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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

Science Translational Medicine

Loss of function of ALDH3B2 transdifferentiates human pancreatic duct cells into β-like cells

Jian Li, Kevin Bode, Yu-chi Lee, Noelle Morrow, Andy Ma, Mulin He, Siying Wei, Jessica da Silva Pereira, Taylor Stewart, Alexander Lee-Papastavros, Jennifer Hollister-Lock, Brooke A. Sullivan, Hui Pan, Jonathan M. Dreyfuss, Susan Bonner-Weir, Peng Yi

Replenishment of pancreatic β cells is key to a cure for diabetes. β cell regeneration is achieved predominantly by self-replication, especially in rodents, but it was also shown that pancreatic duct cells can transdifferentiate into β cells. How pancreatic duct cells are transdifferentiated and whether we can manipulate transdifferentiation to replenish β cell mass are not well understood. Using a genome-wide clustered regularly interspaced short palindromic repeats (CRISPR) screen, we found that the loss of funct …

02.09.2026journal-article

Antimicrobial Agents and Chemotherapy

Comparative transcriptome and proteome analysis of resistant and susceptible Talaromyces marneffei clinical isolates reveals a systemic multitiered defense network against azoles

Zheng Yanqing, Peng Gaoyuan, Pang Xiaofeng, Liang Chaojuan, Luo Xiaolu, Wei Cailing, Qin Jianglong, Zou Jun, Wang Zhiyi, Pan Kaisu, Du Mingwei, Xue Peng, Liao Wanqing, Yu Mei

ABSTRACT Talaromyces marneffei is a thermally dimorphic fungus causing life-threatening systemic mycosis in immunocompromised patients. The emergence of azole-resistant clinical isolates, especially those with reduced susceptibility to voriconazole (VOC) and fluconazole (FLC), presents a critical therapeutic challenge. Although target-gene alterations and efflux-related mechanisms have been reported in pathogenic fungi, the broader molecular basis distinguishing high-minimum-inhibitory concentration (MIC) and low-M …

02.09.2026journal-article

Annals of Plastic Surgery

Impact of State Legislation on Regional Availability of Gender-Affirming Surgeons in the United States

David A. Febre-Alemañy, Jacqueline Ihnat, Paula S. Flores-Pérez, Melanie Vassallo, Sacha C. Hauc, Omar Allam, Karen Bach, Michael Alperovich

Purpose: Provider scarcity is one of the principal barriers to gender-affirming care (GAC) in the United States, with poorly characterized geographic variation. State-level legislation governing access to gender-affirming surgery (GAS) provides a framework for examining how the regulatory environment correlates with surgeon availability. This study examined the geographic distribution of GAS surgeons across the United States and its association with state legislative classification. Methods: Six provider databases …

02.09.2026journal-article

Biomedical Materials

Research progress and future trends in advanced biomaterials for the treatment of liver fibrosis

Benteng Li, Ruisi Zhu, Yonggang Lv, Guobao Chen

Abstract Liver fibrosis is a hallmark pathological feature of chronic liver diseases and poses a major threat to the health of millions of people worldwide. Without timely diagnosis and effective intervention, liver fibrosis can progress to cirrhosis, liver failure, and even hepatocellular carcinoma (HCC). The limited availability of donor organs for orthotopic liver transplantation has driven the continuous search for alternative therapeutic strategies. However, conventional approaches, including pharmacotherapy, …

02.09.2026journal-article

American Journal of Perinatology

Biostatistical Knowledge and Training in Neonatal-Perinatal Medicine Fellowship: A National Needs Assessment of Fellows and Early Career Faculty

Jeanne Alexandra Krick, Margarita M Vasquez, Deirdre O'reilly, Nicole Lock, Megan Gray

Objective: This study aimed to assess the experiences of NPM fellows and early career neonatologists with biostatistics education during fellowship training and to evaluate their confidence in using common biostatistical methods. Study Design: This was an observational cross-sectional survey study of U.S.-based NPM fellows and early career faculty. The survey instrument was designed to assess confidence in various biostatistical techniques and training experience. The anonymous survey was distributed to members of …

02.09.2026journal-article

Journal of Biomedical Optics

Single-fiber reflectance spectroscopy system using unmodified clinical laser fibers for tissue optical property recovery for photodynamic therapy treatment planning

Timothy M. Baran

SignificanceEstimation of tissue optical properties in workflow- and resource-constrained clinical settings is required to support photodynamic therapy (PDT) treatment planning, yet large-scale clinical translation remains limited by spectroscopy probe cost, complexity, and the need for probe-specific inverse models. Single-fiber reflectance (SFR) spectroscopy offers a simple and low-cost option, but previous implementations relied on customized angle-polished fibers.AimThe objective was to develop a proof-of-conce …

