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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
31.08.2026journal-article

European Journal of Trauma and Emergency Surgery

Long-term radiological and clinical outcomes after surgical treatment of non-union: a ten-year follow-up study

Jessica C. Böpple, Jonas Berger, Thomas Ferbert, Tim Niklas Bewersdorf, Gerhard Schmidmaier, Sebastian Findeisen

Abstract Purpose Non-unions are a major challenge in trauma surgery. They are known to affect patients’ lives for years after the initial trauma. Nevertheless, most studies only examine the first two years after treatment. The question what the long-term results look like ten years after surgery was posed in light of observations made in everyday clinical practice. To answer this, our study was designed to examine all patients who underwent non-union surgery in our department ten years ago. Methods All patients who …

31.08.2026journal-article

Journal of Medical Case Reports

Complete radiological and biochemical remission at 26 months in a young adult with primary mediastinal yolk sac tumor: a case report and literature review on multimodal management

Yuanli You, Mingxing Yang, Xiuqing Wang, Wen Dong

Abstract Background Primary mediastinal yolk sac tumor (PMYST) is an extremely rare and highly malignant germ cell tumor that predominantly affects young males and is associated with a poor prognosis. Case presentation We present the case of a 23-year-old non-smoking male diagnosed with stage III (cT4N0M0) PMYST who received comprehensive treatment guided by a multidisciplinary team (MDT). The treatment regimen included 5 cycles of neoadjuvant chemotherapy with BEP (bleomycin, etoposide, and cisplatin), followed by …

31.08.2026journal-article

Frontiers in Oncology

Prognostic significance of the MELK/TMPO-AS1/hsa-let-7b-5p network in lung adenocarcinoma

Kritika Jangir, Niranjan Kumar, Chainsee Saini, Prerna Vats, Bhavika Baweja, Prachi Patidar, Rashi Soni, Husen Lakdawala, Jaikee Kumar Singh, Rajeev Nema

Introduction Maternal Embryonic Leucine Zipper Kinase (MELK) is a key regulator of the G2/M checkpoint and a recognized pan-cancer oncogene; however, its regulatory mechanisms and clinical significance in lung adenocarcinoma (LUAD) remain incompletely understood. This study aimed to investigate the molecular, prognostic, immune, and therapeutic relevance of MELK in LUAD. Methods An integrated multi-omics approach was employed, incorporating gene-expression, survival, transcriptomic, immune-infiltration, regulatory- …

31.08.2026journal-article

Journal of Cutaneous Immunology and Allergy

Case Report: Successful dupilumab treatment for refractory atopic dermatitis-like eczema in a patient with Costello syndrome

Toshihiko Nonaka, Jun Kido, Mika Ogata, Taiga Miyake, Takanobu Yoshida, Satoshi Fukushima, Rie Seyama, Yuri Uchiyama, Naomichi Matsumoto, Kimitoshi Nakamura

Costello syndrome is a rare RASopathy caused by pathogenic variants in HRAS and is characterized by distinctive craniofacial features, growth failure, cardiac abnormalities, tumor predisposition, and various cutaneous manifestations. Although eczema has been reported in patients with Costello syndrome, reports of severe AD-like eczema accompanied by clinically significant allergic manifestations, including food allergy, remain limited. We report a female patient with Costello syndrome caused by a heterozygous HRAS …

31.08.2026journal-article

Frontiers in Oncology

Development and internal validation of a KELIM-integrated prognostic nomogram for long-term survival prediction in epithelial ovarian cancer

Qianqian Liu, Yibin Liu, Guohong Qi, Mengyao Su, Xueqian Miao, Zhiqiang Zhang, Xianghua Huang, Yanfang Du, Zhongkang Li, Li Meng

Introduction Epithelial ovarian cancer (EOC) remains the most lethal gynecological malignancy, and accurate prediction of long-term survival remains challenging. This study aimed to evaluate the prognostic associations of prespecified clinically relevant factors with overall survival (OS) and to develop and internally validate a KELIM-integrated prognostic nomogram. Methods A total of 100 patients with EOC treated at the Second Hospital of Hebei Medical University between May 2014 and June 2021 were retrospectively …

