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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

Frontiers in Immunology

Gift of nature: non-human-derived exosomes showing application prospects in periodontitis treatment

Hongbo Fei, Zhuoran Wang, Yujiao Li, Hongchen Sun, Xiuping Meng, Hongbing Lin

Periodontitis, a chronic inflammatory disorder, results in tooth loss and adversely affects oral and systemic health. Current therapies fail to effectively regenerate bone loss caused by inflammation. Human stem cell-derived exosomes have emerged as important mediators of tissue regeneration and inflammation modulation in periodontitis, yet their clinical use faces ethical and technical challenges. Non-human-derived exosomes present a viable alternative, leveraging their ability to enhance tissue repair, reduce inf …

02.09.2026journal-article

Annals of African Medicine

Neonatal Presentation of Suspected Vici Syndrome: A Case Report with Multisystem Features

Kaoutar Danaoui, Meryem Majdoul, Fatima-Ezzahra Tahiri, Hajar Akki, Kaoutar Ettouni, Mouna Zouine, Abdallah Oulmaati

Abstract Vici syndrome is a rare autosomal recessive multisystem disorder caused by biallelic mutations in the EPG5 gene. It is classically characterized by agenesis of the corpus callosum, oculocutaneous hypopigmentation, combined immunodeficiency with recurrent infections, cataracts, and cardiomyopathy. We report the case of a newborn born to consanguineous parents, with a family history of a sibling death of unspecified cause, presenting with hypopigmentation, generalized hypotonia, agenesis of the corpus callos …

02.09.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Typhoid Fever Surveillance and Vaccination Recommendations: WHO Eastern Mediterranean Region, 2021

Yesser Sebeh, Ashley Longley, Muhammad Tayyab, Nandini Sreenivasan, Kashmira Date, Eric Mintz, Evans Buliva, Lucy Breakwell Nagle

ABSTRACT. Annually, there are 5.57 to 9.23 million typhoid fever cases and 46,200 to 163,000 associated deaths, mainly in low- and middle-income countries. High incidence is estimated in the Southeast Asian, African, and Eastern Mediterranean (EMR) regions of the WHO. We reviewed EMR typhoid surveillance and vaccination recommendations to inform regional prevention and control efforts. Separate surveys were sent to surveillance and immunization officers in all 21 EMR countries and the occupied Palestinian territory …

02.09.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Training Data Recorders with a Manual to Take High-Quality Trachoma Photographs in South Sudan

Madison Bearden-Muse, Nicholas A. Presley, Stephen Ohidor, Tania A. Gonzalez, Lochebe Boniface, Stella Abuba, Shamika V. Chavda, Reida Konga, Fisseha Admassu, E. Kelly Callahan, Yak Yak Bol, Angelia M. Sanders, Scott D. Nash

ABSTRACT. When a country has reached a low trachoma prevalence, it can be difficult to reliably train survey graders to accurately grade trachoma signs. Conjunctival photography provides an opportunity to capture images for grading. Recently, a training manual targeting survey data recorders was published. In July 2023, this manual was used during a photography training, after which certified trainees served as data recorders and photographers during the Enhancing the ‘A’ in SAFE (ETAS) study in South Sudan. Five o …

02.09.2026journal-article

Asian Journal of Research in Infectious Diseases

Bacterial Ecology and Antibacterial Resistance Patterns: A Cross-sectional Study in the Internal Medicine Unit of Centre Médico-Chirurgical des Armées de Bamako, Mali

Lassina Diallo, Abasse Sanogo, Ladji Mohamed Diaby, Hassane Diallo, Sah Dit Baba Coulibaly, Yacouba Cissoko, Issa Konaté, Sounkalo Dao

Background: Antibacterial resistance (ABR) is a major public health threat, particularly in low- and middle-income countries where hospital surveillance data remain limited. This study aimed to describe bacterial ecology, antimicrobial resistance patterns, and factors associated with multidrug-resistant bacteria (MDRB) in the Internal Medicine ward of Centre Médico-Chirurgical des Armées de Bamako, Mali. Aim: This study aimed to characterise bacterial ecology and antimicrobial resistance patterns in this department …

02.09.2026journal-article

European Heart Journal - Case Reports

Transjugular LuX-Valve Plus Transcatheter Tricuspid Valve Replacement for Torrential Tricuspid Regurgitation in a Patient With a Giant Right Atrium and Prior Multiple Valve Interventions: A Case Report

Quntai Qiu, Xinlei Wu, Daozhu Wu, Xinmin Zhang, Lianpin Wu

Abstract Background Transcatheter tricuspid valve replacement (TTVR) is an option for selected patients with severe tricuspid regurgitation (TR) who are at high surgical risk, but experience remains limited in those with extreme right-heart anatomy, including a giant right atrium and a markedly enlarged elliptical tricuspid annulus. Case summary A 62-year-old man was admitted with progressive dyspnoea and lower-extremity oedema (NYHA class IV). He had prior mechanical mitral valve replacement and transcatheter aort …

