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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Frontiers in Immunology

The transformative impact of ultra-rapid nanopore sequencing in precision medicine

Sarah Grasedieck, Brendan J. Keating, Stephen Yip, James Lan, Karen R. Sherwood, Paul A. Keown

Nanopore sequencing has emerged as a transformative technology, offering unprecedented speed, ultra-long reads, and portability at a comparatively low cost. These attributes are fundamentally reshaping clinical diagnostics and personalized medicine. This review synthesizes the technological advancements driving nanopore sequencing and elucidates its pivotal applications in time-sensitive areas such as HLA matching in transplantation, infectious disease management, pharmacogenomics, and oncology. Nanopore sequencing …

03.09.2026journal-article

American Journal of Audiology

Clinical Prevalence and Impact of False Air–Bone Gaps in Clinical Audiometry: A Study of 1,000 Ears

Shai Chordekar, Liron Kariv, Nir Fink

Purpose: Accurate hearing loss classification depends on air–bone relationships; however, “false” air–bone gaps (ABGs) in sensorineural hearing loss (SNHL) frequently compromise diagnostic clarity. By shifting the focus from ABG magnitude to clinical prevalence, this study uses the prevalence of clinical ABGs (≥ 15 dB) as a primary metric to quantify diagnostic ambiguity in routine practice and to evaluate the efficacy of bone-conduction (BC) testing at frequencies where frequent false ABGs occur. Method: We retros …

03.09.2026journal-article

BMC Health Services Research

Improving kangaroo mother care in a rural Kenyan hospital: a multi-component implementation strategy to strengthen neonatal care delivery

John Strutner, Natalie Ash, Giles Hayden

Abstract Background Neonatal mortality remains a leading contributor to under-five mortality globally, particularly in low- and middle-income countries (LMICs). Kangaroo mother care (KMC) is an effective, low-cost intervention for improving outcomes among preterm and low birth weight infants; however, implementation remains inconsistent in resource-limited settings. Methods We conducted a quality improvement study at a rural Kenyan hospital using three sequential six-week cycles. Interventions addressed key barrier …

03.09.2026journal-article

PLOS Digital Health

Deep learning for blood glucose prediction: Reproducibility challenges and factors affecting differential performance

Baiying Lu, Biratal Wagle, Zhaohui Liang, Yanjun Cui, Temiloluwa Prioleau

Blood glucose prediction is a critical component of next-generation diabetes technologies, such as artificial pancreas systems, where reliable performance is essential for safety and effectiveness. Although deep learning methods have achieved promising advances in this area, a critical gap remains in understanding the reproducibility and generalizability of these methods. To contextualize the gap, this study reviewed 67 recent papers that proposed a deep learning method for glucose prediction to identify key reprod …

03.09.2026journal-article

Journal of Intensive Care Medicine

Pan Immune Inflammation Value in Identifying Sepsis High-Inflammatory and Immunosuppressive Phenotype

Xiao Zhu, Qing Lu, Xin Liu, Xianxiang Zeng

Background The Pan-Immune Inflammation Value (PIV) is a potential indicator of immune phenotypes in sepsis. Objective To explore the association between PIV and clinically defined high-inflammatory and immunosuppressive phenotypes in sepsis and to evaluate its potential predictive value. Methods Clinical data from 156 patients with sepsis were retrospectively analyzed. Patients were divided into high inflammatory (n = 82) and immunosuppressive (n = 74) groups based on their immune status. The clinical data and labo …

03.09.2026journal-article

Quality of Life Research

Capturing quality of life in pouch anal and vaginal fistula: development of PAVF-QoL-14, a patient-reported outcome measure

Lillian Reza, Laith Alrubaiy, Lara Bapir, Nusrat Iqbal, Charlene Sackitey, Easan Anand, Sally Hughes, Mina Babbar, Rali Marinova, Petya Marinova, Pearl Avery, Phillip Lung, Ailsa Hart, Sue Clark, Phil Tozer

Abstract Introduction Perianal pouch fistula can significantly affect quality of life, yet no disease-specific patient reported outcome measure (PROM) exists. We have developed and validated a 14-item PROM—the Pouch Anal and Vaginal Fistula Quality of Life scale (PAVF-QoL-14). Methods COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) guidance for PROM development was used to develop and validate PAVF-QoL-14. A systematic literature review and semi-structured patient interviews ( …

