Vollständiger Abstract
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Lay Summary Glioblastoma is the most common and deadly brain cancer in adults. Doctors use brain scans to monitor treatment, but scans can miss early changes. Tumors shed tiny pieces of their DNA into blood and body fluids. Measuring these pieces through a blood draw could track tumor behavior without surgery. We grew glioblastoma cells from patients under different conditions to understand what drives DNA release. DNA levels tracked with living, growing cells rather than dying ones, suggesting tumors actively release DNA. Chemotherapy changed this pattern, increasing release through cell death. We also detected tumor DNA in the blood of mice with brain tumors, showing these signals cross into the bloodstream. These findings support developing blood tests to monitor this disease.
Bibliografischer Nachweis
Publikationsdaten
- Autor:innen
- Sharvari Mankame, Angad S Beniwal, Matthew Dufault, Hersh Nanda, Maria Kyriakidou, Ogechukwu Mbegbu, Nanyun Tang, Nhan L Tran, Michael E Berens, Floris Barthel1
- Quelle
- Neuro-Oncology
- Publikation
- 2026-01-01
- Band / Ausgabe
- Nicht angegeben
- Seiten
- Nicht angegeben
- ISSN / ISBN
- 1522-8517, 1523-5866
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Zitierfähiger Nachweis
Sharvari Mankame, Angad S Beniwal, Matthew Dufault, Hersh Nanda, Maria Kyriakidou, Ogechukwu Mbegbu, Nanyun Tang, Nhan L Tran, Michael E Berens, Floris Barthel1 (2026). Cell-Free DNA Sequencing Captures Tumor Dynamics, Microenvironment Interactions, and Treatment Pressures in Glioblastoma. Neuro-Oncology. https://doi.org/10.1093/neuonc/noag204
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Themen, Förderung und Nutzung
Lizenzhinweise: Lizenz 1