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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

International Journal of Public Health and Pharmacology

Effect of Enabling Factors on Blood Pressure Control: A Community-Based Study among Nigerian Seniors in Selected Local Government Areas in Ogun State Nigeria

Fabiyi Gbolahan Akanji, Nnodimele Atulomah, Bello Olufunmilayo Esther, Obube Olumide Abiodun, Obube Motunrayo Ibukun, Fabiyi Oluwadamola Ibiyemi, Solesi Abiodun Olufunso

Hypertension is a prevalent global health issue, particularly among seniors, contributing to severe health complications such as stroke and heart failure. Despite the availability of effective management strategies, poor adherence to treatment regimens remains a significant challenge. This study investigated the effects of enabling and reinforcing factors on blood pressure control among Nigerian seniors aged 60 years and above. The primary objective was to determine enabling factors on blood pressure control among …

03.09.2026journal-article

Journal of Behavioral Medicine

Examining relationships between delay and probability discounting and perceived stress in a high-income online sample

Mary J. King, Michelle Rockwell, John Epling, Jeffrey S. Stein

Abstract Previous studies have shown a positive association between perceived stress and delay discounting (DD; devaluation of a consequence as a function of its delay); individuals experiencing high levels of stress tend to prefer smaller, immediate rewards over larger, delayed rewards. However, the link between perceived stress and DD may be confounded by their mutual and well-documented association with socioeconomic disadvantage (e.g., low income, scarcity). Moreover, few studies have examined the association b …

03.09.2026journal-article

JPGN Reports

Referral patterns and patient characteristics in pediatric feeding disorder care at a multidisciplinary outpatient clinic

Edward Tannenbaum, Riad Rahhal, Linda Cooper‐Brown, Willow Cover, Adam Vaske, Dina Al‐Zubeidi

Abstract Objectives Pediatric feeding disorders (PFDs) are increasingly prevalent in the United States. Limited research has examined referral characteristics for outpatient feeding programs. This study analyzes patient referral characteristics based on referral patterns, patient demographics, and treatment interventions. Methods A retrospective cohort study was conducted of pediatric patients evaluated in a multidisciplinary outpatient feeding clinic at a tertiary pediatric academic institution from 2021 to 2024. …

03.09.2026journal-article

Bioengineering

Patient-Reported Knee Function Versus Star Excursion Balance Performance as Correlates of Psychological Return-to-Sport Readiness After Anterior Cruciate Ligament Reconstruction

Ryan T. Halvorson, Aidan Foley, Hayden Sampson, Cameron Nosrat, Drew A. Lansdown, Brian T. Feeley, Jeannie F. Bailey

Background: Psychological readiness, quantified by the Anterior Cruciate Ligament Return to Sport after Injury (ACL-RSI) scale, is one of the most consistent correlates of return-to-sport success following ACL reconstruction. Whether psychological readiness reflects an independent construct or is related to measured functional performance is not known. Purpose: To evaluate the associations between patient-perceived knee function and objective performance on a functional task, as quantified by traditional scoring, k …

03.09.2026journal-article

Nutrients

Unmetabolized Folic Acid: Biology, Epidemiology, and Clinical Consequences: A Systematic Review

Richard E. Frye, Daniel A. Rossignol

Background: Mandatory folic acid (FA) fortification prevents neural tube defects but generates unmetabolized folic acid (UMFA) in blood, because hepatic dihydrofolate reductase (DHFR) reduces FA only slowly. Whether UMFA itself, as distinct from high total folate, carries biological consequences is unresolved. Methods: We systematically searched six databases (January 1995–May 2026; PROSPERO CRD420261407616) and included 65 publications describing 61 unique primary studies, yielding 71 analytic contributions (15 me …

03.09.2026journal-article

British Journal of Sports Medicine

Prevalence and cardiac outcomes of T wave inversions in high school athletes: an analysis of 15 years of preparticipation screening ECGs

Zachary P Morehouse, Dermot M Phelan, David E Price

Objective To characterise the prevalence, distribution pattern and clinical relevance of T wave inversion (TWI) on a screening preparticipation 12-lead ECG in high school athletes. Methods A retrospective cohort study analysed ECGs from athletes screened between 2010 and 2025 during a preparticipation event. Athletes with TWI in ≥2 contiguous leads were included. Longitudinal cardiac outcomes were assessed via electronic health records, semistructured interviews and extensive media and death registries review. Resu …

03.09.2026journal-article

PLOS One

Lung cancer risk prediction using interpretable ensemble models on lifestyle and clinical data

