Onkologie: neue Gesundheitspublikationen – Seite 94

29.08.2026journal-article

Discover Computing

High-performance next-generation screening technology system using teaching–learning-based optimization for cancer detection

Alok Kumar Shukla, Shubhra Dwivedi, Sunil Kumar Singh, Neeraj Kumar Sharma

Abstract Early and accurate detection of breast cancer remains challenging due to high-dimensional clinical data, feature redundancy, and limitations of existing diagnostic decision systems. To address these issues, this study proposes a hybrid feature selection and classification framework that improves prediction performance while reducing overfitting. The method combines a filter-based ReliefF algorithm with a wrapper-based Teaching–Learning-Based Optimisation (TLBO), referred to as Re-wTLBO, to identify a compa …

29.08.2026journal-article

Advanced Science

Cancer‐Associated Fibroblasts Promote Glucose Metabolic Reprogramming and Progression of Triple‐Negative Breast Cancer via Exosomal circFAD104‐Mediated Intercellular Communication

Lei Wang, Xiaoyan Li, Yiran Liang, Yifei Wang, Yuhan Jin, Jianing Wang, Dan Luo, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Wenjing Zhao, Bing Chen, Lijuan Wang, Qifeng Yang

ABSTRACT Triple‐negative breast cancer (TNBC) is characterized by high metastatic tendency and poor prognosis, largely driven by dynamic crosstalk between cancer cells and the tumor microenvironment (TME). Cancer‐associated fibroblasts (CAFs) are a major component of the TME, yet their functional contributions to TNBC progression remain incompletely understood. In this study, we isolated exosomes from patient‐derived CAFs and normal fibroblasts (NFs), and profiled their circRNA content using RNA sequencing. circFAD …

29.08.2026journal-article

Maltepe Tıp Dergisi

Letrozole-Induced Hypersensitivity Pneumonitis: A Rare but Serious Pulmonary Complication in Breast Cancer Therapy

Beyza Ekinci, Eylem Tunçay, Elif Torun Parmaksız

65 yaşında, hipertansiyon ve meme kanseri öyküsü bulunan kadın hasta, onkoloji bölümü tarafından kliniğimize yönlendirildi. Başlangıçta asemptomatik olduğu bildirilen hastanın, son dönemlerde ilerleyici nefes darlığı ve öksürük şikayeti mevcuttu. Bir yıldır günde 2.5 mg letrozol kullanmaktaydı. Ayrıntılı sorgulamada, uzun süreli ev temizliği işi yaptığı öğrenildi. Bilgisayarlı tomografi (BT) taramalarında, bilateral kalıcı buzlu cam opasiteleri saptandı ve bu bulguların letrozol kaynaklı aşırı duyarlılık pnömonisin …

29.08.2026journal-article

Asian Journal of Research in Infectious Diseases

Facility Level Factors Influencing Adherence to TB Treatment in Mwingi East Sub County, Kitui County, Kenya

Jacinta Maluki Mumbe, Japheth Mativo Nzioki, Joseph Mutai, Alex Karuiru Ndiritu

Background: Tuberculosis treatment adherence is essential for successful treatment outcomes and control of drug resistance. This study assessed facility-level factors influencing adherence to tuberculosis treatment in Mwingi East Sub-County, Kitui County, Kenya. Methods: A descriptive cross-sectional study was conducted in Nguni and Waita health centres from January to March 2022. A sample of 148 participants was included, with 74 participants selected from each facility. The two facilities were purposively selecte …

29.08.2026journal-article

Human Genetics

Expected costs and benefits of genetic counselling and germline genetic testing in metastatic prostate cancer

Michiel Vlaming, Lambertus A. L. M. Kiemeney, Wouter Koole, Inge M. van Oort, Eveline M. A. Bleiker, Margreet G. E. M. Ausems, Geert W. J. Frederix

Abstract Identifying pathogenic germline variants in men with metastatic prostate cancer is important for therapeutic options and for identifying relatives who may have a high cancer risk. To keep genetic testing costs manageable, it is important to identify which patients should be selected for testing. In this study, we compared expected costs and number of identified pathogenic variants in two scenarios: offering genetic testing to all men with metastatic prostate cancer versus testing only those with additional …

29.08.2026journal-article

Journal of Cancer Education

Self-skin Examination for Skin Cancer Detection in High-risk Populations: A Diagnostic Accuracy Study and Implications for Cancer Education

Mike Climstein, Michael Stapelberg, Ian Miller, Nedeljka Rosic, Jeremy Hudson, Paul Coxon, Nathanial Milani, Chris Robinson, Guillermo De Castro-Maqueda, Joe Walsh

