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31.08.2026journal-article

GSC Biological and Pharmaceutical Sciences

PHYSICOCHEMICAL AND MICROBIOLOGICAL CHARACTERIZATION OF NAUCLEA LATIFOLIA AND PILIOSTIGMA THONNINGII MACERATES USED IN TRADITIONAL MEDICINE FOR THE TREATMENT OF MALARIA

TRAORE Moumouny, KOUAME N´zebo Desire, YORO Thierry Dezay, SANOGO Seydou, TOURE Abdooulaye

Macerates of Nauclea latifolia and Piliostigma thonningii are used by the population of Korhogo for their antimalarial properties. However, the risk of microbial proliferation in the macerate is significant. The overall objective was to determine the physicochemical and microbiological parameters of Nauclea latifolia and Piliostigma thonningii macerates. For the preparation of the macerates, tap water was added to the roots of Nauclea latifolia and the bark of Piliostigma thonningii on day D0. The evolution of the …

31.08.2026journal-article

World Journal of Advanced Research and Reviews

PALPEBRAL CUTANEOUS LEISHMANIASIS MIMICKING AN ADNEXAL TUMOR: DERMOSCOPY AT THE HEART OF THE DIAGNOSIS

Khalil Bouayad, Zakia Douhi, Khawla Moufid, Layla Tahiri, Hanane Baybay, Fatima Zahra, Mernissi Mernissi

Background: Cutaneous leishmaniasis (CL) is a common infection in endemic areas and displays a wide clinical polymorphism that can mimic inflammatory, granulomatous, or tumoral lesions, particularly on the face. Eyelid involvement is rare and may be mistaken for a chalazion, an adnexal tumor, or a basal cell carcinoma, which can delay diagnosis. Case Presentation: We report the case of a 48-year-old man with no relevant medical history who presented with a slowly enlarging nodule of the right lower eyelid that had …

31.08.2026journal-article

Current Cancer Therapy Reviews

Retraction Notice to "Emerging Translational Approaches for Lung Cancer Therapeutics"

Ishpreet Singh Bedi, Pushpendra Jain

It has come to the publisher’s attention that an identical version of this article was previously published in the International Journal of All Research Education & Scientific Methods (IJARESM) under the following link: "https://www.ijaresm.com/ uploaded_files/document_file/Jain_Pk_2tsi0.pdf". As duplicate publication violates ethical publishing standards, the publisher has informed the authors and has decided to retract the article from Current Cancer Therapy Reviews. Bentham Science apologizes to the readers of t …

31.08.2026journal-article

Endocrine Oncology

Clinical application of digital pathology in small intestinal neuroendocrine tumours: proposal of a new G0 category

Nathalie Guedj, Guillaume Cléry, Anaïs Chassac, Nathalie Colnot, Vinciane Rebours, Jérôme Cros, Louis de Mestier, Anne Couvelard, Matthieu Tihy

Abstract Introduction Small intestinal neuroendocrine tumours (siNETs) are usually indolent neoplasms, most classified as grade 1 with very low proliferative activity. In practice, Ki-67 in G1 siNETs is often reported simply as “<3%”, limiting prognostic discrimination. Digital pathology now enables reliable automated quantification of very low Ki-67 values. We investigated whether precise Ki-67 quantification could improve prognostic stratification in G1 siNETs. Methods We retrospectively included 63 consecutive p …

31.08.2026journal-article

Revista San Gregorio

Desafíos del tratamiento farmacológico de la lepra: una revisión sistemática

Carlos Regino Alejandro Polanco, María Alejandra Rivadeneira Lucas, Cindy Giselle Diaz Contino, Lester Willian Loor Vinces

La lepra es una enfermedad infecciosa crónica transmisible, muy Antigua, que afecta principalmente piel, mucosas y nervios periféricos y pudiendo llevar a discapacidad y la muerte. A pesar de los logros en el tratamiento Poliquimioterapia (PQT), persisten deficiencia en los sistemas de salud pública, especialmente en países de tercer mundo. El objetivo del presente estudio es identificar los logros y desafíos del tratamiento farmacológico de la lepra que permita avanzar hacia su erradicación. Se realizó una revisió …

