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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

Annals of Surgery

Safety and Performance of the Colovac Anastomosis Protection Device. A Pooled Analysis of Prospective Studies Compared With Diverting Loop Ileostomy (SAFE-2025)

Patricia Sylla, Katherine Lam, Niels Komen, Jean-Jacques Tuech, Antonio Spinelli, Joseph Martz, Rebecca Rhee, Jorge Marcet, Guy Bernard Cadière, Philippe Rouanet, Aleksei Karachun, Quentin Denost, Narkhodzha Sametdinov, Andre D’Hoore, Sang Lee, Jérémie H. Lefèvre

Objective: To compare the safety and effectiveness of the Colovac Anastomosis Protection Device with standard diverting ostomy (DO) following low anterior resection (LAR) for rectal cancer. Summary Background Data: DO is standard of care (SOC) following LAR for rectal cancer but is associated with substantial morbidity. Colovac Device is designed to divert the fecal stream away from the anastomosis intraluminally. Methods: Three prospective multicenter Colovac trials were pooled and compared with a prospective coho …

02.09.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Prevalence of Parasitic Diseases among Internally Displaced Persons, Ethiopia, 2024

Yohannes Shimelis Masresha, Gizachew Tadesse Wassie, Carolyn Strobel, Francisco Averhoff, Gavin Cloherty, Steven S. Yoon

ABSTRACT. Parasitic diseases remain a major public health concern globally, particularly among vulnerable populations such as internally displaced persons (IDPs), i.e., people who relocate within their own countries due to conflict, natural disasters, or other crises. We assessed the prevalence and associated factors of schistosomiasis, geohelminthiasis, and anemia among IDPs in Ethiopia. We conducted a cross-sectional survey during March and April 2024 among IDPs in camps located in Debre Birhan, Ethiopia. Stool s …

02.09.2026journal-article

Bioinformatics

Identifying expanding TCR clonotypes with a longitudinal Bayesian mixture model and their associations with cancer patient prognosis, metastasis-directed therapy, and VJ gene enrichment

David Swanson, Alexander Sherry, Cara Haymaker, Alexandre Reuben, Chad Tang

Abstract Motivation Examination of T cell receptor (TCR) clonality has become a way of understanding immunologic response to cancer and its interventions in recent years. An aspect of these analyses is determining which receptors expand or contract statistically significantly as a function of an exogenous perturbation such as therapeutic intervention. Results We characterize the commonly used Fisher’s exact test approach for such analyses and propose an alternative formulation that does not necessitate pairwise, wi …

02.09.2026journal-article

Pain Medicine

Does the National Resident Matching Program Rank List Predict Accreditation College of Graduate Medical Education Trainee Performance Among Multispecialty Pain Medicine Fellows? A Multicenter Study

Steven P Cohen, Oludare O Olatoye, Peter Schumaker, Dalia Elmofty, Heejung Choi, Bhavana Yalamuru, Lynn R Kohan

Abstract Background Training programs seek to match fellows who will perform well during training. The National Resident Matching Program (NRMP) allows programs to choose the most capable trainees, with higher ranked applicants expected to perform better. Pain medicine is one of the most popular non-internal medicine fellowships in the U.S., and multiple specialty pathways for entry make selecting candidates challenging. Objective The aim of this study is to correlate fellow rank order and match number with academi …

02.09.2026journal-article

Pure and Applied Chemistry

Development of functional materials for the microplastics removal and treatment in surface water

Fio Febrian, Henny Purwaningsih, Mohammad Khotib

Abstract Microplastics (MPs) are persistent emerging contaminants increasingly detected in aquatic environments and pose potential risks to ecosystems and human health. Conventional single-stage removal technologies may be limited by their treatment efficiency and operational costs. This study aimed to develop a sustainable integrated approach for MP removal by combining aluminum chlorohydrate (ACH) coagulation, polyacrylamide (PAM) flocculation, and column adsorption using phosphoric acid (H 3 PO 4 )-activated bio …

02.09.2026journal-article

Journal of Wound Care

Risk factors for pressure ulcer development among adults undergoing surgery: a systematic review

Sadie Badrie, Pinar Avsar, Sherly George, Shijimol Kurian, Zena Moore, Hannah Wilson

Objective: To examine risk factors for pressure ulcer (PU) development among adults undergoing surgery. Method: A total of five electronic databases were searched from inception to March 2024. Study selection, data extraction and quality appraisal were performed by two independent reviewers, using the Crowe Critical Appraisal Tool (CCAT v1.4; Michael Crowe, James Cook University, Australia), with scores ≥75% indicating high methodological quality. Results were categorised and reported as preoperative, intraoperativ …

02.09.2026journal-article

Journal of Clinical Medicine

Considerations in Using Artificial Intelligence to Simulate Orthodontic Treatment for Implant-Prosthetic Purposes

