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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

Veterinary and Comparative Orthopaedics and Traumatology

Comparing Implant Removal Rates After Tibial Plateau Leveling Osteotomy Performed on a Mobile Service versus in a Specialist Orthopaedic Surgery Center: 916 Cases

Shantavia N. Hayes, Ashley L. Franklin, Samuel P. Franklin

Abstract The aim of this retrospective cohort study was to compare implant removal rate after tibial plateau leveling osteotomy (TPLO) was performed by a single surgeon on a mobile service versus in an orthopaedic exclusive surgical centre (“in-centre”). Records for 916 TPLO performed either on a mobile basis or in-centre were reviewed including whether the implants were subsequently removed. Marginal logistic regression model was used to compare implant removal rates between the two cohorts and based upon type of …

02.09.2026journal-article

Physics in Medicine & Biology

Impact of uniform and Gaussian intracellular activity distribution on DNA damage: a Geant4-DNA study of Auger electron–emitting radionuclides in V79 cells

Ali Azizi Ganjgah, Payvand Taherparvar, Ioanna Kyriakou

Abstract Objective: Auger electron (AE)-emitting radionuclides are highly sensitive to subcellular localization, and even small variations in intracellular distribution can substantially alter DNA damage. Accordingly, this study quantitatively evaluates the influence of radionuclide type, target-source configuration, and, as a novel feature, the effect of intracellular spatial distribution on the DNA strand breaks using Geant4-DNA.
Approach: A detailed V79 cell model containing atomistic chromatin fibers was im …

02.09.2026journal-article

Cancers

Bronchoscopic Ablation and Intratumoral Therapies for Lung Cancer: Expanding Local Treatment Beyond Surgical Resection

Trevor Parton, Mayowa Oturko, Audra J. Schwalk, Aitua C. Salami, Laura Frye

Advances in navigational bronchoscopy, robotic platforms, and intraprocedural imaging have transformed bronchoscopy from a diagnostic modality into a potential therapeutic platform for localized treatment of lung cancer. These developments are particularly relevant for patients who are medically inoperable, have limited pulmonary reserve, or require lung-sparing treatment strategies. This narrative review summarizes current evidence regarding bronchoscopic ablative technologies and intratumoral therapies for lung c …

02.09.2026journal-article

npj Health Systems

A novel use of AI for prediction of clinical deterioration in a post-acute hospital

Alexander Kauffman, Nataša Lazarević, Rahul Joshi, Jordan Pelc

Abstract There is a growing literature on the prediction of risk of deterioration in hospital settings, including by leveraging artificial intelligence (AI) models. However, this literature has focused on acute-care hospitals, rather than post-acute facilities, where the risk of deterioration remains high. Post-acute facilities tend to have lower digital maturity and poorer data foundations, as well as less rich physiologic data, making the implementation of AI tools for deterioration challenging. In this study, we …

02.09.2026journal-article

Annals of African Medicine

Prevalence of Asymptomatic Pyuria in Patients with Type 2 Diabetes Mellitus and Its Association with Glycemia

S. L. Sagar Reddy, Sumanasa Gopala Datta, Umalakshmi Annavarapu, Satish Kumar Samal, Ranjini Chittur Yerat, Mohammed Mahrous, Tanedhar Meghanath Bhargav Theja, Ranjith Mule, Melkunte Shanthaiah Dhananjaya, Vijaya Sarathi

Abstract Background: Type 2 diabetes mellitus (T2DM) is associated with an increased risk of urinary tract infections, including asymptomatic forms like asymptomatic bacteriuria or asymptomatic pyuria (ASP). However, the association between ASP (defined as elevated urinary leukocyte count without symptoms) and glycemic control remains unclear. Hence, this study was conducted to determine the prevalence of ASP in patients with T2DM and evaluate its association with glycemic parameters and urinary abnormalities. Meth …

02.09.2026journal-article

Langenbeck's Archives of Surgery

Clinical and paraclinical parameters association to complications after abdominal closure following vacuum-assisted closure therapy in secondary peritonitis: A retrospective cohort study

