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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Exploration of Neuroscience

Colon cancer in a patient with a mosaic monoallelic germline pathogenic NF1 gene variant

Feras Alsabagh, Karam M. Chaaban, Marlene Girardo, Ehab Harahsheh, Misha B. Asif, Dusica Babovic-Vuksanovic, Mohamad Bassam Sonbol, Mayowa A. Osundiji

Pathogenic variants in the tumor suppressor gene NF1 cause neurofibromatosis type 1 (NF1), one of the most common hereditary cancer predisposition syndromes. Pathogenic NF1 variants have been associated with an increased risk of several cancers; however, the relationship between NF1 variation and colon cancer remains underreported. We report a 41-year-old woman with a mosaic monoallelic germline pathogenic NF1 variant, NM_000267.3:c.1756_1759del (p.Thr586Valfs*18), previously detected on germline multigene panel te …

03.09.2026journal-article

Chinese Journal of International Review

China's Public Diplomacy: Evolution, Domestic Dimensions, and Implications

Dongnu Guo

This paper highlights how China has operated public diplomacy differently. Integrating key scholarly works from China and the West, this paper demonstrates a fundamental distinction: China conceptualizes public diplomacy as a resource to promote the narrative of national rejuvenation and regime legitimacy. This paper also indicates that public diplomacy is a crucial instrument of soft power, and through examining the evolution, paradigm shift, domestic dimensions, as well as implications of China's public diplomacy …

03.09.2026journal-article

Journal of Microscopy and Ultrastructure

Hyalinization in Dentistry: Pathogenesis, Mechanisms, and Clinical Implications

Roja Lakshmi Karri, Hasini Nelakurthi, Amrutha Rudraraju, NavaratnaSowmya Chinta

Abstract Hyalinization is a key histological feature that provides valuable insights into various dental and systemic conditions. It refers to the deposition of a glass-like, homogenous substance in tissues, often signaling tissue damage, necrosis, or abnormal collagen dynamics. In dentistry, hyalinization is observed in periodontal disease, orthodontic treatments, and dental pulp health, as well as in systemic conditions. During orthodontic treatment, excessive forces can induce ischemia in the periodontal ligamen …

03.09.2026journal-article

Wilderness & Environmental Medicine

Kerosene Chemical Burn at Khumbhu Icefall: Report of Two Cases

Suraj Shrestha, Ashish Lohani, Roy Harris, Surya Prakash Joshi, Sabitra Thapa, Buddha Basnyat

Kerosene chemical burns are uncommon but can result in serious injury, particularly among high-altitude porters who carry fuel through difficult terrain and endure prolonged exposure or contact. We describe 2 cases of high-altitude porters who developed chemical burns to the lower back and gluteal region following leakage of kerosene while traversing the Khumbu Icefall in the Everest region. Such injuries highlight the need for awareness among expedition doctors and high-altitude medical personnel, as early recogni …

03.09.2026journal-article

Journal of Intensive Care Medicine

Machine Learning-Based Subtype Classification of Sepsis-Associated Acute Kidney Injury and Differential Responses to Renal Replacement Therapy

Hongkun Zhang, Shengzhi Wang, Tao Zhang, Baisen Wang, Ziqi Jiang, Zhenqi Guo

Background Sepsis-associated acute kidney injury (SA-AKI) is highly heterogeneous with controversial optimal renal replacement therapy (RRT) strategies. Machine learning enables subphenotype identification, and exploring RRT response differences across SA-AKI subtypes is critical for precision care. Methods This retrospective cohort study analyzed adult SA-AKI patients from the Medical Information Mart for Intensive Care IV database. K-means clustering classified SA-AKI subtypes; nine machine learning models were b …

03.09.2026journal-article

World Journal of Nuclear Medicine

Quantitative SPECT/CT SUVmax: Improving Diagnostic Confidence in Differentiating Metastatic from Degenerative Bone Lesions in Breast Cancer

Nitami Oktavia Indiarti, Hendra Budiawan, Trias Nugrahadi, Achmad Hussein Sundawa Kartamihardja

