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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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22 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Pediatric Blood & Cancer

Pain Management After Pediatric Hematopoietic Cell Transplantation: A Narrative Review of Pain Phenotypes, Assessment, and Multimodal Care

Ayodeji Otufowora, Patrice A. Pryce, Aderonke Okusanya, Mona Yuan, Sara Mohamed, Prakash Satwani

ABSTRACT Pain is a common and clinically significant complication of pediatric hematopoietic cell transplantation (HCT). It evolves across conditioning, engraftment, early recovery, and survivorship, and may result from mucosal injury, procedures, graft‐versus‐host disease (GVHD), infection, medication toxicity, immobility, and long‐term complications. Pediatric HCT‐specific guidance remains limited, so practice is often extrapolated from broader pediatric oncology, adult HCT, and supportive/palliative care literat …

03.09.2026journal-article

Diagnostics

Comparison of Diagnostic Performance of Whole-Body 360° CZT Bone SPECT/CT and Planar Bone Scintigraphy in Detecting Bone Metastasis in Small Cell Lung Cancer

Sang Mi Lee, Su Jin Jang, Ju Ock Na, Ki Hyun Seo, Nam Hun Heo, Jeong Won Lee

Background/Objectives: We aimed to compare the diagnostic performances of planar bone scintigraphy and whole-body 360° cadmium–zinc–telluride (CZT) bone single-photon emission computed tomography/computed tomography (SPECT/CT) in detecting bone metastasis in patients with small cell lung cancer (SCLC). Methods: We retrospectively evaluated two separate, non-randomized cohorts of 175 patients with SCLC who underwent staging bone scintigraphy, comprising 93 and 82 patients who underwent planar bone scintigraphy using …

03.09.2026journal-article

Cancers

Postoperative Complications After Lung Cancer Resection in Patients with a Previous History of Head and Neck Cancer

Farzin Falahat-Noushzady, Sonia Herrero-Álvarez, Elisa M. Molanes-López, Roy Camacho-Leone, Carlos Alfredo Fraile-Olivero, Joaquín Calatayud-Gastardi, José Ramón Jarabo-Sarceda, Florentino Hernando-Trancho, Elena María Vara, Ana Maria Gómez-Martínez

Background/Objectives: Surgical pulmonary resection in lung cancer remains the cornerstone of curative treatment; however, it is associated with considerable postoperative pulmonary complications. Patients previously treated for head and neck cancer (HNC) have a significantly increased risk of developing second primary lung cancer (LC) and a higher incidence of adverse pulmonary outcomes after LC resective surgery due to increased baseline frailty. Methods: A retrospective observational longitudinal study was condu …

03.09.2026journal-article

International Journal of Biomathematics

Mathematical modeling of anti-PD-1 and ascorbic acid combination therapy for lymphoma based on tumor–immune interactions

Chenghang Li, Haifeng Zhang, Jinzhi Lei

Lymphoma is a malignant tumor originating from the lymphohematopoietic system. As lymphocytes are vital components of the immune system, their malignant transformation closely links lymphoma development to immune dysregulation. Recent studies suggest that combining ascorbic acid with anti-PD-1 may have significant anti-tumor potential. In this study, we developed a mathematical model to quantitatively characterize tumor–immune interactions and evaluate the therapeutic effect of this combination in lymphoma treatmen …

03.09.2026journal-article

Journal of the Endocrine Society

Intermediate risk thyroid cancer management: physician survey

Annu R Suresh, Amanda Kung, Jiling Chou, Jacqueline Jonklaas

Abstract Context Variability exists in use of radioactive iodine (RAI) treatment in intermediate risk (IR) thyroid cancer. Objective The study surveyed clinicians about their use of RAI in theoretical cases of patients with IR thyroid cancer. Design A survey presented patient cases with pathology results and two variations consisting of baseline thyroglobulin levels of ≤5 ng/mL and >5 ng/mL. Respondents were queried as to their use of RAI therapy in each case. Univariate Bayesian cumulative ordinal regression mo …

03.09.2026journal-article

Frontiers in Oncology

Ultrasound-based shrinkage patterns at mid-neoadjuvant chemotherapy for predicting pathological complete response in invasive breast cancer

Yiting Hong, Wenzhi Zheng, Hong Chen, Jingchao Chen, Ming He, Kangjian Wang, Haolin Shen