Abstract Background/Purpose: Aquatic populations experience high cumulative ultraviolet radiation exposure and elevated skin cancer risk. Self-skin examination is widely promoted within cancer education strategies; however, its diagnostic accuracy in high-risk groups remains unclear. Method: Adults (≥ 18 years) participating in surfing or outdoor swimming (≥ 1 h/week) underwent full-body skin examination by an accredited skin cancer doctor. Prior to examination, participants identified any lesion(s) of concern, ref …

29.08.2026journal-article

BMC Cancer

Prognostic value of circulating tumor DNA and copy-number alterations in patients receiving tandem [225Ac]Ac-/[177Lu]Lu-PSMA-617 therapy for metastatic castration-resistant prostate cancer: a prospective observational study

Mariam Amghar, Thomas Hielscher, Tobias Rausch, Hilal Özgür, Ulrike Bauder-Wüst, Hendrik Rathke, Frank Bruchertseifer, Alfred Morgenstern, Mareike Roscher, Vladimír Beneš, Clemens Kratochwil, Martina Benešová-Schäfer

Abstract Background Prostate-specific membrane antigen-targeted radioligand therapy (PSMA-RLT) demonstrates clinical efficacy in metastatic castration-resistant prostate cancer (mCRPC), yet robust biomarkers for dynamic treatment monitoring and resistance remain lacking. We investigated circulating tumor DNA (ctDNA)-derived tumor fraction (TFx) and genome-wide copy-number alterations (CNAs) as non-invasive biomarkers of treatment response and resistance biology. Methods Seventy-eight patients with advanced mCRPC re …

29.08.2026journal-article

South African Journal of Oncology

Assessing shift in breast cancer stage from the anatomical staging classification to the clinical prognostic staging system

Rahmiz R. Thomas, Tahlia Naidoo, Uchechukwu A.N. Izegbu, Neo H. Mabe, Tanya Augustine, Jenny Edge

Background: Breast cancer is the most frequently diagnosed malignancy among women and a significant health burden in South Africa. The American Joint Committee on Cancer (AJCC) 8th Edition incorporates biological markers (oestrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 [HER2] status and tumour grade) into conventional tumour, node, metastasis staging. Evidence from low-income and middle-income settings with high HIV prevalence remains limited. Aim: We compared the anatomical stag …

29.08.2026journal-article

Bulletin of Mathematical Biology

Eco-Evolutionary Dynamics of Proliferation Heterogeneity: A Phenotype-Structured Model for Tumor Growth and Treatment Response

Lara Schmalenstroer, Haojun Chen, Russell C. Rockne, Farnoush Farahpour

Abstract Intra-tumor heterogeneity in proliferation rates fundamentally influences cancer progression and treatment resistance. To investigate how continuous phenotypic variation shapes eco-evolutionary dynamics, we develop a phenotype-structured partial differential equation framework that explicitly models proliferation heterogeneity as a dynamic trait. Our model integrates three key biological principles: (1) phenotypic diffusion capturing heritable variation in proliferation rates, (2) global resource competiti …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Addressing Gaps in Supportive Care for Pediatric Cancer Patients in Africa: Insights from a Multinational Survey by the SIOP Africa

Reham Khedr, Diriba Fufa, Jaques Van Heerden

Abstract Background In Africa, delivering comprehensive supportive care is hindered by resource constraints, diverse healthcare systems, and cultural variations. To address these challenges, SIOP Africa has established supportive care Research working group. The primary objective of this group is to enhance supportive care practices and outcomes through collaborative research and capacity-building initiatives across the continent. Methods A survey was conducted to identify specific needs, gaps, and priorities in su …

29.08.2026journal-article

Japanese Journal of Radiology

Hemostatic single-fraction 8 Gy radiotherapy for tumor bleeding: a single-centre retrospective study

Kenji Makita, Hidenari Hirata, Masaki Nakamura, Yuichi Hiroshima, Masashi Wakabayashi, Sadamoto Zenda

Abstract Purpose The efficacy of single-fraction 8 Gy radiotherapy (RT) for achieving hemostasis remains unclear. In this study, we assessed (1) hemostatic efficacy, (2) rebleeding, and (3) factors related to hemostatic efficacy and rebleeding associated with single-fraction 8 Gy RT. Materials and methods Patients with tumor bleeding who received single-fraction 8 Gy RT between January 2020 and December 2024 were retrospectively examined. Factors associated with hemostasis and rebleeding (recurrence of bleeding sig …

