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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
31.08.2026journal-article

Uludağ Üniversitesi Tıp Fakültesi Dergisi

The Impact of Hypertension Knowledge Level on Blood Pressure Control and Treatment Adherence: A Cross-Sectional Analytical Study

Murat Atlı, Uğur Ergün

This study aimed to evaluate the effect of hypertension-related knowledge level on blood pressure control and treatment adherence in individuals followed with a diagnosis of essential hypertension. In this cross-sectional analytical study, 200 patients aged 18–80 years who had been diagnosed with hypertension for at least 6 months and were receiving at least one antihypertensive medication were included. Hypertension knowledge level was assessed using the validated Turkish version of the Hypertension Knowledge-Leve …

31.08.2026journal-article

International Journal of Innovative Technologies in Social Science

PSYCHEDELICS IN THE TREATMENT OF POST-TRAUMATIC STRESS DISORDER AND DEPRESSION: A REVIEW OF CLINICAL TRIALS

Anna Maria Szeszko, Weronika Maria Czernek, Magdalena Cichorzewska, Martyna Płachta, Rafał Marcin Wojtan, Małgorzata Lubowiecka

Psychedelic-assisted therapy has emerged as a prominent area for psychiatric investigation particularly with regards to treatment-resistant depression and Post Traumatic Stress Disorder (PTSD). The purpose of this narrative review was to outline the current body of research regarding psychedelic and psychedelic-like compounds in these two psychiatric conditions highlighting psilocybin-assisted therapy for depression and 3,4-methylenedioxymethamphetamine-assisted therapy for PTSD. Searches for this review focused on …

31.08.2026journal-article

Cancer Research

Microenvironmental Prostaglandin F2α Antagonizes FSP1 in Cancer Cells to Sensitize Tumors to Ferroptosis and Immunotherapy

Yu Meng, Qian Zhou, Deze Zhao, Hui Su, Jiayuan Le, Daishi Li, Lei Yao, Ziyu Guo, Yixiao Xiong, Yuming Sun, Xiaowei Liang, Furong Zeng, Guangtong Deng, Xiang Chen

Abstract Induction of ferroptosis is a potential strategy for treating cancer and improving the efficacy of immunotherapy. Ferroptosis is driven by excessive peroxidation of polyunsaturated fatty acid–containing phospholipids, suggesting that microenvironmental lipid metabolites may regulate ferroptotic sensitivity. By integrating single-cell and bulk transcriptomics from immunotherapy cohorts, we identified the prostaglandin (PG) pathway as closely associated with tumor ferroptosis and therapeutic efficacy. Furthe …

31.08.2026journal-article

Clinical and Translational Medicine

Cancer cell‐selective ectopic expression of CD20 as an antigen enables rituximab repurposing for solid tumour immunotherapy

Ziyan Kong, Yile Wang, Yunqi Zhao, Lu Wang, Zhimin Fan, Yongqian Shu, Jinke Wang

Abstract Background Despite the clinical success of cancer immunotherapies, their efficacy is often compromised by antigen‐related problems, including downregulation, loss, and off‐tumour toxicity. Methods To overcome these limitations that challenge the current immunotherapies dependent on native antigens, we here describe a new cancer immunotherapy strategy that artificially and specifically expresses a clinically validated antigen on variant tumours and thus repurposes clinical antibody drugs to treat cancers no …

31.08.2026journal-article

Cancer Research Communications

Vitronectin enrichment in prostate cancer liver metastases promotes adhesion and survival

Jacob Egelberg, Rebecca Kim, Min J. Kim, Jeanne Maria. Dsouza, Alice Bernard-Tessier, Ramyar Molania, Varadha B. Venkadakrishnan, Jingjing Chen, Martin K. Bakht, Himisha Beltran

Abstract The development of liver metastases in prostate cancer is associated with aggressive disease and poor prognosis. Because hepatocytes exhibit high metabolic activity with unique secretory profiles, we hypothesized that hepatocyte-to-tumor cell signaling plays a role in promoting liver metastasis. We evaluated single-cell transcriptomic data and metastatic tissue from patients with castration-resistant prostate cancer spanning androgen receptor (AR)-positive and AR-negative pathologies. Despite extensive int …

31.08.2026journal-article

Research Journal of Biotechnology

Cytotoxic Evaluation of Trastuzumab in HER2-Positive MDA-MB-453 Breast Cancer Cells

Saranraj S., Priya R.

