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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
31.08.2026journal-article

Bioinformation

Treatment of mandibular angle fracture with single miniplate: Intraoral versus transbuccal approach: A novel plating system

Divya Jain

The major objective in treating mandibular fractures is to restore normal anatomy and function. Therefore, it is of interest to assess the treatment outcome of intraoral and transbuccal approaches in fixation of fractures of the angle of the mandible. Hence, 92 patients with mandibular angle fractures were treated with Intraoral (control) and Transbuccal (interventional) method. Time taken for fixation, quality of reduction and healing were assed post-operatively. Thus, the transbuccal method was effective and can …

31.08.2026journal-article

International Journal of Agriculture and Natural Resources

Hydrothermal-treatment-derived food waste liquid as a medium for preparing nitrogen-fixing bacterial fertilizer and promoting soybean growth

Yongjing Wang, Wanyun He, Xinyu Zhang, Zichu Zhang, Yuxin Zhang, Song Gao, Kai Yang, Xingyao Meng, Lianhai Ren

Food waste wastewater (FWW), defined in this study as the aqueous supernatant obtained after hydrothermal treatment and solid–liquid separation of food waste, is rich in soluble organic matter and nutrients and has considerable potential as a low-cost substrate for microbial cultivation. This study investigated the feasibility of using FWW to produce a liquid nitrogen-fixing bacterial (NFB) fertilizer. Five NFB strains were isolated from wheat rhizosphere soil, among which strain N4, identified as Arthrobacter pasc …

31.08.2026journal-article

İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi

Integrated MRI-Derived, Pathologic, and Molecular Biomarkers for Prediction of Neoadjuvant Chemotherapy Response in Breast Cancer

Mehmet Ali Nazlı, Melis Baykara Ulusan, Fadime Didem Trabulus, Rıza Umar Gürsu, Emel Esmerer, Esra Canan Kelten Talu

Aim: To investigate the predictive value of pretreatment breast magnetic resonance imaging (MRI) findings, clinicopathological characteristics, and molecular tumor features for pathological response to neoadjuvant chemotherapy (NACT).Method: This retrospective study included 194 patients with invasive breast cancer who underwent pretreatment breast MRI, received NACT, and subsequently underwent surgery between 2015 and 2020. Pathological response was assessed using the Miller–Payne grading system and categorized as …

31.08.2026journal-article

AFRICAN JOURNAL OF REPRODUCTIVE HEALTH

DNA methylation of ANKRD23 as a novel biomarker for early diagnosis of ovarian cancer

Aydan Alizada, Ozge S. Erdogan, Seda K. Erciyas, Betul C. Demirbas, Ozge Pasin, Ahmet Dinc, Pınar Saip, Hulya Yazici, Seref B. Tuncer

Ovarian cancer (OC) is a leading cause of gynecologic cancer-related mortality and is frequently diagnosed at advanced stages due to the absence of effective early detection tools. Epigenetic alterations, particularly DNA methylation, play a critical role in tumorigenesis and represent promising non-invasive biomarkers. This study investigated the methylation status of the ANKRD23 gene in OC and evaluated its diagnostic potential using peripheral blood samples. A total of 385 serous OC patients, 50 individuals with …

31.08.2026journal-article

Korean Journal of Clinical Oncology

Targetable genes associated with hematogenous metastasis in gastric cancer using the TCGA database

Jaeun Yoo, Hyun Myong Kim, Kyoungyun Jeong, Yie-Ri Yoo, Ji-Yeon Shin, Seungho Lee, Seungbok Lee, Hye Seung Lee, Kyoung Un Park, Seong-Ho Kong, Do Joong Park, Hyuk-Joon Lee, Han-Kwang Yang

Purpose: Gastric cancer is a major global health issue, especially in advanced stages with metastasis. However, anti-angiogenic treatments such as ramucirumab target vascular endothelial growth factor, yet the exact mechanisms behind hematogenous metastasis remain unclear. This study analyzed RNA sequencing data from TCGA to identify angiogenesis-related genes in metastatic gastric cancer.Methods: Patients were categorized into four metastasis types (non-metastasis, hematogenous, locoregional, and lymphatic) based …

31.08.2026journal-article

Frontiers in Surgery

Sodium fluorescein in pediatric brain tumor surgery: a retrospective volumetric analysis of resection extent and consistency

Robert Chrenko, Dana Kuniakova, Milan Liska, Martin Hanko, Alexandra Kolenova, Salome Jakesova, Pavol Kardos, Barbora Nedomova

