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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Frontiers in Public Health

High-magnification inpatient cases under DIP payment reform: prevalence, cost burden, and risk factors in an NHC-administered hospital in China

Jianjun Lu, Zhuochen Lin, Ziyi Xin, Junfeng Liu, Yuting Gu, Ying Xiong, Wujun Zhang

Background The nationwide rollout of Diagnosis-Intervention Packet (DIP) payment reform in China aims to enhance inpatient cost efficiency, yet high-magnification cases impose escalating financial burdens on tertiary hospitals. This study characterized the cost profiles and independent determinants of high-magnification cases under DIP to inform precision cost governance and medical insurance policy optimization. Methods This retrospective observational study included 191,490 consecutive inpatient admissions from a …

03.09.2026journal-article

Frontiers in Clinical Diabetes and Healthcare

Moisturizer formulations for diabetic foot xerosis: a systematic review and meta-analysis of randomized controlled trials

Karin Borgström, Sebastian Björklund, Petri Gudmundsson, Anna Ericsson, Stefan Acosta

Background Foot xerosis in people with diabetes increases the risk of skin fissuring, ulceration and complications like amputation, sepsis and death. Preventive skin care is therefore important, yet evidence-based guidance on the most effective formulations remains limited. This systematic review aimed to identify effective ingredients and formulations to treat diabetic foot xerosis. Methods A literature search was conducted in Medline, Cinahl, Embase, CENTRAL and Scopus. Randomized controlled trials (RCTs) involvi …

03.09.2026journal-article

Journal of the National Comprehensive Cancer Network

Comparative Cost-Effectiveness Analysis of First-Line Immunotherapy for Advanced Melanoma Based on 10-Year Clinical Outcomes

Guiyuan Xiang, Yin Sun, Xue Yang, Yao Liu

Background: Recently, the CheckMate 067, KEYNOTE-006, and RELATIVITY-047 trials demonstrated the long-term efficacy and safety of 5 first-line therapies for advanced melanoma, including nivolumab + relatlimab, with >10 years of follow-up. However, the long-term economic outcomes are still unclear. This study aimed to assess the comparative cost-effectiveness of these strategies from a US health care perspective using more than a decade of clinical trial data. Methods: Based on the data from clinical trial reports, …

03.09.2026journal-article

Frontiers in Digital Health

A pilot study of at-home online cognitive screening prior to primary care wellness visits for older adults

Louisa Thompson, Charles Eaton, Sarah Prieto, Molly Lawrence, Stephanie Czech, Jennifer Rosenbaum, David Anthony, Rabin Chandran, Lauren Kelly, Ivy Ngo, Arnold Goldberg, Caitlin Gillooly, Caroline Richardson, A. Rani Elwy, Richard N. Jones, Dorene M. Rentz

Background Improved methods of cognitive testing are urgently needed for primary care settings faced with a growing older adult population and higher rates of dementia. We tested the feasibility and acceptability of a novel online cognitive test that can be completed at home prior to an annual exam. Methods 32 older adults completed testing at home on personal devices 1–4 weeks prior to an annual exam with their primary care provider. Additional cognitive screening was completed in-clinic to provide preliminary val …

03.09.2026journal-article

International Journal of Gynecology & Obstetrics

Maternal and neonatal outcomes associated with expanded antibiotic therapy in preterm prelabor rupture of membranes

Juan Manuel Burgos‐Luna, Laura Soto Giraldo, Maria Alejandra Suarez‐Revelo, Juan Sebastián Galindo‐Sánchez, Isabella Mejia Rodriguez, Mariana Cordoba Munoz, Albaro Jose Nieto‐Calvache

Abstract Objective To compare maternal and neonatal outcomes in women with preterm prelabor rupture of membranes (PPROM) managed expectantly with either ampicillin–erythromycin or an institutional alternative regimen combining ampicillin, ceftriaxone, and clarithromycin. Methods This was a retrospective historical cohort study at a tertiary referral center in Cali, Colombia, including women with singleton pregnancies and confirmed PPROM between 24 +0 and 34 +6 weeks (January 2019–December 2024). Ampicillin–erythrom …

03.09.2026journal-article

Nutrients

Unmetabolized Folic Acid: Biology, Epidemiology, and Clinical Consequences: A Systematic Review

Richard E. Frye, Daniel A. Rossignol

Background: Mandatory folic acid (FA) fortification prevents neural tube defects but generates unmetabolized folic acid (UMFA) in blood, because hepatic dihydrofolate reductase (DHFR) reduces FA only slowly. Whether UMFA itself, as distinct from high total folate, carries biological consequences is unresolved. Methods: We systematically searched six databases (January 1995–May 2026; PROSPERO CRD420261407616) and included 65 publications describing 61 unique primary studies, yielding 71 analytic contributions (15 me …

