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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

Frontiers in Public Health

Integrating digital therapeutics for patients with mental illness into clinical practice: perspectives for US healthcare professionals

Brandon M. Kitay, David C. Mohr, Stephen M. Schueller

As the landscape of digital health tools has expanded, digital therapeutics have emerged as promising treatment options for various mental health conditions. Although digital therapeutics have demonstrated efficacy in prevention, treatment, and management of mental illness, adoption of these interventions in clinical practice remains low. Here, key questions for healthcare providers about implementation of digital therapeutics into US clinical practice are addressed, focusing on digital therapeutics for mental illn …

02.09.2026journal-article

Revista DCS

ELECTROACUPUNCTURE AND ENDOGENOUS STEM/PROGENITOR CELL MOBILIZATION: A SCOPING REVIEW OF MECHANISMS AND REGENERATIVE MEDICINE IMPLICATIONS

Maxime Moulins, Livia Maria Marques Pereira, Anisio Francisco Soares

The Electroacupuncture (EA) is a nonpharmacological neuromodulatory intervention increasingly investigated for its systemic effects, including potential mobilization of endogenous stem and progenitor cells. This scoping review, conducted according to PRISMA‑ScR, mapped in vivo animal and human studies reporting EA‑induced systemic mobilization and regenerative outcomes across five major databases. Ten studies (nine preclinical, one clinical) showed EA‑associated mobilization of mesenchymal stem cells, endothelial p …

02.09.2026journal-article

Artefactum - revista de estudos interdisciplinares

THERAPEUTIC REFUSAL AND PATIENT AUTONOMY: LIMITS BETWEEN THE RIGHT TO CHOOSE AND HEALTHCARE PROFESSIONALS’ DUTY OF CARE

Carlabianca Cabral de Jesus Canevari, Joyce Lara de Lima Mendes, Izabela Castro e Silva, Glaziélia Ferreira Franco, Ivanei Rodrigues da Silva, Angela Maria Fernandes da Silva, Thalita Sena Ribeiro Silva, Renato Canevari Dutra da Silva

Therapeutic refusal expressed by a competent and conscious patient sits at the point of tension between the fundamental right to self-determination and the duty of care that guides the conduct of healthcare professionals. The research question guiding this article can be stated as follows: what are the legal and ethical limits that reconcile respect for patient autonomy with the healthcare professional’s duty of care when facing refusal of medical treatment, including in life-threatening situations? The article aim …

02.09.2026journal-article

PLOS Medicine

Neutralising antibodies and protection from progression to severe COVID-19: A meta-analysis

Karen M. Elias, Ainslie Mitchell, Eva Stadler, Timothy E. Schlub, Shanchita R. Khan, Claire Xue, Stephen J. Kent, Deborah Cromer, Miles P. Davenport, David S. Khoury

Background Vaccine-induced neutralising antibodies are a well-established correlate of protection against acquisition of COVID-19. Vaccine protection from severe COVID-19 remains high, although the role of neutralising antibodies and the contribution of other immune responses to protection from severe outcomes is less clear. Improving understanding of how vaccines prevent severe outcomes is important for future vaccine development. Methods and findings Here we undertake a systematic search of the literature to obta …

02.09.2026journal-article

JMIR Research Protocols

A Culturally Adapted Smoking Cessation App (IndigeQuit) for American Indian and Alaska Native Adults: Protocol for a Randomized Clinical Trial

Jonathan B Bricker, Margarita Santiago-Torres, Brianna M Sullivan, Kristin E Mull, Hershel W Clark, Chase Kornacki, Trivia Afraid of Lightning-Craddock, Dean S Seneca, Crystal M Stanford, Sierra L Wilcox, Patricia Nez Henderson, Lonnie Nelson

Background Due to limited access to evidence-based cessation support, American Indian and Alaska Native (AI/AN) adults are half as likely to quit commercial cigarette smoking as other racial and ethnic groups. Geographical barriers, underfunded health systems, and limited integration of cessation services into routine care have reduced access to effective treatment in AI/AN communities. These challenges are compounded by a lack of culturally relevant interventions tailored to AI/AN adults. Thus, there is an urgent …

02.09.2026journal-article

Academy for Practical Oncology

Experience with the use of trastuzumab deruxtecan in real-world clinical practice: data from Clinical Oncology Dispensary no. 1 (Krasnodar) and Federal Scientific Clinical Center of the fMBA of Russia

M. Yu. Mostovoy, S. V. Sharov, E. V. Lymar, A. G. Onishchenko, J. A. Bat, A. S. Melnikova, G. G. Lisachenko, A. G. Kedrova, T. A. Greyan