02.09.2026journal-article

Hepatología

Puntos claves de la nueva guía para la prevención, el diagnóstico, la atención y el tratamiento de personas con infección crónica por VHB

Sara Yesenia Munera-Ibagué, Angy Vanesa Murillo-Murillo, Maria Cristina Navas

La infección crónica por el virus de la hepatitis B (VHB) continúa siendo un problema relevante de salud pública, con alta prevalencia y una carga importante de cirrosis y carcinoma hepatocelular. A pesar de las estrategias globales orientadas a su eliminación, persisten barreras importantes como el diagnóstico, criterios terapéuticos restrictivos o acceso limitado al tratamiento, especialmente en países de ingresos bajos. En respuesta a estos desafíos, y a la luz de evidencia reciente que demuestra un riesgo de ca …

01.09.2026journal-article

Journal of Nursing Reports in Clinical Practice

Tuberculosis recurrence rates in various World Health Organization regions from 2010 to 2023

Roohallah Yousefi

Tuberculosis (TB) is a significant disease that causes numerous illnesses and deaths worldwide. TB remains one of the top ten causes of infectious disease deaths globally. The risk of TB increases with age, inadequate treatment, and drug resistance. Multi-drug-resistant TB (MDR-TB) affects 4% of new patients and 18% of those who have undergone previous treatment. Active TB can recur or lead to new infections, which may be linked to untreated dormant bacteria or exposure to different strains. Many human immunodefici …

01.09.2026journal-article

Journal of Nursing Reports in Clinical Practice

Effect of mindfulness-based cognitive therapy on fatigue and the quality of life of patients with decompensated heart failure: A quasi-experimental study

Bahauddin Ahmadpour, Sina Valiee, Fatemeh Rafiei, Mokhtar Mahmoudi

The current study aimed to evaluate the impact of mindfulness-based cognitive therapy (MBCT) on fatigue and quality of life among patients with decompensated heart failure (DHF). This quasi-experimental study with a pretest–posttest control group design was conducted in two cardiology clinics in Saqqez and Baneh, Kurdistan Province, Iran. Patients were randomly allocated to two groups: intervention and control. In the intervention group, the effects of MBCT training were evaluated using the Demographic Information …

01.09.2026journal-article

RadioGraphics

Imaging Review and Clinical Manifestations of Lacunar Stroke Syndromes

Kevin Ryan T. Yu, Thurl Cledera, Stacey Danica L. Gosiaco, Randall Sidney T. Teh, Jose Victor A. Tamayo, Eazels A. Cadag, Philip Lee S. Chua, Timothy Reynold U. Lim, Maria Lucia Brun-Vergara

Imaging plays a crucial role in diagnosis of classic and atypical lacunar syndromes, and detection of acute lacunar infarcts can be improved with correlation of clinical and radiologic features.

01.09.2026journal-article

Journal of the American Veterinary Medical Association

American Association of Veterinary Parasitologists Hookworm Task Force review on best practices for diagnosis and treatment of multidrug-resistant hookworms

Ray M. Kaplan, Pablo D. Jimenez Castro, Antoinette E. Marsh, Jeba R. J. Jesudoss Chelladurai, John S. Gilleard

Abstract Ancylostoma caninum , the canine hookworm, is the most common and clinically important gastrointestinal nematode parasite infecting dogs in the US. Common clinical signs associated with acute infections include anemia, melena, hematochezia, dehydration, and poor weight gain or weight loss. In the past few years, multiple anthelmintic drug resistance to fenbendazole, moxidectin, and pyrantel pamoate has been documented in A caninum in the US, and cases of drug-resistant canine hookworms are increasingly bei …

1 Zitationen
01.09.2026journal-article

Kidney Research and Clinical Practice

Exercise as an adjunctive therapy for patients on maintenance hemodiafiltration

Jessica L. F. Andrade, Ayden T. Heitmann, Miguel K. Rodrigues, Dave K. Marchand, Adelson M. Rodrigues, Bruno P. Biluca, Rene Freitas, Thiago Reis, Miguel A. Goes, Mayron F. Oliveira

Background: Fatigue and sedentarism are common in kidney disease and dialysis treatment. Although hemodiafiltration effectively removes solutes and improves mortality, the influence of exercise as an adjunct therapy on maintenance hemodiafiltration programs remains understudied. Methods: A multicenter 6-month study was assessed comparing individuals with chronic kidney disease enrolled in exercise training (exercise group) during dialysis (intradialytic vs. interdialytic) compared to usual care (control group). Phy …