31.08.2026journal-article

SCIENCE IN THE CENTRAL RUSSIA

ENSURING ENVIRONMENTAL SAFETY IN AGRICULTURAL PRODUCTION BY USING AEROSOL TECHNOLOGY FOR PRE-SOWING SEED TREATMENT

Olga Teterina, Vladimir Teterin, Nadezhda Latyshenok, Nikolay Panferov, Alexey Podyablonsky

The article presents the results of experimental studies on ensuring the environmental safety of agricultural production by using aerosol technology for pre-sowing seed treatment. The purpose of the study is to substantiate the parameters of a device for pre-sowing seed treatment of grain crops with hot fog of humic preparations, which ensures increased environmental safety of agricultural production and improved seed quality. The studies were carried out on a laboratory installation that includes a pickling chambe …

31.08.2026journal-article

Oriental Journal Of Chemistry

Synthesis of New 1,4-dihydropyrimidine Derivatives, Breast Cancer Anticancer, and In-silico Studies

Alaa. M. Abu Alnjaa

This study reports a sustainable and environmentally friendly approach for the synthesis of novel pyrimidine Schiff base derivatives through a multicomponent grinding reaction conducted at room temperature under solvent-free conditions. The synthesis involved pyrimidine, various aldehydes, and p-toluenesulfonic acid as a catalyst. The obtained compounds (1–3) were evaluated for their potential anticancer activity against the breast cancer estrogen receptor alpha (ERα). Structural characterization was carried out us …

31.08.2026journal-article

Diagnostics

Explainable AI-Derived Spatial Pathological Features of Tumor, Necrosis, and Lymphocytes Identify Key Histological Signatures for Residual Cancer Burden Assessment in Breast Cancer

Xin Shu, Fan Wang, Tiancheng Zhao, Yun Zhang, Yao Zhou, Liu Yang, Xiujuan Xiong, Libin Deng

Background: Conventional histopathological assessment of residual cancer burden (RCB) following neoadjuvant therapy for breast cancer relies on manual visual evaluation, lacking objective quantification of spatial interactions among tumor, necrosis, and lymphocyte compartments. This limits prognostic accuracy and impedes personalized treatment stratification. Methods: We developed an explainable AI framework to segment three tissue compartments from H&E patches and constructed 11 spatial pathological features. This …

31.08.2026journal-article

Narra X

A comparative analysis of fecal bile acid profiles in patients with ulcerative colitis and colorectal cancer

Fauzi Yusuf, Desi Maghfirah, Muhammad Luthfi, Ira Y. Fitria

Ulcerative colitis (UC) is a chronic inflammatory disease of the colon in which mucosal inflammation, dysbiosis, and colorectal cancer (CRC) risk are closely linked. Because intestinal bacteria convert primary bile acids into secondary bile acids, fecal bile acid composition may help describe metabolic differences between inflammatory and malignant colorectal disease. Therefore, the aim of this study was to compare fecal bile acid profiles in patients with UC and CRC, with colonoscopy-negative controls included as …

31.08.2026journal-article

Journal of the American Academy of Orthopaedic Surgeons

Nonarthroplasty Treatment Options for Management of Primary Elbow Osteoarthritis

Dennis DeBernardis, Tej Joshi, Mandeep S. Virk

Primary elbow osteoarthritis is a functionally limiting condition, predominantly affecting middle-aged men engaged in repetitive manual labor, and is characterized by pain, stiffness, and mechanical symptoms. Evaluation involves a detailed history focusing on pain, loss of motion, and mechanical symptoms, followed by clinical examination for range of motion deficits, crepitus, and instability. Radiographic assessment, including standard radiographs and, when indicated, computed tomography imaging, is essential for …

