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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

Colorectal Disease

Sexual dysfunction outcomes and reporting disparities after multimodal treatment for rectal cancer: A systematic review and narrative synthesis

Vignesh Lakshmanan, Jennifer Waterman, Alun Meggy, Jared Torkington, Julie A. Cornish

Abstract Background Sexual dysfunction is a recognised adverse outcome after rectal cancer treatments, yet reporting is predominantly male‐focused, with female sexual dysfunction less consistently assessed or reported. This systematic review aimed to assess sexual health domains studied, examine sex‐based reporting disparities, and identify limitations in the current evidence. Methods A systematic review and narrative synthesis were conducted in accordance with PRISMA and registered with PROSPERO (CRD420251178502). …

28.08.2026journal-article

Current Oncology

KRAS in Colorectal Cancer: Tumorigenesis, Surgical Implications and Evolving Treatment Target

Sahar Iftikhar, Alexander H. Xiao, Zhaohui Jin, Emad H. Aly

Purpose: This review aims to provide an updated overview of Kirsten rat sarcoma viral oncogene homologue (KRAS) mutations in colorectal carcinoma (CRC), focusing on their role in tumorigenesis, prognostic implications, and recent advances in targeted therapy. Major findings: KRAS mutations occur in approximately 40% of colorectal cancers and play a central role in tumour initiation and progression through constitutive activation of MAPK pathways. Clinically, KRAS mutations are well established as predictors of resi …

28.08.2026journal-article

Advanced Science

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

Xiangzhuan Zhao, Linlin Yang, Huanxiang Chen, Chenfeng Guo, Hongshen Lu, Ying Zhu, Xuanzhi Wang, Yang Li, Ruike Zhang, Zichong Huang, Yifang Chen, Keyu Jin, Zeduo Xu, Lingxiu Meng, Longfeng Zhang, Yuanyuan Han, Yicong Yan, Qiaozhen Kang, Junhu Wan, Hongyang Liu

ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which advanced or metastatic disease presents limited therapeutic options. While RNA modifications are acknowledged as key regulatory elements in cancer, the role of 5‐methylcytosine (m 5 C) and its modifying enzymes in EC is still largely unstudied. Here, it demonstrates that the m 5 C methyltransferase NSUN6 is significantly upregulated in EC tissues, and its expression correlates with higher tumor grade and unfavorable prognosis. F …

28.08.2026journal-article

Medicine

Association between body roundness index and serum 25-hydroxyvitamin D in women with and without breast cancer

Yajuan Du, Meixiang Huang, Tingting Su, Xiaoyan Huang, Zhenbin Zheng

Breast cancer (BC) is the most prevalent tumor in women, ranking first in incidence and mortality in many countries. Previous studies have suggested that. Body Roundness Index (BRI) is positively correlated with BC risk and negatively correlated with serum vitamin D levels. But few well-designed studies have explored the full impact of BC status on the relationship between BRI and serum vitamin D. So we aimed to evaluate the relationship between BRI and serum 25-hydroxy vitamin D in women without or with BC. We use …

28.08.2026journal-article

Journal of Clinical Medicine

Guselkumab in Inflammatory Bowel Disease: Mechanism, Clinical Efficacy, Safety, and Treatment Positioning

Laura White, Esha Sharma, Jimmy Limdi, Shahida Din, Kamal Patel, Sailish Honap

Guselkumab is a monoclonal antibody directed against the p19 subunit of interleukin-23 (IL-23), thereby preventing IL-23 binding to the IL-23 receptor. IL-23 is a key driver of immune dysregulation and chronic inflammation in inflammatory bowel disease (IBD), making selective IL-23 inhibition an established therapeutic strategy in both Crohn’s disease and ulcerative colitis. Guselkumab is the most recently approved IL-23p19 inhibitor for the treatment of both major forms of IBD. It is the first IL-23p19 inhibitor t …

28.08.2026journal-article

New Zealand Medical Journal

Public support for cancer prevention and care policies in Aotearoa New Zealand: methods of a national survey

Bronwen McNoe, Andrew Gray, Ella Iosua, Rana Peniamina, Louise Signal

aim: Our aim was to describe the shared elements involving design, sampling, weighting and analytic framework of a national survey of public views on cancer prevention and care in Aotearoa New Zealand for the seven topic-specific brief reports in this issue of the New Zealand Medical Journal. methods: We conducted a nationwide, self-administered, cross-sectional online survey of adults aged 18 years or older between November and December 2025. Participants were recruited via an established online research panel usi …

28.08.2026journal-article

SCRIPTA SCORE Scientific Medical Journal

Evolving Paradigms in Video-Assisted Thoracoscopic Surgery for Lung Cancer: Techniques, Outcomes, and Emerging Technologies