2 Zitationen
01.09.2026journal-article

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH

Pure Red Cell Aplasia with Triple Pulmonary Co-infection and Shock-induced Organ Injury: An Autopsy-based Case Report

Nivetha Ambalavanan, Siddharthan Manimuthu, Aravind Sekar, Pulkit Rastogi

Pure Red Cell Aplasia (PRCA) is a rare haematological disorder characterised by profound anaemia, reticulocytopaenia, and selective erythroid precursor depletion. While immunosuppressive treatment is a cornerstone of management, it significantly increases patient susceptibility to life-threatening opportunistic pathogens. The authors present the case of a 26-year-old male with PRCA and hypogammaglobulinaemia who presented with rapidly progressive respiratory failure. Despite intensive care, the patient succumbed wi …

01.09.2026journal-article

Archives of Pathology & Laboratory Medicine

Centenary of Archives of Pathology & Laboratory Medicine: Its Conception, Gestation, Birth, Childhood, and Maturation

James R. Wright

Archives of Pathology & Laboratory Medicine is 100 years old this year. In this article, I describe the milieu into which Archives was conceived, then recount details of its gestation and birth, compare and contrast it with its siblings and cousins, and finally describe its growth and maturation. Throughout the 19th century, pathology was exclusively an academic discipline. During the first 2 decades of the 20th century, the opportunity for laboratorians to provide “clinical pathology” services directed at improvin …

01.09.2026journal-article

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH

Ultrasound-guided Transversus Abdominis Plane Block as Rescue Analgesia following Failed Spinal Anaesthesia in a High Risk Patient: A Case Report

Karuna Taksande, Pardhasaradhi Kapusetti

Opioid-free perioperative analgesia plays a crucial role in patients with significant co-morbidities and a prior history of opioidrelated respiratory depression. Achieving adequate analgesia using regional anaesthesia techniques is of importance in such cases. The present case report details the anaesthetic management of a 58-year-old male with a history of obesity, Obstructive Sleep Apnoea (OSA), stage 4 Chronic Kidney Disease (CKD), hypertension and opioid-induced respiratory depression who was scheduled to have …

01.09.2026journal-article

Journal of Korean Neurosurgical Society

Treatment of Brain Abscess in Patient with Eisenmenger Syndrome

Su Jeong Sung, Dae Lim Koo, Songyi Park, Dong Hoon Shin, Haechan Cho, You Jung Ok, Jin-Young Hwang, Hack-Lyoung Kim, Yoon Hwan Byun

Eisenmenger syndrome (ES) is a complex multisystem disorder caused by untreated congenital heart disease. Management of brain abscess in ES is challenging, as treatment decisions must balance infection control with altered cardiopulmonary physiology, necessitating a multidisciplinary approach. We present a case of a 45-year-old male with ES and symptomatic brain abscess treated successfully with abscess aspiration under monitored anesthesia care and appropriate antibiotic therapy. We share our experience, outline k …

01.09.2026journal-article

Pediatrics in Review

Beyond Survival: Outpatient Treatment for Functional Recovery After Brain Injury

Emily Kivlehan, Uchenna Ewulonu Pelzer, Sophie Leib, Brian D. Wishart

Abstract Acquired brain injuries (ABIs), including hypoxic-ischemic and traumatic injuries, are leading causes of long-term disability in children. While acute treatment has advanced, many survivors face persistent cognitive, emotional, and physical challenges that require coordinated outpatient care. This review aims to equip pediatric providers with the knowledge and tools necessary to provide longitudinal, comprehensive, and family-centered outpatient care for children recovering from ABIs. This review begins wi …

01.09.2026journal-article

RETINAL Cases & Brief Reports

EPIRETINAL HUMAN AMNIOTIC MEMBRANE GRAFT SURGERY FOR MACULAR HOLE WITH MACULAR TELANGIECTASIA TYPE 2

Mark P. Breazzano, Ahmet M. Hondur, Tongalp H. Tezel

Purpose: Macular telangiectasia (MacTel) type 2 is a progressive neurodegenerative condition with complications including macular hole. Conventional repair of an associated hole does not reliably improve vision despite an increasing number of described and advanced surgical techniques. The study objective was to determine whether epiretinal human amniotic membrane grafting can restore anatomy and vision in eyes complicated by macular hole with MacTel. Methods: In this international, multicenter, interventional case …

01.09.2026journal-article

Journal of Cataract & Refractive Surgery

Comparison of lenticular scanning quality and visual outcomes of keratorefractive lenticule extraction between VisuMax 800 and 500 systems

