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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
01.09.2026journal-article

Medical Journal of Australia

Patterns of Osteoporosis Treatment Initiation Following Low‐Trauma Fracture: A Population‐Based Retrospective Cohort Study in New South Wales, Australia, Using Linked Administrative Health Data

Mike Lin, Huy Nguyen, Thach Tran, Robert D. Blank, Dana Bliuc, Jacqueline R. Center

ABSTRACT Objectives To characterise osteoporosis medicine prescribing patterns following low‐trauma fractures and identify predictors of early treatment initiation. Study Type Retrospective population‐based cohort study. Setting New South Wales, Australia, using statewide linked administrative health data. Participants Adults aged ≥ 50 years with an incident low‐trauma fracture between January 2011 and June 2019. Main Outcome Measures Primary outcomes were osteoporosis treatment prescribing patterns and timing of i …

01.09.2026journal-article

The Journal of Applied Laboratory Medicine

Evaluation of a One-Step Serological Test for Lyme Disease

Kirsten Fagan, Marta Urban, P Rocco LaSala, Charles R Caso, James W Needham, Anu S Maharjan

Abstract Background Lyme disease, a vector-borne zoonosis caused by Borrelia species, is classified into early localized and late disseminated infection. Left untreated, infected patients face multisystem pathology involving the joints, heart, and peripheral and central nervous system, making early antibiotic therapy essential. Lyme diagnosis with standard 2-tier test (STTT) and a modified 2-tier test utilize sequential serological assays. In this study, we evaluated the InBios Lyme Detect™ Multiplex ELISA (RUO) (I …

01.09.2026journal-article

Iraqi Journal of Physics

Patient Dosimetry Assessment During Lateral Cervical and Lumbar Spine Radiography in Selected Hospitals and Clinics in Al-Najaf, Iraq

Haider N. Kanbar, Hussien A. Ali Mraity, Amar H. Mahdi

Radiographic examinations of the cervical and lumbar spine are common diagnostic tests that can involve relatively high radiation exposure for the patient, particularly in lateral projections. The objective of this study was to evaluate the Entrance Surface Dose (ESD) in adult patients during lateral radiographic imaging of the cervical and lumbar spine and to benchmark the findings against internationally published data. A prospective survey was conducted in six radiographic facilities, comprising three government …

01.09.2026journal-article

Energy & Fuels

Evolution of Pore-Fracture Structure and Coupled Damage–Seepage Characteristics of Coal Induced by LCO2 Phase-Transition Treatment: A 3D Digital Core Study

Xianke Wang, Yonggang Qiao, Nan Fan, Danping Yuan, Shida Zhang, Yongliang Mu

Abstract This study combines micro-CT scanning with Avizo-based three-dimensional reconstruction technology to quantitatively characterize the evolution of pore-fracture structures in coal during LCO2 phase-transition treatment and systematically investigates the coupled response of damage evolution and seepage behavior under different stress conditions based on digital coal core models. Results show that LCO2 phase-transition treatment significantly reconstructs the coal pore-fracture network, promoting the develo …

01.09.2026journal-article

Plastic and Reconstructive Surgery - Global Open

Financing a Private Practice: A Practical Framework for Plastic Surgeons

Nicholas Mosca, Ferris Zeitouni, Madeline Tierney, Ellen C. Via, Peter J. Wirth, Pradeep K. Attaluri, Venkat K. Rao

Summary: Many plastic surgery trainees enter private or group practice, yet there is little guidance on financing strategies when starting or joining a practice. The aim of this article is to provide physicians starting or joining a private practice with a clear, evidence-based resource on financing options. Common funding avenues are described, ranging from traditional bank and Small Business Administration loans to equipment leasing, hospital joint ventures, and equity-based investments. Comparisons are made to c …

01.09.2026journal-article

Journal of Child Neurology

Clinical Response and Tolerability of Brivaracetam in Pediatric Epilepsy: A Systematic Review and Meta-analysis

Uneeb Ullah Khan, Mohammad Saboor Kamran, Muhammad Ansab, Ali Irtiza Talpur, Ayman Shakeel Ahmed, Ghadeer Mohammed Abbas, Syeda Zahra Hasan, Phan Huu Hung, Syed Hashim Ali Inam, Jabez David John, S.M Washaqul Arfin

This systematic review and meta-analysis aims to synthesize evidence on the safety and efficacy of brivaracetam (BRV) usage in pediatric epilepsy. The primary outcome of our study was to assess the endurability of BRV in a population of children (age ≤18 years) with epilepsy, which was measured by the retention rate. The responder rate, rate of seizure freedom, rate of adverse effects, and rate of withdrawal from the study were all taken as secondary outcomes, with a total number of 12 citations included in our met …

