Revista ft
Evolução clínica e desafios terapêuticos na doença de Parkinson em fase avançada: uma revisão sistemática.
Parkinson's disease (PD) is a chronic, progressive neurodegenerative disorder predominantly characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta and the resulting dysfunction of basal ganglia circuits. Although traditionally associated with motor manifestations such as bradykinesia, resting tremor, and rigidity, its progression involves a broad spectrum of non-motor symptoms, including cognitive, autonomic, psychiatric, gastrointestinal, and sleep disturbances. In the adva …