Vika Kyneissia Gliselda

Background: Video-Assisted Thoracoscopic Surgery (VATS) has transformed lung cancer management by enabling minimally invasive approaches with improved perioperative outcomes. However, rapid advancements in surgical techniques and integration with emerging technologies necessitate a comprehensive synthesis of current evidence. Objectives: This review aims to evaluate the evolving paradigms of VATS in lung cancer, including comparisons between uniportal and multiportal techniques, assessment against robotic-assisted …

28.08.2026journal-article

International Journal of Molecular Sciences

αHSA-proIL-12: A Tumor-Conditional IL-12 Prodrug with Reduced Systemic Toxicity and Potent Antitumor Activity

Xi Wang, Liu Yang, Yuhao Hou, Guanyu Wang, Yu Ding, Yu Zhang, Shuyu Wang, Zhangyong Hong

Interleukin-12 (IL-12) potently promotes the recruitment and activation of immune cells within the tumor microenvironment (TME), highlighting its immense potential for cancer therapy. However, its dose-limiting systemic toxicity and short half-life severely hinder its clinical translation. Here, we design a tumor-conditionally activated IL-12 prodrug termed αHSA-proIL-12. This engineered molecule integrates a cleavable albumin-binding nanobody (αHSA) domain to extend the half-life and enhance tumor targeting alongs …

28.08.2026journal-article

BMC Cancer

Early labor and its long-term impact on cancer risk among older adults in Ecuador: a cross-sectional study analysis

Nahomi Rizzo-Diaz, Marco Faytong-Haro

Abstract Background The long-term health consequences of early labor remain insufficiently understood. This study explores the association between age at labor onset and cancer risk among older adults in Ecuador. Methods We analyzed data from the 2009 Health, Well-being, and Aging Survey (SABE), including 3,791 adults aged 60 and older from mainland Ecuador. Multivariable logistic regression models were used to estimate the association between age at first work (5–12, 13–17, 18–25 [reference group], and 26–35 years …

28.08.2026journal-article

Japanese Journal of Clinical Oncology

Enfortumab vedotin plus pembrolizumab for recurrent metastatic urothelial carcinoma following adjuvant nivolumab

Lan Inoki, Saizo Fujimoto, Mamoru Hashimoto, Yutaka Yamamoto, Teruo Inamoto, Keita Tamura, Takuhisa Nukaya, Kiyoshi Takahara, Wataru Fukuokaya, Takafumi Yanagisawa, Yuki Yoshikawa, Ryoichi Maenosono, Hirofumi Morinaka, Seitetsu Sugiyama, Kazutoshi Fujita

Abstract Adjuvant nivolumab is an established postoperative treatment for high-risk urothelial carcinoma, but evidence for subsequent enfortumab vedotin plus pembrolizumab (EVP) after recurrence is limited. We retrospectively evaluated 17 patients with locally advanced or metastatic urothelial carcinoma who received EVP after recurrence following adjuvant nivolumab in a Japanese multi-institutional cohort. Among 16 response-evaluable patients, the objective response rate was 68.8% (11/16; exact 95% confidence inter …

28.08.2026journal-article

Discover Oncology

Prognostic value of CD8+ TILs and MMR status and their correlation with clinical outcomes in rectal cancer

Baokun Li, Zesong Meng, Feifei Wang, Chaoxi Zhou, Youqiang Liu, Xuhua Hu, Fei Yang

Abstract Objective To explore the associations of CD8⁺ tumor-infiltrating lymphocytes (TILs) and mismatch repair (MMR) status with prognosis in patients with rectal cancer. Methods: Formalin-fixed paraffin-embedded (FFPE) tissue specimens were collected from 414 patients with pathologically confirmed stage I–III rectal cancer. Tissue microarrays (TMAs) with a thickness of 4 μm were constructed. Immunohistochemistry (IHC) using anti-CD8 antibody was performed to detect CD8-positive cell expression. MMR status was ev …

28.08.2026journal-article

RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218

DIABETES MELLITUS GESTACIONAL: RASTREAMENTO, DIAGNÓSTICO, TRATAMENTO E REPERCUSSÕES MATERNO-FETAIS

Karollyne Saulino Campos

O diabetes mellitus gestacional (DMG) é uma das intercorrências metabólicas mais frequentes da gestação e associa-se a desfechos maternos, fetais e neonatais adversos. Objetivo: analisar estratégias atuais de rastreamento, critérios diagnósticos, tratamento, monitorização e repercussões materno-fetais do DMG. Método: revisão integrativa baseada em diretrizes da Sociedade Brasileira de Diabetes, FEBRASGO, Ministério da Saúde/OPAS e literatura internacional de referência. Resultados e discussão: recomenda-se glicemia …

28.08.2026journal-article

Annals of Surgical Oncology

Urban-Rural Disparities in Treatment and Outcomes for Colorectal Liver Metastases in the United States: A SEER-Medicare Analysis

