a key histological feature that provides valuable insights into various dental and systemic conditions. It refers to the deposition of a glass-like, homogenous substance in tissues, often signaling tissue damage, necrosis, or abnormal collagen dynamics. In dentistry, hyalinization is observed in periodontal disease, orthodontic treatments, and dental pulp health, as well as in systemic conditions. During orthodontic treatment, excessive forces can induce ischemia in the periodontal ligamen …

03.09.2026journal-article

British Journal of Sports Medicine

Digital therapeutic combining exercise and cognitive–behavioural therapy reduces pain in patients with chronic patellofemoral pain: a multicentre randomised controlled trial

Jae-Young Park, Sanghee Lee, Jong-Min Kim, Sang Hak Lee, Moon Jong Chang, Kyu Sung Chung, Man Soo Kim, Seong Hwan Kim, Dong Jin Ryu, Tae Hyun Park, Chi-Hyun Choi, Chan Yoon, Chong Bum Chang, Jin Goo Kim

Objectives To evaluate whether an 8-week smartphone-based multidisciplinary digital therapeutic (DTx) combining exercise and cognitive–behavioural therapy reduced usual knee pain at 8 weeks compared with education and exercise instruction in chronic patellofemoral pain (PFP). Methods This multicentre, parallel-group randomised controlled trial included 216 participants with chronic PFP, defined as anterior or retropatellar pain lasting at least 3 months with activity-related provocation, recruited from orthopaedic …

03.09.2026journal-article

British Journal of Sports Medicine

Resistance training and depressive symptoms in subcortical vascular cognitive impairment: secondary results of a randomised clinical trial

Ryan S Falck, Cindy K Barha, Ryan G Stein, Sofia Grant, Alexis Bullock, Ken M Madden, Jennifer C Davis, Roger Tam, Teresa Liu-Ambrose

Objectives Cerebral small vessel disease (CSVD) is associated with depressive symptoms. Exercise may reduce depressive symptoms for people with CSVD. We examined the effects of progressive resistance training (PRT) on depressive symptoms among adults with CSVD and mild cognitive impairment (ie, subcortical vascular cognitive impairment (SVCI)). Methods A single-site, 12-month, parallel group, secondary analysis of a randomised controlled trial (ClinicalTrials.gov identifier: NCT02669394 ). Community-dwelling adults …

03.09.2026journal-article

JAMA Network Open

Regional Variation in Bladder Cancer Clinical Trial Availability in the US

Koral U. Shah, Salvador Jaime-Casas, Ruchi Agarwal, George Zhang, Xiaochen Li, Vitor Abreu de Goes, Daniela V. Castro, Benjamin Mercier, Ruth Simon, Samuel Dickter, Lily M. Lau, Jaya Goud, Akasha Dukkipati, Jadon Fann, Lauren Lau, Joshua Lee, Kyra Shah, Ethan Swarat, Miguel Zugman, Nazli Dizman, Ali Moradi, Regina Barragan-Carrillo, Abhishek Tripathi, Charles B. Nguyen, Alex Chehrazi-Raffle, Sumanta K. Pal

Importance Geographic disparities in cancer clinical trial access are well described in the US, but patterns in bladder cancer remain poorly defined. Objective To evaluate bladder cancer trial availability across US counties and its associations with epidemiologic and socioeconomic factors. Design, Setting, and Participants This cross-sectional study of completed, open, or active bladder cancer clinical trials from June 1, 2019, to June 1, 2025, on ClinicalTrials.gov used data on county-level incidence, mortality, …

03.09.2026journal-article

World Journal of Nuclear Medicine

Quantitative SPECT/CT SUVmax: Improving Diagnostic Confidence in Differentiating Metastatic from Degenerative Bone Lesions in Breast Cancer

Nitami Oktavia Indiarti, Hendra Budiawan, Trias Nugrahadi, Achmad Hussein Sundawa Kartamihardja

Abstract Breast cancer bone metastases are predominantly osteolytic. Tumor-derived parathyroid hormone-related peptide increases receptor activator of nuclear factor-kappa B ligand (RANKL) expression in osteoblasts. RANKL binds receptor activator of nuclear factor-kappa B (RANK) on osteoclast precursors, promoting osteoclast activation and bone resorption. The resulting release of matrix-embedded growth factors, including transforming growth factor-beta and insulin-like growth factors, contributes to tumor progress …