Ask Vang, Pooya Rajabaleyan, Sören Möller, Sardar Khalaf, Uffe Tange Holst, Pedja Cuk, Benjamin Schnack Brandt Rasmussen, Thomas Strøm, Mark Bremholm Ellebaek

Abstract Purpose To evaluate clinical and paraclinical parameters at the time of abdominal closure following vacuum-assisted closure (VAC) therapy in patients with secondary peritonitis, and to identify associations to postoperative complications. Methods This retrospective multicenter cohort study included patients with secondary peritonitis from the small intestine, colon, or rectum who underwent emergency laparotomy and VAC therapy at six hospitals in southern Denmark between 2010 and 2019. Clinical status and l …

02.09.2026journal-article

Polski Przegląd Otorynolaryngologiczny

Use of Alsarhan Maneuver for the treatment of Subjective benign positional paroxysmal vertigo

Haider Alsarhan, Ioana Alexandra Voda, Avinash Bijlani

Introduction:Benign positional paroxysmal vertigo is the most common cause of vertigo worldwide; a subclinical or subjective variant of that disease is defined as the presence of subjective vertigo without corresponding nystagmus; it accounts for 11.5% of all cases of Benign positional paroxysmal vertigo.Materials and methods:A prospective study of 32 patients presented with subjective Benign positional paroxysmal vertigo and had performed Alsarhan ( Rapid Bilateral Sitting Up) maneuver and followed up for a period …

02.09.2026journal-article

Medicine Advances

Nutritional Treatment After Discharge of Older Patients at Nutritional Risk: A Study Protocol for a Feasibility Study

Martine Kjærsgaard Nielsen, Tina Munk, Anne Marie Beck, Jacob Rosenberg, Jesper Ryg

ABSTRACT Background Malnutrition is prevalent among older hospitalized patients, increasing the risk of complications, extended hospital stays, and reduced quality of life. Upon discharge, a nutritional gap frequently arises, leading to insufficient intake for optimal recovery. Ensuring nutritional treatment in research settings after hospital discharge has demonstrated improvements in readmission rates, muscle strength, quality of life, and nutritional status. This study aims to evaluate the feasibility and effect …

02.09.2026journal-article

Science Translational Medicine

Sustained neutrophil extracellular traps cause fracture nonunion

Weixin Xie, Lilly-Charlotte Albertsen, Gesine Eis-Janzyk, Charlotte Kühlwein, Shan Jiang, Carsten Schlickewei, Holger Kleinertz, Ruben Augustin, Jan Sevecke, Saskia Schröder, Mayla Rickert, Samira Weisselberg, Antonia Donat, Haoyan Pan, Paul Knapstein, Verena Fischer, Melanie Haffner-Luntzer, Annika Bay, Michael Amling, Tim Rolvien, Matthias Krause, Thomas Renné, Karl-Heinz Frosch, Anke Baranowsky, Johannes Keller

Fracture healing is an evolutionarily conserved process that depends on the complex interplay of osteogenic, angiogenic, and inflammatory responses. Impaired bone healing is observed in up to 10 to 15% of patients with fractures and can lead to nonunion, which is the absence of bone healing. Here, we explore a role of neutrophil extracellular traps (NETs) in fracture healing and their association with nonunion. In both mice and humans, skeletal injury triggers rapid but transient NET formation at the fracture site. …

02.09.2026journal-article

The Journal of Infectious Diseases

Functional T Cell Responses Are Associated With Prolonged HIV Control After Treatment Interruption

Anders B Andersen, Anna K Juhl, Jesper D Gunst, Thomas A Rasmussen, Martin Tolstrup, Ole S Søgaard

Abstract Background CD8+ T cell responses are thought to be critical for spontaneous control of human immunodeficiency virus (HIV) but findings supporting their role in post-intervention control have been mixed. We hypothesized that HIV-specific T cell proliferation, interferon-γ (IFN-γ) and granzyme B response prior to analytical treatment interruption (ATI) were associated with time to viral rebound. Methods We pooled data from six different HIV cure trials including people living with HIV receiving antiretrovira …

