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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

The Journal of Clinical Endocrinology & Metabolism

Approach to the Patient: Theranostics as precision medicine for neuroendocrine tumors

Regina Koch, Guillaume Pegna, Nadine Mallak, Celeste Winters, Jaydi Del Rivero, Hallbera Gudmundsdottir, Thor Halfdanarson, Erik Mittra

Abstract Context Theranostics has emerged as a precision medicine paradigm in neuroendocrine tumors (NETs), integrating receptor-based imaging with targeted radionuclide therapy to individualize treatment. This approach is particularly valuable in functional and biologically heterogeneous NETs, where hormonal control and variable clinical behavior dominate therapeutic priorities. Case Description We present a three-case series illustrating the application of theranostics across diverse NET contexts. Case 1 describe …

02.09.2026journal-article

American Journal of Biopharmacy and Pharmaceutical Sciences

Evaluation of natural and synthetic photosensitizers in visible light-mediated antimicrobial photodynamic therapy against pathogenic bacteria

Seemi Tasnim Alam, Ferdousi Akhter, Esrat Jahan Toma, Most Farhana Khatun, Sadika Tasnim, Abdullah Bin Hossain Rayhan, Sadi Mahmud Sakib, Mehjabin Ferdous, Md. Aftab Uddin

Objectives: Alternative effective treatment solutions to antibiotic resistance are long overdue. Antibiotic overuse and unfinished antibiotic courses have become globally life threatening, especially in Bangladesh. An alternative way to inactivate pathogenic microorganisms is antimicrobial photodynamic treatment (APDT). This study aims to explore the antimicrobial photodynamic activity of hypericin (a naturally occurring non-toxic photosensitizer [PS]) and methylene blue (a chemical PS), which in combination with l …

02.09.2026journal-article

Clinical Rheumatology

Effectiveness and safety of Janus Kinase inhibitors in patients with rheumatoid arthritis, results from a multicenter observational “real-life” GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale) study

Daniela Iacono, Maura Raimondi, Valentina Marino, Flavia Riccio, Maria Laura Marchesano, Alessandra Milone, Addolorata Corrado, Cinzia Rotondo, Ilaria Firenze, Lidia La Barbera, Chiara Rizzo, Simona Montalbano, Luca Navarini, Alberto Lo Gullo, Marianna Oliva, Elvira Favoino, Ida Orlando, Francesco Paolo Cantatore, Paola Cipriani, Enrico Tirri, Roberto Giacomelli, Federico Perosa, Giuliana Guggino, Piero Ruscitti, Francesco Ciccia

Abstract Objectives To evaluate the “real-life” effectiveness and safety of Janus kinase inhibitors (JAKis) in patients with rheumatoid arthritis (RA) and to analyze the impact of cardiometabolic comorbidities on these outcomes. Methods Patients with RA treated with JAKis were evaluated for disease activity scores, patient-reported outcomes (PROs), and safety in a 12‑month multicenter observational study conducted within the GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale). Patients were g …

02.09.2026journal-article

Life

Voice-Based Screening of Depression and Anxiety Using Machine Learning and Deep Learning: A Scoping Review of Methods and Clinical Readiness

Mădălina Muntean-Codrea, Bogdan Nemeș, Horia George Coman, Ciprian Ionuț Băcilă, Raluca Nicoleta Trifu, Radu Flaviu Oroian, Marinela Minodora Manea, Dana Cristina Herța, Sergiu Șușman

Despite the high global prevalence of depressive and anxiety disorders, access to early clinical assessment remains limited for many. Although this field has grown rapidly, existing reviews have focused primarily on technical performance, with limited systematic attention to whether current models meet the prerequisites for clinical implementation. This scoping review mapped methodological approaches across this domain and evaluated clinical readiness using five predefined indicators: sample size adequacy, external …

02.09.2026journal-article

Liberal Düşünce Dergisi

The Liberal Dilemma: Balancing Security and Freedom in Public Risk Management

Abdullah Demirel

This study examines the tension between risk management in public administration and individual freedoms from a liberal perspective. As state intervention expands across crisis domains, conflicts arise between public security and fundamental rights. Adopting a qualitative comparative approach, the research analyzes risk governance in health, economy, environment, disaster management, and technology, using Türkiye, the US, the EU, and South Korea as cases. The framework focuses on policy instruments, effects on neg …