Purpose Maximizing the extent of resection (EOR) while preserving neurological function remains a key challenge in pediatric brain tumor surgery. Sodium fluorescein (SF) has been proposed as an adjunct to improve intraoperative visualization; however, evidence in pediatric populations is limited. This study evaluated the association between SF use and EOR, including the consistency of surgical outcomes. Methods A retrospective single-center cohort of 58 pediatric patients (19 SF, 39 control) with intended gross tot …

31.08.2026journal-article

Restorative Dentistry & Endodontics

Influence of occlusal reduction on postoperative pain following single-visit root canal treatment in mandibular molars: a randomized controlled trial

Sathvika Kanesalingavelan, Geeth Deepika KG, Anand Sherwood I, Pavithra Chandrasekaran, Azhagu Abirami A

Objectives: Postoperative pain is a frequent complication following root canal treatment, and occlusal reduction (OR) has been suggested as a means to minimize such discomfort. However, existing evidence regarding its effectiveness remains inconclusive. This study aimed to evaluate the influence of OR on postoperative pain following single-visit root canal treatment in mandibular molars. It also examined whether preoperative pain intensity affects the postoperative response to OR. Methods: A total of 280 eligible p …

31.08.2026journal-article

The FASEB Journal

Superantigens in Cancer Immunotherapy: Mechanisms, Engineering Strategies, and Therapeutic Potential

Urooj Yousaf Virk, Hafiza Aasia Malik, Muneera Anwer, Jennifer Wilson, Md. Sifat Rahi, Ming Q. Wei

ABSTRACT Cancer immunotherapy has reshaped modern oncology by enabling the immune system to recognize and eliminate malignant cells. However, many solid tumors still respond poorly because of weak T‐cell activation and an immunosuppressive tumor microenvironment. Bacterial superantigens (SAgs) represent a unique class of immunomodulatory proteins capable of overcoming these limitations through direct activation of large T‐cell populations. Unlike conventional antigens, superantigens bypass classical antigen process …

31.08.2026journal-article

Frontiers in Pharmacology

Generation of a glycogen storage disease mouse model with fatty liver and its treatment by PPAR-α agonist bezafibrate

Yixia Xie, Guoquan Fu, Caixia Fan, Huarong Huang, Junyan Yan, Lifang Jin

Background Fatty liver is considered the pathological basis for the development of glycogen storage disease type Ia (GSDIa); however, due to the lack of suitable animal models, the mechanism underlying fatty liver development in GSDIa is largely unknown. Methods This study employed surrogate breastfeeding to enable the survival of glucose-6-phosphatase catalytic ( G6PC ) knockout (KO) mice into adulthood, and then analyzed fatty liver phenotypes in 3-month-old KO (KO-3), 6-month-old KO (KO-6), and 9-month-old KO (K …

01.09.2026journal-article

Japanese Journal of Applied Physics

Effects of low-temperature heat treatment on continuous feeding bridgman method grown Pb(In 1/2 Nb 1/2 )O 3 –Pb(Mg 1/3 Nb 2/3 )O 3 –PbTiO 3 single crystals

Yan Sun, Yu Xiang, Yohachi Yamashita, Hiroshi Maiwa

The effects of alternating current poling (ACP), direct current poling (DCP), and cyclic low-temperature heat treatment (HT) at 130 °C, corresponding to the tetragonal phase region, on highly thermally stable Pb(In 1/2 Nb 1/2 )O 3 –Pb(Mg 1/3 Nb 2/3 )O 3 –PbTiO 3 (PIN–PMN–PT) single crystals grown by the continuous feeding Bridgman method were investigated. ACP produced a well-ordered lamellar domain structure and yielded superior properties, with a dielectric permittivity of 6900 and a piezoelectric coefficient ( d …

31.08.2026journal-article

Current Oncology

Practical Considerations in the Radiotherapy Treatment Planning for SBRT Pancreas Program

Kurian Joseph, Ben Burke, Amr Heikal, Eugene Yip, Shannah Murland, Clarence Wong, Beena Kunheri

Pancreatic ductal adenocarcinoma is one of the most aggressive tumours, with an estimated 5-year overall survival rate of 5% and median survival of 5–11 months. Approximately one third of patients die of complications due to local disease progression, especially among patients with borderline resectable or locally advanced disease; hence achieving local control is significant for improved survival outcomes. Stereotactic body radiotherapy (SBRT) allows safe and effective delivery of ablative doses of radiation and i …

31.08.2026journal-article

Biology Methods and Protocols

Tensor-Derived Similarity Networks for Characterising Spatial Patterns in Colorectal Cancer