Mayte Bryce-Alberti, Victoria Stoffel, Isabella Blanchard, Maansi Chalasani, Jack Scaife, Antoine Jeri-Yabar, Benjamin A. Bates, David G. Brauer, Charu Verma, Haejin In, Alexander A. Parikh, Hari S. Iyer, Brett L. Ecker

Abstract Background Curative-intent resection of colorectal liver metastases (CRLM) offers an opportunity for long-term survival, yet access barriers correlated with area-level socioeconomic status (SES) and rurality may drive disparities in cancer care. Prior work shows lower liver-directed therapy use and survival in socioeconomically disadvantaged conditions, whereas the association between rurality and CRLM treatment and prognosis has not been previously studied. Methods We conducted a retrospective population- …

28.08.2026journal-article

Frontiers in Immunology

Oncolytic viruses in head and neck cancer: therapeutic promise and translational challenges

Haiting Wang, Hui Shen, Mingjun Zhang, Yakui Mou, Chao Ren, Yu Sun, Wanchen Liu, Caiyu Sun, Dongxian Li, Yumei Li, Peng Qu, Xicheng Song

Head and neck squamous cell carcinoma (HNSCC) remains difficult to treat, particularly in patients with HPV-negative disease. These patients often get diagnosed too late, their cancer doesn’t respond well to treatment, and they don’t live as long. Oncolytic viruses (OVs) can be used for treating cancer instead of using other cytotoxic methods since they can kill malignant cells directly and cause both local and systemic anti-cancer immune responses. In this review, we focus on current evidence of oncolytic virother …

28.08.2026journal-article

Frontiers in Oncology

Case Report: Revealing the truth: how superficial ossification mimics cutaneous tuberculosis in ossifying fibromyxoid tumor

Chao Wang, Hong Li

Ossifying Fibromyxoid Tumor (OFMT) is a rare mesenchymal neoplasm of intermediate biological potential that typically presents as a slow-growing mass. We report a diagnostic challenge involving a 54-year-old male with a 20-year history of a thigh mass that recently exhibited rapid enlargement and ulceration. Initial superficial biopsy led to a high suspicion of cutaneous tuberculosis due to false-positive acid-fast bacilli (AFB) staining and a positive T-SPOT, despite negative tuberculosis serology and normal infla …

28.08.2026journal-article

Nutrition in Clinical Practice

Seeing is believing: The evolving role of muscle ultrasound in comprehensive nutritional care of pediatric oncology patients—A case series

Corey Hawes, Vlad Călin Rădulescu, Senna Munnikhuysen

Abstract Traditional nutritional assessments in pediatric oncology, such as weight and body mass index, often fail to accurately capture changes in body composition, frequently masking significant muscle depletion, or secondary sarcopenia. This retrospective case series evaluates the novel clinical application of muscle ultrasound (mUS) by a pediatric oncology dietitian to help objectively guide and monitor nutrition interventions. We report our observations regarding three pediatric patients with cancer (one schoo …

28.08.2026journal-article

Scientific Reports

A randomized trial comparing the safety and efficacy of straight and articulating instruments (ArtiSential) in laparoscopic gastrectomy for gastric cancer patients

Ji Eun Jung, Shiyeol Jun, Seyeol Oh, In Gyu Kwon

Abstract In conventional multiport laparoscopic radical gastrectomy, there is a lack of evidence demonstrating that articulating instruments (ArtiSential) improve surgical quality, particularly for suprapancreatic lymph node dissection and pancreas-related complications. This study evaluated the efficacy and safety of using an articulating instrument. In this single-center prospective study, 76 patients undergoing laparoscopic radical gastrectomy were randomized to a control or experimental (articulating) group. In …

28.08.2026journal-article

Medicine

Technetium-99m stannous phytate versus technetium-99m sulfur colloid for sentinel lymph node mapping in breast cancer

Chunhuai Liao, Jian Lu, Luz Angela Torres-de la Roche, Rudy Leon De Wilde, Tao Liu, Wenjie Shi, Qiang Wang, Yicheng Jiang, Rui Zhuo, Maya Sophie de Wilde

This study compares technetium-99m stannous phytate (99mTc-PHY) plus methylene blue versus technetium-99m sulfur colloid (99mTc-SC) plus methylene blue for sentinel lymph node (SLN) imaging in early-stage breast cancer (BC). We retrospectively reviewed early-stage BC patients treated from 2019 to 2024. All underwent sentinel lymph node biopsy using either 99mTc-PHY with methylene blue or 99mTc-SC with methylene blue as tracers. A Neoprobe 2000r detector was used to locate nodes. A total of 1151 patients were enroll …

