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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

Phytotaxa

Fungal diversity in landfill soil from a waste treatment plant in Hebei, China with the description of Scytalidium asiaticum sp. nov. (Helotiales, Ascomycota)

YU-HONG LU, PENG-WEI SU, JI-HANG JIANG, YUAN YAO, LI-WEI ZHOU

Soil is one of the most favored habitats for fungi, but fungal diversity from plastic-contaminated soil has rarely been explored. This study focused on landfill soil at a waste treatment plant in Hebei, China, resulting in the isolation of 62 strains. These strains were identified to 25 species, belonging to the genera Alternaria, Aspergillus, Beauveria, Cephalotrichum, Cladosporium, Fusarium, Gliomastix, Marquandomyces, Metarhizium, Mortierella, Mucor, Paraphaeosphaeria, Penicillium, Pseudogymnoascus, Scytalidium, …

02.09.2026journal-article

Genome Medicine

Towards a deep-learning genomic tool for risk stratification and diagnostic support in sporadic ALS

Jiajing Hu, Oliver Pain, Ahmad Al Khleifat, Aleksey Shatunov, Peter Munch Andersen, Nazli Ayşe Başak, Johnathan Cooper-Knock, Philippe Corcia, Philippe Couratier, Mamede de Carvalho, Vivian Drory, Marc Gotkine, John Edward Landers, Jonathan David Glass, Russell McLaughlin, Jesus Santos Mora Pardina, Karen Elaine Morrison, Susana Pinto, Monica Povedano, Christopher Edward Shaw, Pamela Jean Shaw, Vincenzo Silani, Nicola Ticozzi, Philip van Damme, Leonard Hendrik van den Berg, Patrick Vourc’h, Markus Weber, Orla Hardiman, Jan Herman Veldink, Project MinE A. L. S. Sequencing Consortium, Richard James Butler Dobson, Alexander Schönhuth, Ammar Al-Chalabi, Alfredo Iacoangeli

Abstract Background A variety of common and rare genetic factors have been implicated in the development of amyotrophic lateral sclerosis (ALS), and the evidence is that a genetic component is present in most affected individuals. However, our current understanding of ALS genetics causally explains only a small proportion of sporadic ALS, which accounts for over 90% of all people with ALS. This limits the utility of genetic testing in screening, diagnosis and management to the 15–20% of people with ALS who carry a …

02.09.2026journal-article

Critical Pathways in Cardiology: A Journal of Evidence-Based Medicine

Redefining atrial fibrillation treatment success: patient-defined goals for arrhythmia burden and health-related quality of life

Alexander E. Kolomaya, Brian Zenger, Michael Torre, Andrew Redd, T. Jared Bunch, Trudie Lobban, Morgan M. Millar, Jonathan P. Piccini, John A. Spertus, Rachel Hess, Benjamin A. Steinberg

Background: Despite the use of atrial fibrillation (AF) cutoff of 30s as the standard for success in most AF clinical trials, patients consider an AF Severity Scale (AFSS) of ≤ 5 or AF duration ≤ 1 hour as treatment success. Prevalence and factors associated with these patient-defined endpoints are unknown. Methods: We performed a cross-sectional analysis using a single-site cohort of AF patients. We report rates of patient-defined treatment success (AFSS ≤ 5 or AF burden ≤ 1 hour) and multivariable analyses to ide …

02.09.2026journal-article

Annals of African Medicine

Clinico-Hematological Evaluation of Bicytopenia in Adults: A Hospital-based Observational Study

Vidya Kuchanur, Appu Patil, Shivani S. Rao

Abstract Background: Bicytopenia is defined as a reduction in any two of the three major blood cell lineages and may result from a wide spectrum of infectious, nutritional, hematological, and systemic disorders. Early identification of the underlying etiology is essential for appropriate management. Aims: To study the etiological spectrum, hematological profile, clinical presentation, and patterns of bicytopenia among patients attending a tertiary care Center. Materials and Methods: The study analyzed the clinical …

