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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
31.08.2026journal-article

GSC Biological and Pharmaceutical Sciences

SQUAMOUS PAPILLOMA OF THE EXTERNAL AUDITORY CANAL: A RARE BENIGN NEOPLASM WITH BILATERAL PRESENTATION FROM NORTHEASTERN PART OF INDIA—A CASE REPORT AND COMPREHENSIVE REVIEW OF LITERATURE

Dhivya N, Shashi Shekhar Prasad, Vijay Ganesh B

Background: Squamous papilloma is a benign epithelial tumor which is most commonly seen in the oral cavity, larynx, and skin. Its occurrence in the external auditory canal (EAC) is extremely rare, with bilateral presentation in rarest case. Case Presentation: This is a case report of a 34-year-old male from the north eastern part of India who presented with foreign body sensation and aural fullness in both ears for 4-5 months. He was examined and found to have multiple small papillomatous growth in both external au …

31.08.2026journal-article

European Scientific Journal, ESJ

Clinical Significance of DPYD Gene Polymorphism Testing in Colorectal Cancer Patients Receiving Fluoropyrimidine-Based Chemotherapy: A Single-Center Study in Latvia

Sofija Vilisova, Aija Gerina

Background: Fluoropyrimidine-based chemotherapy, including 5-fluorouracil (5-FU) and capecitabine, is a cornerstone of colorectal cancer (CRC) treatment. However, treatment-related toxicity varies substantially among patients and is influenced by pharmacogenetic factors. Variants in the DPYD gene, which encodes the enzyme dihydropyrimidine dehydrogenase (DPD), are associated with reduced enzyme activity and an increased risk of severe toxicity. Aim: To evaluate the prevalence of clinically relevant DPYD polymorphis …

31.08.2026journal-article

International Journal for Research in Applied Science and Engineering Technology

VGG16 and ResNet50 for Brain Tumor Classification: Comparative Performance and Grad-CAM++ Analysis

Ganeshula Sai Raghava

Reliable categorization of brain tumors from magnetic resonance imaging (MRI) is a prerequisite for timely clinical intervention, yet the great majority of transfer-learning studies in this space report a single backbone in isolation, leaving open the question of how much of the reported performance is attributable to the chosen architecture rather than to dataset or training choices. This paper presents a controlled comparative evaluation of two ImageNet-pretrained convolutional backbones, VGG16 and ResNet50, for …

31.08.2026journal-article

Neuro-Oncology

A CAR-T Tonic Signaling Code Predicts Anti-Tumor Efficacy in Diffuse Midline Glioma

Bing Deng, Xiaowen Zhong, Dazhuan Xin, Xiao Huang, Upendra K Soni, Wenkun Ma, Mingjun Cai, Po-Yu Liang, Jun Bai, Qian Qin, Shreya Mishra, Ming Hu, Arman E Bayat, Zaili Luo, Jiajie Diao, Mei Xin, Natasha Pillay-Smiley, Trent R Hummel, Charles B Stevenson, Jessica B Foster, Peter de Blank, Scott Raskin, Carl Koschmann, Jose A Cancelas, Yi Zheng, Q Richard Lu

Abstract Background Diffuse middle glioma (DMG or DIPG) is a fatal pediatric brain tumor. Although chimeric antigen receptor (CAR) T-cell therapy shows promise, clinical outcomes remain inconsistent due to premature exhaustion, underscoring a critical need to improve CAR-T persistence. A major barrier to CAR-T efficacy is antigen-independent tonic signaling, yet the extent to which tonic signaling shapes CAR-T durability and clinical outcomes, particularly in DMG, remains incompletely defined. Methods Using a clini …

31.08.2026journal-article

Korean Journal of Clinical Oncology

The expression of stemness markers in organoids according to histological subtypes of gastric cancer

