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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

British Journal of Sports Medicine

Resistance training and depressive symptoms in subcortical vascular cognitive impairment: secondary results of a randomised clinical trial

Ryan S Falck, Cindy K Barha, Ryan G Stein, Sofia Grant, Alexis Bullock, Ken M Madden, Jennifer C Davis, Roger Tam, Teresa Liu-Ambrose

Objectives Cerebral small vessel disease (CSVD) is associated with depressive symptoms. Exercise may reduce depressive symptoms for people with CSVD. We examined the effects of progressive resistance training (PRT) on depressive symptoms among adults with CSVD and mild cognitive impairment (ie, subcortical vascular cognitive impairment (SVCI)). Methods A single-site, 12-month, parallel group, secondary analysis of a randomised controlled trial (ClinicalTrials.gov identifier: NCT02669394 ). Community-dwelling adults …

03.09.2026journal-article

JMIR Research Protocols

Patient-Centered Clinical Decision Support for Recommended Screenings in French Primary Care: Protocol for a Multicenter Mixed Methods Feasibility Study

Pierre-Yves Meunier, Laurent Magaud, Romain Varnier, Emmie Goetz, Melinda Bekaddour, Ludivine Albert, Inès Khati, Ilhem Bensekka, Julie Haesebaert, Denis Maillet, Julien Péron, Laurent Letrilliart

Background Primary care professionals (PCPs) are responsible for identifying eligibility and supporting patient decisions for a wide range of recommended screenings. However, the number of recommendations (42 for adults in France), complex eligibility criteria, limited consultation time, and competing priorities hinder their systematic delivery. Clinical decision support systems (CDSSs) with patient decision aids may help structure prevention-focused consultations and support shared decision-making, but their feasi …

03.09.2026journal-article

كلية القانون- جامعة سومر

الضبط القانوني للاستخدامات المائية للأنهار الدولية في ضوء قواعد القانون الدولي العام

علي يوسف

في ظل تزايد الطلب على الموارد المائية، شكلت النزاعات على الأنهار الدولية تحدياً دولياً وتنامي النزاعات بين الدول المتشاطئة على الأنهار الدولية بسببها، نتيجة عدم وجود ضابط موحد يحكم تنظيم الأنهار الدولية قواعد القانون الدولي العام، ويرجع ذلك لاختلاف الدول في تحديد المفهوم القانوني للأنهار الدولية، وتحليل الأساس القانوني المنظم لاستغلالها، والمبادئ الأساسية الحاكمة لها، وفي مقدمتها مبدأ الانتفاع المنصف والمعقول ومبدأ عدم الإضرار. لذا فإن هذه الدراسة سعت أن تبين الأسس وقواعد القانون الدولي العام على وجه الخصوص الاتفاق …

03.09.2026journal-article

Regional Anesthesia & Pain Medicine

Procedure-specific effects of intravenous lidocaine in adult spine surgery: a systematic review and meta-analysis of randomized controlled trials

Vitor A Felippe, Carlos D A Bersot, Gabriel L Gonzalez, Gustavo R M Wegner, Estevao L C Braga, Carolina C C Silva, Giulia D Matheus, Bruno V M Santiago, Leonardo B Santos, Marcos A Lessa

Background and objectives Perioperative intravenous lidocaine infusion has been proposed as an opioid-sparing analgesic adjunct in spine surgery, but previous meta-analyses pooled heterogeneous procedures and may have obscured procedure-specific treatment effects. We evaluated the analgesic and opioid-sparing effects of perioperative intravenous lidocaine in adult spine surgery and whether efficacy differs by procedure type. Methods We searched PubMed, Embase, Web of Science, and the Cochrane Library from inception …

03.09.2026journal-article

Journal of Comparative Effectiveness Research

US population-level model of clinical impact of lorlatinib treatment on ALK+ metastatic non-small cell lung cancer outcomes

Adam Kasle, Devin Abrahami, David Veenstra, Robert Morlock, Priya Ramachandran, Lindsay Stansfield, Raymond Mak