31.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Respiratory–Swallow Training in Head and Neck Cancer: Impact on Swallowing Safety and Efficiency

Bonnie Martin-Harris, Kate Davidson, David McFarland

Purpose: This review article provides a programmatic translational synthesis of a research program investigating respiratory–swallow coordination as a modifiable physiologic target underlying swallowing impairment and safety, with a focus on individuals treated for head and neck cancer (HNC). The purpose is to synthesize physiologic evidence, clinical trial outcomes, and translational advances supporting respiratory–swallow training (RST) as a mechanism-based intervention. Method: Evidence is drawn from a series of …

31.08.2026journal-article

Cancer Research Communications

Supermeres containing Discoidin Domain Receptor 1 extracellular domain promote collagen alignment and immune exclusion in microsatellite stable colorectal cancer

Maxwell Stuart. Hamilton, Samuel T. Ellis, Zheng Cao, Oleg S. Tutanov, Alan J. Simmons, Radhika Aramandla, James N. Higginbotham, Marisol Ramirez, Katherine W. Schnee, Matthew E. Bechard, Harsimran Kaur, Jeffrey L. Franklin, Swastika Mandal, Ken S. Lau, Qi Liu, Jeremy A. Goettel, Ambra Pozzi, Robert J. Coffey

Abstract Immune checkpoint blockade (ICB) is an effective treatment for microsatellite instability-high (MSI-H) colorectal cancers (CRCs) that are highly infiltrated by CD8+ T cells. Microsatellite stable (MSS) CRCs are unresponsive to ICB, at least in part, due to the paucity of intratumoral CD8+ T cells. We recently identified Discoidin Domain Receptor 1 (DDR1) as one of four genes associated with CD8+ T-cell exclusion in MSS CRC. There are conflicting reports about the presence and role of the cleaved ectodomain …

31.08.2026journal-article

ChemMedChem

Identification of New Putative Autotaxin Inhibitors via Structure‐Based Virtual Screening and Evaluation of Their Antiproliferative Properties Against Ovarian and Breast Cancer Cells

Angelina Boccarelli, Adriana Coricello, Francesca Alessandra Ambrosio, Valentina Leo, Salvatore Mirabile, Rosaria Gitto, Modesto de Candia, Marco Catto, Francesco Ortuso, Cosimo D. Altomare, Stefano Alcaro

Autotaxin (ATX), a lysophospholipase D playing an important role in several inflammatory diseases, as well as in tumor invasion, progression, and metastasis, is an attractive therapeutic target. Herein, we report a virtual screening study of an in‐house molecular database. In silico simulations highlighted five putative ATX inhibitors. The enzyme assay showed that compound 3 achieves inhibition potency in the submicromolar range (IC 50 = 0.534 µM), whereas all the other test compounds proved to be moderate ( 2 ) or …

31.08.2026journal-article

Journal of Pediatric Gastroenterology and Nutrition

Influence of hispanic ethnicity on the presentation and treatment response in pediatric patients with eosinophilic esophagitis

Jennifer L. Horsley‐Silva, Josealberto S. Arenas‐Martinez, Jordan Pitt, Garrett Sprague, Benjamin L. Wright, Evan S. Dellon, Shauna R. Schroeder

Abstract Objectives Eosinophilic esophagitis (EoE) is a chronic, immune‐mediated disease with rising incidence globally. Described predominantly in White populations, the clinical features of EoE in Hispanic children are poorly characterized. This study evaluated the clinical, endoscopic, histologic, and treatment characteristics of Hispanic versus Non‐Hispanic pediatric patients with EoE. Methods We conducted a retrospective comparative cohort study of pediatric patients newly diagnosed with EoE. Hispanic patients …

31.08.2026journal-article

BMC Cancer

Association of baseline serum albumin with treatment-related toxicities in patients receiving tyrosine kinase inhibitors: a real-world cohort study

Ahmed S. Alanazi, Mohammed Alnuhait, Norah M. Almutairi, Sahar M. Alqurtas, Najla F. Alotaibi, Maryam A. Alenazi, Khlood Aldossary, Nada Alsuhebany