02.09.2026journal-article

Perioperative Medicine

Peri-operative non-surgical determinants of prolonged length of stay following anterior cervical decompression and fusion surgery: a public healthcare perspective

Ella Snowdon, Gokul Raj Krishna, Sayan Biswas, Clementine Wood, Hana Dorey, Hannah Cheng, Rhianne Devlin, Sidharth Suresh, Sayed Farhan Sayed Yaqub Mehdi, Ved Sarkar, K. Joshi George

Abstract Background Prolonged length of stay (PLOS) following anterior cervical discectomy and fusion (ACDF) is associated with increased hospital burden. While surgical and comorbidity-related factors have been widely studied, routinely documented non-surgical and social variables are less consistently reported. This study evaluated univariable associations between these factors and PLOS after ACDF. Methods A retrospective analysis of 1,719 ACDF procedures performed between 2012 and 2022 at a single tertiary centr …

02.09.2026journal-article

Sustainability

Optimization of China’s Urban Waste Sorting Policy Pathways from the Public Perspective Under a Multi-Party Cooperation Framework

Yanfei Deng, Sisi Tang, Lin Zhao, Lei Xu

China has experienced rapid growth in municipal solid waste generation, highlighting the need to improve the effectiveness of waste sorting governance in urban areas. As the implementation of MSW sorting policies relies heavily on public acceptance and sustained participation, evaluating policy implementation from the public perspective is particularly important, yet comprehensive evaluation frameworks remain limited. This study develops a bottom-up evaluation framework integrating large-scale social media discours …

02.09.2026journal-article

Clinical Otolaryngology

Azelastine‐Fluticasone Intranasal Combination Therapy in Otorhinolaryngology: Clinical Evidence, Current Practice Patterns and Future Perspectives

Giorgio Ciprandi, Ignazio La Mantia, Attilio Varricchio

ABSTRACT Background Allergic rhinitis (AR) represents a significant burden in Ear Nose Throat (ENT) practice and markedly affects quality‐of‐life and work productivity of AR patients. The fixed combination of intranasal azelastine and fluticasone propionate (AzeFlu) has emerged as a valuable therapeutic option for moderate‐to‐severe AR. Recent updates to international guidelines and real‐world evidence warrant a comprehensive review of its role in ENT practice, with particular attention to both seasonal and perenni …

02.09.2026journal-article

Journal of Medical Internet Research

A Secure, Scalable Large Language Model–Based System (CIDER) for High-Throughput Clinical Data Extraction From Medical Reports: Retrospective Validation Study

Máté Posta, Aida Figler, Zsófia Dobolyi, Balázs Győrffy

Background A substantial proportion of clinically relevant information remains locked in unstructured narrative documents, creating a bottleneck for clinical research, biobank annotation, registry development, and real-world evidence generation. While large language models (LLMs) enable advanced clinical text mining, adoption is constrained by concerns regarding data security, multilingual performance, and reproducibility. Manual data abstraction remains predominant for registry curation and retrospective research, …

02.09.2026journal-article

Environmental Science and Pollution Research

Integrated physical-chemical remediation and human health risk assessment of multi-metal contaminated industrial soils

Lucia Marsich, Alessio Ferluga, Luca Cozzarini, Paolo Bevilacqua

Abstract This study presents an integrated remediation strategy and human health risk assessment for multimetal-contaminated industrial soil. The sequential treatment combined mechanical screening, high-intensity magnetic separation (HIMS), and chemical extraction using ethylenediaminetetraacetic acid (EDTA). Initial characterization revealed extreme contamination levels, with cadmium and thallium posing significant noncarcinogenic risks, particularly for children (hazard index = 169.4). Physical separation proved …

02.09.2026journal-article

British Journal of Healthcare and Medical Research

Associations of Musculoskeletal Pain with Sociodemographic, Health Related, Reproductive Related, Pain Related, Treatment Seeking Pattern and Outcome Among Postmenopausal Women From Dhaka City

Rojina Akter, Abu Sayed Mohammad Giasuddin, Jasim Uddin, Md. Raisul Hassan

Background: The associations (correlations) of Musculoskeletal pain (MSP) with the presenting characteristics in postmenopausal women from Dhaka City are not known; Objectives: To determine the statistical significance of the associations of MSP with the presenting characteristics in postmenopausal women from Dhaka City; Materials & Methods: Statistically further analyses were done for associations of MSP with the presenting features reported in our descriptive cross-sectional study. The SPSS version 22.0 was used …

