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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

Sociological Inquiry

Social Diseases and Social Problems: An Islamic Framework for Cultural Awareness And Social Diagnosis

Jilani Ben Touhami Meftah

Despite decades of policy interventions, the world suffers from profound social problems including drug abuse, family breakdown, and systemic injustice. The research problem is the persistent gap in existing sociological theories: objective criteria lacking for diagnosing social harm before it becomes visible. This paper addresses the question: What solution does the Islamic maqasid tradition offer for diagnosing social harm missing from existing theories? Approaches such as objectivism, constructionism, and the va …

02.09.2026journal-article

QJM: An International Journal of Medicine

Bubble-Wrapped: An Unusual Developmental Cataract

Akanksha Sharma, Parul Chawla Gupta, Ranjan Kumar Behera

Abstract An 11-year-old girl presented with progressive visual diminution in the right eye, with previous left cataract surgery. Slit-lamp examination revealed multiple discrete, circular lenticular opacities with central dark zones and dense white peripheral halos, producing a distinctive “bubble-wrap” appearance. The lesions were predominantly nuclear and varied in size. Although bubble-like cataract morphologies have been described following ocular trauma and in retinitis pigmentosa, this appearance has not, to …

02.09.2026journal-article

Journal of Surgical Oncology

Morbidity and Mortality of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in Patients Aged 70 Years and Older: A Two‐Center 10‐Year Experience

Ali Ediz Kıvanç, Mehmet Oduncu, Pırıltı Özcan, Özgül Düzgün, Neşet Köksal

ABSTRACT Background and Objectives Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is established for peritoneal surface malignancies, but its use in older patients is debated. We assessed CRS‐HIPEC morbidity and mortality in patients aged ≥ 70 years using a cohort of younger patients as a comparator. Methods We retrospectively reviewed consecutive patients aged ≥ 70 and

02.09.2026journal-article

Biomolecules

Post-Exposure JNJ-26366821 Treatment Attenuates Systemic Inflammation and Limits Cardiotoxic Risk

Nabarun Chakraborty, Gregory P. Holmes-Hampton, Lily S. Neff, Vidya P. Kumar, Swapna Kannan, Amrita Cheema, Chandan Guha, Sanchita P. Ghosh, Rasha Hammamieh

Introduction: Thrombopoietin mimetics (TPOm) are known to increase blood cell counts, thereby ameliorating various diseases, including cardiomyopathy—a leading cause of mortality because of delayed radiotoxic effects. Previous preclinical studies demonstrated significant survival enhancement following lethal radiation exposure with a single dose of JNJ-26366821 in two mouse strains, CD2F1 and C57BL/6. Materials and Methods: In this study, a single dose of JNJ-26366821 (1.0 mg/kg) or saline was administered 24 h pos …

02.09.2026journal-article

Clinics in Colon and Rectal Surgery

The NICE Procedure: Surgical Technique and Technical Considerations

Diego Z. Arellano, Deborah S. Keller, Eric M. Haas

Abstract The NICE (Natural orifice IntraCorporeal anastomosis with transrectal Extraction) procedure represents an evolution in minimally invasive colorectal surgery, combining robotic precision with natural orifice specimen extraction to minimize abdominal wall trauma. The technique involves mesenteric-sparing resection of the diseased segment, transrectal natural orifice specimen extraction, and creation of an end-to-end intracorporeal anastomosis, thereby eliminating the need for an abdominal extraction-site inc …

02.09.2026journal-article

The Cleft Palate Craniofacial Journal

Three-Dimensional High-Resolution Mesh Analysis of Mixed-Dentition Intraoral Models for Predicting Future Orthognathic Surgery in Patients With Cleft Lip and/or Palate

Towako Tanimura, Chihiro Tanikawa, Takashi Yamashiro

Objective To evaluate the 3-dimensional (3D) geometric characteristics of mixed-dentition intraoral models and identify morphological features associated with later inclusion of orthognathic surgery (OGS), rather than camouflage treatment alone (non-OGS/NOGS), as a treatment option in patients with cleft lip and/or palate (CL/P). Design Retrospective cohort study. Setting Institutional study. Participants A total of 320 patients with unilateral or bilateral CL/P who received first-phase orthodontic treatment at age …

02.09.2026journal-article

THE JOURNAL OF THE BULGARIAN ORTHOPAEDICS AND TRAUMA ASSOCIATION

Augmented Internal Fixation of Distal Femoral Fractures: Current Concepts, Biomechanical Rationale, Indications, and Clinical Evidence—A Review