Tuan D Pham

Abstract Spatial transcriptomics enables the study of gene expression within the spatial context of tissue architecture, offering new opportunities for understanding tumour heterogeneity. This study proposes a tensor-derived similarity network framework for analysing spatial organisation in colorectal cancer. Gene expression data from four patients are represented as spatially structured tensors and decomposed using a low-rank canonical polyadic model to extract latent spatial–molecular features. These features are …

31.08.2026journal-article

International Journal of Molecular Sciences

MicroRNA Expression Profiles Before and After Neoadjuvant Chemotherapy in Breast Cancer: Correlations with Molecular Subtypes, Pathological Response, and Clinical Timing—A Pilot Translational Study

Isabela Anda Komporaly, Adelina Silvana Gheorghe, Elena Adriana Iovănescu, Bogdan Georgescu, Dana Lucia Stănculeanu

Neoadjuvant chemotherapy (NAC) is the standard of care for locally advanced breast cancer, yet the molecular predictors of pathological response remain incompletely defined, particularly regarding microRNA (miRNA) dynamics. We investigated paired pre- and post-NAC miRNA expression profiles in relation to molecular subtype, residual cancer burden (RCB), and clinical timing parameters. Seven patients with invasive breast cancer (Luminal A n = 3, Luminal B n = 1, TNBC n = 2, HER2+ n = 1) who received NAC (AC-T or TCHP …

31.08.2026journal-article

Antibiotics

Fungal Identification and Empirical Antifungal Treatment in Critically Ill Patients with Secondary Peritonitis—A Retrospective Cohort Study

Patrícia Bernardo, Susana M. Fernandes, Ana S. Nepomuceno, Denise Pinto, João M. Ribeiro, João Gouveia

Background/Objectives: The clinical impact of empirical antifungal therapy in patients with secondary peritonitis and sepsis remains incompletely established. This study aimed to identify risk factors for fungal infection in this population and the impact of empirical antifungal therapy on clinical outcomes. Methods: This was a retrospective cohort study of critically ill patients who underwent abdominal surgery for visceral lesions. Demographic and microbiological data were extracted from electronic health records …

31.08.2026journal-article

Sains Malaysiana

Single-Cell Sequencing Exploration of Extrinsic Adaptive Resistance to PD-1 Inhibitors: Theory of Acupuncture-Associated Intervention in Advanced Non-Small Cell Lung Cancer

Chenteng Jiang, Zhiwei Zang

PD-1 and PD-L1 are respectively the receptor-ligand molecules on T cells and their target cells. The interaction between them can mediate immunosuppressive signals and induce immune escape of tumors. PD-1/PD-L1 inhibitors have revolutionized advanced non-small cell lung cancer (NSCLC) treatment, both primary resistance and acquired resistance persist due to the immunosuppressive tumor microenvironment and alternative immune checkpoints. Acupuncture shows immunomodulatory potential, but its synergy with PD-1 blockad …

31.08.2026journal-article

Revista ft

Labirintite: aspectos clínicos, diagnóstico e tratamento

Silva Raul Felipe Garcia, Luiz Filipe Vieira Botelho

Labyrinthitis is an inflammatory condition affecting the labyrinth, a structure located in the inner ear responsible for balance and hearing. Clinically, it manifests mainly with intense vertigo, nausea, vomiting, postural instability, and, in some cases, hearing loss. The aim of this study is to review the main epidemiological, pathophysiological, diagnostic, and therapeutic aspects related to labyrinthitis. This is a narrative review of scientific literature based on recent national and international articles. Th …

31.08.2026journal-article

İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi

Effect of miR-105-5p on Cell Proliferation, Colony Formation, and hTERT/P53/P21 Gene Expression in Multiple Cancer Cell Lines

Aylin Örs, Hamide Doğan, Eylem Nas, Aycan Sezan, Mehmet Yağız Çapanoğlu, Taoufik Allababidi, Burcu Saygıdeğer, Yasemin Saygideger

Aim: MicroRNAs are small endogenous RNA molecules that do not code for proteins but have the capacity to influence cancer development by promoting or inhibiting it. They play normal biological roles in regulating cell metabolism, development, apoptosis, and metastasis. While numerous studies on the functional mechanisms of miRNAs exist, there is limited research in the literature on miR-105-5p, a member of the miR-105 family. This study investigated the effects of miR-105-5p on cell proliferation, colony formation, …

31.08.2026journal-article

Urogenital Tract Infection

Efficacy of D-Mannose in the Management of Urinary Tract Infections: From Acute Treatment to Long-term Prophylaxis — A Systematic Review and Meta-analysis

Jae Yong Jeong, Young Joon Moon, Dong Hyuk Kang, Hae Do Jung, Lawrence Kim, Joo Yong Lee