02.09.2026journal-article

Problems of Gathering Treatment and Transportation of Oil and Oil Products

ENVIRONMENTAL ASPECTS OF COMBINED DEPRESSURIZATION AND ELECTROMAGNETIC HEATING METHOD FOR HYDRATE EXTRACTION

Z. Xiao, A.N. Gulkov

Deep-sea natural gas hydrate resources have attracted widespread attention as a new type of energy source, and how to develop natural gas hydrates safely and effectively is currently the focus of research. The most commonly used extraction method for deep-sea natural gas hydrates is the depressurization method, but it faces problems such as the formation of secondary hydrates in the wellbore during the later stages of extraction. Therefore, we have incorporated electromagnetic heating technology into the depressuri …

02.09.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Frequency, Geospatial Distribution, and Subspecies of Echinococcus granulosus Identified in Dog Stool in Urban Public Spaces of an Endemic Area in Cusco, Peru

Miguel M. Cabada, Roberto Pineda-Reyes, Nelson Lozano-Cansaya, Beltran Jalanocca-Janampa, Martha V. Fernandez-Baca, Carol A. Castro, Alejandro Castellanos-Gonzalez, Alonso Bussalleu, Melinda B. Tanabe, Audrey Schulze, Diego Alvarez, Maria L. Morales, Abigail Hitchcock, Ruben Bascope, Jakob Zinsstag

ABSTRACT. The impact of environmental contamination with Echinococcus granulosus eggs on the transmission to humans remains unknown. The control of free-roaming and stray dogs is a public health problem in urban and periurban areas of the Cusco region, such as the city of Sicuani in the Canchis province. Nearly one in four human cystic echinococcosis cases referred to tertiary hospitals in the Cusco region of Peru is referred from the Sicuani district. This study sought to determine the frequency and spatial distri …

02.09.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Dysregulation of Immune Regulatory Mediators and Reduced Antitetanus Toxoid Antibodies Are Associated with Submicroscopic Plasmodium Infection in Pregnancy in Colombia

Catalina Álvarez‐Larrotta, Olga M. Agudelo, Jaime Carmona‐Fonseca, Stephanie K. Yanow, Eliana M. Arango

ABSTRACT. Infection with Plasmodium falciparum or Plasmodium vivax during pregnancy can result in adverse outcomes for both mother and child. Submicroscopic infections are common in malaria-endemic areas but often remain chronic, asymptomatic, and untreated. Chronic infections persistently stimulate the immune system, altering expression of immune mediators and promoting expansion of regulatory T cells. These immune changes could compromise responses to routine vaccinations. This study evaluated the immunomodulator …

02.09.2026journal-article

Hypertension Research

Prevalence, clinical features and emergency department blood pressure management of hypertensive emergencies and uncontrolled hypertension: a retrospective multi-centre study

Alessandro Maloberti, Giulia Capitoli, Tommaso Valobra, Paola Rebora, Nicolas Mavreas, Silvia Vergani, Valentina Giani, Chiara Tognola, Nicolò Capsoni, Michele Galasso, Lorenzo De Censi, Cecilia Ferretti, Andrea Sultana, Gabriele Peraro, Martina Morelli, Annalisa Giacalone, Ilaria Garofani, Filippo Galbiati, Michele Bombelli, Cristina Giannattasio

Abstract Very heterogeneous data have been published concerning prevalence and clinical management of Hypertensive Emergencies (HE) and Uncontrolled Hypertension (UH). The aim of our study was to characterize HE and UH patients evaluating: (i) Blood Pressure (BP) management in Emergency Department (ED), the pharmacological treatment and its adherence to guidelines recommendation; (ii) variables associated with the presence of organ damage; and (iii), as an exploratory analysis, the impact of BP on in-hospital morta …

02.09.2026journal-article

Biosensors

Monitoring EML4-ALK Biomarkers via a Microfluidic Assay for Treatment Efficacy Assessment

Shaked Doron, Lev Brio, Matan Krasner, Efrat Barbiro-Michaely, Doron Gerber

Monitoring prognostic biomarkers is essential for evaluating cancer treatment efficacy in real time. Here, we present a rapid, proof-of-concept microfluidic assay for cancer biomarker quantification and functional therapy evaluation. The assay requires only 5 µL of sample, eliminates tedious sample manipulation, and uses commercial antibodies to track both biomarker concentration and functional activity. We demonstrated the successful detection of VEGF and EML4-ALK proteins in both lung cancer cell culture supernat …

