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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

Apollo Medicine

A Novel Multimodal Approach in AAU Resistant to Conventional Therapies and Tofacitinib: A Case Report

Sumit Kumar Bose

Introduction: Alopecia areata universalis (AAU) is a long-lasting, chronic, recurrent immune-mediated disease characterised by non-scarring hair loss of the scalp and other hair-bearing body areas. Even when treated with various treatments such as oral and topical steroids, anthralin, phototherapy and tofacitinib, recurrence is common after 6 months to 1 year. AAU presents with well-delineated, circumscribed patches of hair loss of the scalp. Remission is observed in 50% of cases within 1 year. Relapse may occur in …

02.09.2026journal-article

Current Reviews in Clinical and Experimental Pharmacology

Safety and Efficacy of Melatonin for Sleep Disorders in Cancer: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Mohammad Mehdi Abbasi, Shiva Pasha, Farbod Khosravi, Amir Reza Boskabadi, Faezeh Jamshidi, Zahra Rahimian, Pooya Eini, Yashar Talebi, Mohammadsadegh Jafari, Sara Bahramabadinejad, Afsaneh Safarian, Hossein Soltaninejad, Mohammad Rahmanian

Introduction/Objective: Sleep disruption is common among patients with malignancy and may worsen quality of life, treatment tolerance, and symptom burden. Melatonin is a circadianregulating hormone with a favorable safety profile and potential sleep-promoting effects. This metaanalysis and systematic review evaluated the safety and efficacy of melatonin for sleep-related outcomes in patients with cancer. Methods: Scopus, PubMed, Web of Science, ScienceDirect, Cochrane Library, ClinicalTrials.gov, and EMBASE were sy …

02.09.2026journal-article

American Journal of Lifestyle Medicine

Paving the Path to Wellness for Okinawan Descendants in Brazil: A Culturally Adapted Lifestyle Medicine Program in Group

Sley Tanigawa Guimaraes, Elizabeth Frates, Julia Pangalangan, Bruna Morais, Fernanda Santos

Noncommunicable chronic diseases (NCDs) are the leading cause of premature death and disability worldwide. Lifestyle medicine group interventions are effective in promoting behavior change and improving health outcomes. This study evaluated the impact of the PAVING THE PATH TO WELLNESS program among Okinawan descendants in São Paulo, Brazil. A longitudinal mixed-methods pilot study was conducted with 16 adults (≥18 years) from the Okinawa Vila Carrão Association. The 8-week group program included weekly sessions ad …

02.09.2026journal-article

Epilepsy Currents

The Odd Couple: Replacement Therapy for Citrate Transporter Deficiency in the Brain and the Liver

Sara Eyal

AAV-mediated gene therapy in a model of SLC13A5 citrate transporter disorder rescues epileptic and metabolic phenotypes Bailey LE, Adams RM, Schackmuth MK, Garza IT, Knight K, Holmes SK, Eller MM, Lee M, and Bailey RM. J Clin Invest . 2026 Feb 19;136(8):e197503. doi: 10.1172/JCI197503. PMID: 41712282; PMCID: PMC13078891. SLC13A5 citrate transporter disorder is a rare epileptic encephalopathy caused by loss-of-function pathogenic variants in the SLC13A5 gene. Loss of sodium/citrate cotransporter function causes a se …

02.09.2026journal-article

Discover Public Health

Identifying social structural factors associated with HIV community based organization service use and community participation among women living with HIV in Metro Vancouver

Sagar Pannu, Eva Oberle, Mark Gilbert, Kate Shannon, Colleen Thompson, Desire King, Wiebke Bartels, Haoxuan Zhou, Sherri Pooyak, Kathleen Deering

Abstract Background HIV Community-Based Organizations (CBOs) remain underfunded, limiting programming and support, with limited research examining factors influencing women’s engagement with HIV CBOs. Therefore, social-structural factors associated with HIV CBO service use and community participation were investigated among women living with HIV to inform engagement strategies that optimize resource allocation amid funding constraints. Methods Data were drawn from the Sexual Health and HIV/AIDS: Women’s Longitudina …

02.09.2026journal-article

Aging Clinical and Experimental Research

Screening of sarcopenia in long-term care facilities using wireless surface electromyography and deep transfer learning: a proof-of-concept study

Andrea Manni, Giacomo Scotti, Gabriele Rescio, Andrea Caroppo, Giulia Pasolini, Alessia Ghidini, Eleonora Macchia, Zaira Romeo, Alvise Bobbo, Marianna Noale, Stefania Maggi, Alessandro Leone, Alessandro Morandi, for the I-COUNT study group

