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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
31.08.2026journal-article

BMC Health Services Research

Translation, cultural adaptation, and descriptive psychometric pilot evaluation of the Swedish Cancer Support Source-caregiver

Maria Samuelsson, Jenny Jakobsson, Benjamin Maus, Carl Magnus Olsson, Marie Louise Möllerberg

Abstract Objective This study aimed to translate the CancerSupportSource-Caregiver (CSS-C), culturally adapt it, and conduct a descriptive pilot evaluation of the psychometric properties of the Swedish version in a sample of Swedish family members of persons diagnosed with cancer. Method Translation and cultural adaptation involved forward-backward translation by professional translators in collaboration with the research team and assessments of comprehensibility and face and content validity by two expert panels c …

31.08.2026journal-article

Ophthalmologica Indonesiana

Characteristics of Conjunctival Melanocytic Tumor Patients in a Tertiary Hospital: A 4-Year Study

Fadhila Khairunnisa Poerwoko, Raja Erinda, Faiza Rizky A.S

Introduction: Conjunctival neoplasms includes melanocytic and nonmelanocytic tumors, and most are benign. Due to their rarity in the general population, it is important to consider the demographic, clinical signs, symptoms, and histopathological features to make the correct diagnosis. This study aims to describe the demographic, clinical, and histopathology of Conjunctival Melanocytic Tumors patients in a Tertiary Hospital. Methods: A retrospective study held from the medical record of patients with diagnosis conju …

31.08.2026journal-article

Biology

Combined Exendin-4 and Rituximab Treatment Improves β-Cell Function and Delays Disease Progression in NOD Mice

Yongbin Wang, Shan He, Huan Yang, Jie Zhang, Likun Yu, Jianjun Xiong, Xingnuan Li, Jiashuo Qiu, Baicheng Ma

Type 1 diabetes mellitus is characterized by immune-mediated pancreatic β-cell loss and progressive impairment of insulin production. This study evaluated the effects of combined rituximab, a B-cell-directed therapy, and exendin-4, a glucagon-like peptide-1 receptor agonist, on β-cell-related function and metabolic outcomes in experimental type 1 diabetes. Pancreatic islets isolated from NOD-scid mice were used for in vitro assessment of viability, metabolic activity, insulin secretion under high-glucose conditions …

31.08.2026journal-article

Journal of Natural Remedies

System Pharmacology Profiling of Plumbago zeylanica Linn. Against HPV-Associated Cervical Cancer

Peraira Jackulin Josephraj, S. Divyashri, Balram Mishra, Prabhavati Umakant Kalu, Ajit Lingayat, Giridhar Vedantam

Background: Cervical cancer remains a significant contributor to cancer-related deaths in women globally, with persistent infection by high-risk Human Papillomavirus (HPV) identified as its principal etiological driver. Aim: This study explored the mechanistic basis of Plumbago zeylanica’s potential anti-cervical cancer activity through a combined network pharmacology and molecular docking framework targeting HPV-associated pathogenic processes. Methods: Bioactive phytoconstituents of P. zeylanica were systematical …

31.08.2026journal-article

HSS Journal®: The Musculoskeletal Journal of Hospital for Special Surgery

CT-Detected Intravertebral Cleft Predicts Radiographic Collapse Progression After Body-Cast Treatment of Acute Osteoporotic Vertebral Fractures

Yugo Morita, Kazushi Otsuka, Shigeo Yoshida, Kohei Nishitani

Background: Progressive radiographic collapse after osteoporotic vertebral fractures (OVFs) may lead to kyphotic deformity. Predictors remain inconsistent, partly because prior studies used heterogeneous conservative treatment protocols that may alter collapse risk. Questions/Purposes: We asked (1) how much vertebral compression progressed after a standardized body-cast protocol, (2) which factors were associated with progression, and (3) whether computed tomography (CT)-detected intravertebral cleft (IVC) independ …

31.08.2026journal-article

The Journal of Hand Surgery (Asian-Pacific Volume)

