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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
19.08.2026journal-article

Bone & Joint Open

Protocol for the ACTIVE trial: a multicentre, open-label, cluster-randomized controlled trial of a quality improvement programme for older adults with hip fracture in resource-limited hospitals in China

Minghui Yang, Tingzhuo Liu, Gang Liu, Ning Tang, Xinyi Zhang, Rebecca Ivers, Yongchen Wang, Maoyi Tian

Aims The primary aim of the Action on Hip Fracture Management Quality Improvement (ACTIVE) trial is to evaluate whether a context-tailored quality improvement programme improves health-related quality of life at 120 days after hospital admission, among adults aged 65 years or older with a hip fracture, in less-resourced hospitals in China. Secondary aims are to compare health-related quality of life at 30 days, complication and morbidity at 30 and 120 days, proportion of patients receiving surgery, proportion of pa …

19.08.2026journal-article

GeroPsych

Violence Against Older Adults and Healthcare Workers' Reporting Obligations in Italy

Fabio Cembrani, Diego De Leo

Abstract: Violence against older adults is a public health problem often underestimated by healthcare workers and not yet included on the international political agenda. Numerous statistical data confirm its increasing frequency and its effects on morbidity, mortality, and rising healthcare costs. Despite the complexity of this phenomenon, violence against older adults is something that can be contained with concrete actions, public awareness campaigns, and training for healthcare workers, including regarding their …

19.08.2026journal-article

People and Nature

Forging environmentalism: The influence of childhood nature experiences on people's pro‐biodiversity value orientations and attitudes

Oriol Garcia‐Antúnez, Christopher M. Raymond, Thomas Beery, Anton Stahl Olafsson

Abstract With the rapid expansion of transnational biodiversity policy instruments promoting large‐scale landscape transformations that depend on public support for their success and feasibility, understanding the mechanisms underlying pro‐biodiversity attitudes has become important. Previous research has demonstrated associations between childhood nature experiences and pro‐biodiversity value orientations, which in turn shape pro‐biodiversity attitudes and behaviours. However, evidence remains limited regarding ho …

19.08.2026journal-article

Clinical Infectious Diseases

Annual vs semi-annual follow-up in low complexity virologically suppressed people with HIV: a randomized interventional trial

Iván Chivite, M J Merino-Peñas, Ana González-Cordón, María Martínez-Rebollar, Berta Torres, Lorena de la Mora, Alexy Inciarte, Alberto Foncillas, Julia Calvo, Juan Ambrosioni, Abiu Sempere, Leire Berrocal, José Luís Blanco, José M Miró, Roger Llobet, Emma Fernandez, Esteban Martínez, Josep Mallolas, Elisa de Lazzari, Montserrat Laguno

Abstract Background The increasing heterogeneity in people with HIV makes it necessary to evaluate new follow-up strategies tailored to clinical/social complexity. Methods Prospective, single-center, randomized, non-inferiority clinical-trial comparing two follow-up strategies - semi-annual standard care (SoC) or annual visits for 24 months- in virologically suppressed people with HIVand low-complexity profile, according to the GeSIDA “HIV Patient Stratification System”. The primary endpoint was non-inferiority (pr …

19.08.2026journal-article

Science Translational Medicine

Carboxyl-terminal blockade of sortilin binding enhances progranulin gene therapy in a mouse model of frontotemporal dementia

Shreya N. Kashyap, Stephanie N. Fox, Vivianna R. DeNittis, Katherine I. Wilson, Nicholas R. Boyle, Mary Bullock, Aniketh S. Tadepalli, Stephanie R. Miller, Jorge J. Palop, Yohannes A. Ambaw, Tobias C. Walther, Robert V. Farese, Charles F. Murchison, Andrew E. Arrant, Erik D. Roberson

Frontotemporal dementia is commonly caused by loss-of-function mutations in the progranulin gene. Potential therapies for this disorder have entered clinical trials, including progranulin gene therapy and drugs that reduce progranulin interactions with sortilin. Both approaches ameliorate functional and pathological abnormalities in mouse models of progranulin insufficiency. Here, we investigated whether modifying the progranulin carboxyl terminus to block sortilin interactions would improve the efficacy of progran …

19.08.2026journal-article

Advanced Engineering Materials

Reinforcement Mechanism of Initial Stress on Artificial Aging of 2198 Al–Cu–Li Alloy Sheet

Shuang‐Qiang Xiao, Ming‐Yang Han, Yan‐Guang Yin, Ying‐Wei Qi, Tian‐Zhang Zhao

This study investigates the effects of applied stress during artificial aging on the 2198 Al–Cu–Li alloy. The results demonstrate that after artificial aging at 145 °C, the 2198 Al–Cu–Li alloy primarily features densely distributed δ′ phases with larger diameters as the main strengthening phase. The application of initial stress during aging at 145 °C induces δ′ phase dissolution, resulting in a 54.8% reduction in δ′ phase density, accompanied by a 4.8% decrease in yield strength. At an artificial aging temperature …

