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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

Journal of Alzheimer’s Disease

Memory, social cognition, and beyond: Neuropsychological markers differentiating Alzheimer's disease and frontotemporal dementia

Jana Marie Freitag, Franz Felix Konen, Johannes Heck, Kirsten Jahn, Stefanie Groba, Martin Klietz, Thomas Skripuletz, Florian Wegner, Martin Schulze Westhoff, Sebastian Schröder

Background Distinguishing Alzheimer's disease (AD) from frontotemporal dementia (FTD) remains a major clinical challenge, particularly in early disease stages due to overlapping symptoms. Although neuropsychological assessment is central to diagnosis, brief cognitive screening instruments often emphasize episodic memory, whereas comprehensive neuropsychological assessment encompasses multiple cognitive domains. Nevertheless, social cognition and other relevant functions may remain underrepresented in routine clinic …

02.09.2026journal-article

Canadian Geriatrics Journal

Erratum: Association Between the Japanese Version of Montreal Cognitive Assessment Tasks and Driving as the Primary Mode of Transport Among Community-Dwelling Older Adults

Yuya Nakajima, Hidenori Onishi, Yasutaka Mizukami, Tomoko Okamoto, Taisei Inoue, Akemi Koujimoto, Naohiro Konoshita, Tokuharu Tanaka, Akiko Matsunaga, Masafumi Kubota, Masamichi Ikawa, Hideaki Hori, Yasutaka Kobayashi, Hiroyuki Hayashi, Osamu Yamamura

Description of error:Following publication of this article, an error was identified on page 89. During production, an author proofreading correction was inadvertently omitted from the final published version. The published text stated: "The MoCA-J identifies MCI in participants with a score of 26 points or more, whereas 25 points or less indicates a normal cognitive range (sensitivity, 93%; specificity, 87%)." The text should have read: "The MoCA-J identifies MCI in participants with a score of 25 points or less, w …

02.09.2026journal-article

Frontiers in Pain Research

Understanding risk and protective factors for pain and healthy aging: an intersectional and resilience-based perspective

Joanna M. Hobson, Indonesia A. Jordan, Shinye Kim, Taylor L. Taylor

Chronic pain (CP) is a major public health concern in the United States, with healthcare costs exceeding $700 billion. Beyond its’ economic burden, CP imposes significant physical, emotional, and functional strain, particularly among populations that are disproportionately affected by pain (i.e., older adults, people with HIV, racial and gender minorities). Despite growing trends in pain research, there remains no consensus on optimal pain management or the mechanisms underlying pain exacerbation. Therefore, this r …

02.09.2026journal-article

Pharmaceuticals

Early Neuroprotective Effects of Erucic Acid and Gentisic Acid on Hippocampal Glutamate Concentrations and Alzheimer-like Molecular Alterations in an Intracerebroventricular Streptozotocin Rat Model

İbrahim Gecili, Muhammed Sait Ertuğrul, Irmak Ferah Okkay, Onur Şenol, Ufuk Okkay, Mustafa Özkaraca, Ziadoon Al-Yaqoobi, Cemil Bayram, A. M. Abd El-Aty, Ali Taghizadehghalehjoughi, Ahmet Hacımüftüoğlu

Background: Alterations in glutamatergic homeostasis have been implicated in Alzheimer’s disease, but the relationship between total hippocampal tissue glutamate and Alzheimer-like molecular alterations remains unclear. This study evaluated the early neuroprotective potential of gentisic acid (GA) and erucic acid (EA) in an intracerebroventricular streptozotocin (icv-STZ)-induced rat model of sporadic Alzheimer-like pathology. Methods: Sixty-four female Sprague–Dawley rats were randomly assigned to eight groups: co …

02.09.2026journal-article

Aging Clinical and Experimental Research

Screening of sarcopenia in long-term care facilities using wireless surface electromyography and deep transfer learning: a proof-of-concept study

Andrea Manni, Giacomo Scotti, Gabriele Rescio, Andrea Caroppo, Giulia Pasolini, Alessia Ghidini, Eleonora Macchia, Zaira Romeo, Alvise Bobbo, Marianna Noale, Stefania Maggi, Alessandro Leone, Alessandro Morandi, for the I-COUNT study group

Abstract Background Sarcopenia is prevalent in long-term care facilities (LTCFs) and is associated with falls, functional decline, and mortality. Aims This proof-of-concept study, within the I-COUNT pilot randomized controlled trial, evaluated the feasibility and diagnostic performance of a non-invasive sarcopenia screening approach based on wearable surface electromyography (sEMG) combined with artificial intelligence. Results Eighteen older adults residing in two Italian LTCFs (6 sarcopenic, 12 controls; 33.3% me …