02.09.2026journal-article

Antimicrobial Agents and Chemotherapy

Adaptive immunity shapes baseline physiology of M. tuberculosis in high-dose versus low-dose infection BALB/c mouse drug treatment models

Jo Hendrix, Reem Al Mubarak, Karen Rossmassler, Holly Nielsen, Elizabeth Wynn, Camile Moore, Isabelle L. Jones, Martin I. Voskuil, Brendan K. Podell, Gregory T. Robertson, Chuangqi Wang, Nicholas D. Walter

ABSTRACT Preclinical tuberculosis (TB) drug evaluation relies heavily on mouse infection models. Drug efficacy varies depending on inoculum and the timing of treatment initiation. These differences reflect, in part, physiological adaptations of Mycobacterium tuberculosis ( Mtb ) to host immune pressure. We used novel molecular markers of pathogen health (RS ratio and SEARCH-TB) to contrast Mtb phenotypes in the BALB/c high dose aerosol (HDA) subacute TB and low dose aerosol (LDA) chronic TB infection models, focusi …

02.09.2026journal-article

Antimicrobial Agents and Chemotherapy

Clinical failure of an extended-pulsed fidaxomicin regimen associated with emergence of a Clostridioides difficile isolate with reduced fidaxomicin susceptibility in an elderly man

Claire E. Kaple, Sarah N. Redmond, Jennifer L. Cadnum, Bryan Hausman, Munok Hwang, Hosoon Choi, Piyali Chatterjee, Chetan Jinadatha, Curtis J. Donskey

ABSTRACT The clinical significance of Clostridioides difficile isolates with reduced fidaxomicin susceptibility is uncertain. We report treatment failure of extended-pulsed fidaxomicin treatment during every other day pulsing associated with emergence of a C. difficile isolate with reduced fidaxomicin susceptibility and a novel rpoC gene mutation, resulting in a novel amino acid substitution (R89K). The reduced susceptibility isolate had no reduction in growth or ability to colonize mice, but in vitro sporulation a …

3 Zitationen
02.09.2026journal-article

Microbiology Resource Announcements

Draft genome sequences of Staphylococcus aureus clinical isolate (SA2-IRQ) from a patient with an ear infection

Ibrahim A. Ahmed, Zaid A. Thabit, Yaseen I. Mamoori, Nisreen S. Hasan

ABSTRACT In the current study, we present the genome sequence of Staphylococcus aureus isolated from a patient suffering from an ear infection. The bacterial genome was assembled into 26 contigs, comprising a total of 2,774,206 bp with a GC content of 32.5% and encoded approximately 2,782 genes, including multiple virulence-associated genes.

02.09.2026journal-article

International Clinical Psychopharmacology

Use of risperidone in-situ microparticles in real world: patterns of prescription and dose selection in patients with psychotic disorders

Ilaria Di Bernardo, Paolo Brambilla, D’Agostino Armando, Mauro Percudani, Giancarlo Cerveri, Giovanni Migliarese, Virginio Salvi, Annabella Di Giorgio, Valentina Dalò, Federica Calorio, Adelaide Panariello, Alessandro Galluzzo, Silvia Paletta, Simone Cavallotti, Antonio Callari, Laura Celebre, Alberto Costa, Luca Belmonte, Giada Versaci, Maurizio Proto, Chiara Nostro, Barbara Scaramelli, Filippo Dragogna, Giorgio Ratti, Michele Scalera, Antonio Vita, Bernardo Dell’osso

Long-acting injectable (LAI) antipsychotics are important for improving adherence and preventing relapse. Risperidone in-situ microparticles (ISM), a once monthly LAI using ISM technology, rapidly achieves therapeutic plasma levels without loading doses or oral supplementation. Real-world evidence on its use remains limited. This multicenter observational–naturalistic–retrospective study assessed prescribing patterns of risperidone-ISM across nine Public Mental Health Departments in Lombardy, Italy. Data from 218 i …

