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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
29.08.2026journal-article

Journal of Neuro-Oncology

Radiological response of primary central nervous system lymphoma after corticosteroid therapy and its predictive value on overall survival: a multicenter study

Florian Scheichel, D. Pinggera, T. Rossmann, B. Popadic, S. Aspalter, V. Schön, A. Woehrer, M. M. Dorostkar, C. Dorfer, C. F. Freyschlag, F. Marhold

Abstract Background Primary Large-B-Cell Lymphoma of the CNS (PCNS-LBCL) is a rare, aggressive tumor often sensitive to corticosteroid therapy (CST). This multicenter study investigated the spectrum of radiological responses to routine CST and evaluated its impact on patient prognosis. Methods The researchers utilized a prospective cohort of 18 patients for volumetric MRI analysis and a combined prospective-retrospective cohort of 31 patients for 2D tumor analysis. Patients received CST post-biopsy, with follow-up …

29.08.2026journal-article

Genes

Clinical Insights into RELA-Associated Disease: From Genotype to Phenotype and Exploring Treatment

Chun Pan, Cuifang Zheng, Yuhuan Wang, Jieru Shi, Lin Wang, Ying Huang

Background/Objectives: RELA encodes the p65 subunit of NF-κB and plays a critical role in immune regulation, epithelial protection, and anti-apoptotic signaling. Pathogenic RELA variants cause monogenic immune dysregulation with heterogeneous clinical manifestations. However, genotype–phenotype relationships and optimal treatment strategies remain incompletely defined. Methods: We conducted a comprehensive literature-based analysis of reported individuals with RELA variants and additionally described a family carry …

29.08.2026journal-article

Veterinary Record Case Reports

Minimally invasive treatment of bilateral membranous choanal atresia in a Labrador puppy using transnasal balloon dilatation alone

Minh Chau Vo, Ninette Keller, John Culvenor

Abstract A 4‐month‐old Labrador Retriever presented with chronic unilateral mucopurulent nasal discharge and mild stertor since birth. Computed tomography (CT) and endoscopy identified bilateral predominantly membranous choanal atresia, characterised by complete obstruction on the right with reduced definition of the ipsilateral nasal turbinates and partial obstruction on the left. Minimally invasive transnasal balloon dilatation of both choanae was performed under fluoroscopic and endoscopic guidance. At 9‐month f …

29.08.2026journal-article

American Journal of Technology Advancement

Trustworthy Artificial Intelligence in Oncology: Managing Bias, Privacy, Explainability, Safety, and Clinical Accountability in Practice

Sangida, Nasir Uddin

Artificial intelligence (AI) has quickly gained traction in oncology, assisting with cancer diagnosis, prognosis prediction, treatment selection, and precision medicine. Numerous concerns, such as bias, privacy, explainability, safety, and clinical accountability, go against the rapid implementation of AI in clinical settings. To ensure trustworthiness of AI systems, safe, equitable, and patient-centered cancer care must be developed. This systematic review will assess evidence on trusted AI applications in oncolog …

29.08.2026journal-article

Jurnal Teknologi (Sciences & Engineering)

CYTOTOXICITY AND IN-SILICO STUDY OF Piper aduncum EXTRACT TO INHIBIT BREAST CANCER CELL GROWTH

Jantje Wiliem Souhaly, Rarastoeti Pratiwi, Laurentius Hartanto Nugroho, Tri Rini Nuringtyas

Breast cancer is the most prevalent cancer among women worldwide and a leading cause of cancer-related deaths. Piper aduncum is a tropical plant recognized for various potential medicinal properties, such as anti-breast cancer. This study aims to investigate the anti-breast cancer potential of bioactive compounds found in P. aduncum leaf ethanolic extract by measuring of cytotoxicity and using a computational approach. Analysis of cytotoxic using MTT assay. Information on active compounds was collected from the KNA …

29.08.2026journal-article

The Journal of Infectious Diseases

Immune control of HIV viraemia in early paediatric infection is associated with induction of HIV-specific CD8+ T-cell activity following multiple treatment interruptions