Yie-Ri Yoo, Kyoungyun Jeong, Jaeun Yoo, Hyun Myong Kim, Ji-Yeon Shin, Min Kyu Kang, Kyoyoung Park, Sa-Hong Kim, Chungyoon Kim, Jeesun Kim, Young Suk Park, Seong-Ho Kong, Hyuk-Joon Lee, Han-Kwang Yang, Do Joong Park

Purpose: Gastric cancer is a heterogeneous disease in which cancer stem cell-associated properties may contribute to tumor heterogeneity and progression. This study aimed to establish paired normal and tumor gastric organoids, characterize stemness-related gene expression, and explore its association with organoid formation.Methods: Normal and tumor tissues were obtained from 12 patients with advanced gastric cancer. A total of 28 independent organoid cultures were established from 24 tissue specimens (12 normal an …

31.08.2026journal-article

Biomedicines

FTO-Driven m6A Demethylation of TNC Promotes Epithelial–Mesenchymal Transition and Gastric Cancer Metastasis

Jiao Deng, Shuang Liu, Feng Xia, Haokun Zhang, Zhen Sun

Background/Objectives: Gastric cancer (GC) remains a leading cause of cancer-related mortality, with metastasis being the primary driver of poor prognosis. The extracellular matrix glycoprotein tenascin-C (TNC) is implicated in tumor progression and metastasis, yet its regulatory mechanisms in GC remain poorly understood. Here, we identify RNA N6-methyladenosine (m6A) demethylase fat mass and obesity-associated protein (FTO) as a key modulator of TNC expression, promoting epithelial–mesenchymal transition (EMT) and …

31.08.2026journal-article

Necmettin Erbakan Universitesi Dis Hekimligi Dergisi (NEU Dent J), Necmettin Erbakan

Evaluation of Subjective Smile Aesthetic Perceptions and Aesthetic Treatment Preferences of Adults Residents of Izmir

Tutku BAYTOK KAVCI, Münevver SÖĞÜT ÇETİN, Hande KEMALOĞLU, Murat TÜRKÜN

Aim: This study aimed to investigate the dental aesthetic satisfaction levels and treatment expectations of adults residents of İzmir, Turkey, and to evaluate the relationship between their subjective aesthetic perceptions and sociodemographic variables. Material and Methods: The cross-sectional study included 400 volunteer participants (200 females, 200 males) residents of İzmir, selected via convenience sampling. Data were collected through a 13-item original Clinical Data Collection Form encompassing demographic …

31.08.2026journal-article

International Journal of Cognitive Research in Science Engineering and Education

Criminal Treatment of The Misuse of Artificial Intelligence in The Creation of Pornographic Content and the Psychological Consequences on the Victim

Maja Petrović, Jelena Matijašević, Milena Galetin

The abuse of artificial intelligence in the creation of pornographic content represents a modern form of socially dangerous behavior that requires an adequate criminal law response and an interdisciplinary approach. The development of generative technologies has enabled the creation of highly realistically manipulated or completely synthetic content, which opens up new types of violation of the right to privacy, dignity and personal safety. These forms of abuse include the use of “deepfake” technology, the digital …

31.08.2026journal-article

International Journal of Frontiers in Engineering and Technology Research

Synergistic effect of hot rolling and T6 Heat Treatment on the Mechanical Behaviour of Gravity Die Cast A356 Alloy

Orhadahwe T.A., Ajide O.O.

Secondary processing techniques offer a practical approach for improving the performance of cast aluminium alloys without introducing reinforcement particles. This study investigated the individual and synergistic effects of hot rolling and T6 heat treatment on the mechanical behaviour of gravity die-cast A356 alloy. The alloy was produced by gravity die casting and subsequently subjected to four processing conditions: as-cast, hot rolled, T6 treated, and hot rolled followed by T6 treatment. Mechanical characterisa …

31.08.2026journal-article

GSC Advanced Research and Reviews

NANO COMPOSITES AND WATER TREATMENT: REVIEW

Fatma Abouzeid

Water scarcity and the contamination of aquatic ecosystems by industrial, agricultural, and emerging pollutants present urgent global challenges that conventional water treatment technologies struggle to address effectively. Nanocomposites—multiphase advanced materials formed by embedding functional nanoscale fillers (such as metal oxides, carbon-based nanostructures, metal-organic frameworks, or biopolymers) into macroscopic polymer, ceramic, or metallic matrices—have emerged as a transformative solution. By syner …