02.09.2026journal-article

International Journal of Advanced Research in Science Communication and Technology

Light Activated Drug Delivery System: A Novel Approach for Controlled and Targeted Therapy

Amol S. Rone, Mrs. Rupali G. Chaudhari, Dr. P. N. Sable

Light-Activated Drug Delivery Systems (LADDS) are advanced drug delivery systems that release drugs only when exposed to a specific wavelength of light. Unlike conventional drug delivery, which often causes uncontrolled drug release and systemic side effects, LADDS provide targeted and controlled drug release at the desired site and time. These systems use photoresponsive carriers such as liposomes, nanoparticles, hydrogels, and micelles, which respond to ultraviolet (UV), visible, or near-infrared (NIR) light. Lig …

02.09.2026journal-article

British Journal of Community Nursing

Beyond substitution: advanced primary care nursing for population health

Nia Boughton

Advanced practice roles in primary care have often emerged in response to workforce pressures and service instability, with medical substitution acting as an initial driver. While these origins are important to acknowledge, focusing on substitution alone risks under representing the contributions that advanced primary care nursing makes towards contemporary healthcare challenges. This article argues that advanced primary care nursing has evolved into an integrative, system level form of practice, shaped by populati …

02.09.2026journal-article

PLOS One

Retinopathy of prematurity as a clinical marker of developmental vulnerability in preschool children: A nationwide Korean Health Screening study

Tae-Eun Kim, Hye Won Park, Sanghyun Park, Hyun Jin Shin

Purpose To determine the Retinopathy of prematurity (ROP) and its association with developmental delay in Korean preschool children. Methods We conducted a nationwide cohort study using the Korean National Health Insurance Service and National Health Screening Program for Infants and Children (NHSPIC). The study included 808,536 children born 2014–2018 who completed the 7th NHSPIC screening at 54–60 months. Development assessed by the Korean Developmental Screening Test (K-DST) in six domains (self-care, cognition, …

02.09.2026journal-article

Natural Resources for Human Health

Rosa multiflora Thunb.: Chemical composition, potential pharmaceutical applications, and future research directions

Le Pham Tan Quoc, Pham My Hao, Pham Thi Quyen, Lam Bach Bao Phuong

Rosa multiflora Thunb., is a widely distributed plant species of the Rosaceae family and used in traditional medicine in many Asian countries. In recent years, this species has attracted increasing attention in the field of medicinal research due to its high content of bioactive compounds. This article aims to systematically evaluate the morphological characteristics, secondary chemical constituents, and major biological activities of R. multiflora, such as antioxidant, antibacterial, and anti-inflammatory properti …

02.09.2026journal-article

British Journal of Clinical Pharmacology

Medicines, misinformation and machines: Navigating infodemics in the generative AI era

Natansh D. Modi, Lisa M. Kalisch Ellett, Michael D. Wiese, Ashley M. Hopkins

Health information is now widely accessed through smartphones, online searches and increasingly through generative artificial intelligence (AI). These systems create new opportunities for communication, and in some routine contexts, well‐governed AI assistants could reduce exposure to lower quality sources by providing cautious, evidence‐aligned answers. During health emergencies, however, evidence is incomplete, and demand for rapid guidance is high. Under these conditions, generative AI could produce or amplify i …

02.09.2026journal-article

BMJ

Secondary use and scholarly impact of a portfolio of clinical trials with shared individual participant level data: cross sectional study

Erfan Taherifard, Maryam Mooghali, Hollin R Hakimian, Sahil R Mane, Mengyuan Fu, Stephen Bamford, Jesse A Berlin, Karla Childers, Nihar R Desai, Cary P Gross, Debbie Hewens, Richard Lehman, Jessica D Ritchie, Tamsin Sargood, Joanne Waldstreicher, Joshua D Wallach, Molly K Willeford, Harlan M Krumholz, Joseph S Ross

Abstract Objective To assess the number, timing, characteristics, and scholarly impact of secondary publications generated using individual participant level data (IPD) from a portfolio of clinical trials shared with external investigators through a data sharing platform. Design Cross sectional study. Setting Yale University Open Data Access (YODA) Project platform. Participants Johnson & Johnson sponsored clinical trials listed on the YODA Project platform with IPD available for external sharing through 2021 and w …

