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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
26.08.2026journal-article

Frontiers in Immunology

Advancing precision tacrolimus therapy: a systems genetics dissection in BXD platform

Wei Zhou, Xin-Bo Wang, Yu-Wei Guo, Bing Hu, Zi-Xuan Wang, Yu Xiong, Xuan-Ming Chen, Bo-Yang Xu, Xiao-Xing Wang, Xiao-Xue Wang, Fei-Fei Han, Jun-Jie Wang, Hao-Jun Zhang, Liang Peng, Li-Li Gong, Lu Lu, Li-Hong Liu

Background Tacrolimus is a core immunosuppressant in organ transplantation, but its narrow therapeutic window and significant pharmacokinetic variability hinder precision dosing. Although CYP3A5-guided strategies have established clinical relevance for tacrolimus initial dose adjustment, they do not fully account for the marked interindividual variability in tacrolimus exposure, highlighting the need for complementary models to decode more complex genetic regulation. This study aimed to identify candidate genetic m …

26.08.2026journal-article

N.N. Priorov Journal of Traumatology and Orthopedics

New import-substituting technology for obtaining cellular plasma therapy drugs

Iurii V. Parakhin, German V. Neustroev, Mikhail V. Parshikov, Nikolai V. Jarigin, Tatiana G. Kuzbaseva, Mikhail V. Govorov

In recent decades, autologous cellular plasma therapy (ACPT) has become a promising method for treating musculoskeletal diseases due to the ability of activated blood cells to secrete growth factors, anti-inflammatory and analgesic cytokines. However, the high cost of foreign consumables and equipment limits the availability of therapy. Study of a new domestic technology for obtaining plasma preparations (L-PE) and its comparison with the foreign RegenLab (RL) technology in terms of production methods, activation m …

26.08.2026journal-article

Frontiers in Endocrinology

Efficacy of endometrial microbiota testing-guided personalized therapy in infertile women stratified by CD138 status: a retrospective cohort study

Fang He, E’Nuo Peng, Jiao Lin, Zhuo Mao, Xiaowei Lu, Hui Xu, Lei Guo, Yangyun Zou, Jing Wang, Sijia Lu, Xianghong Huang

Background Chronic endometritis (CE) is a persistent inflammatory condition of the endometrium associated with infertility. Current diagnosis relies on histopathological markers like CD138, which may not fully assess the functional state of the endometrial microenvironment. This study aimed to investigate whether the endometrial microbiome test (EMT) combined with personalized therapy could improve pregnancy outcomes in infertile women undergoing IVF, compared with standard management based on CD138 results. Method …

26.08.2026journal-article

The Kaohsiung Journal of Medical Sciences

Pretreatment Prediction of Tumor Recurrence in Breast Cancer After Neoadjuvant Systemic Therapy Using Machine Learning With Clinical and CT Radiomics Features

Huei‐Yi Tsai, Jo‐Ching Wang, Wei‐Shiuan Chung, Jui‐Sheng Hsu, Shu‐Yen Lin, Ming‐Feng Hou, Ming‐Chung Chou

ABSTRACT This study aimed to develop machine learning models for predicting tumor recurrence in breast cancer before neoadjuvant systemic therapy (NST) by integrating clinical and radiomic features derived from pretreatment computed tomography (CT). We retrospectively enrolled 235 patients with 237 breast tumors who underwent contrast‐enhanced CT before NST. Datasets were randomly divided into five‐fold training and testing sets using semi‐random partitioning to ensure similar clinical characteristics between the t …

26.08.2026journal-article

Journal of Exercise Rehabilitation

Effects of a neuromuscular exercise program on lower limb alignment and balance ability in individuals with genu varum and knee pain

Hyung-Hoon Moon, Sung-Ki Lee, Jeong-Ha Lee, Sang-Seo Park, Sang-Min Lee, Won-Moon Kim, Yong-Gon Seo

This study examined the effects of a neuromuscular exercise program on knee joint alignment, pain, and static and dynamic balance in pa-tients with genu varum. Forty female patients aged 40–60 years with ra-diographically confirmed genu varum and a Short-Form McGill Pain Questionnaire (SF-MPQ) score ≥18.0 were randomly assigned to either an exercise group (EG, n=20) or a control group (CG, n=20). The EG participated in a supervised neuromuscular exercise program 3 times per week for 12 weeks (60 min/session), while …

26.08.2026journal-article

Acta Psychiatrica Scandinavica

Patients Receiving 100 or More Electroconvulsive Therapy Treatments in a Nationwide Cohort