31.08.2026journal-article

Urogenital Tract Infection

Human Papillomavirus-Related Diseases in Urology: Diagnosis, Treatment, Prevention, and Clinical Considerations for Healthcare Providers

Kyu Won Lee, Amit Mani Upadhyay, Sangrak Bae

Human papillomavirus (HPV) has long been regarded as a gynecologic pathogen, yet its disease burden in men is substantial and rapidly increasing. In Korea, the prevalence of anogenital warts in men has tripled over the past decade, penile cancer continues to rise, and HPV-positive oropharyngeal cancer (OPC) incidence in men has already exceeded that of cervical cancer in comparable high-income countries. This review reframes HPV as an urgent urological, occupational, and public health concern. Drawing primarily on …

31.08.2026journal-article

Small

A Mechanoresponsive Drug‐Releasing Silk Balloon Catheter for Inflation‐Triggered Biophysical and Biochemical Treatment of Cardiovascular Plaque

Heesu Cho, Woojin Choi, Sung‐eun Heo, Yoonsung Noh, Youna Kim, Jiyu Kim, Yunseo Jeong, Dingyun Cui, Hana Yu, Seongeun Cho, Yoogyeong Oh, Won‐Gun Koh, Sungmin Lim, Patrick T. J. Hwang, Jinkee Hong

ABSTRACT Drug‐coated balloon catheters are widely used to dilate narrowed arteries and deliver therapeutic agents to atherosclerotic plaques; however, uncontrolled passive drug leakage during catheter navigation remains a challenge. Herein, we developed a mechanoresponsive drug‐releasing silk balloon catheter that actively releases drugs upon balloon inflation while minimizing passive drug leakage. To this end, we designed a molecular template that induces densely packed hydrophobic domains within the silk fibroin …

31.08.2026journal-article

Sriwijaya Journal of Neurology

Vitamin D Deficiency and the Risk and Severity of Chemotherapy-Induced Peripheral Neuropathy in Adults with Cancer: A Systematic Review and Meta-Analysis

Chrissanty, Ida Ayu Sri Wijayanti, Kumara Tini

Background: Chemotherapy-induced peripheral neuropathy is the commonest neurological complication of cancer treatment and has no established preventive therapy. Vitamin D deficiency is a plausible, cheaply correctable risk factor, but the only previous pooled estimate rested on two studies. Objective: To estimate the association between vitamin D deficiency or insufficiency and the risk and severity of chemotherapy-induced peripheral neuropathy, and to determine how much of the between-study variation is attributab …

31.08.2026journal-article

JNCI: Journal of the National Cancer Institute

Predictive validity of a 10-item frailty index based on a comprehensive geriatric assessment (FI-CGA-10) in older Japanese adults with cancer

Tomohiro F Nishijima, Mototsugu Shimokawa, Kohei Arimizu, Taito Esaki, Masaru Morita, Hyman B Muss

Abstract Background The 10-Item Frailty Index Based on a Comprehensive Geriatric Assessment (FI-CGA-10) is a content- and construct-validated measure for quantifying frailty from a CGA. For criterion validation, we assessed its predictive validity for overall survival (OS) in older adults with cancer. Methods This prospective cohort study included 1,630 patients with cancer who underwent CGA at a geriatric oncology service (median age 80 years). The FI-CGA-10 comprises ten CGA domains; deficits in each domain were …

31.08.2026journal-article

Indian Journal of Medical and Paediatric Oncology

Real-World Impact of Mismatch Repair Immunohistochemistry in Solid Tumors: A South Indian Cohort Study