This article presents a systematic review of international and domestic experience with the use of trastuzumab deruxtecan in patients with HER2-positive and HER2-low metastatic breast cancer. Based on an analysis of key registration studies (DESTINY-Breast01, -03, -04), and confirmatory clinical trials (DESTINY-Breast02, -12) and real-world clinical practice data from the Clinical Oncology Dispensary No. 1 (Krasnodar) (n = 22) and Federal Scientific Clinical Center of the Federal Medical and Biological Agency of Ru …

02.09.2026journal-article

Journal of Laparoendoscopic & Advanced Surgical Techniques

Beyond HbA1c: Multivariate Clustering and Propensity-Weighted Analysis Identify High-Risk Patients with Diabetes Undergoing Bariatric Surgery

Fathima Ruba Shamnad, Juan S. Barajas-Gamboa, Alfredo D. Guerron, Javed Raza, Juan Pablo Pantoja, Juan Cruz Lopez Meyer, Safa Botros Hegazin, Cynthia Salloum, Carlos Abril, John Rodriguez

Introduction: Preoperative glycemic control is a key concern in bariatric surgery. However, the extent to which suboptimal HbA1c levels impact short-term postoperative morbidity remains uncertain. This study evaluated the association between preoperative HbA1c categories and 30-day postoperative morbidity in a large Middle Eastern bariatric surgery cohort, using propensity score weighting and unsupervised clustering to refine risk stratification. Methods: This retrospective cohort analysis included 1778 bariatric s …

02.09.2026journal-article

Annals of Surgery

Transcriptome Dynamics From Primary Gastric Cancer to Peritoneal Metastases: Translational Insights for Surgical Oncology

Maria Bencivenga, Michele Simbolo, Stefano Gobbo, Alessandra Franceschi, Angela Sandri, Alberto Verlato, Federica Filippini, Erica Secchettin, Fabrizio Tedone, Cristina Migliore, Claudio Luchini, Jan Ewald, Rita Teresa Lawlor, Alessia Nottegar, Giovanni de Manzoni

Background and Aims: Peritoneal metastases (PMs) represent the most frequent, clinically challenging dissemination pattern in advanced gastric cancer, especially poorly cohesive (PCGC) subtype, and are associated with poor prognosis. We aimed to characterize the transcriptomic landscape of primary gastric tumors (PGTs) and matched PMs to identify differential molecular programs, tumor-microenvironment (TME) features, and potential biomarkers. Methods: We analyzed 55 FFPE samples from 23 treatment-naïve patients wit …

02.09.2026journal-article

Annals of Surgery

The Impact of Out-of-Hours Liver Transplantation on Outcomes

Mathias V.A. Vidgren, Rose Matin, Samuel A.E. Lundgren, Antonio Romano, Amanda L.M. Habermann, Malin E. Aram, Sebastian P. Forssten, William F.D. Bennet, Gabriel C. Oniscu

Objectives: This national, multicenter retrospective study of 764 adult liver transplantations (LT) in Sweden (2019–2023) employed a data-driven approach to identify the out-of-hours (OOH) high-risk window and evaluate its impact on patient outcomes and health care costs. Summary Background Data: LT logistics often necessitate OOH surgery, but the evidence for an impact on outcomes remains conflicting, partly due to arbitrary window definitions. Methods Using the mathematical principle of permutations and linear re …

02.09.2026journal-article

Sakarya Medical Journal

How Artificial, How Intelligent? LLMs and Medical Experts Face Off in TMA Diagnosis

Gizem Zorlu Görgülügil, Ceyda Kaçar, Elif Şen, Ayça İnci, Volkan Karakuş

Objective: To compare physician specialists and large language models in the differential diagnosis and plasma exchange decision making of standardized thrombotic microangiopathy case vignettes.Methods: This case vignette based comparative study included three standardized TMA scenarios representing atypical hemolytic uremic syndrome, malignant hypertension associated TMA, and acquired thrombotic thrombocytopenic purpura. Nine evaluators participated: two nephrologists, two hematologists, two internal medicine spec …

02.09.2026journal-article

Clinical Kidney Journal

Myocardial injury in systemic lupus erythematosus and lupus nephritis: A silent threat

Eleni Moysidou, Maria-Anna Bazmpani, Alexandros Kallifatidis, Dimitrios Kotzadamis, Efstathios Pagourelias, Theodoros Karamitsos, Maria Stangou, Eleni Frangou

Abstract Systemic lupus erythematosus (SLE) is associated with significant cardiovascular morbidity, with myocardial involvement representing one of the most clinically significant yet underrecognized cardiac manifestations, largely due to its frequently subclinical presentation and diagnostic complexity. Lupus nephritis (LN), a common and clinically significant manifestation of SLE, is further associated with increased cardiovascular risk, reflecting a dynamic cardiorenal interaction driven by persistent immune ac …