Julia E Edgar, Harriet R Parker, Christina Thobakgale, Emily Adland, Andrew J Prendergast, Gareth Tudor-Williams, Henrik N Kløverpris, Søren Buus, Bruce D Walker, Thumbi Ndung’u, Krista Dong, Photini Kiepiela, Philip Goulder

Abstract Background Virus-specific CD8+ T-cells play an important part in HIV cure/remission in adults, yet their role in paediatric immune control is limited by tolerogenic early-life immunity. Very-early ART initiation, while effective in restricting viral reservoir size, also prevents antigenic exposure and, thereby, the induction of HIV-specific CD8+ T-cell responses. Analytical treatment interruption (ATI) is an established tool in cure/remission studies for assessing time to viral rebound and viral setpoint o …

29.08.2026journal-article

Calcified Tissue International

Estimating the Extent of Missed Opportunities for Osteoporosis Treatment Before Hip Fracture Occurrence

Gaetano Paride Arcidiacono, Marco Onofrio Torres, Chiara Ceolin, Mattia Giantin, Giovanni Tripepi, Valentina Camozzi, Anna Bertocco, Mor Peleg Falb, Martin Diogo, Francesca Guidolin, Giacomo Voltan, Maria Grazia Rodà, Elisa Pala, Andrea Angelini, Deris Gianni Boemo, Maria Vittoria Nesoti, Elena Campello, Pietro Ruggieri, Maria Fusaro, Paolo Simioni, Giuseppe Sergi, Sandro Giannini, Marina De Rui, Stefania Sella, the Hip-POS working group, Laura Bellafiore, Martina Maddalena Bellasio, Antonio Berizzi, Ilaria Bragadin, Ester Bukli, Davide Cannavò, Mariachiara Cerchiaro, Vito Cianci, Giacomo Contini, Anna Dall’acqua, Mario Degan, Marta Dianin, Michela Ferrarese, Vanessa Gamba, Alessandro Hijazin

Abstract Hip fractures (HF) are among the most serious consequences of osteoporosis. Many individuals who subsequently sustain a HF may already fulfill recognized criteria for fracture risk assessment, bone mineral density (BMD) evaluation, or anti-osteoporosis treatment before the event occurs, yet remain unidentified and untreated. We aimed to quantify these missed opportunities for osteoporosis management prior to fragility HF occurrence. We performed a cross-sectional analysis of 1,103 patients aged ≥ 50 years …

29.08.2026journal-article

Cancers

Adequacy of Visual Inspection with Acetic Acid (VIA) in Comparison to Pap Smear for Cervical Cancer Screening in Urban and Rural Settings of Tanzania

Crispin Kahesa, Daniela Gonzalez, Kandali Samwel, Duan Loy, Cameron Klein, Abigail Shotwell, Martha Ricaurte, Julius Mwaiselage, Brenda B. Kweyamba, Asafu Munema, Monica K. Angeletti, Kessy Godwin, Elayna Brown, Gleb Haynatzki, Veenu Minhas, John T. West, Charles Wood, Peter C. Angeletti

Background/Objectives: Tanzania is a low-to-middle-income-country (LMIC) which endures significant adverse impact from HIV-1- and HPV-associated malignancies. We investigated the performance of visual inspection with acetic acid (VIA) compared to the Pap smear. Methods: Screening performance was assessed in a cross-sectional study design across rural catchment clinics in Bagamoyo and Chalinze, and an urban site, Ocean Road Cancer Institute (ORCI), in Dar es Salaam. Pap smears were performed and were read in triplic …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

When Fever Meets Resistance: Mortality Risk Factors in Children With Cancer, Neutropenia and MDR Infections

Miguel Ángel Minero Hibert, Martha Avilés Robles

Abstract Background Bloodstream and other invasive infections are frequent complications in children with hematologic and oncologic malignancies. Prolonged neutropenia, mucosal barrier injury and intensive antimicrobial exposure favor colonization and infection by multidrug-resistant (MDR) organisms, which may increase morbidity, mortality and healthcare costs. Data on risk factors for death in pediatric oncology patients with fever and neutropenia (FN) due to MDR bacteria remain limited. Methods We performed an an …

29.08.2026journal-article

Genes

Circulating Tumor Function: A Systems Biology Framework for Liquid Biopsy in Genitourinary Cancers