03.09.2026journal-article

Clinical Pharmacology & Therapeutics

Integrating Patient‐Centric Clinical Pharmacology and MID3 to Advance Biologic Development in Immune‐Mediated Inflammatory Diseases

Sihem Ait‐Oudhia, Li Zhang, Dipak S. Pisal, Brian Cicali

Advances in biologics and model‐informed drug discovery and development (MID3) are transforming the treatment of immune‐mediated inflammatory diseases (IMIDs). By integrating pharmacokinetics and pharmacodynamics, MID3 enables mechanism‐based, patient‐centered strategies to optimize therapies, strengthen benefit–risk assessment, and advance precision medicine. Innovations such as cytokine inhibitors, bispecific antibodies, antibody–drug conjugates, and mRNA therapies have expanded treatment options across dermatolo …

03.09.2026journal-article

Emergency Medicine Australasia

Using Sydney Triage to Admission Risk Tool With Artificial Intelligence ( START ‐ AI ) to Predict Inpatient Admitting Specialty for Emergency Department Patients: Single Centre Deep Learning Analysis

Michael Dinh, Elizabeth Corbett, Thuy Truc Ngo, Eliot Salmon, Saleem Ahmed Khan, Farhana Pethani, Nicholas Moore, Irena Koprinska

ABSTRACT Objective To investigate whether the Sydney Triage to Admission Risk Tool with Artificial Intelligence (START‐AI) model could be used to predict specific inpatient admitting teams based on clinical notes. Methods This was a pre‐trained language model analysis using electronic medical record data from an inner‐city tertiary referral hospital emergency department (ED) in Sydney, Australia. All adult patients who were admitted to an inpatient ward between January 2023 and June 2025 were included. A fine‐tuned …

03.09.2026journal-article

Academic Journal of Education

Construction of a Traditional Chinese Medicine Cultural Education Practice System Driven by “Inheritance–Integration–Innovation”: An Exploration of Integrating Distinctive Traditional Chinese Medicine Resources with Modern Educational Technologies

Ran Zhang, Tao Ruan

Education in traditional Chinese medicine (TCM) culture is an important means of carrying forward China’s fine traditional culture. How to provide this process with a strong cultural foundation while ensuring that it conforms to the principles of educational development has become a key issue in establishing and improving the teaching system for knowledge-oriented courses. Taking “inheritance–integration–innovation” as its three analytical dimensions, this paper defines the practical education system in terms of bo …

03.09.2026journal-article

Clinical Dermatology Review

An Observational Study on Mucocutaneous Eruption Secondary to Mycoplasma pneumoniae: Alphabet Soup of Reactive Infectious Mucocutaneous Eruption or Mycoplasma pneumoniae-induced Rash and Mucositis

Swapnil Shah, Shibhani Sudheer Hegde, Chetan D. Rajput, Sandeep Kulkarni

Abstract Background: In 2015, diagnostic criteria for Mycoplasma pneumoniae -induced rash and mucositis (MIRM) were recommended, and currently, reactive infectious mucocutaneous eruption (RIME) is preferred. Due to the relatively recent introduction of this disorder, clinicians are still not extensively primed regarding the morphology and diagnosis of MIRM. Materials and Methods: A retrospective study was undertaken in a referral children’s hospital in Western India over 6 months where children concomitantly affect …

03.09.2026journal-article

Journal of Hospital Medicine

The implementation of an innovative just‐in‐time educational huddle for faculty development of academic hospitalists

Donna Coetzee, Suman Pal, Elizabeth Davis, Andrew P. J. Olson, Melissa Plesac

Abstract Academic hospitalists supervising residents on inpatient wards face the dual challenge of managing changing patient complexity and learner needs. Resident experience is highly dependent on supervising faculty; however, traditional faculty development often fails to respond to real‐time challenges of clinical teaching. To provide just‐in‐time faculty development, we implemented a weekly educational huddle for hospitalists rotating on resident ward teams using a Community of Practice model. The huddle emphas …

03.09.2026journal-article

Journal of Palliative Medicine

Palliative Surgery to Restore Function and Dignity: A Case of Massive Breast Tumor Debulking in Rural Uganda

Simran Kripalani, Howard Eison, Goretti Nassali, Prossy Nafula, Benjamin Schwarz, Randi Diamond

Background: Palliative surgery plays a critical role in alleviating symptom burden and thus improving quality of life in patients with advanced disease. Case Presentation: This is a case of a 23-year-old female in rural Uganda with an untreated, massive right breast mass present since infancy and progressive abdominal distention of unclear etiology. Over time, the breast mass impaired her mobility, rendering her largely homebound and dependent on others for basic movement. Despite evidence of profound malnutrition, …