Shahid Mohammad Ganie, Pijush Kanti Dutta Pramanik, Zhongming Zhao

Lung cancer remains one of the leading causes of cancer-related mortality worldwide, where early detection and reliable risk assessment are critical for improving outcomes. This study develops and evaluates a range of ensemble learning models for lung cancer prediction using lifestyle and clinical indicators, with an emphasis on both predictive performance and interpretability. Five base learners—logistic regression, k-nearest neighbors, naïve Bayes, support vector machine, and linear discriminant analysis—were use …

03.09.2026journal-article

Frontiers in Endocrinology

Longitudinal clinical trajectories and vascular–inflammatory–neurophysiological associations in diabetic peripheral neuropathy: an exploratory analysis of a TENS-treated cohort

Qian Gao, Liwan Yang, Bin Wang, Lijuan Gao, Qing Yao, Jiangwei Hu

Background Transcutaneous electrical nerve stimulation (TENS) is used as an adjunctive treatment for diabetic peripheral neuropathy (DPN), but long-term clinical trajectories vary among patients. The biological characteristics associated with these different trajectories remain incompletely characterized. This study aimed to identify longitudinal clinical trajectory patterns and examine their associations with vascular, inflammatory, and neurophysiological measures. Methods Prospective 24-month data from 685 patien …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Connective tissue disorders and cardiac arrhythmias: genetic pathways, mechanistic bridges, and clinical implications

Luke Dreher, Hussein Abdul Nabi, Ramzi Ibrahim, Mahmoud Abdelnabi, Omar Baqal, Christopher N. Kanaan, Min Choon Tan, Linnea M. Baudhuin, Fadi E. Shamoun, Hicham Z. El Masry

Background Connective tissue disorders (CTDs) such as Marfan syndrome, Loeys-Dietz syndrome, and Ehlers-Danlos syndromes are traditionally defined by vascular fragility and aortic complications. Increasing evidence, however, demonstrates that CTDs also predispose to atrial and ventricular arrhythmias, often independent of overt cardiomyopathy or severe valvular disease. Content This review integrates emerging data on the arrhythmogenic substrates of CTDs. Four mechanistic bridges are emphasized: (1) diffuse myocard …

03.09.2026journal-article

Frontiers in Pharmacology

The clinical trial landscape of bispecific antibodies in non-small cell lung cancer: mechanistic trends and developmental strategies

Zunyuan Li, Xiyu Wang, Qin Shi, Yuhong Guo, Guirong Dong, Zhidan Liu

Background Non-small cell lung cancer (NSCLC) management remains constrained by acquired resistance to targeted therapies and refractoriness to immune checkpoint inhibitors (ICIs), the latter driven largely by the immunosuppressive tumor microenvironment (TME). Bispecific antibodies (bsAbs) represent a promising modality capable of circumventing these therapeutic hurdles through proximity-driven dual-targeting mechanisms that co-block bypass signaling pathways and reverse immunosuppression. This study systematicall …

03.09.2026journal-article

Ege Tıp Dergisi

Changes in public interest in plastic surgery over time: A comprehensive global perspective using google trends. No job, Yes Aesthetics?

Ecem Esma Yeğin, Mehmet Emre Yeğin

Aim: Google Trends has become an essential resource in health research, providing valuable insights into evolving public interest patterns. Social media platforms significantly influence public interest in cosmetic surgery, with effects observed across age groups. Research shows a clear connection between social media exposure and heightened public interest, serving as a means for surgeons to educate patients and market their services.Material and Methods: This study uses Google Trends data to analyze changes in in …

03.09.2026journal-article

Frontiers in Public Health

Community music activity participation and loneliness among Chinese young adults living alone

Yundi Pian, Yafei Yu

Background Loneliness has become an increasingly salient psychological and social issue among young adults in contemporary urban China. Young adults living alone may be particularly vulnerable because of reduced daily companionship, limited opportunities for sustained social interaction, and relatively weak emotional support networks. As an accessible form of cultural and social participation embedded in community settings, community music activity may be relevant to loneliness among young adults living alone. Howe …

03.09.2026journal-article

British Journal of Nursing

Colostomy formation for neurogenic bowel dysfunction after spinal cord injury: a national survey

Michelle Boucher

Background: Neurogenic bowel dysfunction significantly affects those living with spinal cord injury (SCI). Guidelines position colostomy as a last resort, but this is not reflected in current practice. Pathways and professional attitudes are inconsistent. Aim: Explore the attitudes of health professionals towards colostomy as an option for people living with SCI. Methods: Online questionnaire for health professionals; descriptive statistics and thematic analysis. Results: 122 responses. Indications for colostomy: i …

03.09.2026journal-article

Journal of Cybersecurity and Privacy

QKD-Assisted Secure Transport Framework for Federated Healthcare Systems: A Software Prototype and Baseline Evaluation