Abstract Background Tyrosine kinase inhibitors (TKIs) are widely used across multiple malignancies, but treatment-related toxicities remain a major cause of healthcare utilization and treatment modification. Serum albumin is a routinely available biomarker that reflects nutritional status, systemic inflammation, and physiologic vulnerability and may also influence the pharmacokinetics of highly protein-bound agents. Real-world data evaluating the association between baseline albumin levels and TKI-related toxicity …

31.08.2026journal-article

Chulalongkorn Medical Journal

Factors Associated with Colorectal Cancer Screening Decision-Making among Older Adults at the Comprehensive Geriatric Clinic, King Chulalongkorn Memorial Hospital, Thai Red Cross Society

Chalisa Thanapura, Nawasiri Siriprasert, Thacha Pithayapibulpong, Bhorn-Ake Manasvanich, Vichai Viriyautsahakul

Abstract Background: The incidence of colorectal cancer (CRC) in Thailand is constantly increasing, and is highest in individuals aged 60-75 years. However, the number of older individuals undergoing CRC screening remains suboptimal. Objective: This study aimed to identify factors associated with CRC screening decision-making among Thai older adults attending the Comprehensive Geriatric Clinic at King Chulalongkorn Memorial Hospital. The secondary objective was to identify factors associated with the choice of scre …

31.08.2026journal-article

npj Precision Oncology

Exploratory immunomonitoring during radiochemotherapy in HNSCC and machine-learning reveal immune parameters associated with disease-free survival

Anna-Jasmina Donaubauer, Oliver Tomic, Lia Mogge, Sarina K. Müller, Cecilia Marie Futsaether, Kristian Hovde Liland, Bao Ngoc Huynh, Jens von der Grün, Panagiotis Balermpas, Max Fleischmann, Matthias G. Hautmann, Felix Steger, Christopher Bohr, Thomas Hehr, Carmen Stromberger, Volker Budach, Markus Schymalla, Rita Engenhart-Cabillic, Lukas Kocik, Hans Geinitz, Ursula Nestle, Gunter Klautke, Claudia Scherl, Philipp Schubert, Stefanie Corradini, Rainer Fietkau, Udo S. Gaipl, Benjamin Frey, Marlen Haderlein

Abstract Immunological biomarkers are increasingly relevant for personalized cancer treatment, but peripheral blood-derived biomarkers are not yet used to guide therapy in head and neck squamous cell carcinoma (HNSCC). The prospective non-randomized DIREKHT study (ClinicalTrials.gov: NCT02528955, 2015-08-19) therefore integrated immune monitoring into postoperative radio(chemo)therapy (R(C)T) to explore blood-based biomarkers. In 70 oral cavity and oropharyngeal cancer patients receiving curative R(C)T, the periphe …

31.08.2026journal-article

Revista ft

Acidente vascular cerebral hemorrágico: diagnóstico, manejo e tratamento

Raul Felipe Garcia Silva, Luiz Filipe Vieira Botelho

Hemorrhagic stroke is a severe neurological emergency characterized by blood extravasation into the brain parenchyma or meningeal spaces, resulting in acute neurological damage and high mortality. The aim of this study is to review the main epidemiological, pathophysiological, diagnostic, and therapeutic aspects related to hemorrhagic stroke. This is a narrative review of scientific literature based on recent national and international articles. The results demonstrate that systemic arterial hypertension remains th …

31.08.2026journal-article

Bulletin of the Tomsk Polytechnic University Geo Assets Engineering

Application of complex titanium-containing coagulants in wastewater treatment processes from petroleum products

Yulia D. Peresunko, Sergey V. Azopkov, Natalia E. Kruchinina

Relevance. In the modern world, due to the growth of industrialization and an increase in wastewater disposal, the problem of treating wastewater contaminated with petroleum products is becoming increasingly important. Wastewater treatment is a complex and urgent task that requires an integrated approach. As a rule, the main stage is physico-chemical purification, in particular coagulation. Often, traditional reagents based on metal salts (aluminum, iron, etc.) are characterized by low efficiency due to their narro …

31.08.2026journal-article

Future Pharmacology

Pharmacogenomic vs. Non-Pharmacogenomic Treatment in First-Episode Depression: A Randomized Clinical Trial