03.09.2026journal-article

Journal of Intensive Care Medicine

Hypoxic Hepatitis in Critically Ill Patients: Incidence, Clinical Characteristics, and Outcomes — A Systematic Review and Meta-Analysis

Carlos David Trevilla Martínez, Yeison Cruz Castillo, Mariela Denise Fermin Madera, Supritha Chintamaneni, Brenda Tatiana Camacho Ramirez, Laura A. Gray, Gabriela Flores Monar, Bansi Sutariya, Camila Sanchez Cruz, Ernesto Calderón-Martinez, Sushovan Guha, Rashmi Advani

Background Hypoxic hepatitis (HH), also termed ischemic hepatitis and historically described as shock liver, is an acute liver injury syndrome in critically ill patients characterized by a rapid and marked rise in aminotransferases in the setting of circulatory, cardiac, or respiratory failure, after exclusion of other causes of acute hepatic injury. Despite its clinical relevance, the true incidence and prognostic significance of HH remain unclear. This systematic review and meta-analysis aimed to determine the po …

03.09.2026journal-article

Borneo Nursing Journal (BNJ)

Hubungan Obesitas Sentral Terhadap Kejadian Hipertensi Pada Wanita Di Wilayah Kerja Puskesmas Sedayu 2

Rahma Annisa, Siti Fadhilatun Nashriyah, Dewi Rizzky Mutiarasari

Hypertension is a major non-communicable disease and a significant public health concern because it increases the risk of cardiovascular disease, stroke, and kidney failure. Central obesity, characterized by excessive abdominal fat accumulation, is one of the modifiable risk factors associated with elevated blood pressure. This study aimed to determine the relationship between central obesity and the incidence of hypertension among adult women. An analytical observational study with a cross-sectional design was con …

03.09.2026journal-article

Artefactum - revista de estudos interdisciplinares

LONG COVID THROUGH A ONE HEALTH LENS: CLINICAL, SOCIAL, AND ENVIRONMENTAL FACTORS IN THE AMAZON

Ailson Almeida Veloso Junior, Luiz Fábio Magno Falcão, Junior da Silva Gomes, Yasmin Roque Sousa, Yasmin Barreiros da Silva, Valeria Gonçlaves da Mata, Naylane de Farias Caldas, Gabriele Farias Martins, Valeria Gonçalves da Mata

Objective: To characterize persistent manifestations following COVID-19 and analyze their associations with clinical, social, environmental, and psychosocial factors among individuals from the Brazilian Amazon from a One Health perspective. Methods: This observational, cross-sectional, analytical epidemiological study included a retrospective component addressing acute SARS-CoV-2 infection. The analysis comprised 98 participants. High symptom burden was exploratorily defined as four or more post-COVID manifestation …

03.09.2026journal-article

Humanities and Social Sciences Communications

Psychosocial predictors and justification patterns of traditional and alternative medicine in Peru

Angelo Fasce, Jose Rosales-Trabuco, Javier Rodriguez-Ferreiro, Itxaso Barberia, Elvis Pinedo-Yzaguirre, Juan Manuel Espinoza Nunez, Wilson Marcos Ortiz-Treviños, Christian David Pizarro-Moncada, Mario Reyes-Bossio, Carlos Carbajal-León, Ezequiel Lopez-Lopez

Abstract This mixed-methods study investigates the prevalence, attitudes, psychological predictors, and reasons for perceived effectiveness of traditional and alternative medicine in Peru. A representative national sample ( N = 805) reported their experiences with 16 unconventional medical techniques, alongside psychometric measures of pseudoscientific beliefs, ideological traditionalism, and trust in the medical profession. Traditional medicine was more widely used, while alternative medicine elicited more favorab …

03.09.2026journal-article

El-Mal: Jurnal Kajian Ekonomi & Bisnis Islam

The Effect of Service Quality, Trust, Hospital Image and Facilities on Patient Satisfaction in Outpatient Pharmacy Services

Jaka Arifin Budiyana, Istiatin Istiatin, Oong Ridhoi

This research aims to test and analyze the influence of service quality, trust, hospital image and facilities on patient satisfaction in outpatient pharmacy services at Dr. RM. Soedjarwadi Mental Hospital. The research method used is quantitative. The number of samples used was 100 respondents with instrument testing in the form of validity and reliability tests. Furthermore, the research data was analyzed using Multiple Linear Regression, F-Test, t-test, and Coefficient of Determination. The results of the study i …

03.09.2026journal-article

Frontiers in Oncology

APIM-guided dyadic nursing after colorectal cancer surgery: a propensity score-matched cohort study

Huili Du, Jing Wang

Background Recovery after colorectal cancer surgery is influenced not only by patient symptoms but also by caregiver capacity, psychological distress, self-efficacy, and dyadic coping. However, real-world evidence on Actor–Partner Interdependence Model (APIM)-guided dyadic nursing in routine postoperative care remains limited. Objective To examine the association between documented exposure to APIM-guided dyadic nursing and 6-month postoperative outcomes among colorectal cancer patient–caregiver dyads, and to explo …