29.08.2026journal-article

Journal of Cancer Survivorship

Benefits of prehabilitative exercise on physiological, functional and patient-reported outcomes in patients undergoing oncologic surgery: A systematic review and meta-analysis

Natália Casagrande, Favil Singh, Anderson Rech, Régis Radaelli, Bruna M. Paniz, Guilherme T. Silvestro, Guilherme N. Eberhardt, Janaína Brollo, Maximiliano C. Kneubil, Claudio P. Júnior, Pedro W. M. de Almeida, Maria Cristina F. Magalhães, Francesco Bettariga, Pedro Lopez

Abstract Purpose Prehabilitation, delivered between cancer diagnosis and surgery, may enhance functional reserve and improve tolerance to surgical stress, but evidence remains conflicting across cancer types and outcomes. We aimed to evaluate the effects of prehabilitative exercise on physiological, functional, and patient-reported outcomes in patients undergoing oncologic surgery. Methods A systematic review and meta-analysis was conducted (PROSPERO: CRD420251072796). Randomized controlled trials comparing structu …

28.08.2026journal-article

Frontiers in Cellular and Infection Microbiology

Next-generation microbiome therapeutics: psychobiotics and fecal microbiota transplants for mental health treatment

Daniel Raja Femil Selta, Leggins Abraham, Rangasamy Kavitha, Kongkona Saikia, Abiram Karanam Rathankumar, Monica Mironescu, Ion Dan Mironescu, Chella Perumal Palanisamy, Gopalakrishnan Velliyur Kanniappan

The human gastrointestinal tract (GIT) harbors a diverse microbial community, collectively referred to as gut microbiota, which plays an essential role in maintaining host physiology, metabolism, immune function, and neurobehavioral processes. Mounting evidence highlights the importance of the bidirectional Gut–brain (GB) axis, through which gut microbes influence neural signalling, stress response, and emotional regulation. Dysbiosis of this axis has been associated with psychiatric, neurodevelopmental, and neurod …

28.08.2026journal-article

Koloproktologia

Сomparing the incomparable: methodological problems in surgical treatment strategies for rectal cancer with synchronous liver metastases (review)

P. A. Tikhonov, V. I. Egorov, A. G. Kotelnikov, N. V. Fedotova

AIM: to systematically analyze key methodological challenges encountered when comparing surgical strategies for patients with rectal cancer (RC) and isolated synchronous resectable liver metastases. P ATIENT S AND METHODS: a literature search was performed in PubMed/MEDLINE, Cochrane Library, Web of Science, Scopus, and Elibrary (2000–2026). Studies comparing two or more surgical strategies (simultaneous, rectum-first, liver-first) for RC with synchronous liver metastases, methodological articles, RCTs, prospective …

28.08.2026journal-article

Frontiers in Immunology

Spatial dynamics of cancer-associated fibroblasts links fibroblastic differentiation to immune exclusion and tumor progression

Lingyi Cai, Tai-Hsien Ou Yang, Dimitris Anastassiou

Introduction Although the role of cancer-associated fibroblasts (CAFs) in cancer progression is increasingly recognized, their spatial dynamics and interactions with immune cells remain poorly understood. Methods Here, we present a computational framework that integrates single-cell resolution spatial transcriptomics and standard spatial transcriptomics across multiple tumor types to investigate CAF heterogeneity and its roles in situ . Results Our analysis presents a continuous transition from fibroblast progenito …

28.08.2026journal-article

Journal of Interdisciplinary Research Applied to Medicine

Cancer–Abscess: Multiple Imaging for the Early Identification of Underlying Malignancies and Differential Diagnosis with Presumed Infectious Collections

Manuela Montatore, Federica Masino, Ruggiero Tupputi, Eluisa Muscogiuri, Giuseppe Guglielmi

Distinguishing infectious collections from underlying malignancies may represent a significant diagnostic challenge, particularly when tumors present with necrotic, cystic, perforated, or abscess-like components. Here, we introduce the descriptive concept of “cancer–abscess” as a practical imaging-oriented framework for recognizing underlying malignancies presenting as presumed infectious collections. The first case involves an appendiceal-region malignancy initially interpreted as a postoperative pericecal collect …

28.08.2026journal-article

International Journal of Innovative Technologies in Social Science

HUMAN PAPILLOMAVIRUS (HPV): CURRENT STRATEGIES FOR THE PREVENTION AND TREATMENT OF PRECANCEROUS LESIONS

Wiktor Śliwiński, Jakub Mazur, Mateusz Kosowski, Jakub Marciniak, Daniel Chołuj, Karolina Zarówna, Weronika Pura, Dominika Matecka, Beata Huszcza