Roxana Andra Coman, Andreea Nutu, Lia-Raluca Olari, Stefan Strilciuc, Dana Monica Iancu, Ioana Berindan-Neagoe

Liquid biopsy enables minimally invasive detection and longitudinal monitoring of tumor-derived material in blood and urine. In genitourinary cancers, most applications have focused on genomic alterations in circulating tumor DNA (ctDNA), together with circulating tumor cells (CTCs), extracellular vesicles (EVs), and cell-free RNAs. These measurements are clinically informative but are often interpreted as isolated, predominantly descriptive biomarkers and therefore incompletely represent the adaptive processes tha …

29.08.2026journal-article

Diagnostics

Clinical Outcomes and Device-Related Complications Following Flow Diverter Stent Treatment of Unruptured Intracranial Aneurysms: A Single-Center Retrospective Study

Necat Islamoglu, Ali Can Yalcin, Ilker Coven

Background/Objectives: Flow diverter stents are widely used for the treatment of complex, unruptured intracranial aneurysms. Nitinol-based devices offer improved flexibility and vessel conformability; however, real-world clinical outcome data remain limited. This study aimed to evaluate the safety and clinical outcomes of nitinol-based flow diverter stents in a single-center cohort. We hypothesized that these devices would demonstrate high technical success rates, low rates of device-related complications, and favo …

29.08.2026journal-article

Mini-Reviews in Medicinal Chemistry

Mitochondrial Dynamics and Bioenergetic Reprogramming: Drivers of Cancer Therapy Resistance

Varsha Johariya, Vaibhav Singh, Rakesh Kore, Santosh Kumar, Ravichandran Veerasamy, Amit K. Tiwari, Harish Rajak

Abstract: Mitochondria, often referred to as the powerhouses of the cell, play a pivotal role in maintaining cellular homeostasis through the regulation of energy production, redox balance, and apoptosis. Recent evidence highlights the significance of mitochondrial dynamics, fusion, fission, biogenesis, and mitophagy, enabling cells to adapt to changing physiological and environmental conditions. Dysregulation of these dynamic processes alters mitochondrial function, promoting metabolic reprogramming, evasion of ap …

29.08.2026journal-article

International Journal of Research in Medical Sciences

Clinical characteristics and treatment outcomes of benign laryngeal lesions: a retrospective observational study from a tertiary care centre

Hiranya Prova Saikia, Nilmoni Nath, Maitrayee Deb, Debajyoti Das

Background: The larynx is a complex organ of the upper aerodigestive tract responsible for phonation, respiration, and airway protection. Benign laryngeal lesions commonly present with hoarseness of voice and significantly affect quality of life. Early diagnosis and appropriate management are essential to restore normal vocal function and prevent chronic morbidity. Methods: A retrospective observational study was conducted in the department of otorhinolaryngology, Assam Medical College and Hospital, Dibrugarh, from …

29.08.2026journal-article

International Journal of Research in Medical Sciences

Comparison of efficacy of glucosamine, chondroitin sulfate and a fixed dose combination of glucosamine and chondroitin sulfate in the treatment of osteoarthritis

Krishna Kumar Suruliappan, Sivapriya Balu, Anton Smith Arul Gnana Dhas, Senthilnathan Arumugam

Background: The study aimed to compare the efficacy of glucosamine, chondroitin sulfate and a fixed dose combination (FDC) of glucosamine and chondroitin sulfate in patients with osteoarthritis (OA) of the knee. Methods: This was an open-label prospective comparative cohort study conducted from November 2023 to April 2024. Subjects were recruited consecutively from the orthopaedics outpatient department of GCMCH, Chidambaram, and assigned to one of three treatment groups based on the treating physician's prescripti …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Determinants for antibiotic therapy less or more than 7 days in pediatric oncology patients with bacteremia: a global multicenter retrospective study

Griselda Escobedo-Melendez, Joseph Wardell, Parthasarathi Bhattacharyya, Joanna Acebo, Riyadi Adrizain, Bambang Ardianto, Martha Avilés, Maribel Baquera Arteaga, Shymaa Elsayed, Dolores Freire Jijon, Samanmalee Gunasekara, Asher Hancock, Hilda Hernandez, Kim Hoa, Reham Khedr, Yanina Lagala, Jacqueline Levy, Sergio Licona, Medalit Luna, Alejandra Nava, Genara Santana, Eneida Sánchez Medina, Meenakshi Devidas, César Villegas, Sheena Mukkada