03.09.2026journal-article

Frontiers in Public Health

Drugs in the environment, viruses in the balance: a review of the untold nexus of pharmaceuticals and virology

Ahmed Abd Zaid, Allal Ouhtit

Objectives The pervasive contamination of aquatic and terrestrial ecosystems by active pharmaceutical ingredients (APIs) is a well-documented environmental challenge. However, the impact of this pollution on the most abundant biological entities on Earth viruses has remained a critical blind spot. This review provides the first integrated synthesis of the bidirectional nexus between pharmaceutical pollution and environmental virology. Methods A comprehensive literature search was conducted in PubMed, Web of Science …

03.09.2026journal-article

Frontiers in Public Health

A comparative evaluation of generative AI chatbots for patient-oriented advice on painful diabetic peripheral neuropathy: safety, accuracy, guideline concordance, actionability, and readability

Lina Gu, Zhaole Gong, Xiaoli Qian, Ling Miao, Zhengfeng Gu

Background Patients with painful diabetic peripheral neuropathy (PDPN) increasingly use generative artificial intelligence chatbots for information on symptoms, treatment, foot care, and when to seek professional help. Their usefulness depends on safety, accuracy, guideline concordance, actionability, and readability. Objective To compare five publicly accessible generative AI chatbots in answering standardized patient-oriented questions about PDPN. Methods: Sixty standardized English-language questions covering ei …

03.09.2026journal-article

Healthcare

Development and Validation of a Sitting-Balance Confidence Scale for Individuals with Spinal Cord Injury

J. P. Barfield, Jacqueline M. LaBarbera, Kelly Werts, Kaida Lou, Yinghao Pan

Background/Objectives: Participation in sport and daily activities among individuals with spinal cord injury (SCI) is influenced not only by physical capacity but also by psychological factors such as balance confidence. Existing measures primarily assess performance or fear of falling, leaving a gap in evaluating how perceived balance impacts activity choice. This study aimed to (1) develop a Patient-Reported Sitting Balance Confidence (PR-SBC) interview instrument to enable therapists to assess and evaluate non-a …

03.09.2026journal-article

Revista de Economía del Rosario

Mental Health Disability and Labor Market Participation

Clifton M. Chow, Jose Ordaz

This paper presents the first application of stochastic frontier regression and bivariate probit selection methods to estimate reservation wages for individuals with psychiatric disabilities. Using Employment Intervention Demonstration Program data (n = 1.648), we compare these methods among Supported Employment participants. The stochastic frontier approach yields an average reservation wage of $5.25 per hour, while bivariate probit produces $4.50 per hour. Reliability tests indicate that bivariate probit shows gr …

03.09.2026journal-article

Journal of Medical Internet Research

Digital Health Engagement Behaviors in US Family Caregivers: Trend Analysis Using the Health Information National Trends Survey 2019-2022 Data

Lena Lee, Elisa Son, Li Yang, Chantal Gerrard, Jenny Yarmovsky, Gwenyth Wallen

Abstract Background Digital health has provided caregivers with access to supportive resources without space-time restrictions. Caregivers’ digital health engagement behaviors can help them track their own health and that of care recipients as well as communicate with others. While digital health tools have become more prevalent since the COVID-19 pandemic, the trend in caregiver engagement has been less explored. Objective This study examined the trends and factors associated with selected digital health engagemen …

03.09.2026journal-article

Journal of Imaging Informatics in Medicine

Less Is More: Radiologists Prefer Brief Narratives in LLM-Generated Clinical History Summaries

Shawn Lyo, Satvik Tripathi, Ali Tejani, David Vu, Siddhant Dogra, Hamza Alizai, Tessa Cook

Abstract Clinical histories are essential for accurate radiologic interpretation but are often lengthy and time-consuming to review amid increasing radiologist workloads. Large language models (LLMs) offer a potential solution by generating concise, clinically focused summaries from existing documentation; however, the optimal presentation format for radiologists remains unclear. This retrospective reader study evaluated the readability, efficiency, and radiologist preference for a two-stage LLM-based summarization …

03.09.2026journal-article

Healthcare

The Role of Marital Satisfaction and Paternal Attachment in Relation to Depression During the Transition to Fatherhood: Evidence from Turkey