Amelia Smaranda Roșianu, Sanda Mihaela Popescu, Daniel Adrian Târtea, Stelian Mihai Sever Petrescu, Răzvan Mercuț, Marina Olimpia Amărăscu, Mihaela Ionescu, Ionuț Cristian Reşceanu, Alin Gabriel Ionescu

Background/Objectives: Orthodontic treatment planning software with artificial intelligence has been introduced into practice in recent years. They allow the simulation of the results of orthodontic treatment in several scenarios. The aim of the study was to compare the results of a simulated preimplantation orthodontic treatment plan in cases of oral rehabilitation between two software, with three different setups and their evaluation by an orthodontist. Methods: The in silico study included 10 cases of digital mo …

02.09.2026journal-article

Journal of Cancer Research and Clinical Oncology

Knowledge and attitude towards breast and cervical cancer screening among women caregivers of cancer patients: a cross-sectional study from a tertiary cancer centre in India

Mahak Gupta, Akshay Dinesan, Lahari Udyawar, Ashmitha Prasad, Arathi P Rao, Umesh Velu, Ankita Mehta, Jayashree N P, Sharada Mailankody, Shirley Lewis

Abstract Purpose Female informal caregivers, who provide critical support to cancer patients, may face substantial caregiver burden that may adversely affect their participation in preventive healthcare. We aimed to evaluate their knowledge and attitudes toward breast and cervical cancer screening and its correlation with caregiver burden. Methods A cross-sectional study was conducted at a tertiary cancer centre using a structured questionnaire, which assessed demographics, caregiving burden (using the Zarit Burden …

02.09.2026journal-article

Physics in Medicine & Biology

A three-phase poroelastic-scattering model for skull ultrasound transmission and effective porosity inversion

Le Gao, Yue Pan, Zhiqiang Zhang, Weibao Qiu

Abstract Transcranial ultrasound is increasingly used in brain imaging, neuromodulation, and therapy guidance, but its performance is severely degraded by the skull, whose porous and heterogeneous microstructure induces strong attenuation, scattering, and phase distortion in the MHz range. However, skull-induced transmission loss is still commonly handled empirically, and its quantitative relationship to interpretable microstructural descriptors remains poorly established. In this work, we develop a three-phase por …

02.09.2026journal-article

Military Medicine

Sustained War-Related Emergency Department Presentations and Evolving Civilian Injury Patterns During Recurrent Missile-Related Conflict

Yuval Dadon, Amir Nutman, Orit Mazza, Uri Feinstein, Linoy Gabay, Anat Engel

Abstract Introduction Prolonged missile-related conflicts may generate evolving civilian injury patterns and continuing war-related presentations to emergency departments. Although mass casualty incidents receive substantial attention in the disaster medicine literature, less is known regarding how civilian injury profiles and war-related emergency department presentations evolve during recurrent and prolonged conflict conditions. Understanding these changes is important for healthcare preparedness and continuity o …

02.09.2026journal-article

Current Emergency and Hospital Medicine Reports

A Narrative Review of Medetomidine Toxicity: an Update for Emergency Medicine

Anthony Spadaro, Erin D. Wieruszewski, Brandy N. Hernandez, Brandon M. Carius, Brit Long

Abstract Purpose of Review Unregulated opioids often contain various adulterants, such as alpha-2 agonists, benzodiazepines, and stimulants. Medetomidine, an alpha-2 agonist, has emerged in the United States and has been linked to significant toxicity and severe withdrawal symptoms. This narrative review reviews medetomidine toxicity and withdrawal with a focus on management in the acute care setting. Recent Findings There is significant regional variation in the prevalence of secondarily added adulterants, and reg …

02.09.2026journal-article

IECCMEXICO

Patient-Centered Facial and Orofacial Reconstruction After Cutaneous Cancer Resection: Integrating Function, Aesthetics, and Quality of Life

Sandro José Nava Daza, Erick Fernando Flores García, Luis Felipe Espinal Pérez, Oscar Emmanuel Garcia Moreno, Slendy Dayanna Gil Ayala, Diego Clemente Moreno, Gustavo Adrián Pineda Yañez, Cristian Raziel Pacheco Hernandez, Ashley Jesús García Cortes

Facial and orofacial reconstruction following cutaneous oncologic resection represents a complex clinical challenge in which tumor control must be integrated with preservation of function, restoration of facial appearance, and maintenance of quality of life. This study analyzed contemporary reconstructive strategies used after facial skin cancer excision, with emphasis on the relationship between defect characteristics, anatomical location, surgical technique, functional recovery, aesthetic integration, postoperati …

02.09.2026journal-article

BMC Sports Science, Medicine and Rehabilitation

Biomechanical and neuromuscular correlates of DaeDo output during successful dominant- and non-dominant-leg taekwondo side kicks: a repeated-measures study