Aim: Lorlatinib and alectinib are next-generation anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) approved for the treatment of ALK-positive (ALK+) advanced/metastatic non-small cell lung cancer (NSCLC) after demonstrating superior efficacy over crizotinib (first-generation ALK TKI) in the CROWN and ALEX trials, respectively. This analysis estimated the US population-level clinical impact of first-line (1L) lorlatinib versus alectinib treatment for ALK+ advanced/metastatic NSCLC. Materials & meth …

03.09.2026journal-article

BMC Emergency Medicine

Agreement between handheld ultrasonography and computed tomography for abdominal aortic diameter measurement in unselected emergency department patients: a prospective feasibility study

Alihan Elveren, Ferhat Yildiz, Muhammed Fatih Cırıl, Mustafa Akarca, Ebru Ünal Akoğlu, Tuba Ci̇mi̇lli̇ Öztürk, Burcu Azapoğlu Kaymak

Abstract Background Abdominal aortic pathologies (aneurysm, rupture, or dissection) are among the most critical and life threatening diagnoses in patients presenting to the emergency department (ED) with abdominal or back pain. This study aimed to evaluate the agreement between bedside handheld ultrasonography (HHUS) measurements of abdominal aortic diameter performed by ED physicians and the reference standard, contrast enhanced computed tomography (CT), while also assessing inter rater reliability between clinici …

03.09.2026journal-article

Journal of Fish Health

Potential of Local Microalgae from Lembar Bay Waters for Climate Change Mitigation: Insights from Photosynthetic Assimilation Index

Damai Diniariwisan, Alis Mukhlis, Bagus Dwi Hari Setyono, Awan Dermawan, Rizky Regina Kawirian, Sri Hikmah Wulandari

Climate change mitigation requires innovative approaches to reduce atmospheric carbon dioxide (CO₂) through efficient and sustainable carbon fixation. Microalgae are promising biological agents because of their photosynthetic capacity to assimilate inorganic carbon into biomass. This study aimed to assess the potential of local microalgae communities in Lembar Bay waters, West Lombok, as carbon assimilation agents based on the relationship between chlorophyll-a, net primary productivity (NPP), and assimilation inde …

03.09.2026journal-article

Frontiers in Medicine

Case Report: Monoclonal gammopathy associated enteropathy: a potential MGCS related phenotype with response to plasma cell directed therapy

Guo Chen, Li He, Yuan Yuan Chen, Peng Yang, Jing Tan

Background Chronic inflammatory diarrhea with preserved mucosal architecture remains diagnostically challenging when inflammatory bowel disease, autoimmune enteropathy, and infection are excluded. The potential contribution of monoclonal gammopathy in such cases remains poorly defined. Case presentation We report two patients with long-standing, treatment-refractory chronic diarrhea who underwent comprehensive clinical, histopathologic, and hematologic evaluation. Both demonstrated a consistent intestinal pattern c …

03.09.2026journal-article

Frontiers in Oncology

Factors influencing oncologists’ decisions for germline BRCA testing and adjuvant therapy selection in HER2-negative early breast cancer

Qixin Li, M. Janelle Cambron-Mellott, Xiaoqing Xu, Nicole Kashine-Tack, Jennifer F. Hayes, Kathryn Emily Mishkin, Alexandra Gordon, Oliver Will, Lauren A. Howell, Alejandro Noval, Kathleen Beusterien

Introduction With advances in targeted early breast cancer (eBC) treatment, research is needed to understand the factors influencing biomarker testing and respective treatment selection among physicians in routine clinical practice. The purpose of this study was to evaluate factors influencing oncologist decisions for germline BReast Cancer gene (BRCA) mutation (gBRCAm) testing and adjuvant therapy in human epidermal growth factor receptor 2-negative (HER2-) early breast cancer (eBC). Materials and methods US oncol …

03.09.2026journal-article

Frontiers in Medicine

Ultrasound-assisted modified paramedian approach vs. traditional paramedian approach for spinal anesthesia in lower limb surgery: a single-center randomized controlled trial