02.09.2026journal-article

International Journal of Sports Medicine

Sex and maturity modulate the link between sprint mechanics and multidirectional speed

Pedro Muñoz-Fole, Andrés Baena-Raya, Ezequiel Rey, Filipe Almeida Conceição, Manuel Avelino Giráldez-García, Alexis Padrón-Cabo

This study aimed to (I) evaluate the influence of maturity and sex on the horizontal force-velocity (F-V) profile and multidirectional speed performance in youth basketball players and (II) analyze the sex- and maturity-specific associations of the mechanical variables derived from the horizontal FV profile with curvilinear sprint (CS) and change of direction (COD) performance. Ninety-nine youth basketball players from an elite academy were classified into two maturational groups based on their estimated years from …

02.09.2026journal-article

American Journal of Perinatology

A Comparison of Postnatal Factors between Infants with a Delayed TSH Rise on the Newborn Screen and those with a Timely Diagnosis of Congenital Hypothyroidism

Louis J. Martin, Erica A. Eugster, Preet K. Matharu

Abstract The purpose of this study was to identify postnatal factors that may confer an increased risk for having a delayed thyroid-stimulating hormone (TSH) rise on the newborn screen (NBS) in infants admitted to the neonatal intensive care unit (NICU). NBS results were collected from the Indiana State Department of Health (ISDH) for all cases of congenital hypothyroidism (CH) from 2012 to 2022 and used to identify infants who had a delayed TSH rise (N = 73). Thirty-six infants with a delayed diagnosis were matche …

02.09.2026journal-article

International Journal of Basic & Clinical Pharmacology

Artificial intelligence: transforming drug discovery

Shiva Mishra

Artificial intelligence (AI) has improved medication research and development by shortening schedules, decreasing costs, and raising success rates. AI uses machine learning (ML), deep learning (DL), and natural language processing (NLP) to analyse large datasets and quickly identify pharmacological targets, forecast chemical efficacy, and optimise medication designs. It speeds up lead development by predicting pharmacokinetics, toxicity, and probable side effects. It also improves clinical trial designs through bet …

02.09.2026journal-article

Journal of Tropical Health

Eosinophilic Granulomatosis with Polyangiitis Disguised in a Patient with Episodic Wheezing for Thirteen Years: A Case Report

Dileep Lionel, Madhushan Ranabahu, Dharani Abeyrathna, Lanka Wijekoon, Hemal Senanayake

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare primary small-vessel vasculitis. Diagnosis of EGPA is challenging in the early stage, because the disease is limited to the respiratory system. Similar clinical features are observed in other eosinophilic lung diseases, such as bronchial asthma, allergic bronchopulmonary aspergillosis, and eosinophilic syndrome. Careful clinical follow-up is necessary to detect disease behaviour and support diagnosis. We report a 53-year-old female who has had long-stan …

02.09.2026journal-article

Journal of Clinical Medicine

The Role of Neutrophil Gelatinase-Associated Lipocalin (NGAL) as a Biomarker in Predicting the Function of Kidney Grafts: A Literature Review

Alexander A. Dermanis, Dominic Thompson, Georgios Koimtzis

Background/Objectives: Kidney transplantation is the gold standard treatment for end-stage renal failure. Numerous studies have sought to identify biomarkers that can predict early outcomes. Neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker that is hypothesised to be an important predictor of early surgical outcomes. Methods: A targeted narrative search was performed using prespecified search terms. Reference lists were searched to identify and yield more articles. Discussion: This review has identif …

02.09.2026journal-article

Healthcare

Long-Term Cognitive and Functional Outcomes of Anesthesia and Surgery in Patients with Dementia

Antea Krsek, Lana Sabati, Ivana Krajina, Zofia Nikola Lewandowska, Vlatka Sotosek, Lara Baticic

