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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
31.08.2026journal-article

Discover Oncology

Development and validation of a deep learning model for breast cancer prognosis using the SEER database

Xuanzi Li, Shuyuan Zhang, Shuai Yang, Xueqiang You, Shunli Peng

Abstract Background Breast cancer is the most prevalent malignancy and the leading cause of cancer‑related death in women. Despite the widespread use of the TNM stage, patient outcomes vary considerably due to its molecular heterogeneity. Traditional linear models, constrained by linearity assumptions, are inadequate for modeling complex nonlinear interactions in clinical data. Deep learning has emerged as a promising alternative to capture these intricate relationships and improve predictive accuracy. In this stud …

31.08.2026journal-article

Revista Brasileira Multidisciplinar

Tumor marrom do hiperparatireoidismo

Beatriz Augusto Silva Inácio, Giovana Santa Rosa Santos, Daniel Alves Orlando, Beatriz Birelli do Nascimento, Lourival Antunes Oliveira Filho

Um "tumor marrom" é uma rara lesão óssea causada por intensa atividade osteoclástica, muitas vezes associada ao hiperparatireoidismo. Diferenciá-lo de um tumor benigno de células gigantes é crucial, e a produção excessiva de hormônio da paratireoide é um indicador importante. Relatamos aqui um caso clínico de um paciente com tumor marrom associado ao hiperparatireoidismo, adotando como critério a revisão de prontuário de paciente atendido no interior do estado de São Paulo. O paciente apresentava edema na tíbia e u …

31.08.2026journal-article

International Journal of Molecular Sciences

The Effect of Prolyl Isomerase Pin1 on the Development of Metabolic Dysfunction-Associated Steatohepatitis and a New Treatment Strategy

Yasuka Matsunaga, Masa-Ki Inoue, Machi Kanna, Tomoichiro Asano, Yusuke Nakatsu

Metabolic dysfunction-associated steatohepatitis (MASH) is characterized by fatty liver, inflammation, and fibrosis, which eventually results in hepatocarcinoma. Recently, MASH therapeutics have been approved by the FDA; however, options remain limited, and the discovery of additional molecular targets is ongoing. The prolyl isomerase Pin1 regulates the function of phosphorylated substrates by converting the cis-trans form of proline. Pin1 interacts with specific substrates in each organ and controls lipid and ener …

31.08.2026journal-article

Journal of Obstetrics and Gynaecology Research

Development and Application of a Psychological Expectations Scale for Patients With Middle‐ and Late‐Stage Cervical Cancer in China

Huaiming Zhang, Aonan Liu, Rong Zhang, Yufeng Wang

ABSTRACT Objective The Psychological Expectation Scale for Patients with Middle‐ and Late‐Stage Cervical Cancer (PES‐PMLSCC) was developed to assess the psychological expectations of patients with middle and late cervical cancer, and its reliability, validity, and acceptability were tested. Method Employing classical test theory methodology, a cohort of 148 cervical cancer patients classified as FIGO Stage III or IV (or equivalent TNM staging) was enrolled in this study. The PES‐PMLSCC scale was developed. The init …

31.08.2026journal-article

ANNALS OF ABBASI SHAHEED HOSPITAL AND KARACHI MEDICAL & DENTAL COLLEGE

Quality of Life and Associated Factors among Post-Treatment Oral SquamousCell Carcinoma Patients: A Cross-Sectional Study Using the EORTC QLQ-H&N35

Uzma Zareef, Iqra Ali, Arifa Haque, Afshan Faizan, Maryam, Rabail Khero, Tauseef Ahmed

Objective: To evaluate quality of life among post-treatment OSCC patients and identify clinical and treatment-related factors affecting quality-of-life outcomes using the EORTC QLQ-H&N35 questionnaire.Methods: This cross-sectional study was conducted at Darul Sehat Hospital and Abbasi Shaheed Hospital, Karachi, over six months after institutional approval. A total of 70 post-treatment OSCC patients were included using non-probability convenience sampling.Results: Most patients were male and married, with a large pr …

31.08.2026journal-article

Neuro-Oncology Pediatrics

Evaluating the Impact of Virtual Tumor Boards: A Mixed-Methods Analysis of GAPNO’s Case Discussions

Nuzhat Yasmeen, Nuha Omran, Summaya Sohail Chaudry, Hend Shrafeldin, Jen Chun Foo, Allyson Andujar, Fair Berg, Sergio Licona, Eric Bouffet, Santhosh A Upadhyaya, Daniel C Moreira

Abstract Background Children with central nervous system (CNS) tumors in low- and middle-income countries (LMICs) face substantial disparities in access to specialized multidisciplinary care. Virtual multidisciplinary tumor boards (vMDTs) may help bridge these gaps. This study evaluated the impact of the Global Alliance for Pediatric Neuro-Oncology (GAPNO) vMDT. Methods We conducted a mixed-methods analysis. Case-based and participant-level surveys assessed diagnostic and therapeutic impact, implementation feasibil …