01.09.2026journal-article

Epilepsy Currents

Cause, Consequence, or Compass? The Thalamus in Temporal Lobe Epilepsy Surgery

John D. Rolston

Thalamic organization differentially contributes to clinical conditions in epilepsy. Communications Medicine in press Zhang Q, Javidi SS, Ankeeta A, Sperling MR, Zhang Z, Tracy JI. Communications Medicine in press. Background: The thalamus plays an important role in key clinical conditions of focal temporal lobe epilepsy (TLE), but no investigation has examined whether the same thalamic local and connectome properties shape a patient's status across these different conditions. Methods: This retrospective longitudin …

01.09.2026journal-article

Journal of Arthroscopy and Joint Surgery

Intraoperative and Early Postoperative Complications of Hip Arthroscopy

V. R. K. V. Prasad Gourineni, Sitaram Chopperla, Vishnu Senthil, Durga Prasad Valleri, S. Ravi Kumar, Susmith Koneru

Abstract Background: Hip arthroscopy is widely used for treating various hip pathologies and is considered a safe joint preservation procedure. However, reported complication rate varies considerably, likely reflecting differences in the technique, traction protocols, and patient-related factors. Subjects and Methods: A retrospective review of 1000 consecutive hip arthroscopy surgical procedures was performed to evaluate intraoperative and early complications occurring within 2 weeks postoperatively. Procedures wer …

02.09.2026journal-article

Clinical Case Reports

Persistent Gingival Bleeding After Scaling: A Diagnostic Clue to von Willebrand Disease

Huihui Zhang, Nan Qiu, Zhengguo Cao, Shuhuan Shang

ABSTRACT Von Willebrand disease (VWD) is not a rare inherited bleeding disorder. However, it is frequently underdiagnosed because early mucocutaneous bleeding manifestations are often attributed to local factors such as inflammation or anatomical abnormalities, leading to delayed recognition of the underlying systemic disease. A 31‐year‐old Han Chinese female presented with persistent gingival bleeding after routine dental scaling. Her medical history was notable for lifelong recurrent epistaxis and severe intraope …

01.09.2026journal-article

Journal of Korean Medicine

Factors Associated with Korean Medicine Utilization during the COVID-19 Pandemic Period (2019–2023): A Panel Analysis of the Korea Health Panel

Changyon Han

Objectives: This study investigates factors associated with Korean Medicine (KM) outpatient utilization in 2019–2023, a period that includes the COVID-19 pandemic, using the Andersen behavioral model. It analyzes individual-level panel data to distinguish factors associated with entry (whether KM is used) from those associated with intensity (how much is used), across three dimensions.Methods: This study estimated three outcomes using household-member random-effects panel models in accordance with Andersen’s behavi …

01.09.2026journal-article

Journal of Korean Medicine

Changes in Autonomic Nervous System Indices Assessed by Heart Rate Variability After Mugwort Moxibustion

Jin Suk Koo

Objectives: This study aimed to investigate changes in autonomic nervous system–related indices assessed by heart rate variability (HRV) following mugwort (Artemisia vulgaris) moxibustion.Methods: This quasi-randomized controlled trial enrolled 44 adult outpatients who visited a Korean medicine clinic in Andong, Republic of Korea, with non-specific health complaints such as stress, fatigue, or sleep disturbance. Participants were systematically assigned to either the moxibustion group or the control group based on …

01.09.2026journal-article

Advances in Respiratory Medicine

Precision Medicine in Overlap Syndrome (COPD–Obstructive Sleep Apnea): From Phenotypes and Endotypes to Treatable Traits

Carina Adina Afloarei, Andreea Zabara Antal, David Toma, Adriana Loredana Pintilie, Georgiana Pitusac, Raluca Tiron, Tudor Birladeanu, Teodor Zaharia, Radu Crisan Dabija

Introduction: COPD-OSA overlap syndrome (OVS) is defined by the coexistence of chronic obstructive pulmonary disease and obstructive sleep apnea syndrome in the same patient; it affects 28.3% of patients evaluated for either condition and is associated with significantly higher mortality compared to either pathology in isolation. Current therapeutic approaches, involving PAP therapy and bronchodilation, treat this syndrome as a homogeneous entity and ignore the biological heterogeneity of this patient population. O …

01.09.2026journal-article

ACS Nano

Injectable Biodegradable Non-Hermitian Biotelemetric System Enabling Early Diagnosis of Acute Compartment Syndrome