19.08.2026journal-article

Proceedings of the International Symposium on Human Factors and Ergonomics in Health Care

From Early Warning to Life-Saving Intervention: Case Study Evidence of Persuasive Wearable Health Monitoring in Older Adults and Older Adults With MCI

Emily Gleaton, Emily Parcell, W. Bradley Fain

Consumer persuasive wearables (PWs) collect physiological data and provide feedback that can support self-monitoring. While older adults might benefit from PWs, little is known about how wearable feedback translates into real-world preventive action, particularly for those with mild cognitive impairment (MCI). This paper presents narrative case-study evidence from a longitudinal mixed-methods study of 44 older adults (55–86 years; M = 74.25), including 29 with MCI, who wore a commercially available PW for an averag …

19.08.2026journal-article

Journal of the American Geriatrics Society

Time‐Varying Body Mass Index, Waist Circumference and All‐Cause Mortality in US Adults Aged 65 or Older

Furong Xu, Jacob E. Earp, Bryan J Blissmer, Julie Coiro, Steven A. Cohen, Geoffrey W. Greene

ABSTRACT Background This study examined associations of body mass index (BMI) category and waist circumference (WC) independently and in tandem on all‐cause mortality risk among US adults aged ≥ 65 years. Methods The present study utilized 14 years of longitudinal data (2011–2024) from 6905 participants in the National Health and Aging Trends Study. Cox proportional hazards models were used to estimate the hazard ratios (HRs), adjusted for baseline age, race, education, annual income, smoking status, and homebound …

19.08.2026journal-article

Media Publikasi Promosi Kesehatan Indonesia (MPPKI)

Caring-Based Psychosocial Intervention Associated with Reduced Diabetes Burnout Among Older Adults with Type 2 Diabetes

Ummu Muntamah, Maksum, Wulansari

Introduction: Diabetes burnout is a significant psychosocial challenge among older adults with type 2 diabetes, contributing to emotional exhaustion, maladaptive coping, and reduced quality of life. Conventional diabetes management programmes often emphasise biomedical outcomes while insufficiently addressing psychosocial needs. This study examined whether a caring-based psychosocial approach integrated into a community diabetes programme was associated with reduced diabetes burnout and improved coping mechanisms a …

19.08.2026journal-article

Andrology

Bone Health and Aging in Klinefelter Syndrome

Filippo Vignali, Daniele Renda Livraghi, Francesco Costantino, Sara De Vincentis, Vincenzo Rochira

ABSTRACT Klinefelter syndrome (KS) is typically diagnosed in young adults, but advances in prenatal testing have led to its recognition at a much earlier age. Conversely, diagnosis in late adulthood remains uncommon, but still occurs. Independently from the age at diagnosis, KS individuals now receive more accurate and tailored care management than in the past, thanks to advances in disease knowledge, improvements in health care systems, and greater awareness among both physicians and patients. Thus, individuals wi …

19.08.2026journal-article

Revista Ibero-Americana de Humanidades, Ciências e Educação

OS DESAFIOS PSICOLÓGICOS E SOCIAIS DA VIVÊNCIA DA SEXUALIDADE EM PESSOAS COM DEFICIÊNCIA FÍSICA

Lanna Margoth Barbosa da Costa, Giovanna Regina da Encarnação Gomes, Elizabeth Carvalho Mores, Gesilane Nascimento Maurício, Mary Jane Almeida da Cruz, Neila Maria Vasconcelos da Costa, Ana Thayná de Matos Simplício

A sexualidade é uma dimensão fundamental da vida humana, influenciando a identidade, a autoestima, a afetividade, os relacionamentos e a qualidade de vida. No entanto, pessoas com deficiência física frequentemente enfrentam barreiras psicológicas e sociais que dificultam a vivência plena de sua sexualidade. Entre os obstáculos mais comuns estão o preconceito, o capacitismo, os estigmas sociais, as dificuldades relacionadas à imagem corporal, a baixa autoestima e a visão equivocada de que pessoas com deficiência não …

19.08.2026journal-article

Naturaleza y Sociedad. Desafíos Medioambientales

Las trampas de la gente del centro del mundo: documentación de la pesca tradicional de los pueblos Murui, Bora y Okaina del noroccidente amazónico

Jose Gabriel Dávila Romero

This article presents a process for appropriating and documenting artisanal fishing techniques using traps among the People of the Center (Murui, Bora, and Okaina) in the Colombian Amazon. Far from treating the traps as mere subsistence tools, the paper analyzes them as artifactual assemblages that integrate ecology and cosmology within a situated practice. The analysis encompasses: a) collecting plant fibers, b) manufacturing processes, c) ritual prescriptions, and d) practices of use in relation to hydrological c …