Abstract Breast cancer bone metastases are predominantly osteolytic. Tumor-derived parathyroid hormone-related peptide increases receptor activator of nuclear factor-kappa B ligand (RANKL) expression in osteoblasts. RANKL binds receptor activator of nuclear factor-kappa B (RANK) on osteoclast precursors, promoting osteoclast activation and bone resorption. The resulting release of matrix-embedded growth factors, including transforming growth factor-beta and insulin-like growth factors, contributes to tumor progress …

03.09.2026journal-article

Cancer Research Communications

Transcriptome-based synthetic lethality predictions to improve targeted therapy/immunotherapy treatment prioritization in non-metastatic breast cancer: BC-SELECT

Yewon Kim, Matthew Nagy, Rebecca Pollard, Padma Sheila. Rajagopal

Abstract Patients with non-metastatic triple-negative (TNBC) or HER2-positive (HER2+) breast cancer do not have tools to predict treatment response or prioritize options prior to starting therapy. Pathologic complete response (pCR) is a proxy that requires neoadjuvant treatment. BC-SELECT leverages genetic interactions (e.g. synthetic lethality (SL)/rescue (SR)) to predict treatment response via pCR from breast cancer gene expression data. BC-SELECT involves (1) “Training: Gene-pair identification” that identifies …

03.09.2026journal-article

Egyptian Rheumatology and Rehabilitation

Hand grip strength: age- and gender-stratified normative data in Egyptian population-based study by the Egyptian Academy of Bone and Muscle Health

Yasser El Miedany, Maha Elgaafary, Walaa Elwakil, Rahma A. Elziaty, Reem Sadek, Reem H. Abd Alrahman, Sarah Hossam Abdelrahman, Mohamed Eldaramlly Omar, Abdelrahman Rashwan Radwan, Waleed Hassan, Marwa Yahia, Olfat Gamal Elsaeid, Asmaa Elbanhawy, Marwa Abdrabo, Mohamed El Koumy, Israa Qutob, Bassant Samir, Safaa Mahran

Abstract Objective This study aimed to establish age- and gender-stratified normative data for hand grip strength (HGS) in a population-based sample of healthy Egyptian adults and to analyze its relationship with various socio-demographic and anthropometric parameters. Methods This cross-sectional study evaluated 2,247 healthy Egyptian participants (900 men, 1,347 women). HGS was measured in kilograms (kg) using a digital hand dynamometer following a standardized bilateral protocol. Anthropometric data (including B …

03.09.2026journal-article

Nutrition Today

Gut Microbiome Testing: From Laboratory Methods to Clinical Meaning

Lauren Cornell

As direct-to-consumer (DTC) gut microbiome testing continues to move into mainstream nutrition and medical practice, clinicians are increasingly confronted with reports built on laboratory methods that sound sophisticated but vary widely in what they can realistically deliver. This second article in a 2-part series is designed to demystify the science behind these tests by clearly explaining the primary methodologies they rely on, including 16S rRNA sequencing, quantitative polymerase chain reaction (qPCR), shotgun …

03.09.2026journal-article

JAMA Network Open

Regional Variation in Bladder Cancer Clinical Trial Availability in the US

Koral U. Shah, Salvador Jaime-Casas, Ruchi Agarwal, George Zhang, Xiaochen Li, Vitor Abreu de Goes, Daniela V. Castro, Benjamin Mercier, Ruth Simon, Samuel Dickter, Lily M. Lau, Jaya Goud, Akasha Dukkipati, Jadon Fann, Lauren Lau, Joshua Lee, Kyra Shah, Ethan Swarat, Miguel Zugman, Nazli Dizman, Ali Moradi, Regina Barragan-Carrillo, Abhishek Tripathi, Charles B. Nguyen, Alex Chehrazi-Raffle, Sumanta K. Pal