Purpose: To evaluate the efficacy of D-mannose for preventing recurrent urinary tract infections (UTIs), including in kidney transplant recipients, and to clarify discrepancies between early openlabel and placebo-controlled trials.Materials and Methods: PubMed, Embase, CENTRAL (Cochrane Central Register of Controlled Trials), and Web of Science were searched from inception to February 2026. Randomized controlled trials (RCTs) comparing D-mannose with placebo, no treatment, antibiotics, or active controls were inclu …

31.08.2026journal-article

Frontiers in Oncology

Feasibility and acceptability of ice plant intensive cream in preventing hand-foot syndrome in breast cancer patients undergoing Doxorubicin and/or Docetaxel therapy: a randomized controlled pilot study

Marcela Winkler, Renée Arnhold, Dennis Anheyer, Christel Idler, Felicitas Löffler, Georg Sauer, Claudia Löffler, Holger Cramer

Introduction Hand-Foot Syndrome (HFS) is a common side effect in patients undergoing chemotherapy, particularly with Doxorubicin and Docetaxel and can substantially impair quality of life. This study aimed to assess the feasibility and acceptability of using Ice Plant Intensive Cream ( Mesembryanthemum crystallinum ) to prevent HFS in breast cancer patients, within a predefined recruitment target of 36 participants. Methods In this randomized controlled pilot study, patients with breast cancer scheduled to receive …

31.08.2026journal-article

Life

Airway Response to Dual Bronchodilation and Its Association with Inflammatory Markers in Treatment-Naïve Chronic Obstructive Pulmonary Disease: A Quantitative Computed Tomography Study

Ieva Dimiene, Jurgita Zaveckiene, Kristina Bieksiene, Neringa Vaguliene, Deimante Hoppenot, Kestutis Malakauskas, Marius Zemaitis, Skaidrius Miliauskas

Background/Objectives: Quantitative computed tomography (CT) can be used to characterize airway responses to therapies for chronic obstructive pulmonary disease (COPD), but prospective real-world data in treatment-naïve patients remain limited, and the role of inflammatory markers as potential predictors of structural airway response is poorly understood. Methods: We conducted a prospective real-world study in treatment-naïve patients with moderate-to-severe COPD (n = 47). Lung function and chest CT were assessed a …

31.08.2026journal-article

Frontiers in Immunology

Treatment sequence of stem cell delivered heterologous oncolytic virus impact on tumor microenvironment in immunocompetent ovarian cancer model

Eslam E. Abd El-Fattah, Linda Flores, Jacqueline Lara, Gary Ngai, Rachael Mooney, Karen Aboody

Introduction Ovarian cancer (OC) is a biologically heterogeneous malignancy associated with poor clinical outcomes. Oncolytic viruses (OVs) have emerged as a promising immunotherapeutic strategy; however, optimal approaches to maximize their antitumor efficacy—especially in combinatorial or sequential settings—remain insufficiently defined. To determine how the sequence of administration of two clinically relevant, stem cell–delivered OV platforms influences tumor control and immune remodeling in an immunocompetent …

31.08.2026journal-article

European Heart Journal - Case Reports

Breast Cancer Metastasis Mimicking Pacemaker Pocket Infection: A Diagnostic Pitfall and Long-Term Preservation of the Cardiac Implantable Electronic Device: A Case Report

Francesco De Tommasi, Valentina De Filippo, Tamara Taddei, Alessandra Crocetti, Massimo Scopelliti

Abstract Background Cardiac implantable electronic device (CIED) pocket infection is the most common infectious complication following pacemaker implantation or generator replacement and generally requires complete device and lead extraction according to current international guidelines (1–5). Nevertheless, non-infectious disorders, including malignant disease, may closely mimic pocket infection, creating a challenging differential diagnosis and potentially leading to delayed diagnosis or unnecessary CIED extractio …

31.08.2026journal-article

JNCI: Journal of the National Cancer Institute

Association between genomic classifier scores and initial management of localized prostate cancer in the United States

Michael S Leapman, Rong Wang, Preston C Sprenkle, Isaac Y Kim, Stacy Loeb, Tyler M Seibert, Matthew R Cooperberg, Peter H Gann, Kevin Ginsburg, William J Catalona, Michaela A Dinan, Cary P Gross, Xiaomei Ma

Abstract Background Tissue-based gene expression assays provide prognostic information in prostate cancer, but their influence on decisions regarding immediate treatment vs conservative management, including active surveillance (AS) and watchful waiting (WW), remains uncertain. Methods Using a linkage with the Surveillance, Epidemiology, and End Results program, we evaluated the association between a 22-gene genomic classifier (GC) and initial management among patients with low or intermediate clinical-risk prostat …