Objective To develop an ultrasound-based tumor shrinkage pattern and subsequently construct a predictive model for pathological complete response by analyzing changes in ultrasonic features and measurements at mid-treatment of neoadjuvant chemotherapy (NAC) in invasive breast cancer, ultimately evaluating its clinical applicability. Methods This study included all breast cancer patients who underwent NAC and subsequent surgery between January 2017 and December 2024. All patients received breast ultrasound examinati …

03.09.2026journal-article

General Thoracic and Cardiovascular Surgery

Impact of preoperative nutritional status on longitudinal changes in pulmonary function and prognosis after lung cancer surgery

Kentaro Miura, Daisuke Nakamura, Sachie Koike, Shuji Mishima, Yukihiro Terada, Shunichiro Matsuoka, Hirotaka Kumeda, Takashi Eguchi, Kazutoshi Hamanaka, Kimihiro Shimizu

Abstract Objective Preoperative nutritional status is a known prognostic factor in lung cancer surgery. However, its effect on postoperative pulmonary function over time remains unclear. This study evaluated the association between preoperative nutritional status and longitudinal respiratory changes andoutcomes after curative resection. Methods Patients who underwent resection for non-small cell lung cancer between January 2020 and December 2024 were prospectively analyzed. Patients were classified by prognostic nu …

03.09.2026journal-article

Cancer Drug Resistance

Resistance to third-generation EGFR TKIs - what can be expected from the fourth-generation?

Wolfram C. M. Dempke, Klaus Fenchel, Loretta Sullivan, Martin Reck

Tyrosine kinase inhibitors (TKIs) have significantly changed the treatment of non-small cell lung cancer (NSCLC) harbouring epidermal growth factor receptor (EGFR) mutations, and osimertinib is now established as first-line therapy for NSCLCs. Combination therapies (e.g., osimertininb plus chemotherapy; lazertinib plus amivantamab) have been shown to improve median progression-free survival (mPFS) and median overall survival (mOS) relative to monotherapy. However, due to several resistance mechanisms, patients expe …

03.09.2026journal-article

Endocrinology

BRN2 in Lineage Plasticity: A Prostate Cancer-Focused Perspective

Fatemeh Seilani, Jia Peng, Meng Wu, Mohammad Esfini Farahani, Xinyi Wang, Amos Olalekan Akinyemi, Xiaoqi Liu

Abstract Lineage plasticity is a major mechanism by which prostate cancer adapts to therapeutic pressure, particularly following sustained inhibition of androgen receptor signaling. A central mediator of this process is BRN2, a POU3F2 neural lineage transcription factor that is normally suppressed in AR-dependent luminal prostate epithelium but becomes aberrantly activated during progression to castration-resistant and neuroendocrine prostate cancer. This review examines how BRN2 connects developmental neurogenesis …

03.09.2026journal-article

Frontiers in Oncology

MRI radiomics-based predictive modeling for risk stratification and prognostication in oral tongue carcinoma

Nivedita Chakrabarty, Swapnil U. Rane, Umesh Sherkhane, Sourabh More, Nitin Shetty, Sarbani Ghosh Laskar, Arjun Singh, Vanita Noronha, Kumar Prabhash, Pankaj Chaturvedi

Introduction This study aims to predict recurrence-free survival (RFS) and overall survival (OS), to stratify risk using radiomics, radiology semantic, clinical, and pathology models—individually and in combination—derived from pre-treatment magnetic resonance imaging (MRI), post-operative histopathology, age, and adjuvant therapy details in oral tongue squamous cell carcinoma (OTSCC), and to correlate National Comprehensive Cancer Network (NCCN) low + intermediate- and high-risk groups with the risk stratification …

03.09.2026journal-article

Frontiers in Neurology

Interpretable machine learning–based prediction of 90-day mortality after endovascular treatment in acute large vessel occlusion stroke

Yuanfang Zhou, Xiaoxia Li, Guokuan Feng, Chuanhang Lin, Bao Liao

Background Despite high recanalization rates after endovascular treatment (EVT) for acute ischemic stroke due to large vessel occlusion (AIS-LVO), 15%−20% of patients still die within 90 days. Existing prognostic models predominantly target functional disability rather than mortality, and rarely incorporate calibration, clinical utility, or interpretability. We aimed to develop and internally validate interpretable machine learning (ML) models for dynamic post-EVT in-hospital prediction of 90-day all-cause mortalit …