Importance Geographic disparities in cancer clinical trial access are well described in the US, but patterns in bladder cancer remain poorly defined. Objective To evaluate bladder cancer trial availability across US counties and its associations with epidemiologic and socioeconomic factors. Design, Setting, and Participants This cross-sectional study of completed, open, or active bladder cancer clinical trials from June 1, 2019, to June 1, 2025, on ClinicalTrials.gov used data on county-level incidence, mortality, …

03.09.2026journal-article

Cell and Gene Therapy Insights

Benchmarking emerging chromatographic platforms for mRNA-LNP characterization and scalable process enablement

Sergeja Lebar, Tristan Kovačič, Ana Ferjančič Budihna, Jeremie Parot, Alicja Molska, Nejc Pavlin, Mojca Bavčar, Tjaša Leban, Mojca Tajnik, Mojca Tajnik Sbaizero, Andreja Gramc Livk

Lipid nanoparticles (LNPs) are now the leading delivery platform for nucleic acid therapeutics, supporting applications from prophylactic mRNA vaccines to in vivo gene editing, in vivo CAR-T, protein replacement, and personalized cancer immunotherapy. As formulations incorporate novel ionizable lipids, targeting ligands, and multi-component payloads, analytical complexity increases, and no single method can capture all critical quality attributes (CQAs). This study benchmarks the PATfix LNP Switcher Platform agains …

03.09.2026journal-article

Journal of Clinical Ultrasound

Ultrasonographic Evaluation of Cavum Septum Pellucidum Dimensions and Morphology in the Second Half of Pregnancy: A Prospective Cross‐Sectional Study

Somayeh Shirazinezhad, Somayeh Khanjani, Sonia Rostami Ghorbani, Mohammadreza Elhaie

ABSTRACT Objective To determine normative ultrasonographic dimensions, morphology, and visualization rate of the cavum septum pellucidum (CSP) in structurally normal singleton fetuses between 19 and 40 weeks of gestation and to assess correlations with gestational age and fetal biometric parameters. Methods This prospective cross‐sectional study enrolled 600 consecutive singleton pregnancies with normal fetal anatomy at Beheshti Hospital, Isfahan, Iran (2024–2025). Transabdominal ultrasound was performed in standar …

03.09.2026journal-article

Artefactum - revista de estudos interdisciplinares

THE SUPPORT THAT TRANSCENDS LABOR FORCE: ORGANIZATIONAL PERCEPTION AND SPIRITUALITY AT WORK AMONG EMPLOYEES OF A PUBLIC EDUCATION INSTITUTION IN THE STATE OF RIO GRANDE DO NORTE

Nilton Soares Formiga, Gardênia de Oliveira Galvão, Cleber Medeiros de Lucena, Willian Alber da Silva Farias, Raniere Costa Souza, Ivan do Carmo Lameque

Abstract: Organizational and Positive Psychology emphasizes resources capable of promoting health, well-being, and positive workplace relationships. Among these resources, workplace spirituality stands out as being associated with meaning, purpose, and the quality of professional relationships, while perceived organizational support concerns the recognition of employees’ contributions and the organization’s care for its workforce. This study examined the relationship between perceived organizational support and wor …

03.09.2026journal-article

Migration LAW

A Strong State is the Basis of Public Security

Alik G. Khabibulin, Kamil R. Mursalimov

The article is devoted to the problems of forming a strong state, preserving national statehood, and ensuring public safety. The author argues for a strong state based on an ideology that consolidates the traditional spiritual and moral values of Russian society, uniting the people and defining their creative activities aimed at meeting the public demand.