Jiayi Hu, Yongle Bao, Zhanying Wang, Yiyang Wang, Junjie Yu, Yishan Qian, Xiaoying Wang, Xingtao Zhou, Jing Zhao

Purpose: To compare lenticular scanning quality and visual outcomes between keratorefractive lenticule extraction performed with VisuMax 800 and VisuMax 500 systems. Setting: Single ophthalmic surgical center. Design: Comparative, nonrandomized prospective study. Methods: Consecutive patients aged 18 to 46 years were recruited between November 2024 and March 2025. Opaque bubble layer (OBL) and lenticular surface regularity were measured using intraoperative imaging and scanning electron microscopy. Visual acuity an …

1 Zitationen
01.09.2026journal-article

Obesity Surgery

Robotic Use, Operative Length, and Readmission after Duodenal Switch: A Retrospective Ten-Year MBSAQIP Analysis Using an Interaction Model

Samuel Leslie, Sruthi Shankar, Jordan Sauve, Amogh Kalyanam, Sayeed Ikramuddin, Eric Wise

Abstract Background Robotic-assisted surgery (RAS) is increasingly used in bariatric practice, yet its impact on outcomes after duodenal switch (DS) remains poorly characterized, and whether operative length (OL) modifies the RAS-outcome association has not been assessed. The present study examines the independent and interactive effects of RAS and OL on 30-day readmission after DS using a national cohort of over 17,000 cases from the MBSAQIP database spanning 2015–2024. Methods We analyzed MBSAQIP data from 2015 t …

01.09.2026journal-article

Frontiers in Medicine

Differential diagnosis model for tuberculous and malignant pleural effusion combining U-Net automatic segmentation and deep learning

Chang Song, Chun-Yan Zhao, Shu-Lin Song, Xue-Wen Huang, Hang-Biao Qiang, Xiao-Shi Lin, Zhen-Tao Huang, Zhou-Hua Xie, Qing-Dong Zhu

Background We aimed to construct and validate an intelligent differential diagnosis model that integrates U-Net-based automatic segmentation with a deep learning classification model, and to evaluate its diagnostic performance and clinical value for distinguishing tuberculous pleural effusion (TPE) from malignant pleural effusion (MPE). Methods A total of 281 patients with pleural effusion confirmed by etiological or pathological evidence between January 2018 and August 2025 were included, comprising 143 patients w …

01.09.2026journal-article

Sanatorium Medical Journal

Approach to Hemoptysis: Etiology, Diagnosis, and Management

Emire Pinar Seyfettin Celik

Hemoptysis is defined as the expectoration of blood originating from the pulmonary or bronchial vasculature into the airway. It may range from mild blood-streaked sputum to life-threatening massive bleeding that demands urgent intervention. Although minor hemoptysis is far more common, massive hemoptysis carries a high risk of mortality primarily due to asphyxiation rather than exsanguination. Identifying the underlying etiology is often complex, as causes vary by geography and comorbid conditions. In low and middl …

01.09.2026journal-article

Clinics in Shoulder and Elbow

Preoperative hyperglycemia within 24 hours of surgery is associated with adverse outcomes after rotator cuff repair

Yoli Meydan, Kenny Ling, Bryan Chen, James Gallagher, Edward Wang

Background: Rotator cuff repair (RCR) is a common orthopedic procedure that relies on proper tendon healing for good outcomes. While hyperglycemia is known to worsen outcomes in other surgeries, its effects on RCR remain underexplored. We investigated whether preoperative hyperglycemia is associated with increased complication rates following RCR using a large, multi-institutional database. Methods: Using the TriNetX Research Network, we identified patients who underwent primary RCR between May 2005 and May 2024. P …

01.09.2026journal-article

S.S. Korsakov Journal of Neurology and Psychiatry

Ketogenic diet in the treatment of drug-resistant epilepsy in children: Assessment of clinical efficacy, health care resource consumption, and direct medical costs

E.G. Lukyanova, A.G. Tolkushin, S.O. Ayvazyan, K.V. Osipova, E.A. Pyrieva, A.I. Krapivkin, V.A. Zhestkov

Objective. To evaluate the impact of the ketogenic diet (KD) on clinical outcomes, health resource consumption, including medication burden, hospitalization rates, and outpatient care, and direct medical costs (DMCs) in pediatric patients with drug-resistant epilepsy (DRE). Material and methods. A retrospective, non-interventional observational study was conducted at a specialized medical center. Data were collected from 58 children diagnosed with DRE: 29 patients received the ketogenic diet, while 29 patients comp …