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Redefining atrial fibrillation treatment success: patient-defined goals for arrhythmia burden and health-related quality of life

Alexander E. Kolomaya, Brian Zenger, Michael Torre, Andrew Redd, T. Jared Bunch, Trudie Lobban, Morgan M. Millar, Jonathan P. Piccini, John A. Spertus, Rachel Hess, Benjamin A. Steinberg

Critical Pathways in Cardiology: A Journal of Evidence-Based Medicine · 2026

Vollständiger Abstract

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Background: Despite the use of atrial fibrillation (AF) cutoff of 30s as the standard for success in most AF clinical trials, patients consider an AF Severity Scale (AFSS) of ≤ 5 or AF duration ≤ 1 hour as treatment success. Prevalence and factors associated with these patient-defined endpoints are unknown. Methods: We performed a cross-sectional analysis using a single-site cohort of AF patients. We report rates of patient-defined treatment success (AFSS ≤ 5 or AF burden ≤ 1 hour) and multivariable analyses to identify factors associated with either successful outcome. Results: From 2019 to 2023, 2087 patients had available AFSS symptom scores and 2305 had ambulatory ECG monitoring. Of these, 862 (41%) had AFSS scores ≤5 and 1130 (49%) had AF burden ≤1 hour. After adjusted analysis, older age (OR 1.03, 95% CI 1.02-1.04, p

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Autor:innen
Alexander E. Kolomaya, Brian Zenger, Michael Torre, Andrew Redd, T. Jared Bunch, Trudie Lobban, Morgan M. Millar, Jonathan P. Piccini, John A. Spertus, Rachel Hess, Benjamin A. Steinberg
Quelle
Critical Pathways in Cardiology: A Journal of Evidence-Based Medicine
Publikation
2026-01-01
Band / Ausgabe
Nicht angegeben
Seiten
Nicht angegeben
ISSN / ISBN
1535-2811, 1535-282X
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Alexander E. Kolomaya, Brian Zenger, Michael Torre, Andrew Redd, T. Jared Bunch, Trudie Lobban, Morgan M. Millar, Jonathan P. Piccini, John A. Spertus, Rachel Hess, Benjamin A. Steinberg (2026). Redefining atrial fibrillation treatment success: patient-defined goals for arrhythmia burden and health-related quality of life. Critical Pathways in Cardiology: A Journal of Evidence-Based Medicine. https://doi.org/10.1097/hpc.0000000000000439
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