02.09.2026journal-article

AGING MEDICINE

Expert Consensus on the Management of Obesity in Older Adults (2026 Edition)

Qi Pan, Lixin Guo

ABSTRACT Obesity in older adults has become a prominent public health issue. Owing to age‐related physiological changes and multimorbidity, obesity in this population is associated with complex clinical manifestations and markedly increased difficulty in management. Based on this, a multidisciplinary panel of obesity experts from Beijing Hospital, National Center for Gerontology, formulated this consensus after rigorous evaluation and iterative revision. The consensus emphasizes that management of obesity in older …

02.09.2026journal-article

International Ophthalmology

Glaucoma spectrum findings among the Yanomami Indigenous people of the Brazilian Amazon

Maria Christina Chagas Ferreira, Marcos Antonio Pellegrini, Bianca Jorge Sequeira, Louise Christina Gonçalves Vasconce Siqueira, Hevila Rolim

Abstract Purpose This study provides the first systematic characterisation of IOP, optic disc C/D ratio, and fundoscopic findings in the Yanomami, one of the largest and most geographically isolated Indigenous peoples of the Amazon, and identifies findings suggestive of glaucoma. Methods Cross-sectional observational study conducted June–August 2024 at the Yanomami Indigenous Health House (CASAI-Y), Boa Vista, Brazil. One hundred fifty-eight self-identified Yanomami individuals aged ≥ 5 years were examined. Non-con …

02.09.2026journal-article

Current Opinion in HIV and AIDS

Reframing obesity in aging people with HIV: sarcopenic obesity, muscle quality, and frailty

Vitor H.F. Oliveira, Todd T. Brown, Kristine M. Erlandson

Purpose of review As people with HIV (PWH) age, obesity is increasingly prevalent, yet body weight alone inadequately captures the functional and metabolic consequences of adverse body composition remodeling. This review examines emerging evidence supporting a shift from weight-centric approaches toward a framework centered on sarcopenic obesity, muscle quality, and frailty in aging PWH. Recent findings Weight gain in the contemporary antiretroviral therapy era often reflects increased visceral and ectopic adiposit …

02.09.2026journal-article

Biomedicines

Gut Microbiota and Brain Aging: Identifying Keystone Biomarkers for Cognitive Health

Muskan Bhatia, Sidharth P. Mishra, Raghvendra K. Mishra, Shalini Jain, Hariom Yadav, Rajesh S. Tomar

The fact that the population is getting older has greatly increased the occurrence of cognitive decline and neurodegenerative diseases, underlining the importance of having reliable biomarkers that can measure biological aging before irreversible neurological damage takes place. New evidence shows that brain aging is not just the result of changes within neurons themselves but is also greatly affected by the gut microbiota via immune, metabolic, endocrine, and neurovascular signaling. This review brings together th …

02.09.2026journal-article

BMC Geriatrics

Handgrip strength and/or Timed Up and Go Test are associated with functional independence and psychological well-being in older women

Ziyi Zhong, Reijo Sund, Heli Koivumaa-Honkanen, Konstantinos Prokopidis, Yang Chen, Manlin Zhao, Vanja Pekovic-Vaughan, Arja T. Lyytinen, Heikki Kröger, Parisa Jan Mohammadi, Toni Rikkonen, Masoud Isanejad

Abstract Background Handgrip strength (HGS) and Timed Up and Go (TUG) tests are established measures of physical capacity and widely utilized in geriatric assessments. We aimed to assess their independent and combined association with activity of daily living (ADL) and psychological life satisfaction (LS). Methods Data were analysed from 684 community-dwelling aging women (mean age 81.2 years [SD 2.5]) in the 30-year follow-up (2019) of the Kuopio Osteoporosis Risk Factor and Prevention Study (OSTPRE). Relationship …

02.09.2026journal-article

Animals

Effects of Aging on Muscle Development Based on Transcriptome Sequencing in Dahen Broilers

Jiang-Xian Wang, Mo-Han Qiu, Zeng-Rong Zhang, Shi-Liang Zhu, Xia Xiong, Chen-Ming Hu, Li Yang, Han Peng, Xiao-Yan Song, Jia-Lei Chen, Bo Xia, Long-Huan Du, Jia-Yi Zhao, Yue-Ying Zhang, Jia-Lu Li, Chun-Lin Yu, Chao-Wu Yang

Skeletal muscle growth and development represent a pivotal biological process that determines both the yield and quality of poultry meat. As chickens age, there is an observable shift in their muscle structure, function and metabolic properties. However, the molecular mechanisms by which age regulates chicken muscle development and meat quality formation are not yet fully understood. The objective of this study was to elucidate the fundamental molecular mechanisms through which the aging process influences the deve …

02.09.2026journal-article

Communications Health

Population-based cohort study of modifiable risk factors for dementia and Alzheimer disease mortality in Spain