Masahiro Hata, Yuki Miyazaki, Shun Takahashi

Key Points Significant outcomes In this nationwide cohort, 1% of electroconvulsive therapy recipients received 100 or more treatments, representing an identifiable subgroup of electroconvulsive therapy recipients. Patients receiving 100 or more treatments had treatment durations of several years and substantially more psychiatric hospitalizations and cumulative hospitalization days, indicating prolonged and recurrent psychiatric care. Clozapine use increased across cumulative electroconvulsive therapy exposure cate …

26.08.2026journal-article

JAMA Network Open

Maternal Engagement in HIV Care and Antiretroviral Therapy Uptake Among Children Living With HIV

Jiawei He, Bricia Gonzalez Trejo, Kemal Sherefa Oumer, Amanda Movo, Simon I. Hay, Christopher J. L. Murray, Peng Zheng, Aleksandr Y. Aravkin, Jeffrey W. Imai-Eaton, Hmwe H. Kyu

Importance Children living with HIV (CLHIV) in sub-Saharan Africa have lower rates of antiretroviral therapy (ART) uptake and viral load suppression (VLS) than adults with HIV. The association of maternal engagement in HIV care with child VLS remains underexplored. Objective To estimate the prevalence of ART uptake and VLS among CLHIV, and to examine the association between maternal engagement in HIV care and key steps in the pediatric HIV care cascade. Design, Setting, and Participants This cross-sectional study w …

26.08.2026journal-article

Children

Propranolol as Salvage Therapy for Refractory Congenital Chylous Ascites in a Preterm Neonate: A Case Report and Review of the Literature

Nicoletta Menzella, Francesca Riitano, Simonetta Costa, Francesca Paola Fusco, Simona Fattore, Chiara Tirone, Francesca Stollagli, Giovanni Vento

Background/Objectives: Congenital chylous ascites is a rare neonatal condition characterized by the accumulation of lymphatic fluid within the peritoneal cavity. The disorder can be difficult to manage, as many infants show limited response to standard conservative strategies such as dietary modification and supportive care. Currently, no universally accepted therapeutic guidelines exist. We report the successful use of propranolol in the management of refractory congenital chylous ascites. Methods: Clinical data w …

26.08.2026journal-article

Journal of Exercise Rehabilitation

Analysis of professional football players’ sprint performance efficiency in matches

Jeong-Hyun Shim, Chang-Hwa Joo

The purpose of this study is to analyze the efficiency of the high-intensi-ty exercise performances of professional players during matches. Thirty professional players competed in a total of 38 matches throughout the season. 1,558 sprint efforts were recorded and subsequently analyzed. The sprint efficiency assessment tool ensured good interrater reliability (intraclass correlation coefficient, 0.892; 95% confidence interval, 0.883–0.901) and the validity of the analysis was confirmed by four experts with more than …

26.08.2026journal-article

Frontiers in Medicine

Real-time LC-OCT monitoring of scalp hypertrophic actinic keratosis clearance following cryotherapy, laser, and 5-fluorouracil therapy

Giulio Bortone, Vincenzo Coppolelli, Luca Gargano, Francesca Svara, Mehdi Boostani, Steven Paul Nisticò, Giovanni Pellacani, Carmen Cantisani

Introduction Assessment of treatment response in hypertrophic actinic keratoses (hAKs) remains largely dependent on clinical examination and dermoscopy, although apparent clearance may not reflect complete resolution of imaging features associated with residual disease. Line-field confocal optical coherence tomography (LC-OCT) enables non-invasive, longitudinal visualization of epidermal, dermal-epidermal junction, and superficial dermal changes at near-cellular resolution. Objective To characterize LC-OCT response …

26.08.2026journal-article

Stem Cell Research & Therapy

GMP manufacturing, quality characterization, and GLP-based preclinical evaluation of human nasal turbinate–derived stem cells for the treatment of rheumatoid arthritis

Hyun Ji Lee, Jung Ho Jeon, Junwon Choi, Min Young Ahn, Ye Sol Park, Hyo Min Song, Seong Yeon Yoo, Youngjae Park, Seung-Ki Kwok, Sun Hwa Park, Sung Won Kim

Abstract Background Human nasal turbinate-derived stem cells (hNTSCs) are tissue-derived adult stem cells that are isolated from surgically discarded nasal turbinate tissue and exhibit robust proliferative capacity, and stable phenotypic properties. Unlike conventional MSCs, hNTSCs, although classified as tissue-derived adult stem cells, exhibit MSC-like phenotypes but display distinct gene expression patterns and functional properties that may be advantageous for indications of inflammatory and autoimmune disease. …

26.08.2026journal-article

International Journal of Laboratory Hematology

Myelodysplasia‐Related Gene Mutation Burden Is Associated With Complete Remission After Induction Therapy in Acute Myeloid Leukemia, Not Otherwise Specified: Reclassification According to the Updated Classifications