Jie Li, Jinfeng Zhou, Jianhui Wu, Kaihang Zhang, Yifan Wu, Congying Shen, Xinyu Cai, Jiaqi Lu, Jiafeng Ni, Liangquan Xu, Rui Wan, Chuanrui Chen, Fengling Zhuo, Dinku Hazarika, Weipeng Xuan, Jinkai Chen, Yiying Qi, Gang Feng, Jinjin Cao, Minye Yang, Zhen Cao, Hao Jin, Shurong Dong, Jikui Luo

Abstract Acute compartment syndrome (ACS) requires timely diagnosis, delayed diagnosis can cause irreversible neuromuscular injury, limb loss, and even death, whereas current diagnosis still relies on subjective examination and intermittent invasive pressure measurements. Here, we report an injectable, biodegradable biotelemetric implant for accurate, continuous wireless monitoring of intracompartmental pressure (IcP), and further establish a predictive model that converts pressure-duration signals into quantitativ …

01.09.2026journal-article

Journal of Clinical Oncology

Polatuzumab Vedotin Plus Rituximab, Gemcitabine, and Oxaliplatin in Relapsed or Refractory Diffuse Large B-Cell Lymphoma: Results From the Phase III, Randomized POLARGO Trial

Matthew Matasar, Zhiming Li, Theodoros P. Vassilakopoulos, Juan-Manuel Sancho, Andreas Viardot, Andrew McMillan, Mehmet Sinan Dal, Juliana Pereira, Jin Seok Kim, Lugui Qiu, Connie Lee Batlevi, Rania Ibrahim, Juana Hernandez, Bruce McCall, Yanwen Jiang, Mark Yan, Will Harris, Lisa Musick, Corinne Haioun

PURPOSE Patients with relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL) face an unfavorable prognosis once first-line treatment fails; therefore, there is an unmet need for new treatment options. We evaluated the efficacy and safety of polatuzumab vedotin plus rituximab, gemcitabine, and oxaliplatin (Pola-R-GemOx) as an alternative therapy in patients with transplant-ineligible R/R DLBCL. METHODS The phase III POLARGO trial was a randomized, open-label, global study. Following a Pola-R-GemOx safety …

1 Zitationen
01.09.2026journal-article

Clinics in Shoulder and Elbow

Clinical outcomes of arthroscopic stabilization procedures in patients with shoulder dislocation combined with posttraumatic adhesive capsulitis

Ji-Hyun Seo, Sang-Jin Shin

Background: This study was conducted to analyze clinical outcomes after arthroscopic stabilization procedures in patients with shoulder instability and posttraumatic adhesive capsulitis. Methods: Patients who underwent arthroscopic Bankart repair between 2019 and 2022 with limitation of forward flexion

01.09.2026journal-article

Military Medicine

Нystological changes of healing of an transversoanastomosis made by interrupted single row seromusculosubmucosal sutures

A. Shott, M. K. Nedzvedz

The aim of the study was to determine hystologicchanges of healing of antransversoanastomosis made by interrupted single row seromusculosubmucosal sutures in 30 days after a surgery in the experiment. M aterial and methods. D uring experimental surgery on 6 dogs colonicend-to-end transversoanastomoses were performed with handle interrupted mattress seromusculosubmucosal sutures using vicryl 000 with atraumatic needles. In terms of 2, 6 and 30 days after the operation 99 hystologic specimens of anastomotic wound wer …

01.09.2026journal-article

Military Medicine

Infectious complications of mine-explosive trauma: etiology of wound infections and principles of antimicrobial therapy (literature review)

D. A. Prokopovich, L. V. Lagun, D. A. Yakovlenko

Infectious complications remain the leading cause of mortality and prolonged hospitalisation in military personnel sustaining mine-explosive trauma (MET). The aim of this study was to analyse the current spectrum of infectious complications of MET, evaluate the aetiological structure of wound pathogens, and determine rational principles of antimicrobial prophylaxis and therapy. A systematic review of 18 scientific publications from 2012–2025 was performed. Infectious complications were found to develop in 27–35 % o …

01.09.2026journal-article

Endoscopy International Open

Declining Rates of Surgery for Nonmalignant Colorectal Polyps in the United States Over the Last Decade: A Real-World Analysis of Over 1 Million Patients

Fouad Jaber, Ahmed-Jordan Salahat, Mohammad M. AlMasri, Kinan Obiedat, Mohammed Jaber, Wasseem Skef, Mai Khalaf, Tara Keihanian, Salmaan Jawaid, Mohamed Othman, Fares Ayoub

Abstract Background Despite advancements in endoscopic resection (ER), surgery for nonmalignant colorectal polyps remains common. A prior analysis reported increasing surgical rates from 2000 to 2014. Using the TriNetX US Research Network, we aimed to compare the proportion of patients referred for ER versus surgical colectomy for nonmalignant polyps each year from 2015 to 2023. Methods We identified adults (≥18 years) diagnosed with nonmalignant colorectal polyps following colonoscopy using validated ICD-10 and CP …