31.08.2026journal-article

EJNMMI Radiopharmacy and Chemistry

Development and preclinical evaluation of selective vinyl sulfone-based probes for PET imaging of tumor-associated cathepsins

Oliviero Cini, Alan Miranda, Daan Willocx, Angeliki Karakasidi, Anke de Groot, Thales do Valle Moreira, Ana P. Leandro, Maria M. M. Santos, Rui Moreira, Filipe Elvas

Abstract Background Cysteine cathepsin L (CatL) is emerging as a key biomarker of cancer progression, making it an attractive candidate for non-invasive molecular imaging. To monitor enzymatic activity directly, rather than merely protein expression, activity-based probes (ABPs) enable selective targeting of enzymes through covalent binding at their active sites. Despite vinyl sulfones are well-established irreversible inhibitors of cathepsins, their application as positron emission tomography (PET) ABPs remains un …

31.08.2026journal-article

Esophagus

Real-world trends in radiotherapy modalities for esophageal cancer: analysis of a nationwide claims database in Japan

Kazuya Takeda, Shinsaku Okuda, Rei Umezawa, Takaya Yamamoto, Noriyoshi Takahashi, Hiroshi Onishi, Keiichi Jingu

Abstract Background Recently, the application of Intensity-Modulated Radiotherapy (IMRT) and changes in fractionation schedules have been increasingly introduced in radiotherapy practice for esophageal cancer. However, the extent of their adoption and prevalence in real-world clinical practice remains unclear. This study aimed to describe nationwide trends in radiotherapy for esophageal cancer using a large-scale health insurance claims database. Methods Using the DeSC database, we identified patients newly diagnos …

31.08.2026journal-article

Journal of Applied Microbiology

Constructed wetland treatment increases prevalence of multidrug-resistant Escherichia coli isolates but decreases overall concentrations

Adin C Pemberton, Brian R McMinn, Julie Kelleher, Valerie J Harwood, Asja Korajkic

Abstract Aims Antibiotic resistant bacteria (ARB) are high-risk pathogens of interest in the environment. Treatment wetlands are effective in reducing microbial contamination, but little is known of their ability to remove ARB such as methicillin resistant Staphylococcus aureus (MRSA), vancomycin resistant enterococci (VRE), and low-level ceftriaxone resistant Escherichia coli (LLCR). Methods and Results We measured putative MRSA, VRE, and LLCR E. coli from water column and sediments in five distinct sites within t …

31.08.2026journal-article

Pakistan Journal of Medical Sciences

Efficacy of Cognitive Behavior Therapy, Pelvic Floor Therapy, Integrated Therapy, and Pharmacotherapy in the Treatment of Chronic Pelvic Pain in Women: A Randomized Controlled Trial

Bushra Akram, Ahmad Bilal

Objective: The objective of the current study was to determine the efficacy of Cognitive Behavior Therapy (CBT-cp), Pelvic Floor Therapy (PFT), Integrated Therapy (Combination of CBT-cp and PFT), and Pharmacotherapy in the Treatment of Chronic Pelvic Pain in women, compared with the placebo group. Methodology: A five-arm (four intervention arms and one placebo arm), Randomized Controlled Trial (RCT) was conducted, to examine the effectiveness of CBT-cp, PFT, and Pharmacotherapy in the treatment of Chronic Pelvic Pa …

31.08.2026journal-article

Precision Clinical Medicine

Histone modifications: mechanisms, metabolic regulation and therapeutic targeting in cancer

Lingli Wang, Shiying Li, Xiaoyan Hu, Kui Ming Chan, Yang Meng, Junhong Han

Abstract Histone post-translational modifications are central regulators of chromatin organization and genome function, acting independently of alterations in DNA sequence. This review comprehensively summarizes the multifaceted roles of major histone modifications including acetylation, methylation, ubiquitination, phosphorylation and emerging metabolism-linked acylations in governing critical DNA-templated processes such as replication, transcription, and the DNA damage response. We further discuss the concept of …

31.08.2026journal-article

Psycho-Oncology

Comparative Effects of Various Delivery Methods of Cognitive Behavioral Therapy for Insomnia Among Patients With Cancers: Systematic Review and Network Meta‐Analysis

Chen‐I Lee, Muhammad Amirul Mukminin, Ya‐Wen Jan, Tzu‐Hao Wang, Tsai‐Wei Huang, Hsiao‐Yean Chiu