02.09.2026journal-article

PLOS One

Does randomization matter in rare disease clinical trials

Stephanie Wied, Denis Kirilov Razsolkov, Nicole Heussen, Ralf-Dieter Hilgers

Background Conducting Rare Disease Clinical Trials poses a wide variety of research challenges. Many techniques that are usually considered the best standard for evaluating new therapies are more difficult to implement here. This also holds in terms of randomization in clinical trials. The question arises how to randomize and, especially, which randomization procedure (RP) should be used to prevent the influence of bias focussing on allocation bias as efficiently as possible. Methods We present guidance that suppor …

02.09.2026journal-article

Science Translational Medicine

Tissue origins and immune correlates of viral rebound in SIV-infected rhesus macaques after ART discontinuation

Irena V. King, Malika Aid, Emek Kose, Taina T. Immonen, Charles A. Goodman, Christine M. Fennessey, Alessandro Colarusso, Victoria E. K. Walker-Sperling, Erica N. Borducchi, Romas Geleziunas, William J. Rinaldi, Melissa J. Ferguson, Louis J. Picker, Jeffrey D. Lifson, Brandon F. Keele, Dan H. Barouch

Most persons living with HIV-1 who discontinue antiretroviral therapy (ART) demonstrate viral rebound, but the tissue-level events that lead to rebound viremia remain poorly understood. Here, we report the origin, dynamics, and correlates of viral rebound in 16 rhesus macaques (RMs) infected with molecularly barcoded SIVmac239M, treated with ART for 70 weeks, and necropsied on day 12 after ART discontinuation. Barcode analysis of plasma during daily post-ART sampling identified 1 to 38 rebounding viral lineages per …

02.09.2026journal-article

Aesthetic Surgery Journal

A Modified Delphi Study on the Ethics and Governance of Live Injecting at Aesthetic Conferences. Is There a Better and Safer Alternative?

Greg J Goodman, Mark R Magnusson, Eqram Rahman, Sarah G Boxley, Narendra Kumar, Andrew Clark, Hema A Sundaram, Frank Lin, Michael Clague, Niamh Corduff, Sarah Hart, Peter Callan, Stefania Roberts, Cara B McDonald, Alice Rudd, Katy Wallace, Antoinette Ciconte, Anita Patel, Sean Arendse, Aakriti Gupta, Terence Poon, Catherine E Porter, Philip Bekhor, Lee-Mei Yap, Firas Al-Niaimi, Adrian Lim, Howard M Studniberg, Maeve A Ahern, Angelo Tsirbas, Richard Webb William, Zallmann Michaela, Somia Naveen

Abstract Background Live clinical demonstrations at aesthetic medicine conferences is common, yet concerns regarding patient safety, commercial influence, and ethical governance. This study established a consensus-based governance framework for live injecting and compared expert and attendee perspectives. Methods A two-stage modified Delphi process involved an international expert panel (n=31) alongside a cross-sectional attendee survey of conference (n=218). Round 1 included 46 statements addressing clinical safet …

02.09.2026journal-article

Journal of Genetic Counseling

Unacknowledged Burdens and Clinical Assets of BIPOC Genetic Counseling Students: Qualitative Evidence to Inform Supervision

Yeabsira Tufa, Kimberly Zayhowski, Joselyn Saenz Diaz, Nikkola Carmichael

ABSTRACT As the genetic counseling profession works to diversify its predominantly white workforce, understanding the experiences of Black, Indigenous, and People of Color (BIPOC) students is central to equity efforts. While BIPOC students bring invaluable cultural and linguistic diversity that improves patient care, they often navigate clinical training environments that lack diversity and psychological safety. This article draws on data from a longitudinal constructivist qualitative study to examine how racial an …

02.09.2026journal-article

Clinical and Experimental Dermatology

Subcutaneous nodules of the face: an unusual presentation of Darier–Roussy disease

Sofia Hermosilla, Isidora Wajner, Alberto Lara, Claudio Toloza, Carlo Lozano, Eduardo Rozas, Antonio Guglielmetti, José Hono

Subcutaneous sarcoidosis (Darier–Roussy disease) is an uncommon form of cutaneous sarcoidosis that predominantly affects the extremities. Facial involvement is rare and may represent a diagnostic challenge. We describe a woman presenting with nodules of the cheek and lips, whose histopathological and radiological findings led to the diagnosis of systemic sarcoidosis. This case expands the clinical spectrum of subcutaneous sarcoidosis and emphasizes the need to consider sarcoidosis in the differential diagnosis of g …

02.09.2026journal-article

Operative Neurosurgery

Representation and Educational Content of Spine Surgery in Operative Videos: A 10-Year Journal-Based Analysis