This study aims to provide an integrated computational and experimental approach in the development of recombinant trastuzumab with specificity towards the HER2-positive breast cancer cell surface antigen. Using the molecular docking approach with the HADDOCK protocol, the interaction between the antibody and the antigen is shown to be stable through the computation of the docking scores and the low intermolecular RMSD. In addition, the electrostatic and van der Waals components of the interaction are significant. …

31.08.2026journal-article

Diagnostics

AI-Driven Tumor Characterization and Histological Subtype Classification in Lung Cancer Using CT Imaging

Mohammad Shorfuzzaman, Abdullah Iftikhar, Shaheryar Najam, Jasem Almotiri, Abdullah Fawaz Aljulayfi, Dina Abdulaziz AlHammadi, Ahmad Jalal

Background/Objectives: Lung cancer is still one of the top cancer mortality causes around the world, and there is a need for an accurate and clinically reliable diagnostic tool. While Computed Tomography (CT) imaging is very useful for evaluation of pulmonary nodules and tumor morphology, its interpretation is complicated by inter-patient variability, imaging artifacts, low tissue contrast, and tumor heterogeneity. Although Computer-Aided Diagnosis (CAD) systems have enhanced the diagnostic process, handcrafted fea …

31.08.2026journal-article

International Journal of Innovative Technologies in Social Science

MEDICATIONS USED IN THE TREATMENT OF ADHD AND THEIR EFFECTS ON THE CARDIOVASCULAR SYSTEM

Maria Nowakowska, Kornelia Tyczka, Maria Sierant, Kamila Zmysłowska

Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder frequently requiring long-term pharmacological treatment. The medications used in ADHD management, particularly stimulant agents and non-stimulant therapies, may influence cardiovascular function through effects on sympathetic activity, heart rate, and vascular tone. This review summarizes the available evidence regarding the potential association between ADHD medications and cardiovascular outcomes, with particular emphasis on …

31.08.2026journal-article

Current Medicinal Chemistry

HAMP, G6PD, and CCL18 as Potential Molecular Markers to Guide Treatment Decisions in Anti-PD-1/PD-L1 Immunotherapy for Hepatocellular Carcinoma

Yamei Huang, Huanjun Tong, Qi Xin, Yuanfei Shi

Introduction: This study explored the role of programmed death receptor 1 (PD-1) and programmed death-ligand 1 (PD-L1) in hepatocellular carcinoma (HCC) and established a gene-based model for predicting response to PD-1/PD-L1 treatment. Materials and Methods: The anti-PD-1/PD-L1 treatment data of HCC were derived from the GEO dataset. Differentially expressed genes (DEGs) were analyzed using the DESeq2 package. LASSO regression was performed using the glmnet package. Immune composition was confirmed using CIBERSORT …

31.08.2026journal-article

Journal of Medicinal Chemistry

A 177Lu-Labeled Circular Bivalent Aptamer for PTK7-Targeting Radionuclide Therapy in Ovarian Cancer and Orthotopic Hepatoblastoma

Xiaoning Tong, Yi He, Heng Liu, Wenjie Guo, Wen-Guo Huang, Peng Li, Luoan Wang, Yuntian Zhu, Le Cai, He-Qing Yi, Xue-Qiang Wang, Weihong Tan

Abstract Targeted radionuclide therapy (TRT) is a promising strategy for precision oncology but is limited by the lack of high-performance targeting ligands. Here, we report a lutetium-177 (177Lu)-labeled PTK7-targeted cyclized bivalent aptamer (CBSgc8) for treating an orthotopic hepatoblastoma. The cyclized multivalent design enhances biostability and binding affinity, while 177Lu labeling preserves its functional properties. The resulting 177Lu-CBSgc8 exhibited high serum stability, strong specificity for PTK7-po …