1 Zitationen
02.09.2026journal-article

Journal of Biological Studies

Effect of piperine on antifungal-resistant clinical isolates of Candida albicans and PLB1 expression

Abbas M. Ammari, Noor Abdulhafedh Jajees, Shahrazad Ahmed Khalaf

Candida albicans is the most common cause of oral, cutaneous and vaginal Candidiasis which the incidence ranging up to 50% among those patients. Phospholipase proteins, genes like PLB1 act as virulence genes that code for C. albicans colonization and biofilm formation. Piperine is alkaloids content located in the seed of black pepper (Piper nigrum), and it has antimicrobial effects. This study aimed to study the effectiveness of piperine on resistant isolates of yeast isolated from patients with candidiasis. One hu …

02.09.2026journal-article

Dental Nursing

Safer solutions

Rebecca Waters

Rebecca Waters advises on how to make sure your clinical waste workflows are up to scratch.

02.09.2026journal-article

Dental Nursing

Respect in action

Rochelle Fisher

Rochelle Fisher outlines how dental nurses can foster a stronger culture of respect in dentistry.

02.09.2026journal-article

Journal of Psychosexual Health

Comprehensive Sexuality Education (CSE) in India: Decoding Parental Views and Understanding

Likith R S, Vigneshwaran Subbiah Akkayasamy

Objectives: To explore parental attitudes toward comprehensive sexuality education (CSE), assess their willingness to discuss sexuality-related topics with their children, and generate evidence to support policy advocacy for age-appropriate CSE in Indian schools. Method: A cross-sectional quantitative study was conducted among 113 parents from rural and urban India using a self-administered questionnaire. Descriptive analysis was performed. Results: Parents generally expressed positive attitudes toward CSE; however …

02.09.2026journal-article

Borneo Nursing Journal (BNJ)

Hubungan Antara Pengetahuan Dengan Sikap Tentang Perilaku Hidup Bersih Dan Sehat Pada Siswa Di SDN 15 Bintauna

Fahria Radjiku, A.A.J Telew, Alva Supit, Bukroanah Amir Makkau, Bintang Sri Rejeki Panjaitan, Fredrik A. Makadada

Perilaku Hidup Bersih dan Sehat (PHBS) merupakan salah satu indikator penting dalam peningkatan derajatkesehatan anak usia sekolah. Survei pendahuluan di SDN 15 Bintauna menemukan masalah seperti siswa tidakmencuci tangan dengan sabun, membuang sampah sembarangan, dan kurangnya kesadaran menjaga kebersihanfasilitas sekolah. Data Survei Kesehatan Indonesia (SKI) tahun 2023 mencatat hanya 41,8% penduduk SulawesiUtara mencuci tangan dengan benar, dan pada kelompok usia 10-14. Tahun hanya 46%. Penelitian ini bertujuanu …

02.09.2026journal-article

Experimental & Molecular Medicine

The long non-coding RNA-encoded microprotein MKKS3 drives colorectal cancer chemoresistance

Hui-Fang Hu, Qi Zhou, Jia-Zhen Huang, Jia-Ying Fu, Zhi-Ting Zuo, Qing-Yu He

Abstract Although oxaliplatin is widely used in the frontline treatment of colorectal cancer (CRC), CRC recurrence is commonly observed owing to oxaliplatin resistance. The roles of long non-coding RNAs-encoded microproteins in oxaliplatin chemoresistance remain inadequately explored. In this study, a CRISPR/Cas9 library was developed to target previously identified 314 microproteins translated from long non-coding RNAs, followed by functional screening. This strategy identified MKKS3, encoded by NR_072977, as a ke …

02.09.2026journal-article

Current Opinion in HIV and AIDS

Development of adjuvanted HIV vaccines tailored for early life: immunologic rationale, clinical experience, and future directions

Kinga K. Smolen, Kristina De Paris, Asimenia Angelidou, Troy M. Martin, Simon D. van Haren, Ofer Levy

Purpose of review This review highlights the rationale for and clinical experience in advancing age-specific adjuvantation systems to develop well tolerated and effective pediatric HIV vaccines. Recent findings Due to both cellular and soluble factors, infant immunity is distinct from that of older children and adults, featuring Th2 bias, tolerogenic APC programming, and reduced Tfh support. Due to distinct functional responses downstream of pattern recognition receptor signaling, adjuvant action is age-specific. D …