31.08.2026journal-article

Advanced Science

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu

ABSTRACT Metabolic reprogramming and immune evasion are two key mechanisms that facilitate tumor progression. Tumor cells achieve their energy requirements for rapid proliferation through metabolic reprogramming, such as glucose metabolism, lipid metabolism, and amino acid metabolism. Tumor cell metabolic reprogramming can influence immune cell function in the tumor microenvironment through various mechanisms, ultimately facilitating tumor immune escape. Targeting tumor cell metabolism and combining metabolic regul …

31.08.2026journal-article

Supportive Care in Cancer

Impact of intensive care unit admission on the resumption of treatment in patients with cancer: a systematic review and meta-analysis

Raisa do Val Roso, Renato Daltro-Oliveira, Laveena Munshi, Antonio Paulo Nassar Junior

Abstract Purpose Patients with cancer represent a substantial and growing proportion of the ICU population. Although short-term survival has improved, it remains unclear how often anticancer treatment is resumed after critical illness. We aimed to synthesize the available evidence on treatment resumption following ICU discharge in adult patients with cancer. Methods We searched PubMed, Embase, Scopus, and Web of Science from inception to February 24, 2025 (PROSPERO CRD420251080476). We included studies reporting re …

31.08.2026journal-article

Blood Cancer Discovery

Phosphorylation Protects Oncogenic RAS from LZTR1-Mediated Degradation

Lin Zhang, Arnold Bolomsky, Omar S. Al-Odat, Callie K. VanWinkle, Aaliyah Battle, Papiya Chakraborty, Ronald J. Holewinski, Thorkell Andresson, Bjorn Haupl, Thomas Oellerich, Elizabeth Hill, Mehmet Kocoglu, Qingcai Meng, James D. Phelan, Jagan Muppidi, Ryan M. Young

Abstract Oncogenic KRAS and NRAS mutations are common in hematologic malignancies, but their signaling in this context remains less well characterized than in carcinomas. Using multi-omics screens in multiple myeloma, we sought to identify regulators of RAS activity. We found that the phosphatase PP1C dephosphorylated conserved RAS residue T148, permitting LZTR1-dependent proteasomal degradation. LZTR1 was ineffective against KRAS A146 gain-of-function mutations, which lie adjacent to T148 and are enriched in hemat …

31.08.2026journal-article

Nursing and Health Sciences Journal (NHSJ)

Financial toxicity and quality of life among hospitalized cervical cancer patients in Indonesia: A cross-sectional study

Ida Maryati, Wilan Fitriana, Hesti Platini, Yanti Hermayanti, Ikeu Nurhidayah, Ai Mardhiyah, Mira Trisyani Koeryaman, Syiffa Salsabila Rausanfikra

Cervical cancer significantly impairs patient well-being, particularly in low- and middle-income countries where financial toxicity exacerbates the disease burden. Evidence regarding income-related quality of life (QoL) disparities among Indonesian cervical cancer patients remains limited. This study examined the association between demographic characteristics, specifically income, and QoL among hospitalized cervical cancer patients. A quantitative cross-sectional study was conducted among 60 consecutive patients r …

31.08.2026journal-article

Journal of Education Science and Health

DESEMPENHO DA CULTURA DO SORGO GRANÍFERO EMDIFERENTES ÉPOCAS DE SEMEADURA NO NORTE DO PARANÁ

Pedro Rogério Monteiro, Silvestre Bellettini, Igor Gustavo Pavinatto, João Augusto Pereira dos Santos

O sorgo granífero destaca-se como alternativa para a segunda safra, porém seu desenvolvimento sofre forte influência do clima. O objetivo deste trabalho foi avaliar o impacto de diferentes datas de semeadura no desempenho agronômico e produtivo da cultura. O experimento foi conduzido a campo no município de Bandeirantes, Paraná. Utilizou-se o delineamento inteiramente casualizado (DIC), com quatro tratamentos correspondentes às épocas de semeadura (01/02, 15/02, 02/03 e 16/03) e quatro repetições. Avaliou-se o cicl …