Hristo Hristov, Yordan Andonov

Distal femoral fractures remain difficult to treat, particularly in older patients with poor bone quality and in highly comminuted injuries with loss of medial cortical support. Objective: To review the biomechanical rationale, indications, techniques, and reported outcomes of augmented internal fixation. Methods: A focused review of English-language clinical studies, biomechanical investigations, systematic reviews, and meta-analyses was undertaken. PubMed/MEDLINE and ScienceDirect were searched using terms relate …

02.09.2026journal-article

Plastic & Reconstructive Surgery

“Smile Spontaneity Following Cross-Facial Nerve Grafting: A Systematic Review and Meta-Analysis”

Catherine F. Roy, Elizabeth McGonagle, José A. Correa, Roy Xiao, Tessa A. Hadlock

Background: Contemporary facial reanimation techniques increasingly aim to achieve smile spontaneity, defined by most as an unprompted smile triggered by positive emotions. This study aimed to 1) assess the rate of reporting of spontaneity outcomes and commonly used tools to elicit and assess spontaneity and 2) evaluate the published success rate in achieving spontaneity. Methods: A systematic review of the Ovid MEDLINE, Embase and Cochrane literature from January 1, 2005 to May 13, 2025 was performed. Original stu …

02.09.2026journal-article

Sexual Medicine

Age at first sexual intercourse and frailty: Mendelian randomization and population-based evidence from NHANES and UK Biobank

Kai-Xian Wang, Bao-Peng Liu, Jia-Ning Wang, Kai-Zheng Wang, Yi-Zhan He, Meng-Yao Yu, Zi-Ming Shao, Long Sun, Mei-Xia Xu

Abstract Introduction Age at first sexual intercourse (AFS) is an indicator of sexual initiation and may reflect broader life-course trajectories, but its relationship with frailty remains unclear. To examine genetic evidence for a potential association between AFS and frailty and to characterize nonlinear, threshold, and sex-specific patterns in population-based observational analyses. Methods We performed Mendelian randomization (MR) analyses using summary statistics for AFS and frailty. We further analyzed data …

02.09.2026journal-article

Science Translational Medicine

MicroRNA-224 orchestrates BMP and TGFβ signaling and is a therapeutic target in preclinical pulmonary arterial hypertension

Olympia Bikou, Aymen Halouani, Yifei Sun, Malik Bisserier, Clemens Eisenacher, Samar A. Antar, Petros Avramopoulos, Carlos G. Santos-Gallego, Catherine Swarts, Erik Kohlbrenner, Kiyotake Ishikawa, Marc Humbert, Roger J. Hajjar, Antonio Lax, Stefan Engelhardt, Martin J. Walsh, Sebastien Bonnet, Lahouaria Hadri, Yassine Sassi

Pulmonary arterial hypertension (PAH) is a progressive pulmonary vascular disease that leads to right heart failure and ultimately death. Therapeutic options targeting the underlying mechanisms of the disease are urgently needed. MicroRNAs (miRs) have emerged as critical regulators of cardiovascular homeostasis and disease. Here, we identified microRNA-224-5p (miR-224) as a regulator of pulmonary vascular remodeling and delineate its mechanism of action in PAH. miR-224 expression was increased in the lungs of patie …

02.09.2026journal-article

Problems of Gathering Treatment and Transportation of Oil and Oil Products

DEVELOPMENT OF AN ALGORITHM FOR DETERMINING THE SATURATED VAPOR PRESSURE OF STABLE CONDENSATE IN REAL TIME

E.V. Rudykh, E.V. Shakirova, A.K. Vlaskin, A.N. Buglov

At the gas condensate stabilization unit, product quality control is carried out by regular laboratory analysis of the saturated vapor pressure (VP) of stable condensate. In the current practice, condensate samples are taken twice a day for VP subsequent monitoring. This approach requires significant time and resources personnel participation, transportation of samples and waiting for analysis results. In addition, the obtained VP values are received with a delay, which limits the efficiency of making technological …

02.09.2026journal-article

Frontiers in Physiology

Pulmonary sequelae of SARS-CoV-2 infection: a narrative review of long-term functional, radiological, and clinical outcomes in COVID-19 survivors, with a regional focus on Saudi Arabia

Fatimah Ali Zarbatan, Khaled Alawam, Ali Hakamy

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has left an enduring legacy of pulmonary morbidity among millions of survivors worldwide. While the acute phase of COVID-19 has been extensively characterized, the long-term pulmonary sequelae collectively termed post-acute sequelae of SARS-CoV-2 infection (PASC) or long COVID remain incompletely understood, particularly across diverse geographic and demographic populations. This narrative review synthesizes current evidence on the long-term …

02.09.2026journal-article

Journal of Rehabilitation Medicine

Identifying classes with different disability profiles amongst patients with persistent neck pain