Outcomes of Nonsurgical Treatment of Ulnar-Sided Wrist Pain

Hui-Yin TEH, Liying PANG, Un-San TAI, David Meng Kiat TAN, Ellen Y. LEE

Background: Ulnar-sided wrist pain (USWP) is a frequent complaint, and triangular fibrocartilage complex (TFCC) injuries are amongst its most common aetiologies. Nonsurgical management of USWP is heterogeneous with variable periods of immobilisation. This study describes the outcome of a structured multiphase, conservative program for USWP that was clinically diagnosed as TFCC injuries in a single centre. Methods: Thirty-two individuals with USWP, foveal tenderness ± distal radio-ulnar joint (DRUJ) laxity diagnosed …

31.08.2026journal-article

ACS Applied Materials & Interfaces

Enrichment Performance Assessment of Extracellular Vesicles Using Different Functionalized Magnetic Materials and Application in Urinary Proteomics of Prostate Cancer

Jiayu Xu, Shenyue Zhou, Wen Wu, Yuxing Wen, Yingying Tang, Lili Miao, Yuanyuan Yu, Wanjun Zhang, Zhengyao You, Mengxi Chen, Xiaowei Li, Shoujun Zhou, Weipeng Wang, Haiyang Zhang

Abstract Extracellular vesicles (EVs) are lipid bilayer nanovesicles that mediate intercellular communication and hold significant potential for clinical applications. Although material-based isolation strategies offer promising alternatives to conventional methods, their relative performances have not been systematically evaluated. In this study, we conducted a comparative assessment of magnetic nanomaterials with distinct surface functionalities, including metal oxides (TiO2), metal–organic frameworks (UiO-66), b …

31.08.2026journal-article

Discoveries in Agriculture and Food Sciences

Phenological and Morphological Characterization of Watermelon (Citrullus lanatus L.) Subjected to Spiritual Blessing/Biofield Energy Treatment (SBET)

Dahryn Trivedi, Tejas Bapu Gaikwad, Nikhil Rajendra Phutankar, Vivek Dattaram Kadam, Sambhu Mondal, Snehasis Jana

Watermelon (Citrullus lanatus L.) is a high-value horticultural crop whose yield and quality are heavily dictated by phenological progression and vegetative vigor. Sustainable biostimulatory interventions, such as Spiritual Biofield Energy Treatment (SBET) have emerged as promising non-chemical strategies to modulate plant physiology and developmental dynamics. This study evaluated the effects of SBET on the morphological traits and fruit development parameters of C. lanatus under controlled field conditions. The c …

31.08.2026journal-article

Frontiers in Artificial Intelligence

Supervised vs. adversarially pre-trained pseudo-label generators for semi-supervised breast cancer patch classification

Tomiris Zhaksylyk, Aruzhan Imasheva, Beibit Abdikenov, Birzhan Ayanbayev

Automated breast cancer classification from whole-slide images (WSIs) is hampered by the scarcity of expert-annotated patches and the domain variability inherent to multi-institutional datasets. We propose and compare two semi-supervised frameworks for patch-level tumor classification under limited annotation. The first, a semi-supervised baseline , trains a supervised model on the available labeled data, uses it to generate confidence-filtered pseudo-labels for the unlabeled corpus, and trains a separate classifie …

31.08.2026journal-article

Cancer Drug Resistance

Bracing for the storm: emerging resistance mechanisms to KRAS inhibitors in pancreatic cancer and strategies to overcome them

Marco Pagano Mariano, Enrica Sgarilli, Dirk Mijnlieff, Bonifiya Visuvasam, Andrea Blesio, Graziana Digiacomo, Andrea Cavazzoni, Manuela Ferracin, Elisa Giovannetti

Oncogenic KRAS mutations are a defining feature of pancreatic ductal adenocarcinoma (PDAC), one of the most lethal solid malignancies, characterized by poor responsiveness to conventional chemotherapy. Recent clinical successes of direct KRAS inhibitors in other cancer types have renewed interest in KRAS-directed therapy for PDAC. However, early clinical experience has revealed often short-lived responses, highlighting the rapid emergence of resistance and the need to better understand the mechanisms limiting durab …