Background: Human papillomavirus (HPV) infection is the primary etiology of cervical cancer and its immediate precursors, collectively known as cervical intraepithelial neoplasia (CIN). Although primary prevention via prophylactic vaccination and secondary screening have significantly reduced incidence, cervical cancer remains a major global health burden, particularly in low- and middle-income countries. This comprehensive review evaluates the current landscape of HPV virology, pathogenesis, advanced diagnostic ri …

28.08.2026journal-article

International Journal of Interactive Multimedia and Artificial Intelligence

The Role of Advanced Language Models in MedicalDiagnostics: A Case Study on Breast Cancer Prediction

Habibe Karayiğit, Filiz Kalelioğlu

Breast cancer remains one of the most common and life threatening cancers worldwide, and early detection is strongly associated with improved survival and reduced treatment burden. This study investigates the ability of Large Language Models to perform diagnostic prediction from structured breast cancer related data. We systematically evaluated 12 LLMs across three public datasets with different clinical characteristics: the Wisconsin Breast Cancer Dataset (WBCD) based on cytological features, the Breast Cancer Coi …

28.08.2026journal-article

Clinical Cancer Research

Targetable S100–RAGE Signaling Mediates Intrinsic Trastuzumab Deruxtecan Resistance in Metastatic Breast Cancer

Wenjuan Dong, Shiruo Wang, Bill Chan, Matthew Vasquez, Johnny Z.M. Cui, James Sampson, Caitlin Sannes, Wei Yang, Akshjot Puri, Jenny Chang, Hong Zhao, Xiaoxian Li, Stephen T.C. Wong

Abstract Purpose: Trastuzumab deruxtecan (T-DXd) has improved outcomes in metastatic breast cancer; however, a substantial subset of patients experience early lack of clinical benefit that is not reliably predicted by routine clinicopathologic variables. In an institutional cohort of 109 T-DXd–treated metastatic lesions, HER2 expression level, estrogen receptor (ER)/ progesterone receptor (PR) status, Ki-67 index, and metastatic site were not significantly associated with response, highlighting the need to define m …

1 Zitationen

28.08.2026journal-article

Clinical Cancer Research

FDA Approval Summary: Erdafitinib for FGFR3 -Altered Locally Advanced or Metastatic Urothelial Carcinoma

William F. Maguire, Elaine Chang, Flora Mulkey, Vicky Hsu, Huali Wu, Tien M. Truong, Dana Kappel, Jeffrey Kraft, Jingyu Yu, Xin Gao, William F. Pierce, Nam Atiqur Rahman, Mallorie H. Fiero, Laleh Amiri-Kordestani, R. Angelo de Claro, Daniel L. Suzman

Abstract On January 19, 2024, the U.S. Food and Drug Administration (FDA) granted traditional approval to erdafitinib for patients with locally advanced or metastatic urothelial carcinoma (la/mUC) with susceptible FGFR3 genetic alterations, as determined by an FDA-approved companion diagnostic test, whose disease has progressed on or after at least one line of prior systemic therapy. Substantial evidence of effectiveness was obtained from BLC3001 (THOR, NCT03390504) Cohort 1, which was an open-label trial in which …

28.08.2026journal-article

Medicine

The intellectual structure and thematic evolution of skin cancer research in the Middle East

Ahmad Assiri

Background: Skin cancer research in the Middle East has grown substantially over recent decades, yet its intellectual and collaborative landscape remains underexplored. This study aimed to map the evolution, thematic structure, and collaboration patterns of regional skin cancer research (1946–2025), benchmarking these trends against global trajectories to identify emerging conceptual domains and research priorities. Methods: Six comprehensive Scopus-derived datasets – categorized by duration, document type, and col …

28.08.2026journal-article

Medicine

Causal relationships between oral-gut microbiome and bone neoplasm-related phenotypes

Qinyu Zou, Fengyu Sun, Wantong Xu, Dan Peng, Zhongbiao Jiang, Hongchun Liao

The human oral and gut microbiota are the 4 largest microbial communities in the body and play crucial roles in maintaining homeostasis and influencing disease. Observational studies have suggested links between these microbiota and bone neoplasm-related phenotypes, but establishing causality has been challenging due to confounding factors and reverse causality. We conducted a bidirectional, 2-sample Mendelian randomization (MR) study to investigate evidence consistent with a potential causal association between th …