Konsta Koivunen, Mikhail Saltychev, Juhani Juhola

Objective: To identify latent classes with distinct disability profiles among patients with persistent neck pain using item-level responses from the Neck Disability Index, and to examine demographic, clinical, and lifestyle factors associated with class membership. Design: Cross-sectional survey-based study. Patients: 962 patients with persistent neck pain. Methods: This survey-based study included 962 patients with persistent neck pain. Latent class analysis was performed using the 10 dichotomized items of the Nec …

02.09.2026journal-article

Problems of Gathering Treatment and Transportation of Oil and Oil Products

ANALYSIS OF TECHNOLOGIES AND EQUIPMENT FOR THE TREATMENT OF WASTEWATER CONTAINING ETHYLENE GLYCOL

A.V. Rumyantseva, A.V. Markelov, S.Z. Kalaeva, G.M. Kuznetsova

The article presents a comprehensive analysis of modern technologies and equipment for ethylene glycol removing from industrial airport wastewater. The relevance of the topic is due to intensive use of deicing fluids by Russian civil aviation, which creates a significant environmental burden on natural water bodies due to the toxicity of glycols and their high biological oxygen demand. Furthermore, the irreversible discharge of this reagent leads to direct economic losses for aviation enterprises. The paper examine …

02.09.2026journal-article

Clinical Spine Surgery

Effects of Adding a Cross-Link During Single-Level Lumbar Interbody Fusion for Degenerative Lumbar Spine Diseases: A Computed Tomography-Based Analysis

Koichiro Shima, Bungo Otsuki, Koichi Murata, Takayoshi Shimizu, Takashi Sono, Shintaro Honda, Masaki Sakamoto, Takaki Yoshiyama, Ryohei Saito, Shuichi Matsuda

Study Design: Retrospective study. Objectives: To evaluate whether adding cross-links during single-level lumbar interbody fusion (LIF) improves fusion rates, segmental alignment, and clinical outcomes. Summary of Background Data: Biomechanical studies suggest cross-links enhance rotational stability in single-level posterior lumbar interbody fusion, but clinical evidence for their benefit in degenerative lumbar spine diseases remains limited. No previous clinical study has investigated how cross-link addition affe …

02.09.2026journal-article

Journal of Traditional Medicine & Applications

Medication Adherence and Associated Factors Among Hypertensive Outpatients in Sana’a City, Yemen: A Cross-Sectional Study

Al-Maswari S N, Adnan Ali Alradhi, Taha Ali Al Sorouri, Ahmed Hamood Al-Shahethi

Background: Hypertension is the second most prevalent chronic disease in Yemen and a leading contributor to cardiovascular complications. Poor blood pressure control is often linked to low medication adherence, which remains underexplored in the country. Objective: This study aimed to assess the level of adherence to prescribed antihypertensive medications and identify demographic, socioeconomic, knowledge, and awareness-related factors associated with adherence among hypertensive outpatients in Sana’a City, Yemen. …

02.09.2026journal-article

Annals of Surgery

Multidisciplinary Rehabilitation Following Upper Gastrointestinal Cancer Surgery (RESTORE II)

Linda M. O’Neill, Emily Smyth, Neil Kearney, Grainne Sheill, Louise Brennan, Sophie Grehan, Sanela Begic, Fiona Murphy, Ciara Tansey, Niamh Flanagan, Mikel Egaña, Ricardo Segurado, Marie Galligan, Jinbo Zhao, Ciaran M. Fairman, Claire M. Timon, Suzanne L. Doyle, Deirdre Connolly, Jacintha O’Sullivan, John V. Reynolds, Juliette Hussey, Emer M. Guinan

Objective: RESTORE II compared in an RCT the impact of a 12-week multidisciplinary rehabilitation program versus standard care (SC) on cardiorespiratory fitness and physical function in patients postupper gastrointestinal (UGI) oncologic surgery. Summary of Background Data: The value of multidisciplinary cancer rehabilitation in UGI cancer survivorship is unclear, with limited high-quality data. Methods: Disease-free patients, ≥3 months post-UGI cancer resection were randomized to SC or RESTORE (physiotherapy-led a …

02.09.2026journal-article

Emergency Medicine Australasia

Ultrasound Archiving in the Emergency Department: Implementation, Governance and 4‐Year Outcomes at an Australian Tertiary Emergency Department

Vijay Manivel, Behzad Mirmiran, Claire Helm, Cindy Hastings

ABSTRACT Objective Image archiving is one of the least developed aspects of emergency department ultrasound (ED‐US) in Australasia, despite its recognised role in governance, education, quality assurance (QA) and medicolegal protection. A middleware‐based ED‐US image workflow solution was installed at Nepean Hospital ED in October 2021. We describe our implementation and 4‐year experience with a dedicated ED‐US archiving solution at a tertiary Australian ED. Methods Single‐centre retrospective analysis of service i …