Jie Tong, Jie Zhang, Na Zhu, Xiaoxue Li, Xiaochun Zhu, Yuanyuan Xu, Meiling Liu, Jie Yuan, Xirong Sun

Background: Due to drug efficacy, adverse reactions, and individual differences, clinicians face significant challenges in drug selection for the treatment of depression. However, the study on predicting antidepressant treatment response based on pharmacogenomics has not yet been determined. Methods: A total of 178 participants were recruited and randomly assigned to either pharmacogenomics-guided antidepressant treatment or regular antidepressant treatment. All participants completed pharmacogenomic sampling at ba …

31.08.2026journal-article

Fabad Journal of Pharmaceutical Sciences

DESIGN, SYNTHESIS, AND PRELIMINARY ANTIPROLIFERATIVE EVALUATION OF BENZIMIDAZOLE-1,3,4-OXADIAZOLE HYBRIDS SHOWING PREFERENTIAL ACTIVITY IN BREAST CANCER CELL LINES

Mahmut Gozelle, Şevval Yaman, Züleyha Arslan, Yaprak Dilber Şimay Demir

In this study, a new series of benzylthio-substituted benzimidazole-1,3,4-oxadiazole hybrids was designed, synthesized, and evaluated for their biological activity. The title compounds, 2-((2-(benzylthio)-1H-benzimidazol-1-yl)methyl)-5-aryl-1,3,4-oxadiazoles (1-4), were prepared through a multistep synthetic route starting from 2-mercaptobenzimidazole. The synthesis involved S-benzylation, N-alkylation with ethyl chloroacetate, hydrazide formation, and POCl3-mediated cyclodehydration with selected benzoic acid deri …

31.08.2026journal-article

Molecular Biology and Evolution

No genome-wide correlations and little shared genetic architecture between reproductive life-history traits and estrogen receptor-positive breast cancer risk

Euan A Young, E Yagmur Erten, Erik Postma, Virpi Lummaa, Bert van der Vegt, Geertruida H de Bock, Hannah L Dugdale

Abstract Estrogen receptor-positive breast cancer (ER+ BC) is one of the most prevalent cancers, but the evolutionary processes shaping genetic variation in ER+ BC risk are poorly understood. Both evolutionary life-history theory and evidence from studies of individual ER+ BC risk variants suggest that increased genetic ER+ BC risk is associated with faster maturation, earlier reproduction, and/or increased reproductive success (i.e., there is a trade-off), but it is unclear how well this pattern is replicated when …

31.08.2026journal-article

Current Oncology

Exercise and Childhood Cancer: From Science to Life “The 3rd Pediatric Exercise Oncology Congress Meets FORTEe”

S. Nicole Culos-Reed, Miriam Götte, Jörg Faber, Sabine V. Kesting

Pediatric exercise oncology examines the impact of exercise across the treatment journey and into survivorship. This includes examining potential biological mechanisms; physical, mental, and emotional well-being potential outcomes; and the implementation of exercise interventions across clinical and community settings. Despite the growing evidence on positive impacts, exercise largely remains separate from pediatric cancer care. The Pediatric Exercise Oncology Congress, in conjunction with the European research tea …

31.08.2026journal-article

Diagnostics

Brain Tumor Segmentation and Grading on MRI Using Deep Learning: A Systematic Literature Review and Benchmark-Driven Comparative Analysis

Lama Almudaimeegh, Kholoud Alwashmi, Zuhal Y. Hamd

Background: Magnetic resonance imaging (MRI) is central to brain tumor segmentation and histological grading, and deep learning (DL) has transformed both tasks. Existing reviews rarely span the 2017–2026 architectural arc from CNNs and U-Net variants to transformers and foundation models or appraise reproducibility and clinical-translation readiness. Methods: This preregistered systematic review (PRISMA 2020, PRISMA-S) searched Google Scholar, PubMed/MEDLINE, and IEEE Xplore on 21 May 2026 (January 2017–May 2026). …

31.08.2026journal-article

Pediatric Obesity

Among Multiple Mental Health Symptoms, Only Attention Deficit/Hyperactivity Problems Predict Poorer BMI Outcomes in Family‐Based Behavioural Treatment for Youth With Severe Obesity