03.09.2026journal-article

Cancer Research Communications

Transcriptome-based synthetic lethality predictions to improve targeted therapy/immunotherapy treatment prioritization in non-metastatic breast cancer: BC-SELECT

Yewon Kim, Matthew Nagy, Rebecca Pollard, Padma Sheila. Rajagopal

Abstract Patients with non-metastatic triple-negative (TNBC) or HER2-positive (HER2+) breast cancer do not have tools to predict treatment response or prioritize options prior to starting therapy. Pathologic complete response (pCR) is a proxy that requires neoadjuvant treatment. BC-SELECT leverages genetic interactions (e.g. synthetic lethality (SL)/rescue (SR)) to predict treatment response via pCR from breast cancer gene expression data. BC-SELECT involves (1) “Training: Gene-pair identification” that identifies …

03.09.2026journal-article

JMIR Research Protocols

Patient-Centered Clinical Decision Support for Recommended Screenings in French Primary Care: Protocol for a Multicenter Mixed Methods Feasibility Study

Pierre-Yves Meunier, Laurent Magaud, Romain Varnier, Emmie Goetz, Melinda Bekaddour, Ludivine Albert, Inès Khati, Ilhem Bensekka, Julie Haesebaert, Denis Maillet, Julien Péron, Laurent Letrilliart

Background Primary care professionals (PCPs) are responsible for identifying eligibility and supporting patient decisions for a wide range of recommended screenings. However, the number of recommendations (42 for adults in France), complex eligibility criteria, limited consultation time, and competing priorities hinder their systematic delivery. Clinical decision support systems (CDSSs) with patient decision aids may help structure prevention-focused consultations and support shared decision-making, but their feasi …

03.09.2026journal-article

Wilderness & Environmental Medicine

Kerosene Chemical Burn at Khumbhu Icefall: Report of Two Cases

Suraj Shrestha, Ashish Lohani, Roy Harris, Surya Prakash Joshi, Sabitra Thapa, Buddha Basnyat

Kerosene chemical burns are uncommon but can result in serious injury, particularly among high-altitude porters who carry fuel through difficult terrain and endure prolonged exposure or contact. We describe 2 cases of high-altitude porters who developed chemical burns to the lower back and gluteal region following leakage of kerosene while traversing the Khumbu Icefall in the Everest region. Such injuries highlight the need for awareness among expedition doctors and high-altitude medical personnel, as early recogni …

03.09.2026journal-article

Journal of Intensive Care Medicine

Machine Learning-Based Subtype Classification of Sepsis-Associated Acute Kidney Injury and Differential Responses to Renal Replacement Therapy

Hongkun Zhang, Shengzhi Wang, Tao Zhang, Baisen Wang, Ziqi Jiang, Zhenqi Guo

Background Sepsis-associated acute kidney injury (SA-AKI) is highly heterogeneous with controversial optimal renal replacement therapy (RRT) strategies. Machine learning enables subphenotype identification, and exploring RRT response differences across SA-AKI subtypes is critical for precision care. Methods This retrospective cohort study analyzed adult SA-AKI patients from the Medical Information Mart for Intensive Care IV database. K-means clustering classified SA-AKI subtypes; nine machine learning models were b …

03.09.2026journal-article

Artefactum - revista de estudos interdisciplinares

THE SUPPORT THAT TRANSCENDS LABOR FORCE: ORGANIZATIONAL PERCEPTION AND SPIRITUALITY AT WORK AMONG EMPLOYEES OF A PUBLIC EDUCATION INSTITUTION IN THE STATE OF RIO GRANDE DO NORTE

Nilton Soares Formiga, Gardênia de Oliveira Galvão, Cleber Medeiros de Lucena, Willian Alber da Silva Farias, Raniere Costa Souza, Ivan do Carmo Lameque

Abstract: Organizational and Positive Psychology emphasizes resources capable of promoting health, well-being, and positive workplace relationships. Among these resources, workplace spirituality stands out as being associated with meaning, purpose, and the quality of professional relationships, while perceived organizational support concerns the recognition of employees’ contributions and the organization’s care for its workforce. This study examined the relationship between perceived organizational support and wor …

03.09.2026journal-article

Migration LAW

A Strong State is the Basis of Public Security

Alik G. Khabibulin, Kamil R. Mursalimov

The article is devoted to the problems of forming a strong state, preserving national statehood, and ensuring public safety. The author argues for a strong state based on an ideology that consolidates the traditional spiritual and moral values of Russian society, uniting the people and defining their creative activities aimed at meeting the public demand.