Emine Kurt Can, Veysel Can

Background: Fathers may experience psychological difficulties during the transition to parenthood, and depressive symptoms during the antenatal period may be associated with fathers’ well-being and adjustment to the paternal role. Marital satisfaction and paternal attachment may be important psychosocial factors associated with fathers’ mental health during this period. This study aimed to examine the relationships among marital satisfaction, paternal attachment, and depressive symptoms among expectant fathers. Met …

03.09.2026journal-article

Healthcare

Multisite Musculoskeletal Pain and Associated Psychosocial and Occupational Factors in Male Private Security Officers: A Cross-Sectional Study

Ömer Şevgin, Büşra Kesgin, Saniye Koyuncu, Aysu Güngör, Suzan Aydın

Background/Objectives: Private security work combines prolonged standing, extended schedules and shift demands, yet evidence on multisite musculoskeletal pain, burnout and sleep in this group is limited. In this exploratory cross-sectional study, we examined the 12-month prevalence and anatomical distribution of musculoskeletal pain and its associations with burnout, sleep and occupational characteristics. Methods: A total of 110 male private security officers in Ümraniye, Istanbul, Türkiye (110/127 approached; par …

03.09.2026journal-article

Phytotherapy Research

Catechins and Their Effect on the Gut Microbiome in Health and Cancer

Prakash Monika, Bindu Sadanandan, Honnamachanahalli Ramachandraiah Tejashree, Maitreyi Darbha, Kirti Gupta, Srinivas Reneeka

ABSTRACT Catechins are a group of flavonoids found primarily in green tea, fruits, and berries; they play a significant role in the modulation of the gut microbiota, thereby having an impact on gut health and cancer prevention. Owing to their low bioavailability, catechins are transformed by the gut microbiota into various bioactive metabolites such as valerolactones and glucuronides, which support the growth of several beneficial bacterial species including Bifidobacterium and Lactobacillus while inhibiting harmfu …

03.09.2026journal-article

Journal of Clinical Medicine

Reference Estimates of Mean Tear Film Lipid Layer Thickness Measured with LipiView® and LipiView II® in Healthy Adults: A Systematic Review and Meta-Analysis

Maria Sobol, Jacek Pniewski

Background/Objectives: Tear film lipid layer thickness (LLT) is an important parameter of ocular surface function and can be objectively measured using LipiView ocular surface interferometry. However, reference LLT estimates in clinically healthy populations remain inconsistent. This systematic review and meta-analysis aimed to estimate pooled reference LLT values and explore potential sources of variability. Methods: A systematic search of PubMed, Scopus, and Web of Science was performed according to PRISMA 2020 g …

03.09.2026journal-article

Indian Journal of Nuclear Medicine

A Resource-Efficient End-to-End Multimodal AI Framework for Automated PET-CT Report Generation and TNM Staging in Breast Cancer

Dibya Prakash, Venkatesh Rangarajan, Manoj Kumar

Objectives: Positron Emission Tomography-Computed Tomography (PET-CT) is integral to breast cancer staging. However, manual interpretation is time-consuming and subject to inter-observer variability. While artificial intelligence has shown promise in lesion detection and standardised uptake value (SUVmax) quantification, existing approaches are fragmented and do not generate complete TNM-aligned structured reports. Consequently, there remains a need for an integrated framework capable of translating PET-CT data int …

03.09.2026journal-article

Frontiers in Oncology

Factors associated with clinical research participation among Medicare beneficiaries with prostate cancer in the United States

Ryan A. Hankins, Alysha M. McGovern, Abimbola O. Williams, Virgil H. Simons, Sean P. Collins, Deepak Kumar

Introduction Clinical research participation among patients with prostate cancer remains limited, and demographic, clinical, and contextual factors may influence opportunities for participation. Although disparities in prostate cancer diagnosis and treatment are well documented, less is known about the factors associated with clinical research participation in this population. This study examined patient-level and contextual factors associated with clinical research participation among older Medicare beneficiaries …

03.09.2026journal-article

Borneo Nursing Journal (BNJ)

Hubungan Pola Asuh Ibu Dalam Pemberian Makan Terhadap Kejadian Picky Eating Anak Usia Pra Sekolah