Taegeun Lee, Daehyun Chu, Miyoung Kim, Young‐Uk Cho, Sang‐Hyun Hwang, Je‐Hwan Lee, Yunsuk Choi, Eun‐Ji Choi, Ho Joon Im, Hyery Kim, Seongsoo Jang

ABSTRACT Introduction Updated classifications incorporating myelodysplasia‐related (MR) gene mutations reclassify many cases previously diagnosed as acute myeloid leukemia, not otherwise specified (AML, NOS). We evaluated the clinical significance of MR gene mutation burden, defined by mutation number and variant allele frequency (VAF), in AML, NOS. Methods We retrospectively reviewed adults diagnosed with AML, NOS who underwent next‐generation sequencing between 2018 and 2023. After excluding cases with KMT2A rear …

26.08.2026journal-article

Journal of Occupational & Environmental Medicine

VV-ECMO Support in Acute Respiratory Failure from Occupational Phosgene Gas Exposure: A Case Report

Mahmoud Elamin, Mays Tawayha, Wassim Mosleh, Harsh B. Jain, Xiao Jiantao, Stephen Downing, Craig Vitrano, Christopher J. Wilcox

A 56-year-old male with no antecedent respiratory disease developed acute respiratory failure following workplace exposure to phosgene gas (COCl₂), a toxic industrial compound known for its pulmonary toxicity. He developed refractory hypoxemia, was transferred to our facility, and was promptly placed on venovenous extracorporeal membrane oxygenation (VV-ECMO). The patient was successfully supported through the acute lung injury and recovery phase and was discharged from the hospital within 16 days without supplemen …

26.08.2026journal-article

Frontiers in Bioengineering and Biotechnology

Stimuli-responsive bioengineered platforms for precision cancer therapy

Hossein Omidian, Renae L. Wilson

Stimuli-responsive bioengineered platforms are redefining cancer therapy by shifting therapeutic design from systemic drug exposure toward context-dependent activation within malignant tissue. These systems are engineered to sense and respond to tumor-associated or externally applied cues, including acidic pH, redox imbalance, hypoxia, enzymatic activity, reactive oxygen species, temperature variation, light, ultrasound, and magnetic fields. Across the reviewed evidence, their principal value lies not merely in dru …

26.08.2026journal-article

American Journal of Clinical and Experimental Medicine

Comprehensive Physical Rehabilitation for Respiratory Muscle Dysfunction and Pulmonary Ventilation in Post‑COVID Syndrome

Anatolii Belyaev, Tatiana Kharkovskyay, Olga Fotina

Introduction : Post-COVID syndrome is characterized by persistent respiratory disorders, a key element of which is dysfunction of the respiratory muscles, especially the inspiratory muscles. This leads to dyspnea, reduced exercise tolerance, and decreased quality of life. Objective : To evaluate the clinical efficacy of a physical rehabilitation program combining osteopathic correction, specialized breathing exercises, and classical chest massage in patients with residual effects after COVID-19-associated pneumonia …

26.08.2026journal-article

Exploration of Digestive Diseases

Testosterone replacement therapy in metabolic dysfunction-associated steatotic liver disease: a bench-to-bedside narrative review

Yuchang Li, Vassilios Papadopoulos

Metabolic dysfunction-associated steatotic liver disease (MASLD) is strongly associated with obesity, insulin resistance, and increased cardiovascular risk. Male hypogonadism has emerged as a potentially modifiable risk factor, and testosterone replacement therapy (TRT) has been proposed as a potential adjunctive treatment for MASLD and metabolic dysfunction-associated steatohepatitis (MASH) in hypogonadal men. Cross-sectional and longitudinal studies demonstrate a consistent inverse association between serum testo …

26.08.2026journal-article

Acupuncture & Electro-Therapeutics Research: International Journal of Integrated Medicine

Fu's Subcutaneous Needling Therapy Combined with Intra-Articular Injection of Hyaluronic Acid in Knee Osteoarthritis

Sujie Zhang, Xiaohong Mu

Objective This study investigated the effects of Fu's subcutaneous needling (FSN) combined with sodium hyaluronate (HA) intra-articular injection on knee function and inflammatory factor levels in patients with knee osteoarthritis (KOA). Materials and Methods A total of 122 patients with KOA were randomly assigned to an observation group (OG) or control group (CG). Outcomes included Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), serum inflammatory cytokines, Lysholm Knee Scoring Scale (LKSS …

26.08.2026journal-article

The Journal of the International Association of Adventure and Nature Based Therapies

Integrating Narrative Approaches into Adventure Therapy for Self-Identity Construction

Ieng Chong Leong

This study describes the implementation process of an Narrative Approach to Adventure Therapy (NAT) group within a therapeutic community (TC) for individuals recovering from substance use. The purpose of the study was to provide a practice-based description of how NAT was implemented and how participants experienced self-identity reconstruction through the integration of adventure-based activities and narrative therapy conversations. The study adopted action research and qualitative case series design. Data were co …