Abstract Background Randomized trials support the non-inferiority of short-course (≤7 days) antibiotic therapy for bacteremia; however, these studies commonly exclude immunocompromised patients. Shorter regimens may reduce drug toxicity while optimizing resource utilization and patient quality of life. Evidence to guide treatment duration in immunocompromised children remains limited. Methods We conducted a global, multicenter retrospective study of bacteremia in children with cancer ≤18 years old treated between A …

29.08.2026journal-article

European Journal of Preventive Cardiology

Sex differences in statin treatment after myocardial infarction in Denmark: a time-trend study utilizing Danish national registries

Anna Sofia Vestergaard Andersen, Shaun Theodor Florentz Sødergren, Daniel Modin, Jakob Øystein Simonsen, Abdullahi Ahmed Mohamed, Manan Pareek, Harriette G C Van Spall, Gunnar Gislason, Christian Torp-Pedersen, Tor Biering-Sørensen

Abstract Introduction Sex differences in treatment with statins after myocardial infarction (MI) are widely recognized. This study aimed to assess differences in statin treatment initiation after MI by sex, age groups, and year of MI. Methods and results We conducted a cohort study in Denmark using registries for patients with a first-time MI between 1 January 2000 and 31 December 2024, excluding patients already treated with lipid-lowering drugs up to 180 days before their MI. Descriptive statistics and multivaria …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Design and findings of a workshop to support infection prevention and control practices for pediatric oncology care in multi-partner hospitals in India

Tanya M Paes, Arpita Bhattacharyya, Maya Prasad, Vasudha Rao, Maysam Homsi, Miguela A Caniza

Abstract Background Infection in children with cancer can be prevented through effective infection prevention and control (IPC) practices. The Indian Childhood Cancer Initiative (ICCI), aimed at strengthening the Government of India’s program for pediatric cancer control, has 80 hospitals in 15 of 28 Indian states. The ICCI Supportive Care (SC) Task Force focuses to reduce healthcare-associated infections (HAIs) in pediatric oncology (PO) by strengthening essential IPC interventions (IPC Essentials) including hand …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Risk factors for Cefepime Resistance in Bacteria Causing Gram-negative Bloodstream Infections in a Children’s Cancer Center

Alexander Pruett, Jose Ferrolino, Ronald Dallas, Yilun Sun, Elisabeth Adderson

Abstract Background Strategies that seek to provide timely and effective therapy for febrile neutropenia (FN) in children with cancer or hematopoietic cell therapy (HCT) are threatened by increasing rates of antimicrobial resistance (AR). At our institution clinically stable patients with FN are treated with cefepime but this carbapenem-sparing strategy results in delays in the time to effective antimicrobial therapy and poorer clinical outcomes in patients with Gram-negative bloodstream infection (GNBSI) caused by …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

A Continental Perspective on Managing Antibiotics: Lessons Derived from Children's Cancer Units in Africa

Kauke Zimbwe, Alphonce Marrealle, Agness Chitedze, Reham Khedr, Stijn Verhulst, Bruno Raphael, Jaques van Heerden

Abstract Background Antimicrobial stewardship (AMS) in paediatric cancer services optimises antibiotic use to reduce the development of antibiotic resistance. Yet, very little has been published about AMS in African childhood cancer services. This study assessed AMS implementation, identified facilities offering paediatric cancer and AMS services, and gauged staff willingness in Africa to engage in educational programs for immunocompromised children. Methods A web-based, cross-sectional survey was conducted from Se …

29.08.2026journal-article

Cancers

Immunohistochemical and Transcriptomic Assessment of Cytochrome 2J2 in Prostate and Renal Cancer