31.08.2026journal-article

Brazilian Journal of Oncology

Comparison of Computed Tomography-Guided Transthoracic Core-Needle Biopsy and Fine-Needle Aspiration Biopsy Regarding Diagnostic Yield, Complications, and Molecular Testing Adequacy in Lung Cancer

Levent Arafat, Sibel Yurt, Barış Demirkol, Sultan Rana Ramazanoğlu, İlhan Nahit Mutlu, Ayşe Bahadır, Mehmet Akif Özgül

Abstract Computed tomography (CT)-guided core-needle biopsy (CNB) and fine-needle aspiration biopsy (FNA) are widely used to diagnose lung cancer. With the increasing need for molecular testing, this study compared these methods concerning diagnostic yield, complications, and adequacy for mutation analysis. The present retrospective study included 304 patients (FNA: 214, CNB: 90) who underwent CT-guided biopsy between January 2021 and December 2023 at a single institution. Diagnostic yield, molecular adequacy (100– …

31.08.2026journal-article

Frontiers in Oncology

Integrated bioinformatics and experimental validation identifies SOX2 as a key therapeutic target for chronic atrophic gastritis/gastric cancer-depression comorbidity

Yang Liu, Yuefen Wang, Cuimei Zhao, Wenbo Li, Zongmin Ma, Chen Wang, Zhongxia Yuan, Shaomin Wang, Nan Zhang, Yangang Wang

Objective Gastric cancer (GC) and its precursor chronic atrophic gastritis (CAG) exhibit a high comorbidity with depression. However, the core molecular mechanisms underlying stomach-brain axis-mediated crosstalk between GC/CAG and depression remain poorly clarified. This study attempted to screen pivotal molecules correlated with the bidirectional correlation between GC/CAG and depression, and explore the inflammatory regulatory network through integrated bioinformatics analysis and systematic in vivo and in vitro …

31.08.2026journal-article

Medicina

Prognostic Value of Inflammatory Indices and the Advanced Lung Cancer Inflammation Index (ALI) for Survival Outcomes in Hemodialysis Patients

Demet Yavuz, Mehmet Derya Demirag, Enis Akca, Muhammed Ali Atasever, Mehmet Omer Bostanci, Nihal Aydemir

Background and Objectives: Chronic systemic inflammation and malnutrition drive adverse outcomes in maintenance hemodialysis (HD) patients. This study investigated the prognostic utility of four accessible inflammatory indices—systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), atherogenic index of plasma (AIP), and advanced lung cancer inflammation index (ALI)—in predicting survival. Materials and Methods: This retrospective cohort study evaluated electronic health records of 222 incide …

31.08.2026journal-article

Biomolecules

Stroma-Dominant Colorectal Cancer Harbors CAF-Rich Spatial Architecture and EMT-Associated Cancer Cell Plasticity Detectable After Dissemination

Shuji Kitagawa, Naoki Mimura, Hironobu Kambara, Masaaki Hori, Erina Yamanishi, Ayako Ogo, Tatsushi Shiomi, Kazuhiko Yoshimatsu, Tomio Ueno, Shuya Yano

Colorectal cancers (CRCs) include stroma-dominant tumors with desmoplasia and differentiated, gland-forming tumors with little stroma. We asked whether this difference reflects stromal abundance alone or also involves a distinct cancer cell state. HEST-1K sections were classified as M-type (stroma-dominant; five patient/tissue units) or D-type (differentiated and cancer cell-dominant; seven units). Prespecified EMT/pEMT, ECM/integrin, YAP/TAZ-TEAD, and DTP/persister gene sets were examined across spatial, bulk, and …

31.08.2026journal-article

Bioinformation

Elucidation of putative key genes involved in triple-negative breast cancer progression