02.09.2026journal-article

ANZ Journal of Surgery

Prioritising Psychological Prehabilitation Interventions for Cancer Surgery: An International Delphi Study

Nicholas Hirst, Jesse Gates, Haryana M. Dhillon, Ilona Juraskova, Kate Alexander, Jack Reeves, Zirong Bai, Michael J. Solomon, Kate McBride, Leani Souza Máximo Pereira, Ana Paula Drummond Lage, Daniel Steffens, Global (P)rehabilitation Initiative

ABSTRACT Background Preoperative mental wellbeing is an important determinant of postoperative recovery, yet psychological care is frequently overlooked within multidisciplinary prehabilitation programmes. When included, psychological interventions are fragmented and inconsistently delivered. This study aimed to establish international multidisciplinary consensus on preferred psychological prehabilitation interventions for patients undergoing urogenital, thoracic or gastrointestinal cancer surgery, and to describe …

02.09.2026journal-article

American Journal of Clinical and Experimental Medicine

Tissue Regeneration After Thermal Burns Using Chitosan Derivatives: An Experimental Study

Baykulov Kenjayevich

Thermal burns represent a serious clinical challenge due to extensive tissue damage, high susceptibility to microbial contamination, prolonged inflammatory response, and delayed regenerative processes. The development of multifunctional wound-healing agents combining antimicrobial, anti-inflammatory, and regenerative properties remains a priority in experimental and clinical medicine. Chitosan and its derivatives are natural polysaccharide-based biopolymers characterized by biocompatibility, biodegradability, low t …

02.09.2026journal-article

Journal of Fungi

A Review of the Therapeutic Challenges and Novel Treatment Options in Mitigating Invasive Mycosis Associated with Aspergillus, Candida, Cryptococcus, and Pneumocystis

Elaine Meade, Mark Slattery, Mary Garvey

Globally, invasive fungal diseases are increasing in incidence and are associated with high rates of mortality. A lack of effective diagnostic protocols, antifungal resistance and poor antifungal stewardship contribute to negative outcomes. Aspergillus, Candida, Cryptococcus, and Pneumocystis are the most common pathogens associated with fatal fungal diseases. These species are responsible for 90% of reported invasive fungal deaths globally. Fungal species employ a diverse and effective array of virulence factors t …

02.09.2026journal-article

Physics in Medicine & Biology

Environmental and auto-induced RF-EMF adult and children far-field exposure simulations between 450 MHz and 26 GHz

Robin Wydaeghe, Bram Stroobandt, Silvia Gallucci, Marta Parazzini, Gabriella Tognola, Joe Wiart, Günter Vermeeren, Mònica Guxens, Emmeric Tanghe, Wout Joseph

Abstract Objective. Children’s exposure to radio-frequency electromagnetic fields above 6 GHz lacks characterization. No study spans sub-GHz cellular bands to millimeter wave while including child phantoms. This study quantifies the specific absorption rate (SAR) and absorbed power density (APD) in two adult and two child anatomical phantoms across 15 frequencies from 450 MHz to 26 GHz. Approach. We performed 550 finite-difference time-domain simulations covering environmental (plane-wave) and auto-induced (beamfor …

02.09.2026journal-article

PLOS Mental Health

Alcohol and substance-induced disorder treatment cases in mental health and addiction treatment facilities from 2013 to 2022: A descriptive study

Orrin D. Ware

Substance use disorders may arise when individuals use substances to cope with adverse mental health symptoms. Conversely, mental health symptoms can develop because of substance use, a category of conditions called substance-induced disorders. This study used two United States-based datasets, the Mental Health Client-Level Data and the Treatment Episode Data Set Admissions, to summarize the number of cases with “alcohol-induced disorders” and “substance-induced disorders” from both mental health and substance use …

02.09.2026journal-article

Frontiers in Dental Medicine

Developmental defects of enamel and dentin in individuals born preterm: a scoping review of evidence and mechanisms