02.09.2026journal-article

Behavior and Social Issues

Attachment in Psychotherapy: A Behavioral Approach and Clinical Implications

Rebeca Pardo-Cebrián, Gladis-Lee Pereira, Natalia Andrés-López, Amanda Muñoz-Martínez

Abstract Attachment theory, rooted in psychoanalytic and ethological theories, is one of the most influential models in psychology for understanding relational patterns. Originally developed to explain infant–caregiver bonding within developmental psychology, its application has expanded to clinical contexts as a model of relational intimacy. The assumption that early caregiving experiences shape adult relational functioning has further extended its influence within psychotherapy. However, attachment theory has bee …

02.09.2026journal-article

Physics in Medicine & Biology

Three-point center-of-gravity calculation for crosshair light sharing PET detector

Eiji Yoshida, Fujino Obata, Taiga Yamaya

Abstract Objective. The crosshair light-sharing (CLS) PET detector acquires time-of-flight (TOF) and depth-of-interaction (DOI) information by looping scintillation light through a window at the top of the crystals and distributing it to two photosensors, but light is typically detected by an average of six photosensors, making center-of-gravity (CoG) calculation essential for crystal identification. Approach. In this work, an improved CLS detector achieved a shorter coincidence resolving time (CRT) by employing a …

02.09.2026journal-article

Annals of Clinical and Translational Neurology

Validation of a Cellular Imaging‐Based Method as a Potential Biomarker for SPG4 Hereditary Spastic Paraplegia

Gaia Fattorini, Valerio Licursi, Gianmarco Dalla Zanna, Flavio Dal Canto, Melissa Barghigiani, Nunzio Setola, Salvatore Rossi, Antonio Funcis, Filippo M. Santorelli, Gabriella Silvestri, Carlo Casali, Francesca Sardina, Cinzia Rinaldo

ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP. SPG4/SPAST encodes spastin, a protein involved in microtubule regulation and lipid droplet behavior. SPG4‐HSP shows extreme heterogeneity in both clinical manifesta …

02.09.2026journal-article

Physics in Medicine & Biology

Detector nonlinearity in measuring the bone mineral density based on neural networks

Eunae Lee, Dong Sik Kim

Abstract Objective. A dual-layer flat-panel detector (DFD) allows for the acquisition of dual-energy images with a single x-ray exposure without scanning. In this paper, we aim to perform noise sensitivity analyses on a single-shot approach using DFD in measuring bone mineral density (BMD) and propose a method for calculating BMD using features acquired from a nonlinear response detector without a nonlinearity correction scheme. Approach. We evaluate the condition numbers of the BMD estimate functions and observe t …

02.09.2026journal-article

Journal of Craniofacial Surgery

Combined Botulinum Toxin Type A and Hyaluronic Acid Versus Exclusive Hyaluronic Acid Injections: A Potential Nonsurgical Alternative for Chin Augmentation

Enrico Betti, Mariagrazia Paglianiti, Luigi A. Vaira, Antonio Ricciardi, Giulio Cirignaco, Giuseppe Consorti

Nonsurgical chin augmentation with hyaluronic acid (HA) fillers is a widely used technique in aesthetic medicine. However, outcomes may be influenced by hyperactivity of the mentalis muscle, which may lead to reduced longevity. Botulinum toxin type A (BoNT-A) may improve filler integration through myomodulation of muscles. To evaluate whether a combined protocol using BoNT-A followed by HA provides advantages over HA alone in nonsurgical chin augmentation in terms of aesthetic outcomes, HA volume required, longevit …

02.09.2026journal-article

Aesthetic Surgery Journal

Effectiveness, Patient Satisfaction, and Safety of a Next-generation PLLA Collagen Biostimulator for Nasolabial Fold Augmentation: 12-month Results of a Prospective Multicenter Study

Adriana Ribe, Ulrika Erhardt, Karina De Almeida Caramico, Émilie Souton-Al Gburi, Franco Grimolizzi, Per Hedén

Abstract Background Poly-L-lactic acid (PLLA) dermal fillers induce neocollagenesis through a bioinductive mechanism rather than facial tissue volumization. The next-generation PLLA-LASYNPRO formulation (LASYNPRO, Lactic Acid Induced Synthesis of Collagen Protein), a biomaterial-microsphere technology developed for regenerative aesthetic biostimulation, composed of uniform, non-porous microspheres, has been proposed as an evolution of earlier PLLA products, offering a more controlled, lower-inflammatory regenerativ …

02.09.2026journal-article

Archives of Orthopaedic and Trauma Surgery

Cartilage disruption patterns associated with percutaneous intramedullary screw fixation for metatarsal fractures: a cadaveric study