Yijun Liu, Mengyao Jia

Abstract Objective This study aimed to compare temporal, kinematic, kinetic, and support-side neuromuscular characteristics between dominant- and non-dominant-leg Taekwondo side kicks and to examine their associations with DaeDo output during successful scoring trials. Methods Twelve high-level male Taekwondo athletes, all right-leg dominant, performed side kicks with both legs. Three-dimensional kinematics, force-platform data, support-side surface electromyography (EMG), and DaeDo output were recorded simultaneou …

02.09.2026journal-article

Journal of Clinical Medicine

Anatomical and Functional Outcomes of Repeat Vitrectomy Combined with Encircling Scleral Buckling for First Recurrent Rhegmatogenous Retinal Detachment After Primary Vitrectomy: A Retrospective Cohort Study

Georgios D. Panos, Alex Stubbing-Moore, Dharmalingam Kumudhan, Gavin Orr, Anwar Zaman, Craig Wilde

Purpose: The purpose of this study is to evaluate anatomical, visual, and safety outcomes after repeat pars plana vitrectomy combined with 360° encircling scleral buckling for first recurrent rhegmatogenous retinal detachment following primary vitrectomy. Methods: This retrospective single-centre cohort included 47 eyes of 47 patients treated between October 2016 and October 2023. The primary outcome was freedom from any subsequent retinal re-detachment during available follow-up. Secondary outcomes included final …

02.09.2026journal-article

Systems

When AI Joins the Diagnosis: How Doctor–AI Collaboration Shapes Perceived Doctor Responsibility Under Perceived Diagnostic Errors

Ruxia Cheng, Rui Sun, Wenlong Tang

Artificial intelligence (AI), especially generative AI, is becoming deeply embedded in healthcare, making doctor–AI collaborative diagnosis a common mode of medical decision-making. This development raises a critical question about responsibility attribution: When people perceive that a diagnostic error has occurred, how does AI involvement shape patients’ and observers’ judgments of the doctor’s responsibility? Drawing on responsibility attribution theory, we examine this question across five studies—one event-rel …

02.09.2026journal-article

Acupuncture in Medicine

Tactile length-memorisation training for needle depth control: A pilot study of cross-postural skill transfer

Hirohisa Miyachi, Tsunehiko Wada, Miyono Okinaka

Objective: The aim of this pilot study was to examine whether tactile length-memorisation training practised in a single basic posture could improve insertion-depth control across different needling postures. Methods: In this single-group pre-post pilot study, eight visually impaired acupuncture students at a school for the blind performed needle insertions to a target depth of 15 mm on a prone practice model before and after a 2-week home-based tactile length-memorisation training programme. Insertions were perfor …

02.09.2026journal-article

Revista Ibero-Americana de Humanidades, Ciências e Educação

REVISÃO INTEGRADA DE TECNOLOGIAS LEVES-DURAS NA PRÁTICA MÉDICA CLÍNICA DE HIPERTENSÃO E DIABETES NA ATENÇÃO PRIMÁRIA

Laura Vitória de Melo Niesciur, Dionatan Costa Rodrigues, Bianca Camim Fernandes, Kaizza Martins Alves Aguiar, Camila Carolina Valero Guandalini, Victória Helen Caetano Ribeiro de Oliveira, Aliny Nunes da Cruz, Rosane Maria Andrade Vasconcelos

As doenças crônicas representadas pela Hipertensão Arterial Sistêmica e Diabetes Mellitus são grandes desafios para o sistema de saúde pública, mas para continuar ou pelo menos melhorar a qualidade e eficiência do atendimento prestado, são necessárias inovações inovadoras. Nesse contexto, as tecnologias leves-duras surgem como estratégias que podem qualificar a prática médica e sustentar o tratamento clínico. Investigar as implicações dessas tecnologias na prática e a inovação tecnológica no tratamento de doenças c …

02.09.2026journal-article

Frontiers in Immunology

Gift of nature: non-human-derived exosomes showing application prospects in periodontitis treatment

Hongbo Fei, Zhuoran Wang, Yujiao Li, Hongchen Sun, Xiuping Meng, Hongbing Lin

Periodontitis, a chronic inflammatory disorder, results in tooth loss and adversely affects oral and systemic health. Current therapies fail to effectively regenerate bone loss caused by inflammation. Human stem cell-derived exosomes have emerged as important mediators of tissue regeneration and inflammation modulation in periodontitis, yet their clinical use faces ethical and technical challenges. Non-human-derived exosomes present a viable alternative, leveraging their ability to enhance tissue repair, reduce inf …

02.09.2026journal-article

Annals of African Medicine

Neonatal Presentation of Suspected Vici Syndrome: A Case Report with Multisystem Features

