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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

Experimental & Molecular Medicine

The long non-coding RNA-encoded microprotein MKKS3 drives colorectal cancer chemoresistance

Hui-Fang Hu, Qi Zhou, Jia-Zhen Huang, Jia-Ying Fu, Zhi-Ting Zuo, Qing-Yu He

Abstract Although oxaliplatin is widely used in the frontline treatment of colorectal cancer (CRC), CRC recurrence is commonly observed owing to oxaliplatin resistance. The roles of long non-coding RNAs-encoded microproteins in oxaliplatin chemoresistance remain inadequately explored. In this study, a CRISPR/Cas9 library was developed to target previously identified 314 microproteins translated from long non-coding RNAs, followed by functional screening. This strategy identified MKKS3, encoded by NR_072977, as a ke …

02.09.2026journal-article

Biomedicines

Gut Microbiota and Brain Aging: Identifying Keystone Biomarkers for Cognitive Health

Muskan Bhatia, Sidharth P. Mishra, Raghvendra K. Mishra, Shalini Jain, Hariom Yadav, Rajesh S. Tomar

The fact that the population is getting older has greatly increased the occurrence of cognitive decline and neurodegenerative diseases, underlining the importance of having reliable biomarkers that can measure biological aging before irreversible neurological damage takes place. New evidence shows that brain aging is not just the result of changes within neurons themselves but is also greatly affected by the gut microbiota via immune, metabolic, endocrine, and neurovascular signaling. This review brings together th …

02.09.2026journal-article

World Advances in Renal Medicine

Antibiotic catheter lock: An adjunct therapy for recurrent tunneled hemodialysis catheter infections

Ahmed Atris, Issa Al Salmi, ThaMr.een Al Zadjali, Adham Ahmed, Muhammed Elneel, Michael Mamdouh Soliaman, Hamed Ali Said Al Shahri

The objective of the study is to evaluate the use of antibiotic catheter locks in reducing recurrent catheter-related bloodstream infections (CRBSIs) in hemodialysis (HD) patients. This prospective case series was conducted at ASeeb Renal Dialysis Center, from September 2022 to August 2023, including four hemodialysis outpatients with recurrent catheter-related infections. All patients were unfit for an arteriovenous fistula (AVF) or graft (AVG) and were maintained on dialysis via their last access option, which wa …

02.09.2026journal-article

Journal of Clinical Medicine

The Prognostic Value of the Advanced Lung Cancer Inflammation Index on Disease-Free Survival in Patients with Gastric Cancer Receiving Neoadjuvant Chemotherapy

Mahmut Kara, Muslih Ürün, Senar Ebinç, Yasin Sezgin, Yonca Yılmaz Ürün, Mehmet Naci Aldemir

Objectives: The present study investigated whether the pre-treatment Advanced Lung Cancer Inflammation Index (ALI) could serve as a prognostic indicator of disease-free survival (DFS) in patients with locally advanced gastric cancer treated with neoadjuvant chemotherapy followed by curative D2 gastrectomy. Methods: We retrospectively analyzed 157 patients with gastric adenocarcinoma who received treatment between 2016 and 2025. The pre-treatment ALI was derived from body mass index, serum albumin concentration, and …

02.09.2026journal-article

Sustainability

Ecological Health Assessment of the Yuejiang River in Sichuan Province Based on the PCA–Entropy Weight Method

Diancheng Wang, Wende Chen, Jiali Zhou, Rui He, Yuhang Hou, Heliang Xu

River-health assessment in small rural watersheds requires the integration of multiple environmental indicators, yet correlated variables may be repeatedly represented when they are weighted independently. This study evaluated the ecological health of the Yuejiang River in Dongpo District, Meishan City, Sichuan Province, for 2011, 2018, and 2024 using a principal component analysis (PCA)–entropy weighting framework. Fourteen effective indicators represented riparian habitat, climate–hydrology, water environment, hu …

02.09.2026journal-article

Frontiers in Digital Health

Centering disability in digital health: perspectives and actionable approaches to accessibility

Hilary Touchett, Kelley Arredondo, Stephanie C. Day, Brenda Salgado, Katherine Bay, Jan Lindsay, Felicia Skelton

Digital health innovations hold enormous potential to expand access to care. Yet individuals with disabilities often face inequities due to systemic, environmental, and design-related barriers that limit full participation in digital health ecosystems. These challenges often arise from the ways digital tools and systems are designed rather than the impairment itself. This perspective discusses the intersection of disability, digital health, and equitable access through key disability frameworks including the Intern …