Bailey Keith, Joseph Burke, Kelly Hynes, James Baker, Jeannie Huh

Abstract Purpose Intramedullary screw fixation is an emerging technique for operative metatarsal fractures, yet the extent and location of articular cartilage disruption from retrograde screw insertion remain undefined. This study quantifies cartilage surface disruption and maps injury locations in the metatarsal head following screw placement. Methods Fourteen fresh-frozen cadaveric feet (56 lesser metatarsals) underwent standardized retrograde intramedullary screw fixation using 3.6 mm screws. Following dissectio …

02.09.2026journal-article

Internal and Emergency Medicine

Unsupervised machine learning with Cluster Analysis in patients with rheumatoid arthritis: insights in CV risk phenotypes from a multicentre Italian cohort

Vincenzo Venerito, Elena Bartoloni, Gian Luca Erre, Matteo Piga, Garifallia Sakellariou, Ombretta Viapiana, Andreina Manfredi, Elisa Gremese, Fabiola Atzeni, Francesca Romana Spinelli, Fabio Cacciapaglia

Abstract Rheumatoid arthritis (RA) patients face increased cardiovascular (CV) risk, yet existing 10-year estimation tools often underperform. This study evaluated whether unsupervised machine learning (uML) clustering can identify distinct RA patient phenotypes with varying major cardiovascular events (MACE) potentially improving risk stratification. A cross-sectional, multi-center cohort of RA patients meeting the 2010 ACR/EULAR classification criteria and without prior CV events was enrolled in January 2019 and …

02.09.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Impact of an Educational Intervention on Crimean-Congo Hemorrhagic Fever Knowledge among Nonphysician Healthcare Workers in an Endemic Region

Nurten Nur Aydın, Ayten Yanık, Murat Aydın, Ömer Karaşahin

ABSTRACT. Crimean-Congo hemorrhagic fever (CCHF) poses a significant occupational risk to healthcare workers (HCWs) in endemic regions. Knowledge gaps, especially among nonphysician staff, may compromise infection control. The aim for the present study is to evaluate the effectiveness of a targeted educational session in improving CCHF-related knowledge and infection control attitudes among nonphysician HCWs. A prospective pre-post intervention study was conducted at a tertiary care hospital in an endemic region. A …

02.09.2026journal-article

Oral Surgery

Workforce Planning for Oral Surgery and Oral and Maxillofacial Surgery in the United Kingdom: Aligning Future Service Provision With Patient Need

Adrian Thorp

ABSTRACT Workforce pressures within United Kingdom Oral and Maxillofacial Surgery (OMFS) services include recruitment difficulties, consultant vacancies, increasing demand and concerns about the sustainability of emergency and specialist pathways. Although these challenges require action, workforce expansion should be based on population need, service activity, case mix and the competencies required to deliver care, rather than existing professional or organisational boundaries. This opinion article presents a crit …

02.09.2026journal-article

Chronic Wound Care Management and Research

Expert Roundtable Recommendations on Wound-Bed Optimization in Difficult-to-Heal Wounds: Clinical Positioning of ON101 From a U.S. Multidisciplinary Roundtable

John Lantis, Michael Desvigne, Laura Pfendler, Mark Suski, Greg Bohn, Zwelithini Tunyiswa, Mervin Low, Abigail Chaffin, Brock Liden

Diabetic foot ulcers (DFUs) remain a major clinical and economic challenge and may persist within a dysregulated wound microenvironment characterized by persistent inflammation, impaired cellular signaling, microbial biofilm burden, and failure to progress through normal healing pathways. ON101 is a provider- directed topical wound-bed optimization matrix developed to support progression toward closure in difficult-to-heal DFUs. To review the available evidence and develop structured expert roundtable recommendatio …

02.09.2026journal-article

Florida Journal of Emergency Medicine

The Silent Snowstorm: Complete Hydatidiform Mole Presenting as Asymptomatic Pregnancy of Unknown Location

Maya Itani, Christopher Maguire

Gestational trophoblastic disease (GTD) encompasses a spectrum of hyperproliferative disorders, including molar pregnancy. While GTD classically presents with hyperemesis or vaginal bleeding, early diagnosis can be challenging when the patient is asymptomatic, presenting instead as a pregnancy of unknown location (PUL). This report details a 17-year-old G1P0 who initially presented to the emergency department at an estimated 7 weeks’ gestation as a fully asymptomatic PUL following a non-diagnostic outpatient ultras …

02.09.2026journal-article

British Journal of Community Nursing

Transforming wound care: the role of AI in achieving clinical and financial outcomes

Jackie Stephen Haynes, James Burford

Wound care has significant associated challenges in clinical practice, particularly for chronic wounds such as venous leg ulceration, pressure ulceration and diabetic foot ulceration. This article discusses the emerging and current applications of artificial intelligence in wound care, including wound image analysis, infection detection, predictive modelling and decision support systems. The article explores how artificial intelligence technologies are being leveraged to enhance accuracy and efficiency in wound ass …