31.08.2026journal-article

International Journal of Cancer

Family History of Cancer and Risks of Concordant and Discordant Cancers: A Nationwide Cohort Study of Korean Women

Junghyun Yoon, Somin Jeon, Boyoung Park

ABSTRACT Evidence on discordant familial cancer associations and their relevance in non‐Western populations remains limited. This study assessed concordant and discordant cancer risks across major cancer sites in Korean women by comparing individuals with and without a family history of cancer. In total, 5,015,485 cancer‐free women aged ≥ 40 years who participated in the national breast cancer screening program were included. Participants reported a family history of stomach, colorectal, liver, breast, cervical, or …

31.08.2026journal-article

Biomechanics and Modeling in Mechanobiology

Dynamic image-informed selection of biomechanical tumor growth models

Abdullah Al Noman, Pratyush Kumar Singh, David A. Hormuth, Danial Faghihi

Abstract Glioblastoma progression is strongly influenced by evolving mechanical interactions between the tumor and surrounding brain tissue. However, the extent to which finite-deformation mechanics and constitutive assumptions improve subject-specific prediction as tumor burden evolves remains unclear. We introduce a sequential Bayesian inference and dynamic model selection framework that assimilates longitudinal murine magnetic resonance imaging (MRI) data to calibrate spatially varying tumor diffusivity, prolife …

31.08.2026journal-article

International Journal of Medical and Biomedical Studies

Conservative Treatment Versus Herbert Screw Fixation for Acute Zone-II (Jones) Fractures of the Fifth Metatarsal: Prospective Comparative Study

Prakhyath Mahadev Gowda, Jeetkumar V. Kapapura, Vikas Mishra, Harish D Nyamati

Background: Acute Zone-II fractures of the proximal fifth metatarsal (Jones fractures) occur at a region with relatively limited vascularity and are associated with delayed union, non-union and prolonged functional recovery. Conservative immobilization remains an accepted option in selected patients, whereas intramedullary fixation is often preferred when early stability and mobilization are important. Headless compression implants, including the Herbert screw, provide interfragmentary compression without a promine …

31.08.2026journal-article

Open Forum Infectious Diseases

Efficacy and Safety of Pritelivir Versus Foscarnet for the Treatment of Acyclovir-Refractory Herpes Simplex Virus Infection in Immunocompromised Adults: A Randomized, Open-Label Phase 2 Trial

Camille N Kotton, Kimberly A Workowski, Princy N Kumar, Robin K Avery, Roy F Chemaly, Nicolas C Issa, Moti Ramgopal, Joshua T Schiffer, Joerg Albrecht, Hollis R O’Neal Jr, Pranatharthi Chandrasekar, Tanya S Schreibman, Mayur Ramesh, Michael G Ison, Melanie E Sumner, Aaron Dane, Bernadette Surujbally, Burkhard Timmler, Manickam Rangaraju, Genofeva A Papanicolaou, Alexander Birkmann, Anna Wald

Abstract Background Immunocompromised patients are at risk for severe, prolonged herpes simplex virus (HSV) recurrences. Refractory disease and intolerance to standard therapy drive an unmet medical need. Pritelivir, a novel HSV helicase-primase inhibitor, has shown favorable tolerability and efficacy in immunocompetent adults. Methods PRIOH-1, a multicenter, randomized, open-label Phase 2 trial compared oral pritelivir (400 mg loading dose followed by 100 mg daily) versus intravenous foscarnet (40 mg/kg q8h or 60 …

31.08.2026journal-article

Nephrology Dialysis Transplantation

Sex in CKD trials: representation and treatment effects of cardiorenoprotective therapies

Ioannis Bellos, Maria Athanasiou, Konstantina S Nikita, Vassiliki Benetou

Abstract Background Women comprise a substantial proportion of the chronic kidney disease (CKD) population and differ from men in disease phenotype, progression, and treatment exposure. Underrepresentation of women and limited sex-specific reporting may therefore reduce the generalizability of evidence from contemporary CKD trials. Methods We conducted a meta-epidemiological study of randomized trials evaluating sodium-glucose cotransporter-2 inhibitors, glucagon-like peptide-1 receptor agonists, and non-steroidal …