Sadhvi B, Manju R, Samiksha Uchil, Rupali D, Swagata Saha

Background Preterm birth (<37 weeks of gestation) occurs during critical stages of odontogenesis and is associated with developmental defects in dental hard tissues. Enamel hypoplasia, enamel hypomineralization, and structural dentin alterations may compromise esthetics, function, and long-term oral health outcomes. However, the nature and extent of these defects and their underlying mechanisms have not been comprehensively investigated. Objective To map and evaluate the available evidence regarding developmental d …

02.09.2026journal-article

Molecular Cancer Therapeutics

Molecular Design and Preclinical Evaluation of GenSci143, a Novel B7-H3–Directed and PSMA-Directed Bispecific Antibody–Drug Conjugate, for the Treatment of Prostate Cancer

Yao Xu, Fu Li, Zhiyu Cui, Hongmei Xie, Liang Xu, Yihui Lin, Tete Li, Nan Li, Dechen Cao, Weiming He, Wenqiang Zhai, Xiaozhen Wang, Shu Zhang, Haizhou Zhang, Fanglong Yang, Siqin Wang, Lei Jin, John L. Xu

Abstract Antibody–drug conjugate (ADC) has rapidly transformed the treatment landscape for solid tumors; however, owing to heterogeneity in target antigen expression, suboptimal efficacy and emergence of acquired resistance present significant challenges to the development of curative ADCs for cancers. In this study, we report the preclinical evaluation of GenSci143, a novel B7-H3 × PSMA-directed bispecific ADC, designed to overcome tumor antigen heterogeneity–associated drug resistance for the treatment of metasta …

02.09.2026journal-article

Journal of Rehabilitation Medicine

Home-based digital exercise versus hospital physiotherapy for plantar fasciitis: a propensity-score-matched retrospective cohort study with dual-perspective cost-utility evaluation

Wenbo Xu, Lufeng Yao, Haigang Wang, Chenqin Xu, Pinpin He, Yi Zhang, Jiasong Pan, Shengdi Lu, Lei Huang

Objective: To compare the clinical effectiveness and cost-effectiveness of a 12-week home-based digital exercise programme with 12-week hospital-supervised physiotherapy for plantar fasciitis in routine Chinese tertiary-hospital care. Design: Single-centre retrospective cohort study with 1:2 propensity-score matching on 13 baseline covariates. Subjects/Patients: 587 adults with a clinician-confirmed diagnosis of plantar fasciitis treated in 2022–2024 were matched. Methods: The primary outcome was first-step morning …

02.09.2026journal-article

Frontiers in Public Health

Integrating digital therapeutics for patients with mental illness into clinical practice: perspectives for US healthcare professionals

Brandon M. Kitay, David C. Mohr, Stephen M. Schueller

As the landscape of digital health tools has expanded, digital therapeutics have emerged as promising treatment options for various mental health conditions. Although digital therapeutics have demonstrated efficacy in prevention, treatment, and management of mental illness, adoption of these interventions in clinical practice remains low. Here, key questions for healthcare providers about implementation of digital therapeutics into US clinical practice are addressed, focusing on digital therapeutics for mental illn …

02.09.2026journal-article

Revista DCS

ELECTROACUPUNCTURE AND ENDOGENOUS STEM/PROGENITOR CELL MOBILIZATION: A SCOPING REVIEW OF MECHANISMS AND REGENERATIVE MEDICINE IMPLICATIONS

Maxime Moulins, Livia Maria Marques Pereira, Anisio Francisco Soares

The Electroacupuncture (EA) is a nonpharmacological neuromodulatory intervention increasingly investigated for its systemic effects, including potential mobilization of endogenous stem and progenitor cells. This scoping review, conducted according to PRISMA‑ScR, mapped in vivo animal and human studies reporting EA‑induced systemic mobilization and regenerative outcomes across five major databases. Ten studies (nine preclinical, one clinical) showed EA‑associated mobilization of mesenchymal stem cells, endothelial p …