Yousef M. Al-saraireh, Fatemah OFO Alshammari, Awad Dmour, Ahmed. A. Al-abadleh, Mohannad Ja’Awin, Marwan Herzallah, Fadi Sawaqed, Anas O. Satari, Sameeh A. Al-sarayreh, Sa’ed M. Al-dalain, Aiman Al-Qtaitat, Jehad M. Al Shuneigat, Abulmaaty M. Elsayed, Mohammad Salem Hareedy

Background: Cytochrome P450 2J2 (CYP2J2) has been implicated in tumor biology, but its expression pattern and clinical significance in prostate and renal cancers remain poorly characterized. Methods: Commercially available tissue microarrays containing 208 renal and 121 prostate tissue specimens were used for immunohistochemical (IHC) characterization of CYP2J2 protein expression. We performed transcriptomic analysis and examined correlations with clinicopathological features and survival using the OncoDB 2.0 platf …

29.08.2026journal-article

Biomedicines

BUB1 and CDK4/6 Dual Inhibition Increases Radiation Sensitivity in Glioblastoma, Lung Cancer, and Triple-Negative Breast Cancer

Shivani Thoidingjam, Sushmitha Sriramulu, Asya Haider Muratoglu, Rhea Hede-Sakhardande, Sunita Ghosh, Anthony J. Davis, Stephen L. Brown, Farzan Siddiqui, Benjamin Movsas, Corey Speers, Shyam Nyati

Background: Solid tumors including glioblastoma (GBM), lung cancer (LC), and triple-negative breast cancer (TNBC) exhibit marked radioresistance driven by dysregulated cell-cycle control and genomic instability. Although CDK4/6 inhibitors suppress tumor proliferation, their radiosensitizing capacity is limited by persistent DNA repair. BUB1, a mitotic checkpoint kinase overexpressed in aggressive cancers, has emerged as a regulator of DNA damage signaling. We tested whether co-targeting BUB1 and CDK4/6 enhances rad …

29.08.2026journal-article

Medical Oncology

Risk-adapted first-line therapy selection in advanced EGFR-mutant NSCLC: a practical clinical algorithm integrating tumor biology and patient factors

Ashish Sharma, Joecelyn Kirani Tan, Harendra Kumar, Hareesha Rishab Bharadwaj

Abstract Advanced EGFR -mutant non-small cell lung cancer (NSCLC), specifically tumors harboring classical activating mutations (exon 19 deletions and L858R substitutions, which are the exclusive focus of this review), is no longer a single-treatment landscape. The MARIPOSA and FLAURA2 phase 3 trials have established that combination regimens of amivantamab plus lazertinib and osimertinib plus platinum-pemetrexed, respectively, extend both progression-free and overall survival compared with osimertinib monotherapy. …

29.08.2026journal-article

Medical Oncology

FAK regulates leptin-induced angiogenesis and vasculogenic mimicry in breast cancer

Ana K. Herrera-Vargas, Ricardo Jaime-Cruz, Alejandra Rodríguez-Leviz, Miguel A. Mendoza-Catalán, Monserrat Olea-Flores, Laura Villavicencio-Guzmán, Marcela Salazar-García, Carlos C. Patiño-Morales, Napoleón Navarro-Tito

Abstract Leptin, an adipokine primarily secreted by adipose tissue, has been implicated in tumor progression by regulating angiogenesis. Leptin also plays a key role in tumor vascularization by promoting vasculogenic mimicry (VM). During tumor progression, leptin activates several signaling pathways, including the focal adhesion kinase (FAK) pathway. This study aimed to determine whether leptin promotes and regulates angiogenesis and VM through the FAK pathway. We used the chick chorioallantoic membrane (CAM) as a …

29.08.2026journal-article

Journal of Cancer Education

Digital Divide Among U.S. Adults with and without Cancer: Prevalence and Associated Factors

Yupawadee Kantabanlang, Shushun Ren, Misun Hwang, Rumei Yang, Abdul-Ghaniyu Alidu, Yun Jiang

Abstract Digital technologies have transformed healthcare, yet disparities persist, particularly among older adults and individuals with cancer. The digital divide encompasses not only access but also challenges in electronic communication and cognitive engagement, affecting health equity. This study examined the prevalence of three digital divide dimensions (Access, E-communication, and Cognitive Gaps) among U.S.adults with and without cancer and assessed their associations with sociodemographic factors, clinical …