Aninta Surgiyan Dini, Khoirun Nisa Alfitri, Silvi Lailatul Mahfida

Pola asuh ibu dalam menyajikan makan merupakan salah satu faktor penting yang berperan dalam membentuk perilaku makan anak sejak dini. Penerapan pola asuh yang tidak tepat diduga berkontribusi terhadap munculnya perilaku pilih-pilih makan pada anak usia dini, yang selanjutnya dapat menyebabkan gangguan tumbuh kembang anak. Tujuan dari penelitian ini adalah untuk mengetahui hubungan antara pola asuh ibu dalam memberikan makan dengan kejadian picky feeding anak usia dini. Penelitian ini merupakan penelitian kuantitat …

03.09.2026journal-article

EMBO Molecular Medicine

FFAR2 activation induces IL-22-dependent intestinal immune responses to suppress CNS autoimmunity

Bojan Jevtić, Milica Lazarević, Goran Stegnjaić, Suzana Stanisavljević, Ivan Pilipović, Neda Nikolovski, Zorana Milosavljević, Miljana Momčilović, Ivan Koprivica, Natalija Jonić, Dragica Mićanović, Nataša Radulović, Maša Marković, Ksenija Mirković, Danijela Mišić, Uroš Gašić, Filip Nikolić, Nikola Veselinović, Henrike Körner, Lukas Grimm, Dmitri Lodygin, Alexander Flügel, Graeme Fraser, Tamara Saksida, Mirjana Dimitrijević, Ivana Stojanović, Đorđe Miljković

Abstract Short-chain fatty acids (SCFA) protect against central nervous system (CNS) autoimmunity, but the receptor-mediated mechanisms underlying these effects remain poorly understood, limiting their therapeutic exploitation. Here, we show that selective oral activation of free fatty acid receptor 2 (FFAR2) with the synthetic agonist Cpd1 effectively ameliorates established experimental autoimmune encephalomyelitis (EAE), demonstrating therapeutic efficacy after the onset of the autoimmune response. Cpd1 treatmen …

03.09.2026journal-article

Violence Against Women

“ So Many Survivors I Know Regret Sharing Too Much Too Early ”: Human Trafficking Survivors’ Experiences With Public Storytelling

Chris Ash, Ethan Czuy Levine, Andrea Lorenz, Barbara G. Friedman

Survivor storytelling has been a critical component of anti-trafficking work for decades. However, people with lived experience of trafficking have experienced a range of harms through public storytelling engagements, including but not limited to gatekeeping, mental health impacts, tokenizing, and economic exploitation. Using a mixed methods survey with trafficking survivors in the United States and Kenya, this study explored motivations for public storytelling, prior experiences doing this work, and recommendation …

03.09.2026journal-article

INTERNATIONAL JOURNAL OF HEALTH AND PHARMACEUTICAL RESEARCH

Personality Traits, Social Support and Perinatal Depression Among Women Attending Tertiary Health Institutions in Makurdi, Nigeria

Agada Onmonya Abo

Perinatal depression is a significant public health concern affecting women during pregnancy and the postpartum period. This study examined personality traits, social support, and perinatal depression among women attending tertiary health institutions in Makurdi Local Government Area, Benue State, Nigeria. A cross-sectional survey design was adopted involving 396 perinatal women, 254 prenatal and 142 postpartum attending antenatal clinics and immunization units in selected health institutions (Federal Medical Cente …

03.09.2026journal-article

Journal of Advances in Medicine and Medical Research

Age-related BAX and Ki-67 Expression in Regional Lymph Nodes of Infants who Died from Measles: A Retrospective Immunohistochemical Study

Doniyor Saidovich Turdimatov

Background: Measles can produce substantial lymphoid tissue injury and immunosuppression, but age-related patterns of apoptotic and proliferative activity in regional lymph nodes during fatal measles in infancy remain insufficiently characterised. Aims: To evaluate age-related changes in BAX and Ki-67 immunohistochemical expression in regional lymph nodes of infants who died from measles. Study Design: A retrospective morphological and immunohistochemical study of archived autopsy specimens. Methodology: Regional l …

03.09.2026journal-article

Agriculture and Human Values

The diverse human/bird relationships in backyard bird keeping: implications for health and welfare

Niamh Mahon, Orla Shortall, Carol Kyle

Abstract In 2024 registration of all captive bird flocks became mandatory in Great Britain to improve disease surveillance at a time of increasing avian influenza outbreaks. However, little is known about how health and welfare practices are shaped by the diversity of relationships that characterise UK backyard birdkeeping. We use this moment of change to (1) examine the relationships between backyard keepers, their birds, and the poultry industry, and, (2) explore how registration legislation is responded to by ba …