Abstract Background Sarcopenia is prevalent in long-term care facilities (LTCFs) and is associated with falls, functional decline, and mortality. Aims This proof-of-concept study, within the I-COUNT pilot randomized controlled trial, evaluated the feasibility and diagnostic performance of a non-invasive sarcopenia screening approach based on wearable surface electromyography (sEMG) combined with artificial intelligence. Results Eighteen older adults residing in two Italian LTCFs (6 sarcopenic, 12 controls; 33.3% me …

02.09.2026journal-article

The Journal of Clinical Endocrinology & Metabolism

Approach to the Patient: Theranostics as precision medicine for neuroendocrine tumors

Regina Koch, Guillaume Pegna, Nadine Mallak, Celeste Winters, Jaydi Del Rivero, Hallbera Gudmundsdottir, Thor Halfdanarson, Erik Mittra

Abstract Context Theranostics has emerged as a precision medicine paradigm in neuroendocrine tumors (NETs), integrating receptor-based imaging with targeted radionuclide therapy to individualize treatment. This approach is particularly valuable in functional and biologically heterogeneous NETs, where hormonal control and variable clinical behavior dominate therapeutic priorities. Case Description We present a three-case series illustrating the application of theranostics across diverse NET contexts. Case 1 describe …

02.09.2026journal-article

BMC Sports Science, Medicine and Rehabilitation

Categorizing race profiles in professional men’s and women’s road cycling races using clustering

Annemiek J. Roete, Marije T. Elferink-Gemser, Robert P. Lamberts, Matthias Kempe

Abstract Background Professional road cycling races differ in physiological demands because race profiles vary. Yet no standardized method exists to categorize race profiles across professional road cycling races. Organizer labels are inconsistent or missing. Systematic categorization would enable large-scale analysis of race demands. This study develops a categorization of race profiles in men’s and women’s professional road cycling. Methods The dataset comprised international men’s and women’s races from 2024 sup …

02.09.2026journal-article

Frontiers in Cell and Developmental Biology

Gut microbiota dysbiosis and the gut–lung axis in COPD: mechanisms, clinical relevance, and microbiota-targeted interventions

Yinghui Chai, Junya Lan, Kang Li, Xue Mei, Yanan Chen, Nannan Zhou, Xin Liu, Wenping Gong, Hong Lei

Chronic obstructive pulmonary disease (COPD), which is characterised by persistent inflammation and airflow limitation, has increasingly been linked to the gut-lung axis. Patients with COPD commonly exhibit reduced diversity of gut microbiota, decreased levels of bacteria that produce short-chain fatty acids (SCFAs), increased levels of opportunistic pathogens, and compromised intestinal barrier function. These alterations are driven by factors such as smoking, hypoxia, oxidative stress, medication use and ageing, …

02.09.2026journal-article

AGING MEDICINE

Expert Consensus on the Management of Obesity in Older Adults (2026 Edition)

Qi Pan, Lixin Guo

ABSTRACT Obesity in older adults has become a prominent public health issue. Owing to age‐related physiological changes and multimorbidity, obesity in this population is associated with complex clinical manifestations and markedly increased difficulty in management. Based on this, a multidisciplinary panel of obesity experts from Beijing Hospital, National Center for Gerontology, formulated this consensus after rigorous evaluation and iterative revision. The consensus emphasizes that management of obesity in older …

02.09.2026journal-article

Liberal Düşünce Dergisi

The Liberal Dilemma: Balancing Security and Freedom in Public Risk Management

Abdullah Demirel

This study examines the tension between risk management in public administration and individual freedoms from a liberal perspective. As state intervention expands across crisis domains, conflicts arise between public security and fundamental rights. Adopting a qualitative comparative approach, the research analyzes risk governance in health, economy, environment, disaster management, and technology, using Türkiye, the US, the EU, and South Korea as cases. The framework focuses on policy instruments, effects on neg …

02.09.2026journal-article

PLOS One

Retinopathy of prematurity as a clinical marker of developmental vulnerability in preschool children: A nationwide Korean Health Screening study

Tae-Eun Kim, Hye Won Park, Sanghyun Park, Hyun Jin Shin

Purpose To determine the Retinopathy of prematurity (ROP) and its association with developmental delay in Korean preschool children. Methods We conducted a nationwide cohort study using the Korean National Health Insurance Service and National Health Screening Program for Infants and Children (NHSPIC). The study included 808,536 children born 2014–2018 who completed the 7th NHSPIC screening at 54–60 months. Development assessed by the Korean Developmental Screening Test (K-DST) in six domains (self-care, cognition, …