Wudong Zhuang, Xiaoyuan Li, Jianhua Wang, Ruizhao Lyu, Shan Wang, Rui Liu, Yang Bai

Study objective This randomized controlled trial aimed to determine whether an ultrasound-assisted modified paramedian approach could improve procedural outcomes compared with an ultrasound-assisted traditional paramedian approach for spinal anesthesia in patients undergoing lower limb surgery. Design Prospective, randomized, controlled clinical trial. Setting Operating rooms of Hebei Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine, China. Patients A total of 116 patients aged 18–9 …

03.09.2026journal-article

Frontiers in Surgery

Clinical outcomes of flap reconstruction following lower extremity soft tissue sarcoma resection: a single-center retrospective experience

Xinxin Guo, Jianpeng Li, Jingyu Zhang, Yongcheng Hu

Background Soft tissue sarcomas (STSs) represent a diverse category of tumors with a propensity for the lower limbs. Wide surgical resection is the primary therapeutic approach, often requiring immediate flap reconstruction with or without perioperative adjuvant therapy. This study aims to share our clinical experience and assess the efficacy of customized flap reconstruction designed according to the precise defect area after lower extremity STS resection. Methods This retrospective analysis reviewed 15 cases of l …

03.09.2026journal-article

Frontiers in Public Health

Maternal per- and polyfluoroalkyl substances exposure and the co-occurrence of gestational diabetes mellitus and preeclampsia/eclampsia: a nested case–control study

Nana Li, Lu Li, Ying Deng, Meixian Wang, Yuting Li, Zhen Liu, Hong Kang, Jun Zhu, Ping Yu, Yanping Wang

Objective Few studies have investigated the relationship between maternal exposure to per- and polyfluoroalkyl substances (PFAS) and the co-occurrence of gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy, particularly preeclampsia/eclampsia (PE/E). The present study aimed to explore whether PFAS exposure is associated with the co-occurrence of GDM and PE/E. Methods This study enrolled 333 pregnant women diagnosed with both GDM and PE/E, and 360 healthy controls. First-trimester plasma conc …

03.09.2026journal-article

Exploration of Neuroscience

Colon cancer in a patient with a mosaic monoallelic germline pathogenic NF1 gene variant

Feras Alsabagh, Karam M. Chaaban, Marlene Girardo, Ehab Harahsheh, Misha B. Asif, Dusica Babovic-Vuksanovic, Mohamad Bassam Sonbol, Mayowa A. Osundiji

Pathogenic variants in the tumor suppressor gene NF1 cause neurofibromatosis type 1 (NF1), one of the most common hereditary cancer predisposition syndromes. Pathogenic NF1 variants have been associated with an increased risk of several cancers; however, the relationship between NF1 variation and colon cancer remains underreported. We report a 41-year-old woman with a mosaic monoallelic germline pathogenic NF1 variant, NM_000267.3:c.1756_1759del (p.Thr586Valfs*18), previously detected on germline multigene panel te …

03.09.2026journal-article

Chinese Journal of International Review

China's Public Diplomacy: Evolution, Domestic Dimensions, and Implications

Dongnu Guo

This paper highlights how China has operated public diplomacy differently. Integrating key scholarly works from China and the West, this paper demonstrates a fundamental distinction: China conceptualizes public diplomacy as a resource to promote the narrative of national rejuvenation and regime legitimacy. This paper also indicates that public diplomacy is a crucial instrument of soft power, and through examining the evolution, paradigm shift, domestic dimensions, as well as implications of China's public diplomacy …

03.09.2026journal-article

Journal of Microscopy and Ultrastructure

Hyalinization in Dentistry: Pathogenesis, Mechanisms, and Clinical Implications

Roja Lakshmi Karri, Hasini Nelakurthi, Amrutha Rudraraju, NavaratnaSowmya Chinta

Abstract Hyalinization is a key histological feature that provides valuable insights into various dental and systemic conditions. It refers to the deposition of a glass-like, homogenous substance in tissues, often signaling tissue damage, necrosis, or abnormal collagen dynamics. In dentistry, hyalinization is observed in periodontal disease, orthodontic treatments, and dental pulp health, as well as in systemic conditions. During orthodontic treatment, excessive forces can induce ischemia in the periodontal ligamen …

