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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
24.08.2026journal-article

Biomedicines

Pathogenesis-Informed Phenotype-Guided Therapy for MASH: A Three-Axis Translational Framework Within the MASLD Spectrum

Zishu Zhao, Xiaoyang Hu

Metabolic dysfunction-associated steatohepatitis (MASH) is the progressive inflammatory and fibrotic subtype of metabolic dysfunction-associated steatotic liver disease (MASLD), and its treatment landscape is rapidly moving from nonspecific liver fat reduction towards mechanism-based drug positioning. Since 2024, resmetirom and semaglutide have received U.S. Food and Drug Administration accelerated approval for non-cirrhotic MASH with moderate-to-advanced fibrosis, while tirzepatide, survodutide, and fibroblast gro …

24.08.2026journal-article

Kemakmuran Hijau: Jurnal Ekonomi Pembangunan

Waqf-based rehabilitation of former mining land: Cash waqf linked to infrastructure fund (CWL-FRA) and phytomining models for sustainable economic growth

Biruni Ahmad Safin, Adzka Sya'bani Mas'ud, Ajrul Rais Ananda

Background: Abandoned mining lands in Indonesia face severe environmental degradation caused by heavy metal contamination, limiting their agricultural and productive potential. Rehabilitation therefore requires an approach that simultaneously addresses environmental pollution, economic recovery, and social development. This study aims to develop a cash waqf-based rehabilitation model integrating Islamic social finance with phytomining technology for sustainable post-mining land recovery. Methods: This study employe …

24.08.2026journal-article

ACS Applied Electronic Materials

Dispersion-Engineered Stretchable Electrothermal MWCNT/PDMS Films for Uniform Wearable Thermal Therapy

Xinyu Bai, Xiaona Feng, Yuanzhao Wu, Zidong He, Jinwei Cao, Yiwei Liu

Abstract Flexible electrothermal composites that simultaneously achieve mechanical compliance and uniform Joule heating remain a challenge due to the difficulty in uniformly dispersing nanotubes and constructing stable conductive networks within polymer matrices. Here, we present a dispersion-engineered strategy combining sodium dodecyl sulfate (SDS)-assisted stabilization with isopropanol dilution to fabricate multiwalled carbon nanotube/polydimethylsiloxane (MWCNTs/PDMS) composites with a continuous and robust co …

24.08.2026journal-article

Journal of Society Counseling

Exploring Emotional Regulation through Eco Art Therapy: A Phenomenological Study of College Students

Asti Haryati, Nadia Agesma Astuti, Nesca Anggesti, Tuti Nurhaliza, Tiara Emelisa, Dafit Alfurqan Nur Araaf, Dea Firda Sari

University students in early adulthood face increasing academic, social, and existential pressures that intensify emotional vulnerability. While emotional distress among students is widely documented, limited research has explored integrative counseling approaches that simultaneously address expressive, ecological, and reflective dimensions of emotional regulation. This study investigates how students experience and interpret eco art therapy as they engage in emotional regulation within a prophetic counseling frame …

31.08.2026journal-article

International Journal “Speech Genres”

Genre of the distance learning class in the English language discourse of distance education

Veronika V. Katermina, Irina V. Chernova

The article presents the study of the genre of a distance learning class, the relevance of the study of which is conditioned by the need to research the genres of a new discourse type of modern educational space – the discourse of distance education. The authors define a distance learning session as a communicative educational event unfolding in the virtual space of the Internet, which largely predetermines its media, pragmatic, compositional and structural parameters. The aim of the study is to describe the genre- …

24.08.2026journal-article

Advances in Radiotherapy & Nuclear Medicine

Radiation therapy in head and neck with telecobalt beam quality: Tolerance to 70 Gy dose in a five-week overall treatment time

Ravi Kannan, Ramamoorthy Ravichandran, Kapil Malik, Tarani Mondal, Gopal Datta, Subramania Vijayakanth, Talagadadeevi V.S.S.K. Bharath, Abhishek Kesha, LamLynti Dkhar, Soumya Brata Deb

Head and neck malignancies are associated with accelerated tumor repopulation when overall treatment time (OTT) extends beyond 28 days, potentially compromising the effectiveness of radiotherapy. To address this limitation, a treatment strategy was developed to reduce OTT by delivering a total radiation dose of 70 Gy over five weeks. In a pilot study involving high-grade head and neck malignancies, a total dose of 70 Gy was delivered using cobalt radiotherapy with tissue compensation at 2 Gy per fraction, administe …