02.09.2026journal-article

British Journal of Healthcare and Medical Research

Associations of Musculoskeletal Pain with Sociodemographic, Health Related, Reproductive Related, Pain Related, Treatment Seeking Pattern and Outcome Among Postmenopausal Women From Dhaka City

Rojina Akter, Abu Sayed Mohammad Giasuddin, Jasim Uddin, Md. Raisul Hassan

Background: The associations (correlations) of Musculoskeletal pain (MSP) with the presenting characteristics in postmenopausal women from Dhaka City are not known; Objectives: To determine the statistical significance of the associations of MSP with the presenting characteristics in postmenopausal women from Dhaka City; Materials & Methods: Statistically further analyses were done for associations of MSP with the presenting features reported in our descriptive cross-sectional study. The SPSS version 22.0 was used …

02.09.2026journal-article

International Journal of Advanced Research in Science Communication and Technology

Light Activated Drug Delivery System: A Novel Approach for Controlled and Targeted Therapy

Amol S. Rone, Mrs. Rupali G. Chaudhari, Dr. P. N. Sable

Light-Activated Drug Delivery Systems (LADDS) are advanced drug delivery systems that release drugs only when exposed to a specific wavelength of light. Unlike conventional drug delivery, which often causes uncontrolled drug release and systemic side effects, LADDS provide targeted and controlled drug release at the desired site and time. These systems use photoresponsive carriers such as liposomes, nanoparticles, hydrogels, and micelles, which respond to ultraviolet (UV), visible, or near-infrared (NIR) light. Lig …

02.09.2026journal-article

British Journal of Community Nursing

Beyond substitution: advanced primary care nursing for population health

Nia Boughton

Advanced practice roles in primary care have often emerged in response to workforce pressures and service instability, with medical substitution acting as an initial driver. While these origins are important to acknowledge, focusing on substitution alone risks under representing the contributions that advanced primary care nursing makes towards contemporary healthcare challenges. This article argues that advanced primary care nursing has evolved into an integrative, system level form of practice, shaped by populati …

02.09.2026journal-article

BMJ

Secondary use and scholarly impact of a portfolio of clinical trials with shared individual participant level data: cross sectional study

Erfan Taherifard, Maryam Mooghali, Hollin R Hakimian, Sahil R Mane, Mengyuan Fu, Stephen Bamford, Jesse A Berlin, Karla Childers, Nihar R Desai, Cary P Gross, Debbie Hewens, Richard Lehman, Jessica D Ritchie, Tamsin Sargood, Joanne Waldstreicher, Joshua D Wallach, Molly K Willeford, Harlan M Krumholz, Joseph S Ross

Abstract Objective To assess the number, timing, characteristics, and scholarly impact of secondary publications generated using individual participant level data (IPD) from a portfolio of clinical trials shared with external investigators through a data sharing platform. Design Cross sectional study. Setting Yale University Open Data Access (YODA) Project platform. Participants Johnson & Johnson sponsored clinical trials listed on the YODA Project platform with IPD available for external sharing through 2021 and w …

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02.09.2026journal-article

Clinical Otolaryngology

Azelastine‐Fluticasone Intranasal Combination Therapy in Otorhinolaryngology: Clinical Evidence, Current Practice Patterns and Future Perspectives

Giorgio Ciprandi, Ignazio La Mantia, Attilio Varricchio

ABSTRACT Background Allergic rhinitis (AR) represents a significant burden in Ear Nose Throat (ENT) practice and markedly affects quality‐of‐life and work productivity of AR patients. The fixed combination of intranasal azelastine and fluticasone propionate (AzeFlu) has emerged as a valuable therapeutic option for moderate‐to‐severe AR. Recent updates to international guidelines and real‐world evidence warrant a comprehensive review of its role in ENT practice, with particular attention to both seasonal and perenni …

02.09.2026journal-article

Stem Cell Research & Therapy

Extracellular vesicles from specific muscle progenitor cells as a novel therapeutic strategy for sarcopenia

Bi Zhao, Yao Yao, Hong Shi, Srinivas M. Tipparaju, Muhammad Ashraf, Wanling Xuan

Abstract Background Sarcopenia, characterized by age-related loss of skeletal muscle mass and function, poses a significant challenge to lifelong health and wellbeing. Currently, no effective therapeutic interventions exist. In previous work, we developed specialized muscle progenitor cells (MPCs), termed Givi-MPC, from human induced pluripotent stem cells (hiPSCs). These cells demonstrated robust regenerative capacity in both sarcopenic and dystrophic muscle models. However, the potential of extracellular vesicles …