Ashwin Oommen Philips, Navya Mathew, Mohammed Hashif, Anupam Muraleedharan, Jenice Joy, Kezy Sara Koshy, Sreeja Raju, Unnikrishnan P., Sunu Lazar Cyriac, Donna Liza Thampan, V Raman Kutty, Anilkumar Thazath

Abstract Deficient mismatch repair (dMMR) is a key biomarker for Lynch syndrome screening, adjuvant therapy decisions in early-stage colorectal and endometrial cancers, and immune checkpoint inhibitor (ICI) eligibility. However, real-world evidence on MMR immunohistochemistry (IHC) in resource-limited Indian settings remains limited. The objectives of the study were to determine the proportion of dMMR in solid tumors, to evaluate the patterns of MMR protein loss, to assess the clinical indications for MMR testing, …

31.08.2026journal-article

Jurnal Pengabdian Masyarakat Bestari

Implementation of the Human Papillomavirus (HPV) Vaccination Program to Enhance Primary Prevention of Cervical Cancer among the Academic Community and the Public at the Faculty of Medicine, Mitra Bunda Institute of Health Sciences

Sri Tati Rukiyani, Ditte Ayu Suntara, Dandy Citra, Tonny Yulianto, Yuli Mariany, Yanuarni Wulandari Baji Pamai, Sindy Nurafia, Rundito, Irbath Hamdanie, Farras Arlinda Rachmawati

Human Papillomavirus (HPV) infection is a primary cause of cervical cancer, which remains a significant public health issue in Indonesia. Primary prevention efforts through HPV vaccination need to be continuously enhanced by engaging educational institutions as partners in health promotion. The activity was conducted from February 6–8, 2026, at the Faculty of Medicine, Mitra Bunda Health Institute, Batam, comprising stages of registration, health screening, education, vaccination, and observation for Adverse Events …

31.08.2026journal-article

Indian Journal of Palliative Care

Effectiveness of Laughter Yoga on Stress in Patients with Cancer in a Selected Hospital

Athira Abraham, Jubee Joseph, Susamma Varughese

Objectives: Cancer is a life-changing diagnosis that can cause a lot of emotional pain for both patients and their families. Alongside medical treatments, it is really important to have supportive methods in place that can help ease stress and improve overall well-being. This study aimed to assess the effectiveness of Laughter Yoga in reducing perceived stress among patients with cancer. Materials and Methods: This study employed a time-series, non-randomised control group design with pre-test and post-test measure …

31.08.2026journal-article

Sains Malaysiana

Annual Effective Dose and Excess Lifetime Cancer Risk Associated with Radon Exposure in Tap Water of Chiang Khan District, Loei Province, Thailand

Ing-orn Sittitanadol, Khanuengnij prakhammin, Vitsanusat Atyotha

Objectives of this study were to determine radon concentration in tap water and assess the annual effective dose (AED) and excess lifetime cancer risk (ELCR) associated with radon exposure in tap water in Chiang Khan District, Loei Province, Thailand. A total of 40 water samples were collected to determine radon concentration using the RAD7 radon detector and analyze the physical and chemical properties of the water using a multiparameter water quality meter. The results showed that radon concentrations in tap wate …

31.08.2026journal-article

Sage Sphere International Journal

Impact of Mavacamten in the treatment of hypertrophic cardiomyopathy

Karen Jessica Pilatasig Bazurto, Millie Tiffani León Jiménez, Edison Humberto Ruiz Intriago, Evelyn Yuliana Lara Llanos, Andrés Roberto García Chavarria

Introduction: Hypertrophic cardiomyopathy is a genetic disease characterized by left ventricular hypertrophy and, in some patients, left ventricular outflow tract obstruction. Mavacamten is a primary cardiac myosin inhibitor that reduces hypercontractility, decreases actin-myosin cross-bridge formation, and promotes more efficient diastolic and systolic function. Objective: Synthesize the scientific evidence regarding the impact of mavacamten on the treatment of hypertrophic cardiomyopathy. Methods: A comprehensive …