Kaoutar Danaoui, Meryem Majdoul, Fatima-Ezzahra Tahiri, Hajar Akki, Kaoutar Ettouni, Mouna Zouine, Abdallah Oulmaati

Abstract Vici syndrome is a rare autosomal recessive multisystem disorder caused by biallelic mutations in the EPG5 gene. It is classically characterized by agenesis of the corpus callosum, oculocutaneous hypopigmentation, combined immunodeficiency with recurrent infections, cataracts, and cardiomyopathy. We report the case of a newborn born to consanguineous parents, with a family history of a sibling death of unspecified cause, presenting with hypopigmentation, generalized hypotonia, agenesis of the corpus callos …

02.09.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Typhoid Fever Surveillance and Vaccination Recommendations: WHO Eastern Mediterranean Region, 2021

Yesser Sebeh, Ashley Longley, Muhammad Tayyab, Nandini Sreenivasan, Kashmira Date, Eric Mintz, Evans Buliva, Lucy Breakwell Nagle

ABSTRACT. Annually, there are 5.57 to 9.23 million typhoid fever cases and 46,200 to 163,000 associated deaths, mainly in low- and middle-income countries. High incidence is estimated in the Southeast Asian, African, and Eastern Mediterranean (EMR) regions of the WHO. We reviewed EMR typhoid surveillance and vaccination recommendations to inform regional prevention and control efforts. Separate surveys were sent to surveillance and immunization officers in all 21 EMR countries and the occupied Palestinian territory …

02.09.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Training Data Recorders with a Manual to Take High-Quality Trachoma Photographs in South Sudan

Madison Bearden-Muse, Nicholas A. Presley, Stephen Ohidor, Tania A. Gonzalez, Lochebe Boniface, Stella Abuba, Shamika V. Chavda, Reida Konga, Fisseha Admassu, E. Kelly Callahan, Yak Yak Bol, Angelia M. Sanders, Scott D. Nash

ABSTRACT. When a country has reached a low trachoma prevalence, it can be difficult to reliably train survey graders to accurately grade trachoma signs. Conjunctival photography provides an opportunity to capture images for grading. Recently, a training manual targeting survey data recorders was published. In July 2023, this manual was used during a photography training, after which certified trainees served as data recorders and photographers during the Enhancing the ‘A’ in SAFE (ETAS) study in South Sudan. Five o …

02.09.2026journal-article

Asian Journal of Research in Infectious Diseases

Bacterial Ecology and Antibacterial Resistance Patterns: A Cross-sectional Study in the Internal Medicine Unit of Centre Médico-Chirurgical des Armées de Bamako, Mali

Lassina Diallo, Abasse Sanogo, Ladji Mohamed Diaby, Hassane Diallo, Sah Dit Baba Coulibaly, Yacouba Cissoko, Issa Konaté, Sounkalo Dao

Background: Antibacterial resistance (ABR) is a major public health threat, particularly in low- and middle-income countries where hospital surveillance data remain limited. This study aimed to describe bacterial ecology, antimicrobial resistance patterns, and factors associated with multidrug-resistant bacteria (MDRB) in the Internal Medicine ward of Centre Médico-Chirurgical des Armées de Bamako, Mali. Aim: This study aimed to characterise bacterial ecology and antimicrobial resistance patterns in this department …

02.09.2026journal-article

European Heart Journal - Case Reports

Transjugular LuX-Valve Plus Transcatheter Tricuspid Valve Replacement for Torrential Tricuspid Regurgitation in a Patient With a Giant Right Atrium and Prior Multiple Valve Interventions: A Case Report

Quntai Qiu, Xinlei Wu, Daozhu Wu, Xinmin Zhang, Lianpin Wu

Abstract Background Transcatheter tricuspid valve replacement (TTVR) is an option for selected patients with severe tricuspid regurgitation (TR) who are at high surgical risk, but experience remains limited in those with extreme right-heart anatomy, including a giant right atrium and a markedly enlarged elliptical tricuspid annulus. Case summary A 62-year-old man was admitted with progressive dyspnoea and lower-extremity oedema (NYHA class IV). He had prior mechanical mitral valve replacement and transcatheter aort …

02.09.2026journal-article

PLOS One

Does randomization matter in rare disease clinical trials

Stephanie Wied, Denis Kirilov Razsolkov, Nicole Heussen, Ralf-Dieter Hilgers

Background Conducting Rare Disease Clinical Trials poses a wide variety of research challenges. Many techniques that are usually considered the best standard for evaluating new therapies are more difficult to implement here. This also holds in terms of randomization in clinical trials. The question arises how to randomize and, especially, which randomization procedure (RP) should be used to prevent the influence of bias focussing on allocation bias as efficiently as possible. Methods We present guidance that suppor …