19.08.2026journal-article

Journal of the American Geriatrics Society

Enablers of Careful Hand Feeding Decisions for Persons With Advanced Dementia in Hong Kong: A Qualitative Study of Chinese Family Surrogates

Jacqueline K. Yuen, David Amorim, Irene Au, Vivian Weiqun Lou, Sandra M. Shi

ABSTRACT Background Deciding whether to initiate tube feeding is a significant challenge for family surrogates of persons with dementia. Although clinical guidelines recommend careful hand feeding due to lack of benefit of tube feeding, tube feeding remains the default intervention in Asia. This study aimed to identify factors that enabled Chinese family surrogates to choose careful hand feeding in contexts where tube feeding is the dominant practice. Methods We conducted a qualitative descriptive study nested with …

19.08.2026journal-article

Frontiers in Aging Neuroscience

Reduced BOLD-CSF coupling as a potential functional imaging correlate of semantic fluency decline in MRI-negative temporal lobe epilepsy

Ying Xu, Xiaona Xia, Ying Wang, Ke Xue, Ying Wei, Ling Li, Xiangshui Meng

Introduction This study investigated neurovascular–cerebrospinal fluid dynamic interactions using blood-oxygen-level-dependent–cerebrospinal fluid (BOLD-CSF) coupling metrics and examined their associations with cognitive impairment in patients with MRI-negative unilateral temporal lobe epilepsy (TLE). Methods In this retrospective study, 36 patients with MRI-negative unilateral TLE and 26 healthy controls (HCs) recruited during the same study period were enrolled. Resting-state functional MRI (rs-fMRI) was used to …

19.08.2026journal-article

Journal of Enterprising Communities: People and Places in the Global Economy

Short-term accommodation rentals in local communities: evidence from Messinia, Greece

Ilias A. Makris, Sotiris Apostolopoulos, Nicholas Theodorakopoulos, Panos Dimitrakopoulos, Amvrosios Prodromou

Purpose Taking an institutional approach, this study aims to explore the impact of short-term rental accommodation on rural areas, focusing on economic, social and environmental aspects. Drawing on qualitative research, it examines the views of owners and presidents of rural communities as key informants, theoretically interprets the findings and extends the scant literature on short-term rental accommodation in rural areas. Design/methodology/approach A qualitative approach was employed to trace the views and perc …

19.08.2026journal-article

Journal of Agricultural and Food Chemistry

Identification of Key Aging-Related Aroma Compounds in Sesame-Flavor Baijiu via Chemometrics and Molecular Docking: Insights into Flavor Formation Mechanisms

Xiaotong Lyu, Keen Wang, Meiyi Zhou, Yuchen Dong, Rebecca C. Deed, Liangcai Lin, Guoming Wang, Yanke Li, Changcheng Ren, Yan Zhu, Chunhui Wei, Cuiying Zhang

Abstract On the basis of 12 sesame-flavor Baijiu spanning multiple vintages, this study systematically revealed aging patterns through chemometrics, sensory, physicochemical, and molecular docking analyses. Sensory profiling showed that aging enhanced sesame and aged aromas while weakening fruity and alcoholic notes. Physically, prolonged aging increased the particle size, regularized the morphology, and intensified yellowing. Gas chromatography–olfactometry–mass spectrometry and omission tests confirmed 21 key aro …

19.08.2026journal-article

Healthcare

Ignoring the Older Person’s Voice: Dignity, Ageism, and Epistemic Injustice in Geriatric Nursing Practice—A Nursing-Oriented Conceptual Review and Practice Framework

Georgios Manomenidis, Charikleia Orfanidou, Christos Kleisiaris, Savvato Karavasileiadou, Panagiota Kazakou, Areti Nikiforou, Vasiliki Georgousopoulou

Background/Objectives: Older adults may experience healthcare encounters in which their voices are discounted, redirected through family members, or interpreted through age-related assumptions about cognitive decline. Although such problems are often discussed through dignity, communication, ageism, person-centred care, or shared decision-making, this conceptual review argues that they also involve epistemic harms: harms that occur when older adults are not recognized as credible knowers of their own bodies, needs, …

19.08.2026journal-article

Frontiers in Public Health

Prevalence and associated factors of tuberculosis/HIV coinfection among people living with HIV in Almaty, Kazakhstan: a cross-sectional study

Alfiya Y. Denebayeva, Elizabeth J. King, Zhamilya S. Nugmanova, Ulyana A. Gubareva, Marat S. Tukeyev, Anarkhan K. Nurkerimova, Aigerim B. Alimbekova, Elena Y. Ushanskaya, Roberta Z. Horth, Alexander J. Millman, Dilyara A. Nabirova