24.08.2026journal-article

Indian Journal of Ophthalmology

Local therapy in uveitis: Current concepts and emerging strategies

Tanya Jain, Pallavi Goel, Manisha Agarwal

Local therapy plays a pivotal role in the management of noninfectious uveitis, providing targeted drug delivery with reduced systemic adverse effects. Advances in corticosteroid formulations and delivery routes have significantly improved therapeutic outcomes. Topical corticosteroids remain first-line for anterior uveitis, while periocular and intravitreal injections such as triamcinolone acetonide and dexamethasone implants (Ozurdex®) are effective for intermediate and posterior disease. Long-acting fluocinolone a …

24.08.2026journal-article

European Heart Journal Open

Predictors of Cardiac Rehabilitation Completion After Acute Myocardial Infarction in Young Women: the French WAMIF Registry

Pierre-Guillaume Piriou, Théodora Angoulvant, Claire Bouleti, Geneviève Jarry, Yves Cottin, Pascal Motreff, Stéphanie Marliere, Sabrina Uhry, Guillaume Cayla, Guillaume Leurent, Matthieu Godin, Emmanuelle Filippi Codaccioni, Grégoire Range, Hélène Eltchaninoff, Jules Mesnier, Martine Gilard, Stéphane Manzo-Silberman

Abstract Aims Cardiac rehabilitation (CR) is a cornerstone of secondary prevention after acute myocardial infarction (AMI), yet its implementation remains suboptimal, particularly among women. Young women represent an understudied subgroup with distinct presentations and psychosocial vulnerabilities that may influence access to CR. We aimed to identify factors associated with CR completion within 1 year after AMI in young women. Methods and results This exploratory analysis was conducted within the prospective mult …

24.08.2026journal-article

International Journal of Contemporary Hospitality Management

How could corporate social responsibility alleviate social occupational stigma consciousness?

Linyuan Zhou, Xinyuan Zhao, Yunyao Liu, Nan Hua, Mingqiang Wang

Purpose Although social occupational stigma consciousness reduces individuals’ well-being and work outcomes, research on strategies to mitigate social occupational stigma consciousness remains limited. Based on social identity theory, this study aims to systematically examine the mechanisms through which corporate social responsibility (CSR) influences hotel employees’ social occupational stigma consciousness. Design/methodology/approach Study 1 conducted a content analysis of hotel employee reviews posted on Glass …

24.08.2026journal-article

Diabetes, Obesity and Metabolism

Priorities, Expectations, Perceptions of Time in Tight Range and Support Needs Relating to Closed‐Loop Therapy Among Adults With Type 1 Diabetes: The SELECT HCL Study

Alexandros L. Liarakos, Iskandar Idris, Emma G. Wilmot

ABSTRACT Aims To assess factors influencing closed‐loop system choice, perceptions of treatment satisfaction and glycaemic targets, perceived benefits and expectations of therapy, and support needs among adults with Type 1 diabetes (T1D) using, awaiting initiation of or considering closed‐loop therapy. Materials and Methods SELECT HCL was a cross‐sectional survey study conducted at a specialist secondary care diabetes service between September 2025 and February 2026. Adults with T1D completed an anonymous online qu …

24.08.2026journal-article

Healthcare

Educational Workplace Dietary Interventions and Occupational Well-Being Among Healthcare Professionals: A Scoping Review

Maria Antoniadou, Theodora Kalogerakou, Polyxeni Mangoulia, Theodoros Varzakas

Background: Educational workplace dietary interventions have emerged as a promising approach to supporting occupational well-being among healthcare professionals. This scoping review mapped and synthesized the available evidence on such interventions across healthcare settings. Methods: A scoping review was conducted in accordance with the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) guidelines. PubMed, Scopus, and the Cochrane Library were searched f …

24.08.2026journal-article

International Journal of Molecular Sciences

The Role of Monoclonal Antibody Targeted Therapy (Panitumumab) in the Treatment of Metastatic Colorectal Cancer—A Narrative Review of Current Evidence and Emerging Therapeutic Strategies

Lidia Kwiatkowska, Małgorzata Szczuko

Metastatic colorectal cancer (mCRC) remains one of the leading causes of cancer deaths worldwide. Mutations of the RAS and BRAF genes and the location of the primary tumor determine the choice of systemic therapy. Panitumumab—a fully human anti-EGFR monoclonal antibody—is well-established in the treatment of patients with wild-type RAS and BRAF and left-sided tumor localization. The aim of this review is to summarize the role and potential of targeted therapies for colorectal cancer with monoclonal antibodies such …

24.08.2026journal-article

Current Pharmacogenomics and Personalized Medicine

Benzothiazole-Based Polyfunctional Agents in Alzheimer’s Therapy: Dual Diagnostic and Therapeutic Targeting of Aβ, Tau, and Neuroinflammation