03.09.2026journal-article

Wilderness & Environmental Medicine

Kerosene Chemical Burn at Khumbhu Icefall: Report of Two Cases

Suraj Shrestha, Ashish Lohani, Roy Harris, Surya Prakash Joshi, Sabitra Thapa, Buddha Basnyat

Kerosene chemical burns are uncommon but can result in serious injury, particularly among high-altitude porters who carry fuel through difficult terrain and endure prolonged exposure or contact. We describe 2 cases of high-altitude porters who developed chemical burns to the lower back and gluteal region following leakage of kerosene while traversing the Khumbu Icefall in the Everest region. Such injuries highlight the need for awareness among expedition doctors and high-altitude medical personnel, as early recogni …

03.09.2026journal-article

Journal of Intensive Care Medicine

Machine Learning-Based Subtype Classification of Sepsis-Associated Acute Kidney Injury and Differential Responses to Renal Replacement Therapy

Hongkun Zhang, Shengzhi Wang, Tao Zhang, Baisen Wang, Ziqi Jiang, Zhenqi Guo

Background Sepsis-associated acute kidney injury (SA-AKI) is highly heterogeneous with controversial optimal renal replacement therapy (RRT) strategies. Machine learning enables subphenotype identification, and exploring RRT response differences across SA-AKI subtypes is critical for precision care. Methods This retrospective cohort study analyzed adult SA-AKI patients from the Medical Information Mart for Intensive Care IV database. K-means clustering classified SA-AKI subtypes; nine machine learning models were b …

03.09.2026journal-article

World Journal of Nuclear Medicine

Quantitative SPECT/CT SUVmax: Improving Diagnostic Confidence in Differentiating Metastatic from Degenerative Bone Lesions in Breast Cancer

Nitami Oktavia Indiarti, Hendra Budiawan, Trias Nugrahadi, Achmad Hussein Sundawa Kartamihardja

Abstract Breast cancer bone metastases are predominantly osteolytic. Tumor-derived parathyroid hormone-related peptide increases receptor activator of nuclear factor-kappa B ligand (RANKL) expression in osteoblasts. RANKL binds receptor activator of nuclear factor-kappa B (RANK) on osteoclast precursors, promoting osteoclast activation and bone resorption. The resulting release of matrix-embedded growth factors, including transforming growth factor-beta and insulin-like growth factors, contributes to tumor progress …

03.09.2026journal-article

Cancer Research Communications

Transcriptome-based synthetic lethality predictions to improve targeted therapy/immunotherapy treatment prioritization in non-metastatic breast cancer: BC-SELECT

Yewon Kim, Matthew Nagy, Rebecca Pollard, Padma Sheila. Rajagopal

Abstract Patients with non-metastatic triple-negative (TNBC) or HER2-positive (HER2+) breast cancer do not have tools to predict treatment response or prioritize options prior to starting therapy. Pathologic complete response (pCR) is a proxy that requires neoadjuvant treatment. BC-SELECT leverages genetic interactions (e.g. synthetic lethality (SL)/rescue (SR)) to predict treatment response via pCR from breast cancer gene expression data. BC-SELECT involves (1) “Training: Gene-pair identification” that identifies …

03.09.2026journal-article

Egyptian Rheumatology and Rehabilitation

Hand grip strength: age- and gender-stratified normative data in Egyptian population-based study by the Egyptian Academy of Bone and Muscle Health

Yasser El Miedany, Maha Elgaafary, Walaa Elwakil, Rahma A. Elziaty, Reem Sadek, Reem H. Abd Alrahman, Sarah Hossam Abdelrahman, Mohamed Eldaramlly Omar, Abdelrahman Rashwan Radwan, Waleed Hassan, Marwa Yahia, Olfat Gamal Elsaeid, Asmaa Elbanhawy, Marwa Abdrabo, Mohamed El Koumy, Israa Qutob, Bassant Samir, Safaa Mahran