Julián Benito-León, José Ignacio Serrano, María Dolores del Castillo, Álex Escolà-Gascón, Carla María Benito-Rodríguez, Cristina Ramo-Tello, Ritwik Ghosh, Félix Bermejo-Pareja

Abstract Background Although many modifiable factors are linked to dementia risk, their association with dementia and Alzheimer disease (AD) mortality remains unclear. We aimed to identify late-life modifiable factors associated with these outcomes and assess sex differences. Methods In the population-based Neurological Disorders in Central Spain (NEDICES) cohort, we followed 3085 older adults enrolled in 1994–1995 through 2017. We examined 13 modifiable factors measured at study entry. Dementia and AD deaths were …

02.09.2026journal-article

PLOS One

Social isolation and intrinsic capacity among older Hispanic adults in the United States: Exploring associations across geographic and social contexts

Cai Xu, Juehyun Shin, Graciela Muniz-Terrera

Objectives We examined the association between social isolation (SI) and intrinsic capacity (IC) among older Hispanic adults in the United States and explored patterns of association across geographic and social subgroups. Methods Using 2022 Health and Retirement Study data, we analyzed 615 Hispanic adults aged ≥60 years. IC (0–10) was derived from five domains, and SI (0–4) was measured using a composite index. Survey-weighted linear regression models were used to estimate the overall association between SI and IC …

02.09.2026journal-article

Journal of the American Geriatrics Society

Direct‐To‐Home Tele‐Neuropsychological Assessment in Older Adults: A Systematic Review

James M. King, Dana Pourzinal, Emily McCann, Alexandra Hawes, Elton H. Lobo, Deborah Brooks, Leander K. Mitchell, Nadeeka N. Dissanayaka

ABSTRACT Background Neuropsychological assessment via remote videoconference and telephone administration in the home setting (i.e., direct‐to‐home tele‐neuropsychological assessment) could increase service provision to older adults. However, current evidence has not yet been synthesized to guide use. Objective A systematic review was conducted to summarize and evaluate available data on (1) the feasibility and acceptability of direct‐to‐home tele‐neuropsychological assessment in older adults; and (2) the reliabili …

02.09.2026journal-article

Biomedicines

Aging Biology of Bone-to-Tendon Healing and the Epigenetic Clock: A Biological-Age Readout of Rotator Cuff Healing Capacity

Jong Pil Yoon, Sung-Jin Park, Dong-Hyun Kim, Chul-Hyun Cho, Yuki Yoshida, Hailey Nam, Seok Won Chung

The “unexplained failure” of rotator cuff repair is multifactorial, but its structural endpoint is anatomically consistent, i.e., the failure of the tendon-to-bone interface (enthesis) to heal. The native enthesis is a four-zone fibrocartilaginous gradient that does not regenerate but heals as a mechanically inferior fibrovascular scar, so the outcome of repair hinges on the interface’s healing capacity—which chronological age predicts poorly. This review organizes the aging biology governing bone-to-tendon healing …

02.09.2026journal-article

Journal of Alzheimer’s Disease

A dual-branch time–frequency fusion network for EEG-based classification of Alzheimer's disease and frontotemporal dementia

Xiaoli Yang, Xiao Li, Chenchen Wang, Angchao Duan, Jiayi Zhou, Jiawen Wang, Ziyan Jiang, Mengjie Li

Background Alzheimer's disease (AD) and frontotemporal dementia (FTD) exhibit substantial overlap in clinical manifestations and patterns of brain functional degeneration, which poses significant challenges for automated classification based on electroencephalography (EEG). Objective This study aims to develop an EEG-based framework capable of simultaneously capturing temporal dynamics and frequency-related characteristics of EEG signals for discrimination among AD, FTD, and cognitively normal (CN) subjects. Method …

02.09.2026journal-article

The International Journal of Aging and Human Development

Searching for Answers: Health Literacy and Digital Navigation in Midlife and Older Adults

Matteya A. Proctor, Carolyn R. Pagán, Samina Rahman, Maureen Schmitter-Edgecombe

As digital, internet-based health communication becomes more common, understanding the factors influencing midlife and older adults’ ability to navigate online resources is essential. This study investigated whether health literacy interacts with communication format to affect health search performance. Seventy-eight community-dwelling midlife and older adults classified as having high or low health literacy using the Newest Vital Sign completed a counterbalanced print- and internet-based health search task. A 2 × …

02.09.2026journal-article

Canadian Geriatrics Journal

Fall Risk Identification with Innovative Technologies for Aging in Place: A Clinical Needs Assessment Study

Titilola Yakubu, Nooshin Jafari, Michael Lim, Jamie Lam, Michelle Lin, Di Jiang, Kendall Ho