Fardin Muttaki, Aqeel Sahi, Shahab Abdulla

Decentralised machine learning requires authenticated transport to secure exchanged model updates. To this end, this study presents a healthcare-focused proof of concept integrating a quantum key distribution (QKD) simulation with HKDF-SHA-256, AES-256-GCM, role-based access control, replay detection, and sample-weighted federated averaging (FedAvg), and evaluates it on 42,989 medical records across 1107 synthetic patients. A trusted server decrypted authorised updates before plaintext aggregation. Centralised logi …

03.09.2026journal-article

Geriatrics

A Patient- and Function-Centric Model/Approach for Hypoglycemia Management in Older Adults

Kannayiram Alagiakrishnan, Laurie Mereu, Gulelala Rahim, Mahua Ghosh, Albert Vu

Diabetes-related hypoglycemia contributes substantially to increased morbidity, mortality, health-care utilization, and reduced quality of life. Older adults with diabetes represent a heterogeneous group of patients who need individualized blood glucose targets to avoid hypoglycemia. Since the elderly present with varying degrees of functional and cognitive status and individualized health needs, their management varies among individuals. Complicating this, the hypoglycemia risk in older adults treated with insulin …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Integrating conformal prediction with machine learning for uncertainty-aware risk stratification in coronary artery disease

Shengnan Lin, Xuyang Hu, Yang Zhang, Qi Zhang, Xiaoning Wang, Yang Yang, Fuzheng Song, Yutong Li, Yushan Liu, Yuanpeng Zhao, Dingjian Zhao, Minghua Nan, Changchuan Bai

Background Predictive models are increasingly used in clinical decision-making in coronary artery disease (CAD). However, most existing models focus on discriminative ability while ignoring individual prediction uncertainty, which is particularly prominent in small-sample contexts, limiting clinical applications. Methods We developed an uncertainty-aware model integrating machine learning and conformal prediction (CP) for CAD prediction in a small-sample setting cohort ( N = 297). Logistic regression (LR) and rando …

03.09.2026journal-article

Frontiers in Dental Medicine

Case Report: Dental treatment under general anesthesia for a child with Ullrich congenital muscular dystrophy

SokIok Cheang, WeiYun Chen, Shuang Wang, XinXin Wang, Kuo Wan, Lin Ma

Background Ullrich congenital muscular dystrophy (UCMD) is a rare inherited myopathy caused by mutations in the COL6 gene and is frequently associated with multisystem complications affecting the respiratory and skeletal systems, which may increase airway and anesthetic risks during dental treatment. Case report This report describes a 4-year-old girl with UCMD who presented with pain in the left lower molar. After a comprehensive multidisciplinary evaluation by the Department of Stomatology, Anesthesiology, and Pe …

03.09.2026journal-article

Frontiers in Public Health

High-magnification inpatient cases under DIP payment reform: prevalence, cost burden, and risk factors in an NHC-administered hospital in China

Jianjun Lu, Zhuochen Lin, Ziyi Xin, Junfeng Liu, Yuting Gu, Ying Xiong, Wujun Zhang

Background The nationwide rollout of Diagnosis-Intervention Packet (DIP) payment reform in China aims to enhance inpatient cost efficiency, yet high-magnification cases impose escalating financial burdens on tertiary hospitals. This study characterized the cost profiles and independent determinants of high-magnification cases under DIP to inform precision cost governance and medical insurance policy optimization. Methods This retrospective observational study included 191,490 consecutive inpatient admissions from a …

03.09.2026journal-article

Frontiers in Clinical Diabetes and Healthcare

Moisturizer formulations for diabetic foot xerosis: a systematic review and meta-analysis of randomized controlled trials

Karin Borgström, Sebastian Björklund, Petri Gudmundsson, Anna Ericsson, Stefan Acosta

Background Foot xerosis in people with diabetes increases the risk of skin fissuring, ulceration and complications like amputation, sepsis and death. Preventive skin care is therefore important, yet evidence-based guidance on the most effective formulations remains limited. This systematic review aimed to identify effective ingredients and formulations to treat diabetic foot xerosis. Methods A literature search was conducted in Medline, Cinahl, Embase, CENTRAL and Scopus. Randomized controlled trials (RCTs) involvi …

03.09.2026journal-article

British Journal of Sports Medicine

Graft type is not associated with revision ACL reconstruction in football players: a nationwide cohort analysis of subsequent ACL reconstructions