Daniel Faraj, William Rabon, H. Forbes Fowler, Chad J. Urquhart, Zoe Robinow, Michael A. Galgano

BACKGROUND AND OBJECTIVES: Video-driven education offers a powerful tool for illustrating intricate techniques and critical anatomic insights for surgical residents. Surgical procedures of the spine require a wide field of view, making their capture difficult. The objective of this study is to quantify the representation and educational content of published spine videos in peer-reviewed journals. METHODS: From 2015 to 2026, 1581 videos were identified across 4 peer-reviewed journals that routinely publish spine sur …

02.09.2026journal-article

Acta Poloniae Pharmaceutica - Drug Research

Multidrug-Resistant Acinetobacter baumannii: an Overview of Therapeutic Options and Treatment Regimens

Paweł Sacha, Mateusz Modzelewski, Łukasz Korczak, Elżbieta Tryniszewska

Acinetobacter baumannii, a Gram-negative coccobacillus, is an opportunistic pathogen originating from the natural environment (soil, water, and plants). This bacterium is common in the human skin microbiota and is capable of colonizing diverse environments (e.g., hospital environments). A. baumannii is a bacterium naturally resistant to multiple antibiotic classes. In recent years, due to its ability to acquire resistance genes from other bacteria, it has become a critical threat, particularly in intensive care uni …

02.09.2026journal-article

Science Translational Medicine

Elevated translocator protein in skull bone marrow is linked to human chronic pain

Mehrbod Mohammadian, Nikos Efthimiou, Katherin Gabriel, Ludovica Brusaferri, Joya Cooper-Hohn, Minhae Kim, Jennifer P. Murphy, Zeynab Alshelh, Grace Grmek, Jack H. Schnieders, Courtney A. Chane, Thomas G. Carmichael, Danika Yang, Julia J. Schubert, Federico E. Turkheimer, Rafael A. Cazuza, Peter M. Grace, Ciprian Catana, Steven M. Stufflebeam, Robert R. Edwards, Vitaly Napadow, Kimberly Sullivan, Matthias Nahrendorf, Theodore J. Price, Jodi M. Gilman, Marco L. Loggia

The skull bone marrow (SBM) is emerging as a critical hub for neuroimmune signaling, yet its role in chronic pain is unknown. Using integrated positron emission tomography/magnetic resonance imaging, here, we show that the levels of 18-kilodalton translocator protein (TSPO), a putative marker of immune cell density, are elevated in the SBM of individuals with chronic pain [ n = 125; chronic low back pain (cLBP), n = 88; knee osteoarthritis (KOA), n = 37] compared with healthy controls ( n = 22). These elevations we …

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02.09.2026journal-article

Journal of Medical Internet Research

Consumer and Patient Health Information Seeking With Generative AI Tools: Scoping Review of Facilitators and Barriers

Lilach Alon, Inbar Levkovich

Background Generative AI (GenAI) tools powered by large language models (LLMs) are increasingly used by the public to seek health information. Unlike traditional web search, these systems generate conversational responses that may alter how users assess credibility, manage uncertainty, verify information, and decide whether to consult clinicians. As GenAI becomes more embedded in everyday health information practices, a clearer synthesis of the emerging empirical evidence is needed. Objective This scoping review ma …

02.09.2026journal-article

Journal of Pressure Vessel Technology

Controlling Mechanism of Local Rapid Cooling Heat Treatment to Reduce Internal Cladding Residual Stress of Pressure Vessels

Yun Luo, Yanbin Liu, Yao Zhang, Wenbin Gu, Wenchun Jiang, Qian Zhang

Abstract Due to different material parameters between the cladding layer and the base metal, significant tensile residual stresses still remain within the internal cladding layer after traditional heat treatment, seriously affecting the service safety of pressure vessels. Local rapid cooling heat treatment is an effective method to reduce the tensile residual stress in the cladding layer until a compressive stress state is achieved. In this paper, the influence of local rapid cooling heat treatment process paramete …

02.09.2026journal-article

Skin Health and Disease

Dermatology residency education in the treatment of testosterone-induced acne and androgenic alopecia in trans men: a cross-sectional survey of academic dermatologists in the USA

Thinh Q Nguyen, Zachary Neubauer, Angela Zaladonis, Sherry Yang

This cross-sectional survey study explores the experience, comfort and knowledge of dermatology residents and attendings in managing testosterone-induced acne (TiAV) and androgenic alopecia (TiAGA) in trans men. While most respondents reported some level of comfort treating these conditions, objective knowledge scores were modest and revealed gaps across both conditions, particularly TiAGA. Our findings suggest that current LGBTQIA+-focused education may be perceived as adequate but may not translate into knowledge …

02.09.2026journal-article

Physics in Medicine & Biology

GATE/Geant4 simulation of key dosimetric correction factors for alanine dosimetry in 12 C ion beams