02.09.2026journal-article

Physics in Medicine & Biology

A physics-constrained Bayesian framework for QSM with uncertainty quantification and variational susceptibility source separation

K A Shahriar, Maruf Ahmed

Abstract Objective . Quantitative susceptibility mapping (QSM) requires inversion of a convolutional dipole operator whose null-space renders susceptibility reconstruction severely ill-posed, making the estimated susceptibility highly sensitive to measurement noise and modeling errors. Existing deep learning methods primarily produce deterministic reconstructions and typically perform susceptibility source separation as an independent post-processing step without explicitly modeling inversion uncertainty or incorpo …

02.09.2026journal-article

Health Physics

Measurement of Radon Levels and Radiological Risk Assessment of Borehole Water in Oil-Producing Area of Ukwuani, Southern Nigeria

Augustine Onyema Nwabuoku

A number of communities in Ukwuani Local Government Area of Delta State are known to host several crude oil companies with exploration activities ongoing and may be responsible for the presence of high radon levels in drinking water. Radon ( 222 Rn) has emerged as a major health concern due to its radiotoxic effects and radiation dose to internal organs. Therefore, this work aimed to measure radon levels in borehole water and assess the radiological risk. Thirty water samples were collected from borehole sources in …

02.09.2026journal-article

Current Opinion in HIV and AIDS

Development of adjuvanted HIV vaccines tailored for early life: immunologic rationale, clinical experience, and future directions

Kinga K. Smolen, Kristina De Paris, Asimenia Angelidou, Troy M. Martin, Simon D. van Haren, Ofer Levy

Purpose of review This review highlights the rationale for and clinical experience in advancing age-specific adjuvantation systems to develop well tolerated and effective pediatric HIV vaccines. Recent findings Due to both cellular and soluble factors, infant immunity is distinct from that of older children and adults, featuring Th2 bias, tolerogenic APC programming, and reduced Tfh support. Due to distinct functional responses downstream of pattern recognition receptor signaling, adjuvant action is age-specific. D …

02.09.2026journal-article

Physics in Medicine & Biology

Biologically optimized 3D range modulators for fast conformal carbon ion therapy: in vitro validation, treatment planning, and robustness analysis

Sae Hyun Hailey Ahn, Domenico Ivan Filosa, Peter Lysakovski, Stephan Brons, Amir Abdollahi, Jürgen Debus, Ivana Dokic, Thomas Tessonnier, Andrea Mairani

Abstract Objective. Patient-specific 3D range modulators (RMs) allow rapid and conformal particle therapy with monoenergetic beams and may support motion management and ultra-high dose rate (UHDR) studies. For carbon ions, however, relative biological effectiveness (RBE) varies strongly with depth, so RM geometry should be optimized for biological effect rather than physical dose alone. This work presents a translational pathway for biologically optimized 3D RMs (bio-RMs) for carbon ion therapy, evaluated through d …

02.09.2026journal-article

Pediatric Nephrology

Patient-reported ratings of transfer to adult care among young adults with chronic kidney disease

Kelsey L. Richardson, Brett Boyer, Kim Grzesek, Cozumel Pruette, Rebecca J. Johnson, Susan L. Furth, Bradley A. Warady, Matthew B. Matheson, Stephen R. Hooper, for the CKiD study investigators

Abstract Background Effective healthcare transitions and transfers of care are crucial for improving long-term health outcomes among adolescents and young adults (AYA) with chronic kidney disease (CKD). Patient-reported outcomes are an important tool to understand patient experience and are underused in CKD transfer evaluation. This study sought to preliminarily identify differences in the transfer experience among AYAs with CKD and identify contributing factors. Methods Participants enrolled in the Chronic Kidney …

02.09.2026journal-article

Revista de Geopolítica

A IMPORTÂNCIA DO SANEAMENTO BÁSICO PARA A SAÚDE PÚBLICA: UMA ANÁLISE DA APLICABILIDADE NO MUNICÍPIO DE COLORADO DO OESTE NA ÓTICA DA POPULAÇÃO COLORADENSE

Rafael Norberto De Aquino, Gisely Storch Do Nascimento, Ericky Vinicius Medeiros Félix Da Cruz, Gabrielly Valente Dos Santos, Maria Clara Pereira Macagnan, Poliana Samara Alkimin Da Silva