31.08.2026journal-article

Cancer

FDA approves test for molecular residual disease monitoring in patients with solid tumors

Leah Lawrence

This news section offers Cancer readers timely information on events, public policy analysis, and topical issues. In this issue, the FDA approves a test that enables the identification of patients who are positive for ctDNA and can benefit from adjuvant atezolizumab after cystectomy. In addition, the HERMES trial supports a shortened stereotactic body radiation therapy schedule without added toxicity for patients with prostate cancer, and the FDA grants accelerated approval to BCL‐2 inhibitor sonrotoclax for mantle …

31.08.2026journal-article

International Journal of Molecular Sciences

Molecular Determinants of Intravitreal Anti-VEGF Durability: Drug Architecture, Intraocular Pharmacokinetics, Target Biology and Treatment Resistance

Georgios D. Panos, Theo Empeslidis, Efstratia Amaxilati, Georgios N. Tsiropoulos, Nikolaos Topouzis, Panagiotis A.G. Konstas, Eleftherios Chatzimichail, Zisis Gatzioufas, Winfried Amoaku

Intravitreal inhibition of vascular endothelial growth factor (VEGF) has transformed the management of neovascular age-related macular degeneration, diabetic macular oedema and macular oedema secondary to retinal vein occlusion, but frequent monitoring and retreatment remain major burdens. Ocular half-life is often used as shorthand for durability, although the clinical interval is produced by a wider molecular and biological system. This narrative review examines how dose, molecular format, hydrodynamic size, bind …

31.08.2026journal-article

International Journal of Research Publication and Reviews

Bioinspired Polymer Nanoparticles for Tumor-Specific Drug Delivery

Riswat F Musbaua, Precious-Esther O Efuneshib, Ayomide Alaoc, Ronke Oluokund, Hameedah O Adebimpee, Theophilus Tolulope Fayinkaf, Malik O Rabiuq

Bioinspired polymer nanoparticles integrate the physicochemical control of synthetic polymers with functions derived from cells, proteins, extracellular vesicles, natural macromolecules, or biological transport mechanisms. Their objective is not merely to resemble nature, but to solve specific failures in tumor drug delivery: rapid immune clearance, unstable circulation, inadequate tumor access, weak tissue penetration, nonspecific cellular uptake, endosomal sequestration, and premature or incomplete payload releas …

31.08.2026journal-article

GSC Biological and Pharmaceutical Sciences

PHYSICOCHEMICAL AND MICROBIOLOGICAL CHARACTERIZATION OF NAUCLEA LATIFOLIA AND PILIOSTIGMA THONNINGII MACERATES USED IN TRADITIONAL MEDICINE FOR THE TREATMENT OF MALARIA

TRAORE Moumouny, KOUAME N´zebo Desire, YORO Thierry Dezay, SANOGO Seydou, TOURE Abdooulaye

Macerates of Nauclea latifolia and Piliostigma thonningii are used by the population of Korhogo for their antimalarial properties. However, the risk of microbial proliferation in the macerate is significant. The overall objective was to determine the physicochemical and microbiological parameters of Nauclea latifolia and Piliostigma thonningii macerates. For the preparation of the macerates, tap water was added to the roots of Nauclea latifolia and the bark of Piliostigma thonningii on day D0. The evolution of the …

31.08.2026journal-article

Frontiers in Genetics

Lymphangiogenesis-related gene signature–based risk model for prognostic assessment of cervical cancer: immune–metabolic characterization and molecular subtype analysis