Alexander Sandon, Magnus Forssblad

Objective To determine whether autograft type (hamstring, patellar or quadriceps tendon) is associated with risk of revision anterior cruciate ligament reconstruction (ACLR) or contralateral ACLR in football players. Methods Nationwide cohort included all primary ACLRs performed in registered football players in Sweden between 2014 and 2023, identified by linkage of the Swedish Knee Ligament Registry and the Swedish Football Association. Return to competition (RTC) was defined as participation in at least one offic …

03.09.2026journal-article

Journal of Clinical Medicine

Association Between Lactate Trajectories and Clinical Outcomes in Critically Ill Patients with Sepsis-Associated Liver Injury

Hong Wei, Jian Zhang, Sijie Yu, Cheng Zhang, Yunlong Weng, Min Shao

Background: Sepsis-associated liver injury (SALI) is a severe complication of sepsis that significantly increases the risk of mortality in intensive care unit (ICU) patients. While lactate is recognized as a prognostic biomarker for sepsis, the predictive potential of dynamic lactate trajectories in patients with SALI has not been investigated. This study aims to elucidate the association between serum lactate trajectories and clinical outcomes. Methods: Latent class trajectories of serum lactate dynamics were mode …

03.09.2026journal-article

Journal of Clinical Oncology

Molecularly Guided Therapy Versus Continued Chemotherapy in Unfavorable Cancer of Unknown Primary: Updated Efficacy and Safety From the Randomized, Phase II CUPISCO Study

Alwin Krämer, Tilmann Bochtler, Chantal Pauli, Kai-Keen Shiu, Natalie Cook, Juliana Janoski de Menezes, Roberto A. Pazo-Cid, Ferran Losa, Debbie G.J. Robbrecht, Jiří Tomášek, Cagatay Arslan, Mustafa Özgüroğlu, Panoraia Arni, Frederic Bigot, Sun Young Kim, Yoichi Naito, Antoine Italiano, Nasséra Chalabi, Gonzalo Durán-Pacheco, Ning Ma, Jeremy Scarato, Jeffrey S. Ross, Holger Moch, Linda Mileshkin

CUPISCO (ClinicalTrials.gov identifier: NCT03498521 ) demonstrated longer progression-free survival (PFS) with comprehensive genomic profiling (CGP) and subsequent molecularly guided therapies (MGTs), versus standard platinum-based chemotherapy, in patients with previously untreated, unfavorable cancer of unknown primary (CUP) who reached disease control after induction chemotherapy (three cycles). We report efficacy and safety after >1 year of additional follow-up. Eligible patients were randomly assigned (3:1) to …

03.09.2026journal-article

PLOS Medicine

Association between nirsevimab coverage and pediatric emergency department visits for bronchiolitis in 12 European countries: An interrupted time-series analysis

Léa Lenglart, Luigi Titomanlio, Ilaria Alberti, Laura Almeida, Camille Aupiais, Esra Akyüz Özkan, Michael Barrett, Romain Basmaci, Ahmet Birbilen, Dorine Borensztajn, Catarina Braz Schönenberger, Silvia Bressan, Danilo Buonsenso, Teresa Campos, Susana Castanhinha, Antonio Chiaretti, Gemma Claret, Francesca De Zan, Sheena Durnin, Laszlo Fodor, Borja Gomez, Susanne Greber-Platzer, Romain Guedj, Alexander Huege, Fiona Leonard, Ian K. Maconochie, Robin Marlow, Gregorio Milani, Miguel Angel Molina Gutierrez, Anna Maria Musolino, Rianne Oostenbrink, Zanda Pucuka, Simon Rivière, Damian Roland, Malin Ryd Rinder, Maria Chiara Supino, Ozlem Teksam, Victoria Trenchs, Zaba Valtuille Liebert, Bento Vanda

Background Nirsevimab was introduced to prevent Respiratory Syncytial Virus (RSV) bronchiolitis in infants. Despite its proven effectiveness and similar guidelines across Europe, bronchiolitis reduction varied across Europe. This study explored whether nirsevimab coverage among targeted populations (born in- and out-of-season) was associated to this variability. Methods and findings We used routinely collected data from 27 pediatric emergency departments across 12 European countries (01/2018–03/2024). All bronchiol …

03.09.2026journal-article

Academia de Direito

A influência das organizações internacionais na legislação brasileira: um olhar aplicado ao direito internacional público e sua internalização normativa

Carolina Martins de Andrade, Mallú de Mendonça Barros

The phenomenon of globalization has intensified the role of international organizations in shaping national legal systems. In this context, the study aimed to analyze how international organizations influence the formation and evolution of Brazilian legislation, particularly in the context of international cooperation and the recovery of illicit assets, with the specific objectives of examining the main instruments or means of influence used by international organizations under Brazilian law—such as treaties, guide …