31.08.2026journal-article

Brain Sciences

Omega-3 Polyunsaturated Fatty Acids as Adjunctive Therapy to Antipsychotic Treatment in Adults with Schizophrenia: A Systematic Review and Meta-Analysis

Aura Patricia Yepes Sarmiento, Thayra Gomez, Kimberly Barrios, Hernan F. Guillen-Burgos

Background/Objectives: Schizophrenia causes substantial disability and reduced life expectancy, while symptoms frequently persist despite antipsychotic treatment. Long-chain n-3 polyunsaturated fatty acids (n-3 PUFAs) have been proposed as adjunctive therapy because of their anti-inflammatory and neurobiological properties. This systematic review and exploratory meta-analysis evaluated the efficacy and safety of adjunctive n-3 PUFAs in adults with schizophrenia. Methods: The review followed PRISMA 2020 and was pros …

31.08.2026journal-article

International Journal for Research in Applied Science and Engineering Technology

Early Prediction of Breast Cancer Using a Multilayer Neural Network with Adam Optimization

K. Tulasi Krishna Kumar, Pasupuleti Monica Martin

Breast cancer remains one of the most prevalent malignancies among women worldwide and a major public-health concern, with prognosis and survival strongly dependent on the stage at which the disease is detected. This paper presents a deep-learning-based decision-support model for the early prediction of breast cancer using a multilayer feed-forward neural network trained with the backpropagation algorithm. The proposed architecture consists of an input layer, three hidden layers, and a sigmoid output layer, optimiz …

31.08.2026journal-article

Pakistan Armed Forces Medical Journal

Comparative Efficacy of topical 5% Potassium Hydroxide and Liquid Nitrogen in the Treatment of Plane Warts

Sana Aslam, Bushra Muzaffar, Muhammad Adeel Siddiqui, Majid Hussain, Zahra Nigar, Sara Ilyas

Objective: To study the efficacy while comparing Potassium Hydroxide 5% with Liquid Nitrogen in treatment of plane warts. Study Design: Randomized-controlled trial (ClinicalTrials.gov: NCT05895071) Place and Duration of Study: Department of Dermatology, CMH-Abbottabad Pakistan, from Nov 2022 to April 2023. Methodology: The sample size of 60 patients (aged 4 to 30 years was randomly assigned into two Groups i.e. from 60 patients, in Group-A 30 were advised topical 5%-Potassium Hydroxide solution on affected area onc …

31.08.2026journal-article

Scientific Reports

An adaptive hierarchical class-aware deep ensemble strategy for robust brain tumor classification

Motea Alsamawi, Fatima Ali Amer Jid Almahri, Waled Hussein Al-Arashi, Mohammed M. Alkhawlani, Noman Qaid Al Naggar

Abstract Automated magnetic resonance imaging (MRI) classification can support differentiation of brain tumor categories, but conventional ensembles often depend on opaque probability fusion. This study proposes a validation-driven adaptive hierarchical class-aware ensemble that treats VGG19 and Darknet53 as complementary experts. A balanced working set of 7,200 images representing glioma, meningioma, no tumor, and pituitary classes was stratified into training (70%), validation (15%), and independent test (15%) pa …

31.08.2026journal-article

Frontiers in Oncology

Expression of nectin-4 in squamous cell carcinoma of prostate: a pilot study and case report

Xizhen Zhao, Fang Yu, Rui Zhou, Jiantao Xiao, Jianjun Fang, Tao Liu, Zhonghua Yang

Background Squamous cell carcinoma of the prostate (SCCP) is a rare subtype of prostate cancer with a poor prognosis, and no consensus exists regarding the treatment of SCCP. Nectin-4, a cell adhesion molecule predominantly expressed in a wide variety of cancers, emerged as a promising therapeutic target due to its over expression. Case presentation A 69-year-old male patient received transurethral resection of the prostate for lower urinary tract symptoms (LUTS) and was diagnosed with prostatic acinar adenocarcino …