Meghana Devaraj, Prashant Tiwari, Sonal Dubey

Abstract: Alzheimer's disease is known to be a multifaceted neurodegenerative disease, which includes events like amyloid-β (Aβ) plaque deposition, tau protein hyperphosphorylation, oxidative damage, neuroinflammation, and cholinergic dysfunction, for which the conventional pharmacotherapies only bring temporary symptomatic relief. Benzothiazoles are known to be novel polyfunctional agents, acting as multi-target directed ligands, owing to their privileged heterocyclic structure, making it more feasible to accompli …

24.08.2026journal-article

Frontiers in Bioengineering and Biotechnology

Gene therapy for genodermatoses at the crossroads of innovation and clinical translation

Alessandra Fabrizi, Marta Valenti, Silvia Zacchino, Katia Russo, Erica Baschetti, Laura De Rosa, Michele De Luca

Inherited genodermatoses are a heterogeneous group of rare monogenic disorders. Among these, epidermolysis bullosa (EB) and ichthyoses represent paradigmatic disorders characterized by severe skin fragility and hyperkeratosis, respectively, and impaired barrier function, often with profound effects on quality of life and systemic health. Current management remains largely palliative, underscoring the urgent need for disease-modifying therapies. Over the past 2 decades, advances in epithelial stem cell biology, vect …

24.08.2026journal-article

International Journal of Basic & Clinical Pharmacology

Underrecognized phototoxicity from prolonged doxycycline therapy: a case highlighting early nail involvement

Kashish Jindal, Prakash Tendulkar, Ravi Kant, Dheeraj Dheeraj

A 27-year-old man developed photo-onycholysis and a facial phototoxic rash after taking doxycycline, cefuroxime and aceclofenac for about 40 days following incision and drainage of a wrist abscess. He had no other illness. The wound healed well and his laboratory results were unremarkable, but several fingernails turned reddish-brown and became so tender that light pressure was painful, and both cheeks developed erythematous maculopapular lesions. The toenails were normal. There was no separation of the nail plate, …

24.08.2026journal-article

Indian Journal of Ophthalmology

New pharmacological and biotechnological approaches for the treatment of neurotrophic keratopathy: From growth factors to gene therapy

Mukaddes Damla Ciftci, Mehmet Gurdal, Ozlem B Selver

Neurotrophic keratopathy (NK) is a serious ocular surface disease that develops due to a reduction or loss of corneal innervation. Conventional therapeutic approaches, such as the use of artificial tears and autologous serum, primarily serve as symptomatic relief measures and do not target the underlying neurodegenerative process. The introduction of recombinant human nerve growth factor (rhNGF, cenegermin) has marked the first disease-modifying pharmacological therapy for NK, providing evidence of enhanced epithel …

24.08.2026journal-article

Journal of Back and Musculoskeletal Rehabilitation

Validity and reliability of the six-minute pegboard and ring test for assessing upper limb functional capacity in patients with rheumatoid arthritis

Başak Kavalcı Kol, Merve Fırat, Figen Tuncay, Ceren Demir

Background Rheumatoid arthritis (RA) is a disease that affects upper extremity function early on, leading to significant limitations in activities of daily living. Therefore, assessing upper extremity function using reliable and valid measurement methods is clinically important. Objective The aim of study was to determine the validity and reliability of the six-minute pegboard and ring test (6-PBRT) in patients with RA. Methods The study included forty RA patients (32 females, 8 males; age 57.90 ± 10.82 years). All …

24.08.2026journal-article

Frontiers in Medicine

Case Report: Dynamic susceptibility-informed therapy for bile leak-associated intra-abdominal Stenotrophomonas maltophilia infection

Zhipeng Yang, Bin Zhu, Jianfeng Chen

Iatrogenic bile leak complicated by intra-abdominal infection is a rare but serious complication after laparoscopic cholecystectomy. Stenotrophomonas maltophilia is intrinsically resistant to carbapenems and is an uncommon but clinically relevant pathogen of intra-abdominal infection, particularly in patients with immunosuppression, indwelling drains, and broad-spectrum antibiotic exposure. We report the case of a 55-year-old immunosuppressed man who developed bile leak due to Hem-o-lok clip-associated common bile …

24.08.2026journal-article

The American Surgeon™

Early Recurrent Arteriovenous Fistula Stenosis: Identifying Patients Most Likely to Benefit From Drug-Coated Balloon Therapy

Peijin Bai, Zhi Wang, Genghuang Lin, Juan Pei, Jun Zhang, Shizhi Chen, Linghui Zhou, Leping Shao, Xiuhua Xu