Abstract Objective This study aimed to establish age- and gender-stratified normative data for hand grip strength (HGS) in a population-based sample of healthy Egyptian adults and to analyze its relationship with various socio-demographic and anthropometric parameters. Methods This cross-sectional study evaluated 2,247 healthy Egyptian participants (900 men, 1,347 women). HGS was measured in kilograms (kg) using a digital hand dynamometer following a standardized bilateral protocol. Anthropometric data (including B …

03.09.2026journal-article

Nutrition Today

Gut Microbiome Testing: From Laboratory Methods to Clinical Meaning

Lauren Cornell

As direct-to-consumer (DTC) gut microbiome testing continues to move into mainstream nutrition and medical practice, clinicians are increasingly confronted with reports built on laboratory methods that sound sophisticated but vary widely in what they can realistically deliver. This second article in a 2-part series is designed to demystify the science behind these tests by clearly explaining the primary methodologies they rely on, including 16S rRNA sequencing, quantitative polymerase chain reaction (qPCR), shotgun …

03.09.2026journal-article

JAMA Network Open

Regional Variation in Bladder Cancer Clinical Trial Availability in the US

Koral U. Shah, Salvador Jaime-Casas, Ruchi Agarwal, George Zhang, Xiaochen Li, Vitor Abreu de Goes, Daniela V. Castro, Benjamin Mercier, Ruth Simon, Samuel Dickter, Lily M. Lau, Jaya Goud, Akasha Dukkipati, Jadon Fann, Lauren Lau, Joshua Lee, Kyra Shah, Ethan Swarat, Miguel Zugman, Nazli Dizman, Ali Moradi, Regina Barragan-Carrillo, Abhishek Tripathi, Charles B. Nguyen, Alex Chehrazi-Raffle, Sumanta K. Pal

Importance Geographic disparities in cancer clinical trial access are well described in the US, but patterns in bladder cancer remain poorly defined. Objective To evaluate bladder cancer trial availability across US counties and its associations with epidemiologic and socioeconomic factors. Design, Setting, and Participants This cross-sectional study of completed, open, or active bladder cancer clinical trials from June 1, 2019, to June 1, 2025, on ClinicalTrials.gov used data on county-level incidence, mortality, …

03.09.2026journal-article

Cell and Gene Therapy Insights

Benchmarking emerging chromatographic platforms for mRNA-LNP characterization and scalable process enablement

Sergeja Lebar, Tristan Kovačič, Ana Ferjančič Budihna, Jeremie Parot, Alicja Molska, Nejc Pavlin, Mojca Bavčar, Tjaša Leban, Mojca Tajnik, Mojca Tajnik Sbaizero, Andreja Gramc Livk

Lipid nanoparticles (LNPs) are now the leading delivery platform for nucleic acid therapeutics, supporting applications from prophylactic mRNA vaccines to in vivo gene editing, in vivo CAR-T, protein replacement, and personalized cancer immunotherapy. As formulations incorporate novel ionizable lipids, targeting ligands, and multi-component payloads, analytical complexity increases, and no single method can capture all critical quality attributes (CQAs). This study benchmarks the PATfix LNP Switcher Platform agains …

03.09.2026journal-article

Journal of Clinical Ultrasound

Ultrasonographic Evaluation of Cavum Septum Pellucidum Dimensions and Morphology in the Second Half of Pregnancy: A Prospective Cross‐Sectional Study

Somayeh Shirazinezhad, Somayeh Khanjani, Sonia Rostami Ghorbani, Mohammadreza Elhaie

ABSTRACT Objective To determine normative ultrasonographic dimensions, morphology, and visualization rate of the cavum septum pellucidum (CSP) in structurally normal singleton fetuses between 19 and 40 weeks of gestation and to assess correlations with gestational age and fetal biometric parameters. Methods This prospective cross‐sectional study enrolled 600 consecutive singleton pregnancies with normal fetal anatomy at Beheshti Hospital, Isfahan, Iran (2024–2025). Transabdominal ultrasound was performed in standar …