03.09.2026journal-article

Frontiers in Medicine

Redox imbalance in infertility and assisted reproduction: biomarkers, mechanisms, multi-omics integration, and personalised therapeutic strategies

Braulio Peramo, Divyesh Upadhyay, Linda Bouhafs, Habiba Alsafar

Redox biology occupies a central but paradoxical role in human reproduction. Reactive oxygen species (ROS) are indispensable mediators of sperm capacitation, oocyte activation, embryo development, and trophoblast invasion, yet excessive ROS generation causes oxidative stress that damages gametes, impairs preimplantation development, and compromises implantation. Conversely, reductive stress, an emerging but still underappreciated state in which antioxidant defences exceed physiological need, may suppress the low-le …

03.09.2026journal-article

Frontiers in Nutrition

Beyond donor eligibility: nutritional and lifestyle heterogeneity and implications for long-term donor health preservation

Elisa Mazza, Samantha Maurotti, Yvelise Ferro, Francesca Rita Noto, Carmelo Pujia, Nancy Paone, Alessia Sestito, Marta Moraca, Ilda Fatima Martino, Arturo Pujia, Tiziana Montalcini

Background Blood donor eligibility is essential for donation safety, but it may not fully capture nutritional, metabolic, and lifestyle-related vulnerabilities that can affect donor health over time. As transfusion systems increasingly rely on regular donors, identifying modifiable factors that may support long-term donor health and retention is becoming increasingly relevant. This study aimed to characterize nutritional and lifestyle heterogeneity, peri-donation dietary behaviors, and donation-related outcomes in …

03.09.2026journal-article

American Journal of Audiology

Exploring the Continuing Education Experiences and Needs of Hearing Health Care Professionals: A Survey-Based Study

Robin O'Hagan, Janani Rajendra, Chris Allan, Marlene Bagatto, Ioan Aurelian Curca, Matt Lucas, Ewan Macpherson, Christine Meston, Sheila Moodie, Vijay Parsa, David Purcell, Jack Scott, Susan Scollie, Susan Stanton, Danielle Glista

Purpose: Continuing education in hearing health care encompasses a range of opportunities, including formal academic training, professional certification and credentialing, technical or job-specific instruction, professional development events, and personal or general skill enhancement. This study examined the continuing education experiences and needs of hearing health care professionals to inform the design and delivery of future educational initiatives tailored to this workforce. Method: Members of the National …

03.09.2026journal-article

Frontiers in Nutrition

The effects of maternal dietary fiber and short-chain fatty acids on the health of offspring: a mini review

Shaozhi Liu, Senling Feng, Zhongwen Yuan, Zhengrong Mei, Jinjin Yin, Lei Chen, Yongxia Zhang

Maternal nutrition during pregnancy is a critical determinant of offspring long-term health. Dietary fiber has emerged as a key modifiable factor. Through gut microbial fermentation, fiber is converted into short-chain fatty acids (SCFAs), primarily acetate, propionate, and butyrate. This mini review synthesizes current evidence from molecular, animal, and human studies on the role of maternal SCFAs in programming offspring metabolic and immune health. Mechanistically, SCFAs act via two complementary pathways: acti …

03.09.2026journal-article

Frontiers in Neuroscience

How physician relationships with neurotechnology companies impact clinical practice: interviews with physicians

Meredith V. Parsons, Judith M. Mwobobia, Erin D. Solomon, Michael Kudom-Agyemang, James M. DuBois, Tristan McIntosh

Introduction Physicians and neurotechnology companies each play a critical collaborative role when integrating neurotechnology into clinical practice. Physicians serve as gatekeepers and decision-makers in adopting neurotechnology, while companies often support the development, training, and maintenance of these devices. Relationships with industry require physicians to navigate complex clinical, ethical, and technological factors that affect their clinical roles. To understand physicians’ relationships with neurot …

03.09.2026journal-article

Frontiers in Medicine

Development and validation of an automatic machine learning-based myocardial contusion prediction model in rib fracture patients: a retrospective multicenter cohort study

Yan Yang, Ping Liu, Ni Jia, Yisha Xu, Peng Wu, Zhigang Zhang, Tingyong Han, Yan Jiang, Xianpeng Huang, Long Li

Objective This study aims to construct an automatic machine learning-based prediction model to accurately identify the risk of myocardial contusion in traumatic rib fracture patients, addressing the core limitations of insufficient sensitivity in traditional diagnostic methods and difficulties in clinical translation of existing prediction models. Methods A multicenter retrospective study design was adopted, including 1,038 rib fracture patients from 8 hospitals (training set: 808 cases; testing set: 230 cases) fro …