31.08.2026journal-article

Korean Journal of Clinical Oncology

Pathological tumor response and its association with recurrence patterns and survival after neoadjuvant chemoradiotherapy and esophagectomy for esophageal squamous cell carcinoma: a tertiary care center experience from India

Feroz Khan, Suraj Surendran, Inian Samarasam, Myla Yacob, Negine Paul, Jansi Rani, Rajesh Isiah, Simon Pavamani, Balu Krishna Sasidharan, Manu Mathew

Purpose: Neoadjuvant chemoradiotherapy (NACRT) followed by esophagectomy is a standard treatment for locally advanced esophageal squamous cell carcinoma (ESCC). Pathological response, assessed using tumor regression grade (TRG), is an established prognostic marker; however, evidence regarding its association with the pattern and timing of recurrence remains limited. This study evaluated recurrence patterns, timing of recurrence, and survival outcomes according to pathological tumor response following NACRT and esop …

31.08.2026journal-article

International Journal of Molecular Sciences

OX40 (TNFRSF4) Tracks Immune Infiltration in Small Cell Lung Cancer and Shows a Cohort-Specific, Non-Replicated Association with the POU2F3/SCLC-P Subtype: A Multi-Source In Silico Analysis

Mehmet Turan Özer, Faruk Recep Özalp

OX40 (TNFRSF4) is a costimulatory T-cell receptor and OX40 agonists are in clinical development, yet its role in small cell lung cancer (SCLC) is still to be characterised. We analysed the discovery cohort (n = 77, 48 events), GSE60052 (n = 79 tumours; 48 with survival), GDSC1+GDSC2 (61 SCLC cell lines, 542 drugs) and human SCLC single-cell atlas (77,143 cells from primary and metastatic sites, 20 donors), using Cox models, FDR-controlled correlation, nested-model comparison and deconvolution. High TNFRSF4 showed a …

31.08.2026journal-article

Current Cancer Drug Targets

Clinicopathological Profiles and Prognosis of Postoperative HER2-Mutant Non-Small Cell Lung Cancer: A Real-World Analysis

Guangjian Yang, Linyan Tian, Xiaoyong Tang, Yan Wang

Background/Introduction: Patients with non-small cell lung cancer (NSCLC) harboring HER2 mutations remain at high risk of recurrence, even following radical resec-tion for early-stage disease. Currently, there is a paucity of research investigating the clini-copathological characteristics and disease-free survival (DFS) outcomes of this specific postoperative population. Methods: This retrospective study investigated the clinicopathological and molecular char-acteristics of 77 patients with surgically resected HER2 …

31.08.2026journal-article

Journal of Personalized Medicine

Personalized Risk Assessment and Treatment in Ruptured Isolated Posterior Spinal Artery Aneurysm: A Rare Case and Systematic Literature Review

Elisa Garbin, Nicola Cavasin, Luca Basaldella, Salima Magrini

Background: Ruptured isolated spinal artery aneurysms (SAAs) are not common. Posterior spinal artery aneurysms (PSAAs) are less common. Either is rarely the cause of spontaneous spinal subarachnoid hemorrhage (sSAH). Due to a few published reports, the natural course, diagnosis and optimal therapeutic strategy remain debatable and challenging. We report the case of a 60-year-old male presenting with lumbar and abdominal pain, which swiftly became associated with headache, photophobia and worsening neck pain. Spinal …

31.08.2026journal-article

Korean Journal of Clinical Oncology

Suppression of MCM2 reduces cancer stem cells and epithelial-mesenchymal transition-related phenotypes in breast cancer cells

Rae-Kwon Kim

Purpose: Minichromosome maintenance protein 2 (MCM2) is a key regulator of DNA replication and has been implicated in tumor progression. While previous studies have demonstrated its role in lung cancer stem cells (CSCs), its role in breast cancer remains unclear. This study aimed to investigate whether MCM2 regulates CSCs and epithelial-mesenchymal transition (EMT) in breast cancer.Methods: MCM2 expression and its prognostic significance were analyzed using public breast cancer datasets. MDA-MB-231 breast cancer ce …