O saneamento básico constitui um elemento fundamental para a promoção da saúde pública, da qualidade de vida e da proteção ambiental, porém ainda apresenta importantes desigualdades de acesso e qualidade no Brasil. Nesse contexto, o presente estudo teve como objetivo analisar a percepção da população de Colorado do Oeste, Rondônia, acerca da importância do saneamento básico para a saúde pública, considerando os serviços de abastecimento de água, esgotamento sanitário, manejo de resíduos sólidos e drenagem urbana. A …

02.09.2026journal-article

Natural Resources for Human Health

Structure Activity Relationship of Flavonoids Isolated from Angelica Shikokiana Makino and Other Analogues as Acetylcholine Esterase Inhibitors

asmaa sherif, Amira Mira, Ahmed Ashour, Kuniyoshi Shimizu

Five Flavonoids; Kaempferol, luteolin, quercetin, kaempferol-3-O-rutinoside and kaempferol-3-O-glucoside were isolated from the aerial part of Angelica shikokiana and were examined for acetylcholine esterase inhibition using Ellman’s method. To understand the structure activity relationship, other 17 flavonoids from different classes were also tested. The results showed that 3, 3' and 4' -OH groups are essential for revealing potent activity. Increasing number of OH gp at ring B increase the activity. Position of h …

02.09.2026journal-article

PLOS Digital Health

Assessing body composition via a smartphone computer vision application: High repeatability but method-dependent agreement compared with BODPOD and Inbody

Jahliya Sisohor, Jatin P. Ambegaonkar, Bryndan Lindsey, Qi Wei, Yosef Shaul, Joel Martin

Accurate assessment of body composition is essential for monitoring health status, fitness progress, and disease risk. Traditional methods such as air displacement plethysmography (BODPOD) and bioelectrical impedance analysis (BIA) are widely used to estimate body fat percentage (BF%), fat mass (FM), and fat-free mass (FFM), but can be costly or inaccessible. Smartphone applications utilizing computer vision (CV) offer a promising alternative. This study evaluated the relative agreement and same session repeatabili …

02.09.2026journal-article

PLOS Global Public Health

Newborn screening in Karnataka: A scoping review of the landscape

Liz Maria Kuriakose, Diwakar Mohan, Mohua Chakraborty Choudhury

Newborn screening (NBS) using dried blood spot (DBS) analysis is an important public health intervention to detect serious congenital disorders early, and reduce childhood mortality, and lifelong disabilities. While institutionalized for decades in high-income countries, NBS remains limited in low- and middle-income countries such as India. Despite recommendations in national child healthcare policies, few Indian states have adopted NBS. Even Karnataka, a state performing well in maternal and child health indicator …

02.09.2026journal-article

Scandinavian Journal of Public Health

Wellbeing, mastery and work participation: Effects of the Five Ways to Wellbeing course—a randomized controlled trial

Maja Eilertsen, Nikolai O. Czajkowski, Tone K. Omsland, Espen Røysamb, Ragnhild Bang Nes

Background: Rising ill health, declining wellbeing, and absenteeism threaten societal sustainability amid an ageing population. Promoting health, wellbeing and work participation is essential. The Five Ways to Wellbeing course is a six-week programme designed to enhance wellbeing through five core activities: connecting, being active, taking notice, learning, and giving. A digital, shorter version has shown effectiveness in the general population, but the physical course has not been evaluated by randomized control …

02.09.2026journal-article

Borneo Nursing Journal (BNJ)

Motivasi Lansia Terhadap Penggunaan Gigi Tiruan Di Posyandu Lansia Sekar Arum Gubeng Surabaya

Vidya Saradevi, I.G.A Kusuma Astuti N.P, Rohisotul Laily, Agus Marjianto

Kehilangan gigi merupakan salah satu permasalahan kesehatan gigi dan mulut yang banyak dialami lansia sertadapat menurunkan fungsi pengunyahan, kemampuan berbicara, estetika, dan kualitas hidup. Meskipunpenggunaan gigi tiruan merupakan upaya rehabilitasi yang efektif, tingkat pemanfaatannya masih rendah. Studiini dirancang guna mengkaji pengaruh motivasi lanjut usia terhadap pemanfaatan gigi tiruan di Posyandu LansiaSekar Arum, Gubeng, Surabaya. Penelitian ini menerapkan metode analitik observasional dengan pendeka …