26.08.2026journal-article

BMC Cancer

Reconstruction of epithelial transcriptional trajectories reveals heterogeneous progression and early therapy-resistance programs in high-grade serous carcinoma precursors

Michail Sideris, Eleni Maniati, Tanjina Kader, Sandro Santagata, Ronny Drapkin, Frances Balkwill, Ranjit Manchanda

Abstract Background Serous-tubal intraepithelial-carcinoma (STIC) is considered the principal precursor of tubo-ovarian high-grade serous-carcinoma (HGSC), yet its biological uniformity, progression risk and potential response to poly(ADP-ribose) polymerase-inhibitors (PARPi) remain poorly defined. Methods We performed trajectory-based transcriptomic reconstruction of Fallopian-tube epithelial regions spanning histologically normal-appearing epithelium, precursor lesions, STIC, and invasive carcinoma using pseudoti …

26.08.2026journal-article

American Journal of Physical Medicine & Rehabilitation

Aerobic versus Core‑stabilization Training after Caudal Epidural Steroid İnjection for Lumbar Disc Herniation

Serpil Arslan, Ceyhun Türkmen, Kenan Şimşek, Tülin Düger

Objective: To compare the effects of adding supervised aerobic or core stabilization exercise to physiotherapy on pain and function after caudal epidural steroid injection (CESI) in individuals with lumbar disc herniation (LDH) and radicular pain. Design: Three-arm parallel-group randomized controlled trial with 12-week follow-up. Thirty-five individuals were divided into three groups. For six weeks, the control group received physiotherapy. Aerobic and stabilization groups received the same programme plus 20 min o …

26.08.2026journal-article

Journal of modern medicine

EFFECTIVENESS OF DIFFERENTIATED THERAPY FOR FIBROCYSTIC BREAST DISEASE IN WOMEN WITH OVARIAN DYSFUNCTION CONSIDERING HORMONAL STATUS

Z.R. Kholdarova, D.Sh. Polatova

Fibrocystic mastopathy developing in the setting of ovarian dysfunction is a heterogeneous hormone-dependent condition whose clinical course is largely determined by disturbances in hypothalamic-pituitary-ovarian regulation. Luteal phase insufficiency, anovulatory cycles, relative estrogen excess, progesterone deficiency, and abnormalities in prolactin secretion stimulate proliferative processes in breast tissue and may reduce the effectiveness of standard unified treatment regimens.The aim of this study was to eva …

26.08.2026journal-article

Journal of Nursing, Midwifery and Allied Health Sciences

Knowledge, Attitudes, Availability and the Use of Digital Health Tools Among Public Health Nurses in Primary Health Care Centres in Rivers State, Nigeria

Deborah Unity Atikpe, Grace Odinkenma Onyeabor

Background: Digital health adoption in primary health care remains poorly understood in Rivers State, Nigeria, where Public Health Nurses (PHNs) serve as the frontline health workforce. Most prior Nigerian studies have not measured infrastructure availability as an independent variable, limiting the accuracy of findings on adoption barriers. Objective: To assess knowledge, attitudes, availability, and utilisation of digital health tools among PHNs in Rivers State and identify independent predictors of utilisation. …

26.08.2026journal-article

Journal of Xenobiotics

Tri-Combination Antiretroviral Therapy Induces Dose- and Time-Dependent Disruption of Intestinal Epithelial Barrier Function and Repair Responses in Human T84 Cells

Yaswanthi Yanamadala, Kuppan Gokulan, Sangeeta Khare

Antiretroviral therapy (ART) is essential for controlling human immunodeficiency virus (HIV) infection, requiring strict daily adherence for lifelong viral suppression. However, this continuous oral dosing results in persistent exposure of the gastrointestinal tract (GIT), raising the need to investigate the effects of TC-ART (Tri-combinationL: Abacavir, Dolutegravir, Lamivudine–ART) on epithelial integrity, barrier recovery mechanisms, and surface barrier architecture. TC-ART exposure (125 µM to 4000 µM) showed ma …

26.08.2026journal-article

World Journal of Stem Cells

Letter to the Editor: Metabolic reprogramming - unlocking the full potential of stem cell therapy in wound repair

Si-Feng Wang, Xiang-Wen Peng

The study by Dilimulati et al published in the World Journal of Stem Cells offers an elegant and powerful solution to the “Achilles’ heel” of stem cell therapy: Poor post-transplantation survival. The authors demonstrate that a simple pretreatment with alpha-ketoglutarate activates hypoxia-inducible factor-1α, a master metabolic switch, endowing adipose-derived stem cells with dual survival advantages: A “shield” enhances antioxidant defence via glutamine metabolism, and “sustenance” glycogen reserves to counteract …