02.09.2026journal-article

Critical Pathways in Cardiology: A Journal of Evidence-Based Medicine

Angiography-Derived vs Wire-Based Physiological Assessment in Coronary Artery Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Muhammad Mudasir, Abdul Rehman, Muhammad Ibrahim Rashid, Mohammad Salah, Muhammad Jawad, Ramesha Tahir, Raja Muhammad Umer, Prem Kumar, Rohin Kumar

This study aimed to determine whether angiography-based physiological assessment yields clinical outcomes comparable to those of conventional wire-based pressure measurements in patients with coronary artery disease (CAD) undergoing evaluation of intermediate coronary stenoses. A systematic literature search was conducted in PubMed, Embase, and the Cochrane Central Register of Controlled Trials through April 12, 2026. Randomized controlled trials comparing angiography-derived indices (such as QFR, vFFR, and angiogr …

02.09.2026journal-article

Prävention und Gesundheitsförderung

Von der Ottawa-Charta zur künstlichen Intelligenz

Kevin Dadaczynski, Hajo Zeeb, Orkan Okan

Zusammenfassung Hintergrund Die digitale Transformation ist für die Entwicklung der Gesundheitsförderung und Prävention nicht folgenlos geblieben. Internetbasierte Informations- und Kommunikationstechnologien prägen heute den Alltag von Menschen und eröffnen neue Möglichkeiten zur Förderung von Gesundheit, zur Prävention von Krankheiten sowie zur Unterstützung gesundheitsbezogener Entscheidungen. Ziel und Methode Der Beitrag verfolgt das Ziel, die Entwicklungslinien der digitalen Gesundheitsförderung und Prävention …

02.09.2026journal-article

Annals of African Medicine

Neurobehavioral Evaluation of Renin-Angiotensin System Modulators in an MPTP-Induced Model of Parkinson’s Disease in Swiss Albino Mice

K.G. Prakash, K. Saniya, Shubham Jaju, Madhavrao Chavan, K. Mythili Bai, Aishwarya Mantri

Abstract Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by motor and nonmotor deficits. Emerging evidence suggests a role of the renin-angiotensin system (RAS) in neurodegeneration, making it a potential therapeutic target. Aim: To evaluate the neuroprotective effects of RAS-modulating drugs such as captopril, perindopril, and losartan in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced model of PD. Methods: An experimental in vivo study was conducted usi …

02.09.2026journal-article

American Journal of Biopharmacy and Pharmaceutical Sciences

Evaluation of natural and synthetic photosensitizers in visible light-mediated antimicrobial photodynamic therapy against pathogenic bacteria

Seemi Tasnim Alam, Ferdousi Akhter, Esrat Jahan Toma, Most Farhana Khatun, Sadika Tasnim, Abdullah Bin Hossain Rayhan, Sadi Mahmud Sakib, Mehjabin Ferdous, Md. Aftab Uddin

Objectives: Alternative effective treatment solutions to antibiotic resistance are long overdue. Antibiotic overuse and unfinished antibiotic courses have become globally life threatening, especially in Bangladesh. An alternative way to inactivate pathogenic microorganisms is antimicrobial photodynamic treatment (APDT). This study aims to explore the antimicrobial photodynamic activity of hypericin (a naturally occurring non-toxic photosensitizer [PS]) and methylene blue (a chemical PS), which in combination with l …

02.09.2026journal-article

Australian Occupational Therapy Journal

Exploring successful implementation of occupational therapy led home fall‐hazard reduction interventions

Susan Melchert, Richard Franklin, Daniel Lowrie

Abstract Introduction Falls among older adults are a major cause of death, injury, and loss of independence. High‐certainty evidence demonstrates that comprehensive, occupational therapy–led home fall‐hazard reduction interventions can reduce the number of falls among older adults at high risk. Despite this evidence, these interventions are not routinely implemented in practice. Current literature provides limited insight into the factors that influence successful implementation of home fall‐hazard reduction interv …

02.09.2026journal-article

BMC Musculoskeletal Disorders

Effectiveness of dynamic neuromuscular stabilization exercises on clinical variables in postoperative rehabilitation of patients with lumbar disc herniation: a randomized controlled trial

Burak Buğday, Büşra Arısüt, Elif Esma Bayraktar, Ömer Şevgi̇n

Abstract Purpose This study evaluates the effects of an 8-week Dynamic Neuromuscular Stabilization (DNS) program on disability, physical activity, and fear-avoidance behaviors in postoperative lumbar disc herniation (LDH) patients. Method The study was designed as a randomized controlled trial. Participants of both sexes, aged 35–50 years, were recruited from a single-center postoperative outpatient physiotherapy setting and randomized into DNS (intervention) and standard care (control) groups. The DNS program emph …