28.08.2026journal-article

International Journal of Extreme Manufacturing

New strategy for strength and ductility synergy enhancement in Ta-12W refractory alloy: selective laser melting + rolling + inter-pass electrical treatment

Peng Li, Wei Fan, Renzhi Hu, Chuan Lei, Tao Wang, Zhihui Xia, Qingxue Huang

Abstract Tantalum-tungsten alloys are critical for extreme aerospace applications. However, oxidation sensitivity and processability limitations associated with conventional manufacturing routes severely constrain the mechanical performance and manufacturability of tantalum-tungsten alloys. This study proposes a new process for fabricating Ta-12W alloys using “selective laser melting + rolling + inter-pass electrical treatment” (ET-AMR), which achieves a synergistic enhancement of both strength and ductility. First …

28.08.2026journal-article

JITSS (Journal of Innovation and Trend in Social Sciences)

Management of Knee Pain in Osteoarthritis: A Narrative Review of Current Treatment Options

Tymoteusz Białowąs, Dominika Karolak, Natalia Sara Kuśmierowska, Monika Kuś, Grzegorz Słomkowski, Kacper Cholewiński, Daria Valipur Kolti, Milena Polak, Magdalena Natalia Nowak, Konrad Wiśniewski

Knee osteoarthritis is a common and progressive musculoskeletal condition that contributes substantially to pain, functional limitation, and reduced quality of life, particularly among middle-aged and older adults. The increasing diversity of available treatments highlights the need for an integrated understanding of their roles in clinical management. This narrative review aims to synthesize current therapeutic strategies for knee pain associated with osteoarthritis and examine their position within a stepwise tre …

28.08.2026journal-article

Angewandte Chemie International Edition

Neural Engineering Tailored by Molecular Motors With Self‐Reporting for Neuron Activation and Depression Treatment

Pengpeng Lu, Xinjian Guo, Tao Liu, Yang Tian, Limin Zhang

ABSTRACT The discovery of mechanical regulation to neuronal behavior offers a novel perspective for understanding nervous system function and advancing neural engineering. A key challenge lies in achieving precise mechanical control of neurons while simultaneously monitoring their activity in real time. Here, we engineered a novel molecular machine equipped with self‐reporting capability, MM‐VSD1, enabling stable anchoring into the plasma membrane. This integrated molecular tool comprises a light‐driven rotary mole …

28.08.2026journal-article

Al-Turath Journal of Nursing

Awareness of Pre-Graduating Female Students Concerning Early Detection of Breast Cancer at University of Kerbala, Iraq in 2025

Hadeel Rasheed Seger, Taher Mohsin Al-Fahham, Hussein Khleif Kitab

Background: Breast cancer is a major killer in women globally and in developing regions where the early cancer detection facilities are unavailable. Awareness would be a tool to fight this disease through early detection and there by decrease the morbidity and mortality. This study aimed to assess the awareness of pre graduating female students regarding early detection of breast cancer at University of Kerbala in Iraq. Methods: A cross- sectional design was conducted from 27th January 2024 to May 2025 at Kerbala U …

28.08.2026journal-article

Journal of Nanomaterials and Applications

ADVANCED SPINEL FERRITE NANOPARTICLES FOR SUSTAINABLE WASTEWATER TREATMENT: A COMPREHENSIVE REVIEW ON SYNTHESIS, CATION DISTRIBUTION, AND MECHANISM-DRIVEN PERFORMANCE

Vidya Singh

Spinel ferrites have emerged as one of the most versatile multifunctional magnetic oxides owing to their tunable electronic structure, excellent chemical stability, and magnetic separability. Ferrites have attracted increasing attention for environmental remediation owing to their excellent magnetic recoverability, tunable electronic structures, and remarkable catalytic activity because of their high resistance and saturation magnetization. Enhancing ferrite characteristics by different synthesis methods and doping …

28.08.2026journal-article

Journal of Neuro-Oncology

Pathology-validated structural and physiologic habitat imaging for differentiating radiation necrosis from tumor recurrence in brain metastases

Ji Eun Park, Guowen Shao, Shivani Baisiwala, Nakyoung Kim, Amelia Tan, Francesco Sanvito, Andrea Liang, Zexi Wang, Gianluca Nocera, Catalina Raymond, Viên Lam Le, Ho Sung Kim, Noriko Salamon, Whitney B. Pope, Won Kim, Benjamin M. Ellingson, Jingwen Yao

Abstract Purpose Differentiating tumor recurrence from radiation necrosis (RN) after stereotactic radiosurgery (SRS) remains a major diagnostic challenge in brain metastasis. We aimed to validate established MRI-based tumor habitat analysis for distinguishing tumor from RN in an independent cohort with histopathological ground truth. Materials and methods This retrospective study included 104 patients (104 lesions) with pathologically confirmed recurrent metastatic tumors ( n = 68) or RN ( n = 36) who underwent str …