Dementia is one of the leading causes of disability and dependence among older adults and is increasingly encountered in patients undergoing surgery. As populations age and surgical interventions become more common, understanding the perioperative care of patients with pre-existing dementia has become an important clinical priority. Dementia is associated with reduced cognitive reserve, chronic neuroinflammation, synaptic dysfunction, blood–brain barrier impairment, neurotransmitter abnormalities, and cerebrovascul …

02.09.2026journal-article

Scientific Reports

Clinical validation of a handheld structured light device for 3D facial morphometric

Annalisa Cappella, Alessandro D’Amelio, Riccardo Solazzo, Claudia Dolci, Jacopo Burger, Giuseppe M. Facchi, Daniele M. Gibelli, Giuliano Grossi, Raffaella Lanzarotti, Chiarella Sforza, Gianluca M. Tartaglia

Abstract Handheld systems for three-dimensional (3D) imaging of facial soft tissues are gaining increasing attention due to their affordability, portability, and user-friendliness. However, their reliability for 3D facial analysis should be verified before being integrated into clinical and research settings. We tested a novel device, the Revopoint MIRACO Pro, on 55 adults and a mannequin head, and we compared it with two validated devices. Intra- and inter-instrument reliability for traditional anthropometric para …

02.09.2026journal-article

JAMA Cardiology

Long-Term Outcomes Following Bilateral vs Single Internal Thoracic Artery Grafts

David P. Taggart, Mario Gaudino, Stephen Gerry, Marek Jasinski, Belinda Lees, Alastair M. Gray, Vipin Zamvar, Marek Deja, Siven Seevanayagam, Fernando Ribeiro de Moraes Neto, Janusz Konstanty-Kalandyk, Rafal Pawlaczyk, Lokeswara Rao Sajja, Guglielmo Actis Dato, Alice Guazzelli, Jo Cook, Carol Wallis, Umberto Benedetto, John D. Puskas, Marcus Flather, Arterial Revascularization Trial investigators, Stanislaw Wos, Dheeraj Mehta, Peter O'Keefe, Uday Trivedi, Stephen Clark, Andrzej Bochenek, Ragheb Hasan, Danny Keenan, Ranjit Deshpande, Jatin Desai, Lucie Garner, Chris Choong, Sukumaran Nair, Catherine Sudarshan, Alex Cale, Mustafa Zakkar, Tom Spyt, Jullien Gaer, Jerzy Sadowksi

Importance Bilateral internal thoracic artery grafting has been proposed to improve survival compared to standard single internal thoracic artery grafting during coronary artery bypass graft (CABG) surgery, but any survival benefit may emerge only with longer-term follow-up. Objective To report 15-year extended follow-up of a randomized clinical trial of bilateral vs single internal thoracic artery grafting for CABG. Design, Setting, and Participants This is a secondary analysis of an unblinded randomized clinical …

02.09.2026journal-article

Diabetic Medicine

The effect of social determinants of health on use of diabetes‐related mobile health applications in older adults with type 2 diabetes

Damilola Adissa, Cody Makinson, Melissa A. Elafros, Kara Mizokami‐Stout, Eva L. Feldman, Brian C. Callaghan, Evan L. Reynolds

Abstract Aims Determine associations between social determinants of health (SDOH) and use of diabetes‐related mobile health (mHealth) applications in older individuals with type 2 diabetes. Methods We identified participants that self‐reported having type 2 diabetes who completed the National Poll on Healthy Aging, a nationally representative survey of older adults in the United States. Co‐primary outcomes were use of mHealth applications to (1) track diabetes medications and (2) track blood glucose levels. SDOH fa …

02.09.2026journal-article

International Journal of Molecular Sciences

Nanoplate Digital PCR for Identification of α0-Thalassemia (SEA Deletion): Carrier Screening and Possible Application to Prenatal Diagnosis

Apisit Pattrakorn, Supawadee Yamsri, Attawut Chaibunruang, Anupong Pansuwan, Wanicha Tepakhan, Kritsada Singha, Supan Fucharoen, Hataichanok Srivorakun