03.09.2026journal-article

Journal of Feline Medicine and Surgery Open Reports

EXPRESS: Use of subconjunctival cyclosporine implants for treatment of feline eosinophilic keratoconjunctivitis: a case report

Lynn Willems, Jordan Kay Roberts

Case summary A 5-year-old neutered male domestic shorthair cat was presented for evaluation of chronic bilateral eosinophilic keratoconjunctivitis (EK). The patient had a history of recurrent corneal plaques and conjunctivitis that were initially managed with systemic and topical immunosuppressive therapy. Long-term disease control was limited by poor tolerance of topical ophthalmic medications, resulting in inconsistent treatment and repeated disease recurrence affecting both eyes. Over several years the cat was t …

03.09.2026journal-article

Monaldi Archives for Chest Disease

Treatment outcomes and factors associated with unfavorable outcomes among drug-resistant tuberculosis patients treated with a bedaquiline-based oral regimen

Oki Nugraha Putra, Julaeha Julaeha, Nurhayati Nurhayati, Telly Purnamasari, Nurul Damayanti, Dewi Ramdani, Ahmad Erlan, Paisal Paisal, Rini Sasanti Handayani, Nur Indah

The treatment success rate for drug-resistant tuberculosis (DR-TB) in Indonesia remains below the national target. Identifying factors associated with unfavorable treatment outcomes is essential to inform more targeted interventions. This retrospective study analyzed medical records of patients with DR-TB who received treatment at Surabaya Haji Hospital between 2020 and 2024. Demographic, clinical, behavioral, and treatment-related variables were evaluated in relation to unfavorable treatment outcomes, defined as a …

03.09.2026journal-article

Discover Oncology

Identification of FN1 and TIMP1 as macrophage-associated programmed cell death-related prognostic markers in glioblastoma via integrated bulk and single-cell RNA sequencing

Feng Li, Caifeng Wang, Zhesen Tian, Chunmei Liu, Yufeng Zhang, Jiankai Yang, Xiaojing Chang

Abstract Background Glioblastoma (GBM) is the most common primary intracranial malignancy in adults, characterized by poor survival and high mortality. Emerging evidence suggests that macrophage-associated programmed cell death (MacPCD) plays a critical role in GBM pathogenesis. However, the underlying mechanisms remain poorly understood. This study aimed to identify MacPCD-related prognostic genes in GBM and explore their functional roles. Methods Transcriptomic data from the GSE68848 dataset were integrated with …

03.09.2026journal-article

Frontiers in Endocrinology

The circadian–melatonin axis in breast cancer metastasis: molecular mechanisms, organ-specific metastatic niches, and therapeutic opportunities

Ching-Hsiang Wang, Kian-Hwee Chong, Ching-Feng Cheng, Yao-Jen Chang, Kuo-Wang Tsai

Breast cancer metastasis remains the leading cause of disease-related mortality despite major advances in systemic therapy. Increasing evidence indicates that the circadian–melatonin axis may influence metastatic progression by coordinating endocrine signaling, metabolism, immune responses, and tumor cell plasticity. In this review, we summarize current epidemiological, mechanistic, and translational evidence linking circadian disruption and melatonin to breast cancer metastasis. We discuss how core circadian clock …

03.09.2026journal-article

Frontiers in Oncology

A deep transfer learning radiomics nomogram using chest CT for differentiating anterior mediastinal cysts from low-grade thymomas

Li Zhao, Dengwang Zhao, Tong Zhou, Xueqing Sui, Pei Nie, Chongfeng Duan

Objectives The objective of this study was to develop a nomogram by integrating clinical features, radiomics predictive results, and deep transfer learning (DTL) predictive results to differentiate between anterior mediastinal cysts (AMCs) and low-grade thymomas. Methods The training set included 149 cases of AMCs and low-grade thymomas, whereas the test set included 49 cases of AMCs and low-grade thymomas. Contrast-enhanced chest CT images were used for analysis. A deep transfer learning radiomics (DTLR) nomogram …

03.09.2026journal-article

Frontiers in Oncology

Surgical resection with postoperative stereotactic radiosurgery versus stereotactic radiosurgery alone for large (>3 cm) multiple brain metastases: a propensity score-matched analysis

Xufei Guo, Kuanyu Wang, Shiqi Shi, Li’ao Wang, Yutong Zhao, Dan Xiao, Wang Jia, Shibin Sun, Deling Li