ABSTRACT Background Insomnia affects 30%–60% of cancer survivors, with around 20% meeting criteria for insomnia disorder. Cognitive behavioral therapy for insomnia (CBTi) is the first‐line treatment, but access is limited by cost and therapist availability, prompting exploration of alternative delivery modes, including digital interventions. Purpose To systematically review and conduct a network meta‐analysis (NMA) of the efficacy of different CBTi delivery methods for managing insomnia in cancer survivors. Methods …

31.08.2026journal-article

Frontiers in Immunology

Treatment-related lymphopenia predicts long-term survival in locally advanced head and neck cancer: Post-Hoc analysis of a randomized phase III trial

Gulidanna Shayan, Xin Guo, Xiaodong Huang, Kai Wang, Yuan Qu, Ye Zhang, Runye Wu, Xuesong Chen, Jingwei Luo, Jianghu Zhang, Jingbo Wang, Junlin Yi

Purpose To evaluate the prognostic value of treatment related decline of peripheral absolute lymphocyte count (ALC) in patients with locally advanced head and neck squamous cell carcinoma (LA-HNSCC) after preoperative radiation therapy (RT) with or without chemotherapy. Methods This post-hoc analysis was performed using data of 222 patients from a phase III, randomized controlled trial in LA-HNSCC. ALCs were measured before, during, and after RT. The ALC decline was defined as the difference between pre-treatment A …

31.08.2026journal-article

Periodontology 2000

Flapless submucosal instrumentation treatment of peri‐implantitis: Contemporary evidence and clinical protocol

José Nart, Neus Carrió, Gonzalo Blasi, Maria Costanza Soldini, Ramon Pons, Matteo Albertini, Beatriz de Tapia

Abstract Background/Aim Peri‐implantitis is a plaque‐associated disease characterized by inflammation of the peri‐implant mucosa and progressive loss of supporting bone, representing a growing clinical and public health challenge. Conventional nonsurgical therapies often provide limited and unpredictable outcomes, while surgical approaches are associated with increased morbidity and variable long‐term success. In this context, minimally invasive strategies, particularly flapless submucosal instrumentation, have eme …

31.08.2026journal-article

Technology audit and production reserves

Development of a fungicidal varnish for the onychomycosis treatment in men

Roman Kachan, Volodymyr Bessarabov, Olena Ishchenko, Vladyslav Strashnyi, Vadym Lisovyi

The object of research is the production of a polymer cosmetic product with fungicidal and cosmetic-masking effects for the onychomycosis treatment in men. This work addresses the problem of the lack of products for men to treat onychomycosis and simultaneously mask the negative aesthetic changes of the nail caused by it. Onychomycosis is a common nail infection, which is an acute problem for military personnel due to moisture in shoes, lack of hygiene and stress. The existing therapy has disadvantages: low permeab …

31.08.2026journal-article

Journal of Endourology

Upper Urinary Tract Surgery with Hugo TM RAS: A Systematic Review

Andrea Noya-Mourullo, Pietro Pasquini, Sara Tamburini, Francesco Cei, Edoardo Beatrici, Mario de Angelis, Vincenzo Cavarra, Enrico Vecchio, Claudio Brancelli, Francesco Pepillo, Niki Rashidian, Ruben De Groote, Alexandre Mottrie, Geert De Naeyer, on behalf of ERUS kidney cancer working group

Background: Pelvic procedures with the Hugo™ RAS system maintain a stable setup with minimal variations, and upper urinary tract procedures exhibit significant variability in configurations and approaches. This review investigates the feasibility and safety of the Hugo™ RAS system in upper urinary tract procedure, analyzing the heterogeneous configuration possibilities offered by this multicart robotic platform. Methods: A systematic review was designed following the PICO framework and conducted in accordance with …

31.08.2026journal-article

Sri Lanka Journal of Food and Agriculture

Optimization of Seed Germination of Berrya cordifolia by Novel Seed Treatment Techniques

S. M. C. Senanayaka

Berrya cordifolia is a deciduous tree that can grow up to 40 meters tall, though in some parts of its range it barely exceeds 6 meters. The bole can be 10 - 50cm in diameter and is unbranched for up to eleven meters. The tree is having fibrous bark, the showy green colour flowers are produced in large tight clusters. The tree can be found in Southeast Asia and the Pacific Region. The plants are valuable for their timber. Berrya cordifolia is a valued timber species in Sri Lanka, where it is commonly exploited from …

31.08.2026journal-article

International Journal of Molecular Sciences

USF2-Mediated APOE-Cholesterol Signaling Promotes CTC Clustering and Metastasis in Non-Small Cell Lung Cancer

Zheng Li, Meng Cui, Li Sun, Hao Qin, Xiaoyong Shen, Wen Gao

Circulating tumor cell (CTC) clustering is a key driver of metastatic progression in non-small cell lung cancer (NSCLC), but the underlying molecular mechanisms remain largely unknown. Here, we performed single-cell proteomic sequencing on CTC clusters and individual CTCs isolated from lung cancer patients, identifying 912 proteins in total, of which 246 were significantly upregulated in clusters versus single CTCs. Enrichment analyses revealed a prominent involvement of lipid and cholesterol metabolism pathways. A …