03.09.2026journal-article

npj Primary Care Respiratory Medicine

Barriers and facilitators to RSV vaccine acceptance among pregnant women and older adults in Hong Kong: a qualitative study guided by the Theoretical Domains Framework

Claire Chenwen Zhong, Man Kin Yim, Zehuan Yang, Vera MW Keung, Chung Yi Lo, Xiaoshu Zhang, Mingtao Chen, Junjie Huang, Martin CS Wong

Abstract Respiratory syncytial virus (RSV) poses a significant health risk to pregnant women, infants, and older adults, yet vaccine uptake remains suboptimal globally. This study aimed to explore the barriers and facilitators influencing RSV vaccine acceptance among pregnant women and older adults in Hong Kong. A qualitative design was employed, involving semi-structured interviews with pregnant women and older adults in Hong Kong. The interview guide was informed by the Theoretical Domains Framework (TDF) to capt …

03.09.2026journal-article

Odovtos - International Journal of Dental Sciences

Lifestyle Intervention Based on the 8S Model in a Patient with Benign Migratory Glossitis: A Case Report

José García López, Francisco Javier Tejeda Nava, Juan Antonio Cepeda Bravo, José Arturo Garrocho Rangel, José Andres Flores García, Saray Aranda Romo

Benign migratory glossitis (BMG) is widely regarded as a harmless anatomical variant, which historically accounts for the absence of a standardized management protocol. However, given that multiple associated factors have been described in the literature, a broader clinical assessment and an individualized management approach may be warranted in symptomatic cases. This case report describes the management of a 21-year-old female patient with BMG, who presented with multiple irregular, well-demarcated areas of papil …

03.09.2026journal-article

Medical Technology and Public Health Journal

An Analysis of Emergency Drills in Enhancing Self-Readiness and Emergency Preparedness Behavior Among Employees at Taman Dolan Tourist Site

Rachmy Rois, Anita Sulistyorini, Dian Puspitaningtyas Laksana

Natural tourism areas are highly vulnerable to disasters, making employees a crucial factor in ensuring visitor safety. One important mitigation strategy is the implementation of emergency drills, also known as emergency response exercises. However, the effectiveness of training in improving employee preparedness remains uncertain. This study aimed to analyzed the effect of emergency drills on self-readiness and emergency preparedness behavior among employees at Taman Dolan Nature Tourism, Batu City. A quantitative …

03.09.2026journal-article

Electronics

A Hybrid VMD–GWO–BiLSTM–Attention Framework for Accurate State-of-Health Prediction of Lithium-Ion Batteries Under Complex Degradation Dynamics

Chenglin Ding, Hui Liu, Enze Hu, Xuesheng Wang

Accurate State-of-Health (SOH) prediction for lithium-ion batteries is essential for the safe and stable operation of Battery Management Systems (BMSs). However, achieving high-precision estimation remains challenging due to the complex interplay of non-stationary degradation characteristics, observation noise, and bidirectional temporal dependencies. This study proposes a robust hybrid temporal prediction framework integrating Variational Mode Decomposition (VMD), Bidirectional Long Short-Term Memory (BiLSTM) netw …

03.09.2026journal-article

Review of Clinical Pharmacology and Pharmacokinetics

Therapeutic landscape for diabetic macular edema: durable strategies with a focus on aflibercept 8 mg

Martín Roberto Basile-Alvarez, Erick André Escalante-Buendía, Karen A. Palacios-Aguirre, Alejandro Ortega Desio, Omar Yaxmehen Bello-Chavolla

To evaluate current therapies for diabetic macular edema (DME), with emphasis on durability, safety, access, and the evidence supporting aflibercept 8 mg. An expert-selected narrative synthesis of primary clinical trials, pharmacologic studies, regulatory documents, and selected real-world evidence published from January 1, 2000, through August 8, 2026, was performed. Anti-vascular endothelial growth factor therapy remains first-line treatment for most center-involved DME with visual impairment, but observation or …

03.09.2026journal-article

BMC Urology

Clinical application of systematic prostate biopsy combined with contrast-enhanced ultrasound guided targeted biopsy in patients with PSA gray zone

Yan-Xia Cheng, Sha Hu, Qing-xin He, Xuan Hu, Li-Lan He, Yue Song, Zhi-Kai Lei

Abstract Objective To investigate the clinical value of combining systematic prostate biopsy with contrast-enhanced ultrasound (CEUS)-guided targeted biopsy in patients with serum prostate-specific antigen (PSA) levels in the gray zone. Methods A total of 167 patients in the PSA gray zone treated at Zhejiang Provincial Hospital of Traditional Chinese Medicine from January 2022 to October 2024 were retrospectively analyzed and divided into a systematic biopsy group and a combined biopsy group. Both groups underwent …

