10.3389/fpsyg.2012.00132

Vollständiger Abstract

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Skin aging involves complex endogenous and extrinsic mechanisms, driving oxidative stress, cellular senescence, DNA damage, and extracellular matrix degradation. This narrative review synthesizes preclinical evidence on traditional Chinese medicine (TCM)-derived botanical drugs and formulae targeting these pathways. We identified 19 single-botanical drug and 17 formula studies. The most consistently reported effects include Nrf2/ARE activation, reduced reactive oxygen species (ROS) and malondialdehyde (MDA), increased superoxide dismutase (SOD) activity, matrix metalloproteinase (MMP) inhibition, and lower senescence markers [p16, p21, and senescence-associated β-galactosidase (SA-β-Gal)]. Additional modulated pathways include MAPK/AP-1, PI3K/Akt/mTOR, TGF-β/Smad, and NAD+/Sirtuin, collectively contributing to reduced inflammation, enhanced antioxidant defense, and preserved dermal collagen. These findings suggest multi-pathway modulation rather than true pharmacological synergy. This system-level approach highlights a shift from monotherapy toward holistic intervention. However, clinical evidence remains extremely limited and consists mainly of small human studies, including trials described as randomized or double-blind but incompletely reported, and single-arm evaluations; no adequately powered, preregistered, high-quality randomized controlled trial (RCT) has yet established clinical efficacy for TCM interventions in skin aging. Therefore, future research should prioritize rigorous RCTs, dose-response designs, and phytochemical standardization.

Abstract: PubMed · Datensatz