Objective To evaluate the outcomes of drug-coated balloon (DCB) vs high-pressure balloon (HPB) angioplasty for the treatment of early recurrent arteriovenous fistula (AVF) stenosis. Methods This retrospective study analyzed 164 maintenance hemodialysis patients treated for early recurrent AVF stenosis (recurrence within 6 months) between 2019 and 2024. Patients were stratified into DCB and HPB groups. Propensity score matching (PSM) was utilized to balance baseline characteristics, resulting in 60 pairs for final a …

24.08.2026journal-article

JNCI: Journal of the National Cancer Institute

Concurrent chemotherapy and external radiation therapy (ConCERT): phase 3 noninferiority randomized clinical trial of cisplatin weekly vs every 3 weeks in locally advanced squamous cell carcinoma of the head and neck

Atul Sharma, Manish Kumar Choudhary, Suman Bhasker, Akash Kumar, Alok Thakar, Raja Pramanik, Ahitagni Biswas, Kapil Sikka, Surya V S Deo, Ashok Kumar, Supriya Mallick, Amit Chirom Singh, Pooja Sethi, Amit Sehrawat, Vishnubhatla Sreenivas, Rajeev Kumar, Saphalata Baghmar, Aanchal Kakkar, Vinod Sharma, Babita Kataria, Ranjit Sahoo, Aman Sharma, Prasanth Ganesan, Sudhir Kumar, Amol Patel, Smriti Panda, Sanjay Thulkar, Sandeep Seth, Shikha Halder, Manoj Gupta, Ashish Dutt Upadhyay

Abstract Introduction Concurrent chemoradiotherapy with cisplatin (100 mg/m² every three weeks) is the standard for locally advanced head and neck squamous cell carcinoma (LA-HNSCC), but it is uncertain if weekly cisplatin (40 mg/m²) is non-inferior. Method This open-label, multicentre, phase III non-inferiority trial randomised patients with non-nasopharyngeal LA-HNSCC in a ratio of 1 1 to receive either the standard cisplatin regimen (100 mg/m² every three weeks) or the experimental weekly regimen (40 mg/m²), bot …

24.08.2026journal-article

JMIR Formative Research

Quality Evaluation Using the Mobile App Rating Scale for Speech Therapy in Parkinson Disease: Systematic Search and Evaluation

Tooba Haris, Harshvi Shah, Jose F Florez-Arango

Abstract Background As the global population ages, Parkinson disease (PD) has emerged as the second most prevalent neurodegenerative condition after Alzheimer disease. People with PD often experience speech problems, including reduced volume, monotone pitch, breathiness, and word slurring. Interventions such as speech therapy through mobile apps provide reassurance and easier access to care for patients having this neurodegenerative condition. Mobile apps offer patients with PD greater access to care and the reassu …

24.08.2026journal-article

Arthroscopy, Sports Medicine, and Rehabilitation

Over Half of Patients Progress to Cartilage Restoration After Initial Cartilage Biopsy in a Military Population

Ryan M. Sanborn, Natalia A. Pluta, Kenneth J. Fellows, Christian A. Cruz, Jeanne C. Patzkowski, Daniel J. Cognetti

Purpose To evaluate the rate of matrix‐induced autologous chondrocyte implantation (MACI) after cartilage biopsy in a military population. Methods A retrospective review was conducted of all patients who underwent a cartilage biopsy at 2 large regional military health centers between January 2021 and May 2023. Patients 17 years of age or older who underwent an index biopsy more than 2 years prior to chart review were eligible for inclusion. The primary outcome was progression from cartilage biopsy to MACI. Secondar …

31.08.2026journal-article

International Journal “Speech Genres”

The category of “genre type” in the epistemological system of historical poetics

Viacheslav M. Golovko

The analysis of “the evolution of poetic consciousness and its forms”, substantiated as the main subject of historical poetics by A. N. Veselovsky, provides for the renewal of the categorical system of this scientific trend, the introduction of “additional categories of description” of literary phenomena and events into the conceptual apparatus. The article substantiates the relevance of introducing the category of “genre type” into the epistemology of historical poetics. The author realizes the task of concretizin …

24.08.2026journal-article

Infectious Disorders - Drug Targets

Fatal Rickettsial Multiorgan Dysfunction in an Adolescent Despite Standard Antimicrobial Therapy: A Case Report

Jitendra Singh, Keshav Suman, Anju Dinkar, Nivedita Verma, Rajeev Verma, Munna Lal Patel, Amit Anand

Background: Rickettsial diseases have re-emerged as significant causes of acute febrile illness in India and can occasionally evolve into rickettsial endovasculitis, characterized by widespread endothelial infection and vascular inflammation, leading to increased vascular permeability, tissue ischemia, and multiorgan dysfunction. Early diagnosis remains challenging because the initial clinical presentation is often nonspecific, and rapid diagnostic facilities are not uniformly available in many healthcare settings. …