Xijing Fan, Lu Chen, Jing Xu, Shunjie Zheng, Qi Pan, Yifei Hu

Background Lymphangiogenesis promotes tumor dissemination and may shape the immune contexture of cervical cancer, yet lymphangiogenesis-related prognostic stratification and its immunometabolic implications remain insufficiently defined in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC). Methods TCGA-CESC transcriptomes and clinical data were obtained from UCSC Xena and integrated with normal cervix tissues from the Genotype-Tissue Expression Project after batch correction. Prognostic LYMRGs …

31.08.2026journal-article

Neuro-Cell Molecular Research

Antineoplastic Effects of Ankaferd Hemostat on Hep-2 Laryngeal Cancer Cells: Involvement of Apoptosis and PI3K/Akt/mTOR Signaling

Yaser Said Çetin, Mehmet Zeki Erdem, Mehmet Berköz

To investigate the cellular and molecular effects of Ankaferd Hemostat on human laryngeal squamous carcinoma Hep-2 cells, with particular emphasis on cell viability, apoptosis, oxidative stress, cell cycle progression, migration, invasion, and PI3K/Akt/mTOR signaling. Hep-2 cells were treated with increasing concentrations of Ankaferd Hemostat (50-1600 nL/mL) for 24, 48, and 72 h. Cell viability, clonogenic survival, apoptosis, cell cycle distribution, migration, invasion, nuclear morphology, DNA fragmentation, int …

31.08.2026journal-article

Neuro-Oncology

Cell-Free DNA Sequencing Captures Tumor Dynamics, Microenvironment Interactions, and Treatment Pressures in Glioblastoma

Sharvari Mankame, Angad S Beniwal, Matthew Dufault, Hersh Nanda, Maria Kyriakidou, Ogechukwu Mbegbu, Nanyun Tang, Nhan L Tran, Michael E Berens, Floris Barthel1

Lay Summary Glioblastoma is the most common and deadly brain cancer in adults. Doctors use brain scans to monitor treatment, but scans can miss early changes. Tumors shed tiny pieces of their DNA into blood and body fluids. Measuring these pieces through a blood draw could track tumor behavior without surgery. We grew glioblastoma cells from patients under different conditions to understand what drives DNA release. DNA levels tracked with living, growing cells rather than dying ones, suggesting tumors actively rele …

31.08.2026journal-article

Astana Medical Journal

PLGA‑PEG nanoparticles loaded with the Cdc42 inhibitor CASIN suppress migration and invasion of colorectal cancer cells in Vitro

Sanazar Kadyr, Altyn Zhuraliyevа, Aislu Yermekova, Daulet Kaldybekov, Ellina A. Mun, Farkhad Olzhayev, Denis Bulanin, Alena Khalzova, Aisulu Karenkina, Bauyrzhan Umbayev

Introduction. Colorectal cancer remains one of the most lethal malignant tumours, and the deterioration in prognosis is largely due to the development of metastases. Cdc42, a small Rho GTPase, regulates the actin cytoskeleton, cellular polarity, and invasively metastatic phenotype, making it an attractive cancer therapy target. The low molecular weight Cdc42 inhibitor CASIN has antitumor activity, but its use is limited by unfavourable physico-chemical properties. We previously developed PLGA-PEG nanoparticles load …

31.08.2026journal-article

Drugs in Context

How to manage radioiodine-refractory thyroid cancer in the era of precision medicine

Olga Karapanou, Grigoris Effraimidis, Marina Michalaki, Katerina Saltiki

Differentiated thyroid cancer has a favourable clinical course. However, a minority of patients with distant metastases lose the ability for radioiodine uptake. In case of refractoriness, the implementation of local therapies, that is radiofrequency/cryoablation or embolization, stabilizes metastasis and delays disease progression. A wait-and-see strategy can be a viable option in slow disease progression. On the other hand, in symptomatic patients with progressive disease, the alternative is systemic therapy with …

31.08.2026journal-article

Frontiers in Medicine

Comparison of the efficacy and safety of 755-nm picosecond alexandrite laser with diffractive lens array vs. fractional microneedle radiofrequency for the treatment of facial photoaging: a retrospective study