Introduction Tuberculosis (TB) is the leading cause of death among people living with HIV (PLHIV). Kazakhstan faces a growing number of new HIV diagnoses alongside a high incidence of multidrug-resistant TB. This study aimed to determine the prevalence and risk factors for TB among PLHIV in Almaty, Kazakhstan. Methods We conducted a cross-sectional study of adult PLHIV receiving care at the Almaty AIDS City Center by 2022. Participants were randomly selected from the HIV registry. TB/HIV coinfection was defined as …

19.08.2026journal-article

Frontiers in Immunology

Anti-inflammatory diet, physical activity, and risk of all-cause mortality in older adults: a prospective cohort study

Minghui Sun, Tian Li, Ling Cong, Xinyan Ma, Mengdi Hou, Hao Ai, Zhiyun Wu, Chao Huang

Background Anti-inflammatory dietary patterns are associated with a lower risk of several chronic diseases, but their association with all-cause mortality in Chinese older adults is unknown. In this first study of a Chinese population, we investigated this association and its joint effects with physical activity, to inform strategies for healthy longevity. Methods This analysis included 6,468 participants aged ≥65 years from the Chinese Longitudinal Healthy Longevity Survey. Anti-inflammatory diet was assessed usin …

19.08.2026journal-article

Frontiers in Pharmacology

Molecular mechanisms of traditional Chinese medicine in skin aging: a narrative review

Sisi Yin, Huilan Zheng, Qingjing Yang, Xingyu Chen, Qianqian Yang, Qifeng Yang, Hongbin Cheng, Jingping Wu

Skin aging involves complex endogenous and extrinsic mechanisms, driving oxidative stress, cellular senescence, DNA damage, and extracellular matrix degradation. This narrative review synthesizes preclinical evidence on traditional Chinese medicine (TCM)-derived botanical drugs and formulae targeting these pathways. We identified 19 single-botanical drug and 17 formula studies. The most consistently reported effects include Nrf2/ARE activation, reduced reactive oxygen species (ROS) and malondialdehyde (MDA), increa …

19.08.2026journal-article

Experimental & Molecular Medicine

Hematopoietic stem cell aging: a review of transcriptional and multi-omics insights and potential paths for AI integration

Bongsoo Park, Hagai Yanai, Jun Ding, Isabel Beerman

Abstract Hematopoietic stem cell (HSC) aging underlies age-related immune decline, anemia and increased risk of hematologic malignancies, including clonal hematopoiesis and leukemia. Many available microarray and bulk RNA sequencing studies have elucidated conserved transcriptional hallmarks, such as myeloid bias, inflammation dysregulation, and self-renewal reinforcement in aged HSCs across mouse and human models. Here, we review key publicly available transcriptome and epigenome datasets from landmark studies, hi …

19.08.2026journal-article

Frontiers in Medicine

Comparative efficacy of non-pharmacological interventions on fatigue in people undergoing hemodialysis: a systematic review and network meta-analysis

Juncai Li, Zhe Meng, Jing Yang, Longjie Wei, Qirui Zhang, Yijia Lin, Bonolo William, Xiuling Zhou

Background Fatigue is a prevalent and debilitating symptom among people undergoing maintenance hemodialysis (MHD). Pharmacological options for fatigue are limited, and treatment may be complicated by altered pharmacokinetics, polypharmacy, and adverse effects. Non-pharmacological interventions have therefore received increasing attention, but their comparative efficacy remains uncertain. This study aimed to compare and rank their efficacy for fatigue relief in people undergoing MHD. Methods PubMed, Embase, the Coch …

19.08.2026journal-article

Humanity & Society

The Rights of Indigenous Deaf People to Language, Education, and Culture in the United States

Britnee Nguyen, Melanie McKay-Cody

Individuals who are Indigenous and Deaf have a unique experience walking in multiple cultural and linguistic worlds. This requires a formal recognition of their rights that support their way of being, doing, and knowing. Indigenous Deaf people have rights to language acquisition, Indigenous cultural engagement, educational attainment, and community involvement. Communication is the essential foundation for the lives of Indigenous Deaf people, as it is necessary for realizing all of their rights. This includes the r …

19.08.2026journal-article

Frontiers in Aging Neuroscience

Cell-type-dependent decline of IGF1 and IGF1R in the prefrontal cortex contributes to age-related behavioral changes

Shuwen Yue, Christian Young, Arushi Garg, Tyler Sarovich, Lu Chen, Kendall Dickerson, Zi-Jun Wang

Insulin-like growth factor 1 (IGF1) signaling plays a critical role in brain function and declines significantly with aging. However, how these changes occur across different brain regions and cell types, and how they contribute to behavioral dysfunction, remains poorly understood. The prefrontal cortex (PFC), a key regulator of cognitive, emotional, and social behaviors, is particularly vulnerable to age-related changes. Here, we investigated age-associated changes in IGF1 and its receptor (IGF1R) in major neurona …