The Southeast Asian deletion (--SEA), the most prevalent α0-thalassemia mutation in Southeast Asia, is a major target of regional thalassemia prevention programs. Coinheritance of α0-thalassemia with other hemoglobinopathies, particularly hemoglobin E (Hb E), complicates routine hematological screening and requires reliable molecular confirmation. This study developed and validated a duplex nanoplate digital polymerase chain reaction (dPCR) assay for simultaneous identification of the wild-type α-globin and --SEA d …

02.09.2026journal-article

Oral Science and Homeostatic Medicine

Healing of diabetic cutaneous wound mediated by small extracellular vesicles derived from mesenchymal stem cells

Tianyi Li, Wenting Zhang, Yingjie Sun, Xianbin Zeng, Yuhui Sun, Gang Ding

Abstract Diabetic cutaneous wounds, particularly diabetic foot ulcers, are among the most severe chronic complications of diabetes mellitus and remain a major clinical challenge because of persistent inflammation, oxidative stress, impaired angiogenesis, and delayed tissue regeneration. Although conventional therapies such as debridement, infection control, and growth factor application can partially improve wound conditions, their overall efficacy remains limited. Mesenchymal stem cell-derived small extracellular …

02.09.2026journal-article

Problems of Gathering Treatment and Transportation of Oil and Oil Products

IMPROVING THE METHOD FOR DETERMINING THE FUEL GAS CONSUMPTION FOR COMPRESSION USING PHYSICALLY MOTIVATED FEATURES

V.O. Smolnikov, D.A. Godovsky

This paper addresses the pressing issue of improving the energy efficiency of gas transportation systems by developing a highly accurate method for predicting fuel gas consumption by gas compressor units at booster compressor stations. To assess the operating efficiency of booster compressor station equip-ment, a method for reliably determining the fuel gas consumption of gas compressor units is required. Traditional methods of standardization and forecasting, based on industry standards, are characterized by signi …

02.09.2026journal-article

Current Issues in Molecular Biology

Clinical Efficacy of TM02® in Allergic Rhinitis: Significant Symptom Alleviation Associated with IL-5 Downregulation and Reduced Allergic Inflammation

Hao-Dong Tan, Sien-Hui Tan, Boon-Hong Kong, Chee-Kuan Wong, Revadi Govindaraju, Tengku Ahmad Shahrizal Tengku Omar, Shin-Yee Fung

Allergic rhinitis (AR) is a chronic inflammatory disease that substantially affects quality of life. Despite available therapies, symptom control remains suboptimal owing to treatment burden. Cultivated sclerotium of Lignosus rhinocerus (TM02®), known for its allergy-dampening bioactivities, is a promising adjunctive AR treatment. A randomized, double-blinded clinical trial was conducted in 108 AR patients, who received either TM02® or placebo for 30 days. Primary outcomes consisted of Total Nasal Symptom Score (TN …

02.09.2026journal-article

Journal of Clinical Medicine

Sex Bias in the Clinical Diagnosis of ADHD: A Critical Review

Farzad Salehpour, Francisco Gonzalez-Lima

Background: Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder that manifests differently across sexes, potentially impacting symptomatology, diagnosis, and treatment. Nevertheless, these legitimate sex differences in ADHD are further shaped by multiple sources of bias that distort prevalence estimates and clinical recognition. Methods: This critical review synthesizes evidence on a variety of factors, including sampling bias, referral bias, DSM criteria, and diagnostic overs …

02.09.2026journal-article

Journal of Cancer Research and Clinical Oncology

Optimized surgical treatment and study management for oncology patients in East Saxony (MISSION4Sax): study protocol of a multicentre pilot study

Christin Richter, Anne Döring, Floris Berg, Michelle Roost, Andreas Hasselberg, Carola Martin, Hannes Schlieter, Daniela Piontek, Olaf Schoffer, Jochen Schmitt, Jürgen Weitz, Grit Krause-Jüttler, Johanna Kirchberg

Abstract Purpose MISSION4Sax aims to develop and pilot new concepts for cross-sectoral oncological care, data integration and networking between maximum care centres and rural practitioners in medical underserved, enabling access to guideline-based therapy, innovative surgery, and clinical trials. Methods This pilot project is an exploratory multicentre, prospective longitudinal study. It assesses the feasibility, acceptability, implementation and data-quality aspects of the proposed care model and study infrastruc …