02.09.2026journal-article

Healthcare

Turkish Cross-Cultural Adaptation of the BRIEF-MPI in Older Adults with Cancer: Convergent and Discriminative Validity Compared with the G8 and Clinical Frailty Scale

Sercan On, Haydar Cagatay Yuksel, Semih Sergen Semerci, Ecem Ozdemir, Mustafa Kagan Ozdel, Fatma Ozge Kayhan Kocak

Background: Older adults with cancer represent a heterogeneous population with varying levels of frailty and multidimensional vulnerability. Rapid screening tools are needed to identify patients who may benefit from comprehensive geriatric assessment (CGA). This study aimed to translate and culturally adapt the Brief Multidimensional Prognostic Index (BRIEF-MPI) into Turkish and evaluate its performance in older adults with cancer. Methods: This cross-sectional methodological study included 177 patients aged ≥65 ye …

02.09.2026journal-article

Indian Journal of Community Medicine

Monitoring Field-Level Compliance and Temporal Trends of Statutory Pictorial Health Warnings on Tobacco Products in India, 2020–21: A 21-City Observational Study

Shivam Kapoor, Puneet Chahar, Garima Bhatt, Jyoti Choudhary, Aastha Bagga, Surjeet Singh, Rana J. Singh, Amit Yadav

Abstract Objective: To strengthen the WHO-Framework Convention on Tobacco Control (FCTC) MPOWER “warn” component, India implemented 85% pictorial health warnings (PHWs) on all tobacco packs in 2016, allowing a two-month grace period to clear old stock. We monitored compliance and the time taken to comply with the revised PHW rules effective December 1, 2020, during December 2020–May 2021. Methods: A cross-sectional survey assessed one prominent tobacco point-of-sale (PoS) in each of 21 cities across nine Indian sta …

02.09.2026journal-article

Medicine Insights

Analyzing the Intrinsic Links and Common Therapeutic Targets between Diabetic Foot Ulcers and Liver Disease through Bioinformatics

Wenbo Li, Xudong Xin, Tianyi Shen, Zhenhao Zhang, Jihua Wei

Background. Diabetic foot ulcer (DFU) is a critical and prolonged complication of diabetes associated with high disability and mortality rates. Lipid metabolism disorders resulting from liver diseases are a key etiology in the development of diabetes mellitus and diabetic foot. Currently, there are no effective therapeutic targets or medications for treating DFU in combination with liver diseases such as nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH) and liver cirrhosis (LC). The intri …

02.09.2026journal-article

Journal of Clinical Psychopharmacology

The Randomization Effect in a Double-Blind Placebo-Controlled Depression Study

Steven D. Targum, Paulette Ceesay, Christopher Lines, Michael E. Thase, Gerard Sanacora, Aristide Merola

Background: Double-blind, placebo-controlled trials are often affected by higher-than-anticipated placebo responses that may contribute to study failure. It is common to observe symptomatic improvement immediately after randomization regardless of treatment allocation. Methods: This post hoc analysis examined the early randomization effect in a recent 4-week double-blind, placebo-controlled study that examined a novel presynaptic mGluR2 inhibitor, MK-1942, in a daily or twice-weekly dosing strategy versus placebo a …

02.09.2026journal-article

Frontiers in Medicine

Toward nursing-integrated biomarker surveillance for immune-related adverse events during immune checkpoint inhibitor therapy

Jiafeng Jin, Liwen Zheng, Yali Tian, Minjuan Chu, Beinuo Cao

Immune checkpoint inhibitors (ICIs) have transformed cancer care but can cause immune-related adverse events (irAEs) involving almost any organ system. Delayed recognition may permit reversible inflammation to progress to organ dysfunction, treatment interruption, prolonged immunosuppression, or death. Biomarker surveillance offers an objective complement to symptom assessment, yet no single marker is sufficiently accurate for universal prediction. This Mini Review examines the mechanistic basis and clinical eviden …

02.09.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Malaria Incidence, Growth, and their Relationship among a Cohort of Malawian Children

Divya Hosangadi, Liana R. Andronescu, Patricia Mawindo, Don P. Mathanga, Terrie Taylor, Miriam K. Laufer, Andrea G. Buchwald

ABSTRACT. Child growth impairment and Plasmodium falciparum ( P. falciparum ) infection pose substantive public health challenges, particularly in sub-Saharan Africa. There is a paucity of evidence regarding how P. falciparum infection, which causes clinical malaria, relates to child growth in children under 24 months old. To assess the temporal associations between P. falciparum infection and weight-for-age Z score (WAZ), a secondary analysis of a prospective cohort study conducted from 2016 to 2018 in which 86 Ma …