Alok Kumar

The molecular basis of TNBC development is poorly understood. Therefore, it is of interest to identify key genes and pathways involved in TNBC development and progression using a systems biology approach, followed by experimental validation. Gene ontology and KEGG enrichment analyses were performed to identify DEG-regulated biological functions and pathways; a PPI network was constructed using the STRING online database. The expression and prognostic value of the hub genes were validated by TCGA survival analysis, …

31.08.2026journal-article

Journal of Palliative Medicine

Life Duration of Pediatric Patients with Cancer Enrolled on Concurrent Hospice Care: A Retrospective Decedent Study

Meaghann S. Weaver, Rachel Jalfon, Emily Zeng, Shankari Kalyanasundaram, Erica C. Kaye, Marta Salek, Brittany Cowfer, Liza-Marie Johnson, Tricia Mamer, Belinda Mandrell, Lisa C. Lindley, Deena R. Levine

Background: The Affordable Care Act established concurrent hospice care for children, yet access and timely referral remain limited. Pediatric oncology prognostic trajectories are variable, complicating hospice timing. Objective: To quantify survival after hospice enrollment among pediatric patients with cancer and identify characteristics associated with death ≤6 versus >6 months. Methods: Three-year retrospective decedent cohort study at a single site, including all children with cancer (0–21 years) who died whil …

31.08.2026journal-article

Physiotherapy Canada

Treatment Fidelity in a Multi-Centre Study of Early Physical Rehabilitation in Mechanically Ventilated Patients: A Secondary Analysis of the CYCLE Pilot RCT

Christopher Farley, Heather K. O’Grady, Timothy Karachi, Bram Rochwerg, Alison E. Fox-Robichaud, Sunita Mathur, Karen E.A. Burns, Ian M. Ball, Diane Heels-Ansdell, Sue Berney, Deborah J. Cook, Jen Hoogenes, Mark Duffett, Dina Brooks, Michelle E. Kho

Abstract Purpose: To determine the relationship between patient characteristics and treatment fidelity in adult ICU patients enrolled in the CYCLE Pilot randomized controlled trial. Method: We conducted a secondary analysis of a pilot trial in which patients were randomly assigned to in-bed cycling plus usual physiotherapy (PT) or usual PT alone. We calculated protocol fidelity for each patient as the proportion of planned days when the assigned treatment was delivered or did not occur due to medical instability. U …

31.08.2026journal-article

ANNALS OF ABBASI SHAHEED HOSPITAL AND KARACHI MEDICAL & DENTAL COLLEGE

Cone Beam Computed Tomography in Oral Cancer: A Review of Bone Invasion Radiomics, and Artificial Intelligence

Bahaa Aldeen Hadi, Hussein Kadhim

Cone beam computed tomography (CBCT) is prevalent in maxillofacial imaging due to its high-resolution bone detail and quick, chairside operation that generally exceeds conventional CT in radiation dose efficiency. However, recent clinical claims about its effectiveness in oral squamous cell carcinoma (OSCC) are not fully supported by physics. Current verified literature (up to June 2026) clarifies that CBCT should be reserved for secondary purposes like bone invasion evaluation, surgical planning, and radiotherapy, …

31.08.2026journal-article

International Journal for Research in Applied Science and Engineering Technology

Evaluation of Complete Blood Count (CBC) among patients with Breast, Ovarian and Colon Cancer Patients Before and After Chemotherapy Administration at Shendi Oncology Center, Sudan- 2026

Wala Eldin Osman Elradi, Aisha A. S. Abdallatif, Alaa B. M. Abdrhman, Alaa G B Ibrahim, Ibtisam K. A. Anwar, Omer F A. Mohammed, Maab Shames AL-deen G. A, May A. M. Ashmaig

Background: Chemotherapy administrated to cancer patients as it toxic and aiming to confine cancer spread for normal organs has effects, it observed that changes in hematological parameters during anti-cancer drugs differ before starting treatment. To this study aimed to evaluate changes may occur among 3 different cancers’ patients attended to Shendi Oncology center- River Nile State. Method: The study was approved by Sudan International University-hospital administration as well as patients as they already consen …