Pascal Saße, Jessica Stolzenberg, Kilian-Simon Baumann, Vanessa Delfs, Ralf-Peter Kapsch, Hugo Palmans, Bjoern Poppe, Hui Khee Looe

Abstract Objective: Alanine has been used frequently as a reference dosimeter in clinical dosimetry. However, its high LET dependence poses a challenge for practical applications. Determination of the required beam quality correction factors requires Monte Carlo simulations. This makes the application of alanine infeasible if dedicated Monte Carlo tools or computing resources are not available. This work sets out to determine generalized alanine correction factors in clinical 12 C beams. Approach: Mathematical expr …

02.09.2026journal-article

Physics in Medicine & Biology

Lu-176 based time skew correction method for TOF-PET detectors

Eiji Yoshida, Fujino Obata, Taiga Yamaya

Abstract Objective. Time calibration is an important procedure for correcting time shifts inherently included in TOF-PET. In this work, we developed a time skew (TS) correction method that uses the intrinsic radioactivity originating from the natural decay of 176 Lu, a constituent element of the scintillator. Approach. The TOF-PET detector has a one-to-one optical coupling between the scintillators and photosensors, enabling independent readout of each channel. For electrical TS correction caused by the electronic …

02.09.2026journal-article

Indian Journal of Surgical Oncology

Patient-Reported Body Image, Pain, and Satisfaction After Breast-Conserving Surgery, Mastectomy, and Mastectomy With Reconstruction: A Cross-Sectional Cohort Study

Noam Weiner, Eran Sharon, Tal Kind, Helit Nakar, Tomer Mimouni, Yehonatan Noyman, Lior Har-Shai, Assi Levi

Abstract Background Surgical treatment for breast cancer may affect long-term body image, pain, and satisfaction, yet the relative contribution of surgical approach and patient-level factors remains uncertain. We evaluated patient-reported outcomes after breast-conserving surgery, mastectomy without reconstruction, and mastectomy with reconstruction. Methods In this cross-sectional cohort study, 230 women treated between 2015 and 2021 at a single Israeli tertiary center completed an investigator-developed Hebrew te …

02.09.2026journal-article

Journal of Craniofacial Surgery

Outcomes and Satisfaction of Chin Augmentation With Expanded Polytetrafluoroethylene (ePTFE) Implants: A 12-Month Retrospective Study

Phung Nguyen Van, Nguyen Thanh Van

Aim: To evaluate the aesthetic outcomes, patient satisfaction, and safety of chin augmentation using expanded polytetrafluoroethylene (ePTFE) implants over 12 months. Methods: Of 152 patients who underwent intraoral ePTFE chin augmentation, 105 with complete 12-month follow-up were analyzed (85 women, 20 men; mean age 29.3 years; all with isolated microgenia and Angle Class I occlusion). The labiomental angle, chin projection, FACE-Q satisfaction score, and complications were assessed preoperatively and at 3, 6, an …

02.09.2026journal-article

Journal of Clinical Medicine

Male Breast Cancer: An Analysis of Clinicopathological Features, Treatment Patterns, and Survival Outcomes over 10 Years from a Tertiary Center

Hüseyin Tepetam, Cemal Ugur Dursun, Mustafa Mert Hanilce, Solen Nasifoglu, Nursena Ciflik, Duygu Gedik, Sermin Kokten, Sule Karabulut Gul

Background/Objectives: Male breast cancer (MBC) is a rare malignancy accounting for less than 1% of all breast cancers, and current treatment recommendations are largely extrapolated from studies in women. We aimed to evaluate the clinicopathological characteristics, treatment patterns, survival outcomes, and prognostic factors of male breast cancer patients treated at a tertiary referral center. Methods: We retrospectively reviewed 45 patients with histopathologically confirmed MBC treated between January 2015 and …

02.09.2026journal-article

Journal of Clinical Medicine

Spermatocytic Tumor Arising in a Cryptorchid Testis: A Case Report and Narrative Review

Laurențiu Augustus Barbu, Stelian-Stefaniță Mogoantă, Liliana Cercelaru, Marius Cristian Marinaș, Nicolae-Dragoș Mărgăritescu, Mihai Popescu, Valentina Căluianu, Gabriel Florin Răzvan Mogoș, Liviu Vasile, Tiberiu Stefăniță Țenea Cojan

Background: Spermatocytic tumor (ST) is a rare non-GCNIS-derived testicular germ cell neoplasm that predominantly affects older men and generally follows an indolent course. Its occurrence in a cryptorchid testis is exceptionally uncommon. Methods: A narrative literature review was conducted using the PubMed database, including studies published up to August 2026. The search used combinations of the terms “spermatocytic tumor”, “spermatocytic seminoma”, “cryptorchidism”, “undescended testis”, “immunohistochemistry” …