02.09.2026journal-article

Current Traditional Medicine

Phytoconstituents of Kalyanaka Ghrita in Cognitive Enhancement: An Integrative Ayurvedic Mini- Review

Qadir Alam, Sharad Daulatrao Pawar, Shakti Bhushan, Suparna Saha, Sudipta Roy, Rabinarayan Acharya

Introduction: Kalyanaka Ghrita is an ancient Indian medicinal formulation renowned for its holistic approach to treating various brain disorders. Rooted in the Ayurvedic system of medicine, it is a cow Ghrita(clarified butter-based) polyherbal classical remedy traditionally used to manage Daurbalya(debility),Smritidaurbalya (memory impairment), and Buddhimandyata (intellectual impairment). Its formulation includes twenty-eight potent neuroprotective herbs combined with goghrita, which have been employed since ancie …

02.09.2026journal-article

Montenegrin Journal of Sports Science and Medicine

Understanding Legal Anti-Doping Literacy in Sport: The Roles of Coaching, Sport Context, and Regulatory Socialization

Blanka Mateša, Jelena Rodek, Antonela Sinković

Adequate legal anti-doping knowledge promotes informed decision-making, reduces the risk of uninten- tional rule violations, and supports the integrity and fairness of sport. The aim of this study was to exam- ine (i) whether legal anti-doping knowledge differs between athletes and coaches and (ii) whether such differences are specific to sport type by comparing participants involved in team and individual sports. The participants were 188 athletes and 35 coaches involved into team sports (112 athletes and 18 coach …

02.09.2026journal-article

Peace Economics, Peace Science and Public Policy

Consumer Welfare and Energy Supply Shocks Induced by Armed Conflicts: Evidence from Europe

Ján Buleca, Maryna Tatar, Ermanno Affuso, Jr. Franklin G. Mixon

Abstract In the context of increasing global geopolitical instability, this study examines the association between worldwide armed conflict exposure and household energy market outcomes in Europe. Using annual panel data for 29 European countries over 1995–2021, household energy supply and demand are estimated within a two-stage dynamic panel framework employing the Difference Generalized Method of Moments estimator. Global armed conflict exposure is measured as the annual count of armed conflicts worldwide, servin …

02.09.2026journal-article

Southern African Journal of HIV Medicine

Adherence thresholds of tenofovir diphosphate in dried blood spots for HIV treatment and pre-exposure prophylaxis: A scoping review

Mohammed K. Alghamdi, Mohammed W. Ali, Anel Schoonees, Tamara Kredo, Eric Decloedt, Roland van Rensburg

Background: Tenofovir (TFV) is a key antiretroviral used in HIV pre-exposure prophylaxis (PrEP) and treatment, with efficacy contingent on adherence. Quantifying TFV concentrations in dried blood spots (DBS) as tenofovir diphosphate (TFV-DP) is a robust method for determining long-term adherence. However, standardised TFV-DP adherence thresholds in DBS have not been established. Objectives: To map the existing literature on TFV-DP concentration thresholds in DBS for assessing adherence to TFV-based HIV prevention a …

02.09.2026journal-article

Communications Health

Population-based cohort study of modifiable risk factors for dementia and Alzheimer disease mortality in Spain

Julián Benito-León, José Ignacio Serrano, María Dolores del Castillo, Álex Escolà-Gascón, Carla María Benito-Rodríguez, Cristina Ramo-Tello, Ritwik Ghosh, Félix Bermejo-Pareja

Abstract Background Although many modifiable factors are linked to dementia risk, their association with dementia and Alzheimer disease (AD) mortality remains unclear. We aimed to identify late-life modifiable factors associated with these outcomes and assess sex differences. Methods In the population-based Neurological Disorders in Central Spain (NEDICES) cohort, we followed 3085 older adults enrolled in 1994–1995 through 2017. We examined 13 modifiable factors measured at study entry. Dementia and AD deaths were …

02.09.2026journal-article

International Journal of Pharmaceutical and Healthcare Marketing

Perceptions of doctors disclosing AI use in their online biographies: evidence from an experiment

Evan K. Perrault, Gladys M. Momade, Eylül Yel

Purpose Health-care systems are continuing to integrate artificial intelligence (AI) into their workflows and promote its adoption. Therefore, the purpose of this study was to investigate how prospective patients feel about individual providers harnessing AI within their own practices. Design/methodology/approach This study experimentally exposed participants (n = 466) to online biographies of primary care physicians disclosing that the physician either consulted with AI, or physician colleagues, in their medical p …