31.08.2026journal-article

Cell Death & Disease

Hypoxia drives ERO1A-dependent angiogenesis in ovarian cancer cells promotes peritoneal metastasis and platinum resistance

Siyang Zhang, Yutong Liu, Xinyi Wang, Shimin Zhang, Linru Quan, Jiarui Wang, Yuli Zhang, Jixin Li, Shuangyan Liu, Xinyue Li, Meiyao Li, Tianhao Wu, Qing Liu, Xin Zhou

Abstract High-grade serous ovarian cancer (HGSOC) is characterized by early peritoneal dissemination and frequent platinum resistance, yet the epithelial states and mechanisms that couple metastasis, angiogenesis, and therapy response remain incompletely defined. We integrated in-house single-cell RNA sequencing of 82,149 cells from 21 treatment-naïve HGSOC specimens with external spatial transcriptomic and single-cell datasets to identify metastasis-associated epithelial programs. A hypoxia-enriched epithelial sub …

31.08.2026journal-article

Frontiers in Public Health

Digital tools to enhance adherence to cervical cancer prevention practices: systematic review

Ayagyoz Umbetzhanova, Adina Kusniyeva, Gulmira Derbissalina, Almabayeva Aigul, Çigdem Çaglayan, Gulnur Tanbayeva, Vitaliy Koikov, Naila Toktarova, Zhanagul Bekbergenova

Background Human papillomavirus (HPV) vaccination and regular cervical screening are fundamental pillars of the World Health Organization (WHO) strategy to eliminate cervical cancer. While conventional one-way digital notifications moderately support preventive uptake, the specific behavioral impact of two-way, interactive patient-facing digital assistants-such as conversational artificial intelligence (AI) and gamified health applications-warrants rigorous, isolated synthesis. Objective To systematically assess wh …

31.08.2026journal-article

Thoracic Cancer

Central Nervous System Activity of Lazertinib in EGFR ‐Mutated NSCLC With Prior EGFR TKI Exposure: A Pooled Analysis of KCSG‐LU20‐15 and LU21‐01

Dong Hyun Kim, Min Hee Hong, Hyun Ae Jung, Tae Min Kim, Chang Gon Kim, Hee Kyung Ahn, Youngjoo Lee, Yu Jung Kim, Miso Kim, Jeonghwan Youk, Jong‐Mu Sun, Se‐Hoon Lee, Jin Seok Ahn, Dong‐Wan Kim, Myung‐Ju Ahn, Yoon Ji Choi, Sun Min Lim, Jin Hyoung Kang, Bhumsuk Keam, Hye Ryun Kim

ABSTRACT Background Central nervous system (CNS) involvement remains a major cause of mortality in patients with epidermal growth factor receptor (EGFR)‐mutated nonsmall cell lung cancer (NSCLC), particularly, after progression on EGFR tyrosine kinase inhibitors (TKIs). This pooled analysis evaluated the efficacy of lazertinib in patients with EGFR ‐mutated NSCLC and CNS involvement, using data from two Phase II trials. Patients and Methods Patients with EGFR ‐mutated NSCLC and CNS involvement following prior EGFR …

31.08.2026journal-article

Journal of Pediatric Orthopaedics B

Clinical outcomes after surgical treatment of open thigh muscular tears in skeletally immature patients

Marco Turati, Angelo Mosca, Marco Crippa, Stéphane Tercier, Giulio Leone, Nicolas Nicolaou, Nicolas Bremond, Barbara Kwiatkowski, Aurelien Courvoisier, Marco Bigoni

Open thigh muscle lacerations in skeletally immature patients are rare, and evidence on optimal management and outcomes is limited. Among sports, skiing represents a frequent mechanism of injury due to sharp ski edges, yet data on pediatric cases remain scarce. We aimed to describe injury patterns, surgical management, and recovery of pediatric patients with open quadriceps tears. In a retrospective two-center cohort, we included skeletally immature patients with open thigh muscular lacerations treated surgically. …