Xixin Wu, Houhuang Qiu, Jingchun Chen, Yunkai Zhu, Jialu Xu, Xi Chen, Yutong Wu, Fangfang Wang, Ping Zhong, Qiusheng Lin, Fei Li, John Chen, Hongduo Chen, Tianhua Xu

Objective To compare the efficacy and safety of a 755-nm picosecond alexandrite laser combined with a diffractive lens array (PSAL-DLA) vs. fractional microneedle radiofrequency (MNRF) in the treatment of facial photoaging. Methods This retrospective study enrolled 51 patients with facial photoaging (Glogau scale ≥ II), including 22 in the PSAL-DLA group and 29 in the MNRF group. Objective assessments were performed at baseline and within 3 months post-treatment using the VISIA skin analysis system (spots, wrinkles …

31.08.2026journal-article

World Journal of Advanced Research and Reviews

PALPEBRAL CUTANEOUS LEISHMANIASIS MIMICKING AN ADNEXAL TUMOR: DERMOSCOPY AT THE HEART OF THE DIAGNOSIS

Khalil Bouayad, Zakia Douhi, Khawla Moufid, Layla Tahiri, Hanane Baybay, Fatima Zahra, Mernissi Mernissi

Background: Cutaneous leishmaniasis (CL) is a common infection in endemic areas and displays a wide clinical polymorphism that can mimic inflammatory, granulomatous, or tumoral lesions, particularly on the face. Eyelid involvement is rare and may be mistaken for a chalazion, an adnexal tumor, or a basal cell carcinoma, which can delay diagnosis. Case Presentation: We report the case of a 48-year-old man with no relevant medical history who presented with a slowly enlarging nodule of the right lower eyelid that had …

31.08.2026journal-article

Current Cancer Therapy Reviews

Retraction Notice to "Emerging Translational Approaches for Lung Cancer Therapeutics"

Ishpreet Singh Bedi, Pushpendra Jain

It has come to the publisher’s attention that an identical version of this article was previously published in the International Journal of All Research Education & Scientific Methods (IJARESM) under the following link: "https://www.ijaresm.com/ uploaded_files/document_file/Jain_Pk_2tsi0.pdf". As duplicate publication violates ethical publishing standards, the publisher has informed the authors and has decided to retract the article from Current Cancer Therapy Reviews. Bentham Science apologizes to the readers of t …

31.08.2026journal-article

BMC Cancer

Association of baseline serum albumin with treatment-related toxicities in patients receiving tyrosine kinase inhibitors: a real-world cohort study

Ahmed S. Alanazi, Mohammed Alnuhait, Norah M. Almutairi, Sahar M. Alqurtas, Najla F. Alotaibi, Maryam A. Alenazi, Khlood Aldossary, Nada Alsuhebany

Abstract Background Tyrosine kinase inhibitors (TKIs) are widely used across multiple malignancies, but treatment-related toxicities remain a major cause of healthcare utilization and treatment modification. Serum albumin is a routinely available biomarker that reflects nutritional status, systemic inflammation, and physiologic vulnerability and may also influence the pharmacokinetics of highly protein-bound agents. Real-world data evaluating the association between baseline albumin levels and TKI-related toxicity …

31.08.2026journal-article

Chulalongkorn Medical Journal

Factors Associated with Colorectal Cancer Screening Decision-Making among Older Adults at the Comprehensive Geriatric Clinic, King Chulalongkorn Memorial Hospital, Thai Red Cross Society

Chalisa Thanapura, Nawasiri Siriprasert, Thacha Pithayapibulpong, Bhorn-Ake Manasvanich, Vichai Viriyautsahakul

Abstract Background: The incidence of colorectal cancer (CRC) in Thailand is constantly increasing, and is highest in individuals aged 60-75 years. However, the number of older individuals undergoing CRC screening remains suboptimal. Objective: This study aimed to identify factors associated with CRC screening decision-making among Thai older adults attending the Comprehensive Geriatric Clinic at King Chulalongkorn Memorial Hospital. The secondary objective was to identify factors associated with the choice of scre …