Vilde A. Skodvin, Hanna F. Skjåkødegård, Helge Molde, Denise Wilfley, Rachel P. K. Conlon, Pétur B. Júlíusson, Yngvild S. Danielsen

ABSTRACT Large variability exists in outcome following Family‐based treatment (FBT) for severe obesity in youth. In the present study, we aimed to expand our understanding of how mental health impacts FBT outcomes. In total, 90 participants (58.9% girls) 5.9–18.6 years (mean ± SD: 13.2 ± 3.1) were enrolled in a 17‐session FBT‐programme. Baseline mean percentage above the IOTF threshold for overweight (%IOTF25) was 146 ± 13, and Body Mass Index standard deviation score (BMIz) was 3.02 ± 0.52. Mental health predictor …

31.08.2026journal-article

Cancer Medicine

Prognostic Impact of Arterial Phase Hyperenhancement After Proton Beam Therapy for Untreated Solitary Hepatocellular Carcinoma

Hikaru Niitsu, Masashi Mizumoto, Yinuo Li, Masahiko Harada, Takuya Sawada, Masaaki Goto, Taisuke Sumiya, Keiichiro Baba, Takeshi Fujisawa, Masatoshi Nakamura, Toshiki Ishida, Takashi Iizumi, Takashi Saito, Haruko Numajiri, Kei Nakai, Yoshiko Oshiro, Hideyuki Sakurai

ABSTRACT Purpose To evaluate the significance of persistent arterial‐phase hyperenhancement (APHE) on contrast‐enhanced CT/MRI at 6 and 12 months after proton beam therapy (PBT) for hepatocellular carcinoma (HCC). Methods We retrospectively analyzed 108 patients with solitary HCC without vascular invasion who underwent definitive PBT as initial treatment between January 2008 and December 2020. APHE was assessed on contrast‐enhanced CT/MRI at approximately 6 and 12 months. Overall survival (OS), local control (LC), …

31.08.2026journal-article

Caucasian Medical Journal

Knowledge and Practice Gaps in Gastric Cancer Prevention Among Physicians in Azerbaijan: Results of the TOGAS National Survey

Z.A. Nasibova, H.I. Ibrahimli, G.H. Babayeva

Background: Despite continuous advances in gastric cancer prevention, delayed recognition of premalignant gastric lesions and inconsistent implementation of evidence-based recommendations remain major barriers to reducing gastric cancer incidence and mortality. International guidelines emphasize Helicobacter pylori eradication, standardized biopsy protocols, OLGA/OLGIM risk stratification, and risk-adapted endoscopic surveillance. However, little is known regarding physicians’ awareness and adherence to these recom …

31.08.2026journal-article

European Journal of Trauma and Emergency Surgery

Long-term radiological and clinical outcomes after surgical treatment of non-union: a ten-year follow-up study

Jessica C. Böpple, Jonas Berger, Thomas Ferbert, Tim Niklas Bewersdorf, Gerhard Schmidmaier, Sebastian Findeisen

Abstract Purpose Non-unions are a major challenge in trauma surgery. They are known to affect patients’ lives for years after the initial trauma. Nevertheless, most studies only examine the first two years after treatment. The question what the long-term results look like ten years after surgery was posed in light of observations made in everyday clinical practice. To answer this, our study was designed to examine all patients who underwent non-union surgery in our department ten years ago. Methods All patients who …

31.08.2026journal-article

Journal of Medical Case Reports

Complete radiological and biochemical remission at 26 months in a young adult with primary mediastinal yolk sac tumor: a case report and literature review on multimodal management

Yuanli You, Mingxing Yang, Xiuqing Wang, Wen Dong

Abstract Background Primary mediastinal yolk sac tumor (PMYST) is an extremely rare and highly malignant germ cell tumor that predominantly affects young males and is associated with a poor prognosis. Case presentation We present the case of a 23-year-old non-smoking male diagnosed with stage III (cT4N0M0) PMYST who received comprehensive treatment guided by a multidisciplinary team (MDT). The treatment regimen included 5 cycles of neoadjuvant chemotherapy with BEP (bleomycin, etoposide, and cisplatin), followed by …