Background Falls are a leading cause of injury and loss of independence among older adults. While gait-monitoring technologies offer promise for early fall risk detection, adoption is hindered by usability, cost, and integration challenges. Few studies incorporate perspectives from both patients and providers to inform user-centred design. Objective To identify barriers, facilitators, and design considerations for implementing gait-monitoring and fall-assessment technologies among older adults, caregivers, and heal …

02.09.2026journal-article

Frontiers in Immunology

Platelet factor 4 in cognitive, immune and hematopoietic aging: emerging evidence and translational challenges

Yingying Guo, Zihua Liu, Weiwei Lu, Hao Zhuo, Zhicheng Wang, Xiaoning Wang

Platelet Factor 4 (PF4) is a CXC chemokine abundantly sequestered within platelet α-granules. Its modulatory roles in age-related dysfunction across cognitive, immune, and hematopoietic systems have garnered increasing research attention in recent years. PF4 modulates an array of biological pathways associated with the attenuation of aging-related cellular defects; these pathways are activated by physical activity, young plasma exposure, and Klotho-related signaling cascades. Mechanistically, PF4 engages CXCR3 and …

02.09.2026journal-article

npj Dementia

Sleep and stress as modifiable drivers of Alzheimer’s disease

Darcy Wear, S. Abid Hussaini, Wai Haung Yu

Abstract Proper sleep and stress maintenance are essential for health and may contribute to disease progression when dysregulated. This review highlights the intricate links between sleep, stress, and Alzheimer’s disease, including underlying neural circuitry and mechanisms that contribute to disease. Sleep is essential for protein clearance pathways including autophagy and the glymphatic system, which are impaired in neurodegenerative diseases. Similarly, chronic stress incites neuroinflammatory responses known to …

02.09.2026journal-article

Perspectives of the ASHA Special Interest Groups

Reconsidering the Clinical Fellowship: Lessons From the 2025 Centers for Medicare & Medicaid Services Clarification for Speech-Language Pathology Services to Older Adults

Amber Heape

The 2025 Centers for Medicare & Medicaid Services (CMS) clarification, which initially excluded clinical fellows (CFs) from the definition of a qualified speech-language pathologist, revealed broader issues in how the clinical fellowship aligns with contemporary licensure and health care systems. Although CMS later clarified that provisionally licensed CFs could bill under state law, the rapid shift in guidance resulted in uncertainty, hiring delays, and care disruptions for older adults in Medicare-funded settings …

02.09.2026journal-article

npj Dementia

Sex differences in dementia with Lewy bodies: a systematic review

Heidi Isaksen, Karina Fuglestein Bru, Alexey Shadrin, Per Selnes, Ole A. Andreassen, Arvid Rongve, Jodi Maple Grødem

Abstract Sex differences are increasingly recognized across neurodegenerative disorders, including Dementia with Lewy Bodies (DLB). Despite ongoing refinement of diagnostic criteria, DLB remains frequently misdiagnosed—particularly among females—reflecting gaps in our understanding of sex-specific disease presentation. Thus, there is a need to understand how clinical features, symptom patterns, and biomarkers manifest differently in female versus male patients with DLB. This review aims to synthesize current eviden …

02.09.2026journal-article

AGING MEDICINE

Association Between Hair Cortisol, Sarcopenia, and Sarcopenic Obesity: Results From the ELSA ‐Brasil Study

Christiano Barbosa da Silva, Isiyara Taverna Pimenta, Rosane Harter Griep, Arlinda Barbosa Moreno, Isabela Judith Martins Bensenor, Sandhi Maria Barreto, Maria Inês Schmidt, Anissa Daliry, Maria de Jesus Mendes da Fonseca

ABSTRACT Objectives Hair cortisol has been increasingly used as an important biomarker of chronic stress, as it reflects prolonged systemic exposure to cortisol over time. Such exposure has been associated with alterations in body composition; however, the associations with sarcopenia and sarcopenic obesity have still received little attention in the scientific literature on aging. The study aimed to assess the association between hair cortisol, dynapenia, sarcopenia, and sarcopenic obesity in a multicenter and mul …

02.09.2026journal-article

Journal of Enterprising Communities: People and Places in the Global Economy

Understanding the factors influencing social entrepreneurial intentions among Indian youth: a multi-group analysis

Mridul Trivedi, Latika Sharma, Himanshu Bagdi

Purpose This study aims to forecast university students’ intentions towards social entrepreneurship (SE). The research investigated the individual entrepreneurial orientation (IN-EO) dimensions and contextual factors that shape the intentions of Generation Z (business and engineering students) using gender like a control variable. Design/methodology/approach The data was gathered from 438 engineering and 412 business students in north-west India using a questionnaire which was self-administered. The data was furthe …