03.09.2026journal-article

Frontiers in Medicine

From benchmarking to global leadership: Singapore’s health sciences authority’s journey to WHO maturity level 4 and WHO-Listed Authority status for medicines

Dorothy Toh, Adena Lim, Agnes Chan, Alvin Chia, Pei San Ang, Annie Tan, Belinda Foo, Betty Chan, Limei Chong, Qiuyi Choo, Chih Tzer Choong, Christine Ho, Siew Wei Chua, Shin Chet Chuah, Clare Louise Rodrigues, Damian Chuah, Debbie Sun, Diana Koh, Doris Yeo, Esther Tan, Eugene Goh, Evelyn Lee, Flavian Ee, Freddie Foo, Xiao Wei Ge, Cheong Hian Goh, Phey Yen Han, Jalene Poh, Jean Low, Jessica Teo, Joyce Ng, Weng Fai Lai, Hui Keng Lee, Boon Kian Lim, Li Lian Lim, Na Lim, Sharon Lin, Boon Lee Ling, Lisa Tan, Yee Hoo Looi

This article aims to describe Singapore Health Sciences Authority’s (HSA’s) multi-year journey to attaining World Health Organisation (WHO) Maturity Level 4 (ML4) and WHO-Listed Authority (WLA) status for medicines regulatory functions, presenting HSA as a descriptive policy case study on the practical application of the WHO Global Benchmarking Tool (GBT) and WLA frameworks. It outlines the benchmarking and Performance Evaluation (PE) processes, including the scope of assessment, phased reviews, and key milestones …

03.09.2026journal-article

Frontiers in Public Health

The mediating role of psychological capital between work stress and compassion fatigue among clinical nurses: a cross-sectional study

Chengxi Huang, Dengbin Liao, Yunting Luo, Yiran Xu, Haoyang Luo, Lingxiao He

Objective To explore the parallel multiple mediating effects of the sub-dimensions of psychological capital (self-efficacy, hope, resilience, and optimism) between work stress and compassion fatigue among clinical nurses. Methods A cross-sectional study was conducted using convenience sampling. Clinical nurses from a tertiary hospital were recruited. Data were collected using a general demographic questionnaire, the Nurse Work Stress Scale (NWSS), the Psychological Capital Questionnaire-revised (PCQ-R), and the Pro …

03.09.2026journal-article

Crop Health

Advances in semiochemicals of the sweet potato weevil, Cylas formicarius, and its application in pest management

Shuyan He, Chao Li, Yulin Gao

Abstract The sweet potato weevil (SPW), Cylas formicarius , is one of the most destructive pests of sweet potato, Ipomoea batatas L., across tropical and subtropical regions worldwide. The concealed feeding habits of larvae and the nocturnal activity of adults render conventional chemical-based control largely ineffective. Semiochemical-based management, especially the use of female-produced sex pheromone, has emerged as a promising strategy for integrated pest management (IPM) for this pest insect. This review pro …

03.09.2026journal-article

Frontiers in Psychology

Profiles of sleep hygiene, insomnia, sleep locus of control, and psychological well-being among nursing students: a cluster analysis

Ramya Kundayi Ravi, Daljit Kaur, Shaimaa Hashem Elsalous, Nilda Ensomo Ogsimer, Gifty Thomas, Lakshmi Ramamoorthy, Jaison Jacob, Priya Baby

Introduction Psychological well-being is crucial for nursing students, who often face academic and clinical stressors that disrupt their sleep patterns. Insomnia severity, sleep hygiene, and sleep locus of control are key sleep-related factors that potentially influence mental health. However, the combined effects of these factors on psychological well-being remain underexplored, particularly among Indian nursing students. Methods A cross-sectional analytical study was conducted among 418 nursing students from two …