28.08.2026journal-article

Urologia Journal

Clinical and epidemiological characteristics of penile cancer in a hospital-based cohort from southwestern Colombia

Nicolás Guerrón Morales, Philippe E. Spiess, Herney Andrés García-Perdomo

Objective: To describe the clinical and epidemiological characteristics of patients diagnosed with penile cancer in a hospital-based cohort from southwestern Colombia. Methods: A retrospective cross-sectional study was conducted using medical records from the Urology Department of a tertiary hospital in Cali, Colombia, between January 2013 and February 2024. Patients with confirmed penile cancer were identified through ICD-10 codes. Sociodemographic, clinical, pathological, and treatment data were extracted and ana …

28.08.2026journal-article

Frontiers in Oncology

ANP32A interacts with LDHA to modulate glycolysis and ferroptosis in hepatocellular carcinoma

Bixia Chi, Zhi Cui, Xinyue Hou, Hongfang Ding, Linjun Li, Rui Ai, Yizhuang Yang, Yue Zhao, Liyan Wang, Juan Wang

Acidic leucine-rich nuclear phosphoprotein 32A(ANP32A) is known to possess multi-functions and has been observed to exhibit different roles across various malignancies. Although the expression of ANP32A has been shown to correlate with metastatic spread and reduced survival in Hepatocellular carcinoma(HCC), the underlying mechanisms have not been fully elucidated. This study utilized univariate Cox regression, differential gene analysis, and WGCNA to identify ANP32A as closely associated with poor HCC prognosis. Ou …

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Aktuelle Forschung nach Fachgebiet

High-performance next-generation screening technology system using teaching–learning-based optimization for cancer detection

Cancer‐Associated Fibroblasts Promote Glucose Metabolic Reprogramming and Progression of Triple‐Negative Breast Cancer via Exosomal circFAD104‐Mediated Intercellular Communication

Letrozole-Induced Hypersensitivity Pneumonitis: A Rare but Serious Pulmonary Complication in Breast Cancer Therapy

Facility Level Factors Influencing Adherence to TB Treatment in Mwingi East Sub County, Kitui County, Kenya

Expected costs and benefits of genetic counselling and germline genetic testing in metastatic prostate cancer

Self-skin Examination for Skin Cancer Detection in High-risk Populations: A Diagnostic Accuracy Study and Implications for Cancer Education

Prognostic value of circulating tumor DNA and copy-number alterations in patients receiving tandem [225Ac]Ac-/[177Lu]Lu-PSMA-617 therapy for metastatic castration-resistant prostate cancer: a prospective observational study

Assessing shift in breast cancer stage from the anatomical staging classification to the clinical prognostic staging system

Eco-Evolutionary Dynamics of Proliferation Heterogeneity: A Phenotype-Structured Model for Tumor Growth and Treatment Response

Addressing Gaps in Supportive Care for Pediatric Cancer Patients in Africa: Insights from a Multinational Survey by the SIOP Africa

Hemostatic single-fraction 8 Gy radiotherapy for tumor bleeding: a single-centre retrospective study

Benefits of prehabilitative exercise on physiological, functional and patient-reported outcomes in patients undergoing oncologic surgery: A systematic review and meta-analysis

Next-generation microbiome therapeutics: psychobiotics and fecal microbiota transplants for mental health treatment

Сomparing the incomparable: methodological problems in surgical treatment strategies for rectal cancer with synchronous liver metastases (review)

Spatial dynamics of cancer-associated fibroblasts links fibroblastic differentiation to immune exclusion and tumor progression

Cancer–Abscess: Multiple Imaging for the Early Identification of Underlying Malignancies and Differential Diagnosis with Presumed Infectious Collections

HUMAN PAPILLOMAVIRUS (HPV): CURRENT STRATEGIES FOR THE PREVENTION AND TREATMENT OF PRECANCEROUS LESIONS

The Role of Advanced Language Models in MedicalDiagnostics: A Case Study on Breast Cancer Prediction

Targetable S100–RAGE Signaling Mediates Intrinsic Trastuzumab Deruxtecan Resistance in Metastatic Breast Cancer

FDA Approval Summary: Erdafitinib for FGFR3 -Altered Locally Advanced or Metastatic Urothelial Carcinoma

The intellectual structure and thematic evolution of skin cancer research in the Middle East

Causal relationships between oral-gut microbiome and bone neoplasm-related phenotypes

Clinical and epidemiological characteristics of penile cancer in a hospital-based cohort from southwestern Colombia

ANP32A interacts with LDHA to modulate glycolysis and ferroptosis in hepatocellular carcinoma