31.08.2026journal-article

Cancer

GPRC5D‐targeting bispecific and trispecific antibodies in multiple myeloma: Current evidence and emerging strategies

Darren Pan, Anupama Kumar, Jodi J. Lipof, Alfred Chung, Jeffrey L. Wolf, Thomas G. Martin, Shagun Arora, Peter H. Sayre, Ajai Chari

Abstract G‐protein–coupled receptor class C group 5 member D (GPRC5D) has emerged as a crucial immunotherapy target in relapsed/refractory multiple myeloma. Although the T‐cell‐engaging bispecific antibody talquetamab is currently the only approved anti‐GPRC5D therapy, numerous promising agents are undergoing clinical evaluation. While anti‐GPRC5D chimeric antigen receptor T cells show potential, this review focuses specifically on T‐cell‐engaging bispecific and trispecific antibodies. We highlight how GPRC5D diffe …

31.08.2026journal-article

Necmettin Erbakan Universitesi Dis Hekimligi Dergisi (NEU Dent J), Necmettin Erbakan

Retrospective Evaluation of Dental Treatment Modalities Performed Under General Anesthesia in Pediatric Patients

İsmail Haktan ÇELİK, Hatice TÜRKOĞLU, Ayça Hande SARI, Özgür DOĞAN

Aim: This study aimed to evaluate dental procedures performed under general anesthesia (GA) in children and to analyze the associations of treatment types with age group, gender, and tooth type. Materials and Methods: A retrospective review was conducted on pediatric patients who underwent comprehensive dental treatment under GA between 2017 and 2025. Data from 2703 treated teeth were analyzed, including demograph-ic variables, tooth type (primary or permanent), and treatment categories (preventive, restorative, en …

31.08.2026journal-article

JOURNAL OF BASIC SCIENCES

Impacto financiero y clínico de la ciclofosfamida y bendamustina en el tratamiento de cáncer en México

Irlanda Guadalupe Díaz Martínez, Víctor Florentino Castro Georgana, Daniel Alejandro Vázquez Cahuich, Juan José De la Cruz López, Kenia Paola García Jesús, María Teresa Flores Dorantes, Pascual Pedraza Montero

Cancer is a serious global health problem. Various oncological treatments allow patients to achieve better therapeutic outcomes. Cyclophosphamide and bendamustine are drugs used in different cancer treatments that can be evaluated through pharmacoeconomic studies, such as cost-minimization analysis. This study compared cost the associated with the use of cyclophosphamide and bendamustine through a pharmacotherapeutic and cost-minimization evaluation across different types of cancer, as well as a compilation of adve …

31.08.2026journal-article

Research Journal of Biotechnology

Inverse Vaccines: A Promising Breakthrough in the Treatment of Autoimmune Diseases

Deepa K.P., Thajuddin N.

Inverse vaccines also known as tolerogenic vaccine are an innovative strategy in immunology, designed to promote immune tolerance instead of triggering an immune response. In contrast to conventional vaccines that activate the immune system to combat pathogens, the goal of tolerogenic vaccines is to suppress harmful immune reactions, making them particularly valuable for managing autoimmune disorders, allergies and issues related to organ transplantation. These vaccines function by specifically targeting self-react …

31.08.2026journal-article

Endocrine-Related Cancer

ARGININE VASOPRESSIN DEFICIENCY: TOWARDS A BETTER CHARACTERIZATION

Cihan Atila, Clara Consoli, Mirjam Christ-Crain

Abstract Arginine vasopressin (AVP) deficiency, previously termed central diabetes insipidus, arises from impaired AVP synthesis or secretion by the hypothalamus and/or the posterior pituitary gland and presents with hypotonic polyuria and polydipsia. To differentiate AVP deficiency from AVP resistance and primary polydipsia, a stepwise diagnostic work-up is required. In recent years, copeptin, as a reliable surrogate marker of AVP secretion, has been incorporated into diagnostic algorithms, and copeptin-based stim …

31.08.2026journal-article

Dermatology and Skin Science

POTUS’ Neck Rash: Impact on Public Skin Cancer Awareness

Nicolas Kluger

Media attention on a visible neck rash on US President Donald Trump, first noted 2 March 2026, at a White House ceremony, prompted dermatologists to speculate that the rash resulted from topical treatment for actinic keratosis (AK), though no official diagnosis was confirmed, as the White House physician only cited a “preventative skin treatment”. Google Trends and Wikipedia pageview data for related search terms (AK, imiquimod, fluorouracil, photodynamic therapy, rash, skin cancer) from January–April 2026 showed s …