Purpose While surgery plus stereotactic radiosurgery (SRS) is established for solitary brain metastases, its role in multiple brain metastases (MBM) remains unclear. This study compared survival in MBM patients undergoing resection of the largest tumor plus postoperative SRS versus SRS alone. Methods This retrospective study included adults with 2–4 MBM, a dominant lesion >3 cm, and Karnofsky Performance Status ≥70. We compared patients undergoing resection of the dominant lesion plus SRS against those receiving …

03.09.2026journal-article

Frontiers in Oncology

Ultrasound radiomics for preoperative evaluation of Ki-67 proliferation index in papillary thyroid carcinoma

Hui Shi, Jiayi Qiu, YuLu Wu, Ying Zhang, HengQi Zhang, YunYun Liu, YiTong Li, JiaHui Ni, ChongKe Zhao, HuiXiong Xu, LiPing Sun, LeHang Guo, YiFeng Zhang

Purpose To explore the predictive value of radiomics features, ultrasound (US), and gene mutation status based on interpretable random forest (RF) models for predicting high Ki-67 expression in papillary thyroid carcinoma (PTC). Methods This retrospective analysis included 627 patients with surgically confirmed PTC who underwent testing for BRAF V600E and TERT promoter mutations, as well as immunohistochemical assessment of Ki-67 expression from December 2015 to June 2023. The eligible patients were randomly divide …

03.09.2026journal-article

Journal of Clinical Medicine

The Association of SARIFA with Poor Prognosis and Aggressive Tumor Phenotypes in Cancers: A Meta-Analysis

Jiaqi Lao, Guangwei Tian, Lin Guan

Background: SARIFA (Stroma Areactive Invasion Front Areas) is an emerging histopathological biomarker defined by direct tumor–adipocyte contact at the invasive front. Preliminary studies suggest its association with poor prognosis, but evidence remains fragmented across cancer types. This meta-analysis aims to systematically evaluate the prognostic value of SARIFA for overall survival (OS) and its correlation with aggressive tumor phenotypes. Methods: Following PRISMA guidelines, we searched PubMed, Embase, Web of …

03.09.2026journal-article

Ege Tıp Dergisi

Preoperative halp score in gastric cancer patients undergoing upfront gastrectomy: Clinicopathological associations and survival outcomes

Erkan Güler, Melih Taşkın

Aim: This study aimed to evaluate the association of the preoperative hemoglobin–albumin–lymphocyte–platelet (HALP) score with clinicopathological characteristics and overall survival in gastric cancer patients undergoing primary curative-intent gastrectomy.Materials and Methods: This retrospective single-center study included patients who underwent gastrectomy for histologically confirmed gastric adenocarcinoma between January 2010 and December 2025. Of 149 initially evaluated patients, 12 who received neoadjuvant …

03.09.2026journal-article

Journal of Neuro and Oncology Research

Autoimmune-Associated Lymphocytic Central Nervous System (CNS) Vasculitis Presenting as a Tumefactive Cerebral Infarct Mimicking Multicentric Glioma

Pankaj Patil, Shelja Jha, Sujata Prabhu, Akash Prabhu, Arshiet Dhamnaskar, Santosh Prabhu

Purpose: Central nervous system vasculitis may rarely present as a tumor-like lesion with enhancement, edema, mass effect and multifocality, closely mimicking glioma. We report an uncommon case of autoimmune-associated lymphocytic CNS vasculitis presenting as a tumefactive cerebral infarct radiologically mimicking multicentric glioma. Methodology: Clinical history, neurological examination, preoperative imaging, operative findings, histopathology, immunohistochemistry, postoperative course and blood-based autoimmun …

03.09.2026journal-article

Journal of Cancer Survivorship

Survivorship care for melanoma patients: a scoping review

Madlen Hörold, Sasha Schutkowski, Karl-Philipp Drewitz, Sebastian Haferkamp, Jochen Schmitt, Friedegund Meier, Maike Bergmann, Benjamin Küster, Marlon Pape, Christian Apfelbacher

Abstract Purpose Despite significant advances in melanoma treatment, many survivors continue to experience long-term effects of disease and therapy. Various survivorship care programs have been developed in recent years, but these differ in terms of their scope, content, and delivery. The aim of this scoping review was to summarize existing literature on melanoma survivorship care. Methods The search strategy was developed using the PCC (Population, Concept, Context) framework for scoping reviews. We conducted syst …