02.09.2026journal-article

MedComm

Early Local Treatment Delays Multiple Metastases in Non‐Small Cell Lung Cancer With Solitary Distant Metastasis: A Multicenter Retrospective Cohort Study

Kang Miao, Siyu Lei, Xiaobin Zheng, Shanshan Yang, Yujing Li, Sihui Chen, Qian Miao, Longfeng Zhang, Zihua Zou, Haipeng Xu, Gen Lin

ABSTRACT Solitary distant metastasis (SDM) is a distinct oligometastatic subtype associated with a relatively favorable prognosis. This multicenter retrospective study including 139 non‐small cell lung cancer (NSCLC) patients with SDM (2019–2024) was conducted to investigate prognostic factors for multiple metastases and identify the critical time window for local treatment. Statistical analyses included Cox regression, Kaplan–Meier survival analysis, and restricted mean survival time (RMST). Results showed that dr …

01.09.2026journal-article

Revista Ibero-Americana de Humanidades, Ciências e Educação

TRATAMENTO LAPAROSCÓPICO VERSUS CIRURGIA ABERTA NA ÚLCERA PÉPTICA PERFURADA: COMPARAÇÃO DOS DESFECHOS PÓS-OPERATÓRIOS

Leonardo Schaucoski Cizeski, Ana Caroline Gomes de Miranda Linhares, Caio Ferraz Gomes Barros, Eduarda Siqueira Cesário, Lucas Venancio Tavares, Pedro Henrique Borges Silvestre, Sayd Abrantes de Lima Pereira

A úlcera péptica perfurada constitui uma emergência cirúrgica associada a elevada morbimortalidade, decorrente principalmente de peritonite, sepse e deterioração fisiológica progressiva. Embora a cirurgia aberta permaneça amplamente utilizada, o tratamento laparoscópico vem ganhando espaço devido ao potencial de reduzir trauma cirúrgico e complicações pós-operatórias. O objetivo deste estudo foi comparar os principais desfechos pós-operatórios associados ao tratamento laparoscópico e à cirurgia aberta na abordagem …

01.09.2026journal-article

Frontiers in Science

Large language medicine: defining a new paradigm in human health

Ahmad Guni, Wanheng Hu, Jessica Morley, I. Glenn Cohen, Payam Barnaghi, Hutan Ashrafian

Artificial intelligence (AI) is poised to revolutionize our understanding of disease and pre-disease, which could transform the way medicine is practiced. Advances in deep learning systems, alongside the advent of generative AI and large language models, promise to usher in an era of multimodal AI systems that permeate every aspect of medicine. AI is expected to support the full spectrum of public health and clinical functions, including surveillance, monitoring, protection, health promotion, and disease prevention …

1 Zitationen
01.09.2026journal-article

Cancer Medicine

Effect of Tertiary Lymphoid Structures on Immune Cell Infiltration in the Tumor Microenvironment and Prognosis in Lung Adenocarcinoma

Sihong Le, Weidan Fang, Yitao Le, Ling Zhang

ABSTRACT Tertiary lymphoid structures (TLSs) modulate immune responses in various solid tumors, but their comprehensive role in lung adenocarcinoma (LUAD) remains unclear. In this study, we analyzed RNA‐seq data from 539 LUAD patients in The Cancer Genome Atlas (TCGA) and microarray data from 223 samples from the Gene Expression Omnibus (GEO, GSE13213, and GSE37745). TLS signatures were evaluated via unsupervised consensus clustering based on 12 chemokine transcriptome signatures. The relationships between TLS and …

01.09.2026journal-article

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH

Dexmedetomidine versus Clonidine as Intrathecal Adjuvants to Hyperbaric Ropivacaine for Subarachnoid Block in Patients with History of Scorpion Bite undergoing Infraumbilical Surgery: A Double-blinded Randomised Clinical Study

Mouna Rao, Naseema V Kanase, Namrata Mandirwala, Neha Manoj Kushe

Introduction: Patients with previous scorpion sting may show variable response to spinal local anaesthetics because scorpion toxins can alter voltage-gated sodium-channel behaviour. Ropivacaine and intrathecal alpha-2 agonists may improve block reliability in this subgroup. Aim: To compare intrathecal dexmedetomidine and clonidine as adjuvants to 0.75% hyperbaric ropivacaine for Subarachnoid Block (SAB) in patients with history of scorpion bite undergoing infraumbilical surgery. Materials and Methods: This double-b …